HRP20150371T1 - Supstituirani derivati 1,2,3,4-tetrahidroizokinolina - Google Patents

Supstituirani derivati 1,2,3,4-tetrahidroizokinolina Download PDF

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Publication number
HRP20150371T1
HRP20150371T1 HRP20150371TT HRP20150371T HRP20150371T1 HR P20150371 T1 HRP20150371 T1 HR P20150371T1 HR P20150371T T HRP20150371T T HR P20150371TT HR P20150371 T HRP20150371 T HR P20150371T HR P20150371 T1 HRP20150371 T1 HR P20150371T1
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Croatia
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acid
phenyl
sleep
compound according
disorders
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HRP20150371TT
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English (en)
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Thomas Weller
Ralf Koberstein
Hamed Aissaoui
Martine Clozel
Walter Fischli
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Actelion Pharmaceuticals Ltd.
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Publication of HRP20150371T1 publication Critical patent/HRP20150371T1/hr

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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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Claims (11)

1. Spoj, naznačen time, daje to (2R)-2-{(S)-6,7-dimetoksi-1-[2-(4-trifluorometil-fenil)-etil]-3,4-dihidro-1H-izokinolin-2-il}-N-metil-2-fenil-acetamid: [image] ili njegova farmaceutski prihvatljiva sol.
2. Spoj prema zahtjevu 1, naznačen time, da je to (2R)-2-{(S)-6,7-dimetoksi-1-[2-(4-trifluorometil-fenil)-etil]-3,4-dihidro-1H-izokinolin-2-il}-N-metil-2-fenil-aeetamid u obliku slobodne lužine.
3. Spoj prema zahtjevu 1, naznačen time, da je to (2R)-2-{(S)-6,7-dimetoksi-1-[2-(4-trifluorometil-fenil)-etil]-3,4-dihidro-1H-izokinolin-2-il}-N-metil-2-fenil-acetamid u obliku farmaceutski prihvatljive soli adicijske kiseline; pri čemu je kisela komponenta od navedene farmaceutski prihvatljive soli odabrana iz skupine koju čine klorovodična kiselina, bromovodična kiselina, jodovodična kiselina, sumporna kiselina, fosforna kiselina, dušična kiselina, limunska kiselina, mravlja kiselina, octena kiselina, maleična kiselina, vinska kiselina, fumarna kiselina, benzoeva kiselina, pamoična kiselina, stearinska kiselina, metansulfonska kiselina, p-toluensulfonska kiselina, salicilna kiselina, sukcinska kiselina i trifluoroctena kiselina.
4. Spoj prema zahtjevu 1, naznačen time, da je to (2R)-2-{(S)-6,7-dimetoksi-1-[2-(4- trifluorometil-fenil)-etil]-3,4-dihidro-1H-izokinolin-2-il}-N-metil-2-fenil-acetamid-sol klorovodične kiseline.
5. Spoj prema bilo kojem od zahtjeva 1 do 4, naznačen time, da se upotrebljava kao lijek.
6. Farmaceutski sastav, naznačen time, da obuhvaća najmanje jedan spoj prema bilo kojem od zahtjeva 1 do 4 i farmaceutski prihvatljiv prijenosni materijal.
7. Uporaba spoja prema bilo kojem od zahtjeva 1 do 4, naznačen time, da je za proizvodnju lijeka za prevenciju ili liječenje poremećaja ili bolesti odabrane iz skupine koju čine poremećaji hranjenja i poremećaji spavanja.
8. Uporaba prema zahtjevu 7, naznačen time, da poremećaji hranjenja obuhvaćaju metaboličku disfunkciju, kompulzivne pretilosti, emeto-bulimiju ili anoreksiju zbog nervnog poremećaja.
9. Uporaba prema zahtjevu 7, naznačen time, da poremećaj ili bolest je poremećaj spavanja.
10. Uporaba prema zahtjevu 9, naznačen time, da navedeni poremećaj spavanja obuhvaća nesanice, narkolepsiju i ostale poremećaje pretjerane pospanosti, distonije povezane sa spavanjem, sindrom nemirnih nogu, apneje u spavanju, sindrom "jet-lag" (kliničko stanje poremećaja dnevnog ritma spavanja zbog putovanja kroz vremenske zone), sindrom "shift- work" (kliničko stanje poremećaja dnevnog ritma spavanja zbog rada u smjenama), sindrom zakašnjelog ili preuranjenog vremena spavanja.
11. Uporaba prema zahtjevu 9, naznačen time, da navedeni poremećaj spavanja je nesanica.
HRP20150371TT 2004-03-01 2015-03-30 Supstituirani derivati 1,2,3,4-tetrahidroizokinolina HRP20150371T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2004002020 2004-03-01
PCT/EP2005/001879 WO2005118548A1 (en) 2004-03-01 2005-02-23 Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
EP05804734.1A EP1751111B1 (en) 2004-03-01 2005-02-23 Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

