CY1116103T1 - Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης - Google Patents

Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης

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Publication number
CY1116103T1
CY1116103T1 CY20151100188T CY151100188T CY1116103T1 CY 1116103 T1 CY1116103 T1 CY 1116103T1 CY 20151100188 T CY20151100188 T CY 20151100188T CY 151100188 T CY151100188 T CY 151100188T CY 1116103 T1 CY1116103 T1 CY 1116103T1
Authority
CY
Cyprus
Prior art keywords
substituted
tetrahydroisoquinoline derivatives
compounds
preparation
pharmaceutical compositions
Prior art date
Application number
CY20151100188T
Other languages
English (en)
Inventor
Thomas Weller
Ralf Koberstein
Hamed Aissaoui
Martine Clozel
Walter Fischli
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1116103T1 publication Critical patent/CY1116103T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Η εφεύρεση σχετίζεται με νέα παράγωγα 1,2,3,4-τετραϋδροϊσοκινολίνης του γενικού χημικού τύπου (I), όπου τα R1, R2, R3 και Χ είναι όπως ορίζονται στις αξιώσεις, και με τη χρήση τους ως δραστικά συστατικά στην παρασκευή φαρμακευτικών συνθέσεων. Η εφεύρεση αφορά επίσης σχετικές αποδόσεις που περιλαμβάνουν διαδικασίες για την παρασκευή των ενώσεων, των φαρμακευτικών συνθέσεων που περιλαμβάνουν μια ή περισσότερες εξ' αυτών των ενώσεων και μεθόδους θεραπείας που περιλαμβάνουν τη χορήγηση των εν λόγω ενώσεων σε κάποιο θηλαστικό.
CY20151100188T 2004-03-01 2015-02-20 Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης CY1116103T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004002020 2004-03-01
EP05804734.1A EP1751111B1 (en) 2004-03-01 2005-02-23 Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
CY1116103T1 true CY1116103T1 (el) 2017-02-08

Family

ID=34960649

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100188T CY1116103T1 (el) 2004-03-01 2015-02-20 Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης

Country Status (24)

Country Link
US (2) US7763638B2 (el)
EP (1) EP1751111B1 (el)
JP (1) JP4094050B2 (el)
KR (1) KR100848747B1 (el)
CN (1) CN1926109B (el)
AR (1) AR047823A1 (el)
AU (1) AU2005250077B2 (el)
BR (1) BRPI0508263B8 (el)
CA (1) CA2557163C (el)
CY (1) CY1116103T1 (el)
DK (1) DK1751111T3 (el)
ES (1) ES2533389T3 (el)
HR (1) HRP20150371T1 (el)
IL (1) IL177798A (el)
MY (1) MY144992A (el)
NO (1) NO337299B1 (el)
NZ (1) NZ550216A (el)
PL (1) PL1751111T3 (el)
PT (1) PT1751111E (el)
RU (1) RU2378257C2 (el)
SI (1) SI1751111T1 (el)
TW (1) TWI301129B (el)
WO (1) WO2005118548A1 (el)
ZA (1) ZA200606974B (el)

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