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HRP20150371T1 true HRP20150371T1 (hr) 2015-05-08

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EP (1) EP1751111B1 (hr)
JP (1) JP4094050B2 (hr)
KR (1) KR100848747B1 (hr)
CN (1) CN1926109B (hr)
AR (1) AR047823A1 (hr)
AU (1) AU2005250077B2 (hr)
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CA (1) CA2557163C (hr)
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DK (1) DK1751111T3 (hr)
ES (1) ES2533389T3 (hr)
HR (1) HRP20150371T1 (hr)
IL (1) IL177798A (hr)
MY (1) MY144992A (hr)
NO (1) NO337299B1 (hr)
NZ (1) NZ550216A (hr)
PL (1) PL1751111T3 (hr)
PT (1) PT1751111E (hr)
RU (1) RU2378257C2 (hr)
SI (1) SI1751111T1 (hr)
TW (1) TWI301129B (hr)
WO (1) WO2005118548A1 (hr)
ZA (1) ZA200606974B (hr)

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Publication number Priority date Publication date Assignee Title
WO2005118548A1 (en) * 2004-03-01 2005-12-15 Actelion Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
JP4582722B2 (ja) * 2006-03-15 2010-11-17 アクテリオン ファーマシューティカルズ リミテッド 記憶機能を向上させるテトラヒドロイソキノリン誘導体
US8003654B2 (en) 2006-04-11 2011-08-23 Actelion Pharmaceuticals Ltd. N-glycinsulfonamide derivatives and uses as orexin receptor antagonists
CA2647077A1 (en) * 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
CA2657623A1 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
WO2008078291A1 (en) 2006-12-22 2008-07-03 Actelion Pharmaceuticals Ltd 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
WO2008122513A1 (en) * 2007-04-04 2008-10-16 F. Hoffmann-La Roche Ag Heterocycles as orexin antagonists
WO2008143856A1 (en) 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
NZ580887A (en) 2007-05-23 2012-03-30 Merck Sharp & Dohme Pyridyl piperidine orexin receptor antagonists
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
PE20091010A1 (es) * 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
JP5100298B2 (ja) * 2007-10-11 2012-12-19 株式会社トクヤマ 光学活性α−スルホニルオキシカルボン酸アミド誘導体及びその製造方法
WO2009079637A1 (en) * 2007-12-18 2009-06-25 Concert Pharmaceuticals, Inc. Tetrahydroisoquinoline derivatives
CA2709694C (en) * 2007-12-28 2016-04-05 Actelion Pharmaceuticals Ltd Trisubstituted 3,4-dihydro-1h-isoquinolin compound, process for its preparation, and its use
ES2552022T3 (es) * 2007-12-28 2015-11-25 Actelion Pharmaceuticals Ltd. Procedimiento de preparación de un derivado de 3,4-dihidro-isoquinolina trisustituido enantiomérico
AU2009259494A1 (en) 2008-06-16 2009-12-23 F. Hoffmann-La Roche Ag Heteroaromatic monoamides as orexinin receptor antagonists
EP2307417A2 (en) * 2008-06-25 2011-04-13 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
BRPI0922353A2 (pt) 2008-12-02 2018-06-05 Glaxo Group Ltd Derivados de n-{[(1r,4s, 6r-3- (2-piridinilcarbonil) - 3azabiciclo [4.1.0] hept-4-il] metil}-2-heteroarilamina e usos dos mesmos
WO2010064212A1 (en) 2008-12-05 2010-06-10 Actelion Pharmaceuticals Ltd Method for obtaining an optically pure 1,2,3,4 tetrahydro-isoquinoline derivative
GB0823467D0 (en) 2008-12-23 2009-01-28 Glaxo Group Ltd Novel Compounds
WO2010095106A1 (en) 2009-02-20 2010-08-26 Actelion Pharmaceuticals Ltd Solid forms of ( 2r) -2- { ( is ) -6, 7 -dimethoxy- 1- [2- (4-triflu0r0methyl-phenyl) -ethyl] -3, 4-dihydr0-1h -isoquinolin-2-yl} -n-methyl-2-phenyl-acetamide hydrochloride
JP2012524760A (ja) 2009-04-24 2012-10-18 グラクソ グループ リミテッド オレキシンアンタゴニストとして使用される３−アザビシクロ［４．１．０］ヘプタン
WO2011001373A1 (en) 2009-06-30 2011-01-06 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
EP2451281A4 (en) * 2009-07-09 2013-03-13 Merck Sharp & Dohme ANTAGONISTS OF OREXIN RECEPTORS BASED ON TETRAHYDRONAPHTHYRIDINE
WO2011023578A1 (en) 2009-08-24 2011-03-03 Glaxo Group Limited 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder
US20120149711A1 (en) 2009-08-24 2012-06-14 Glaxo Group Limited Piperidine derivatives used as orexin antagonists
CZ2009686A3 (cs) 2009-10-19 2011-04-27 Zentiva, K. S Zpusob prípravy (1S)-6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-1,2,3,4-tetrahydroisochinolinu
KR20120105449A (ko) 2009-10-23 2012-09-25 얀센 파마슈티카 엔.브이. 오렉신 수용체 조절제로서의 이치환된 옥타하이드로피롤로［3,4-ｃ］피롤
CZ2009791A3 (cs) 2009-11-25 2011-06-01 Zentiva, K. S. Krystalická a amorfní forma hydrochloridu (2R)-2-{(1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-fenyl)-ethyl]-3,4-dihydro-1H-isochinolin-2-yl}-N-methyl-2-fenyl-acetamidu (almorexantu) a zpusob jejich prípravy
CZ20106A3 (cs) * 2010-01-05 2011-08-10 Zentiva, K. S Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
EP2608787B1 (en) 2010-08-24 2019-11-20 Idorsia Pharmaceuticals Ltd Proline sulfonamide derivatives as orexin receptor antagonists
UA108510C2 (en) 2010-09-22 2015-05-12 Eisai R&D Man Co Ltd Cyclopropane compound
WO2012063207A1 (en) 2010-11-10 2012-05-18 Actelion Pharmaceuticals Ltd Lactam derivatives useful as orexin receptor antagonists
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
WO2012089607A1 (en) 2010-12-28 2012-07-05 Glaxo Group Limited Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
WO2012089606A1 (en) 2010-12-28 2012-07-05 Glaxo Group Limited Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
JP5987005B2 (ja) 2011-02-18 2016-09-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン拮抗薬として有用な新規なピラゾール及びイミダゾール誘導体
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
US8980910B2 (en) * 2011-04-01 2015-03-17 Indiana University Research And Technology Corporation Treatment of glaucoma
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
DK2776430T3 (en) 2011-11-08 2016-05-09 Actelion Pharmaceuticals Ltd 2- (1,2,3-triazol-2-yl) benzamide and 3- (1,2,3-triazol-2-yl) PICOLINAMIDDERIVATER AS orexin receptor antagonists
JP6346862B2 (ja) 2012-02-07 2018-06-20 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
US9732075B2 (en) 2012-06-04 2017-08-15 Idorsia Pharmaceuticals Ltd Benzimidazole-proline derivatives
JP6244365B2 (ja) 2012-10-10 2017-12-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ［オルトビ−（ヘテロ−）アリール］−［２−（メタビ−（ヘテロ−）アリール）−ピロリジン−１−イル］−メタノン誘導体であるオレキシン受容体アンタゴニスト
WO2014141065A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
SI3077389T1 (en) 2013-12-03 2018-01-31 Idorsia Pharmaceuticals Ltd (S) - (2- (6-CHLORO-7-METHYL-1 H-BENZO (D) IMIDAZOL-2-YL) -2-METHYLPYROLIDIN-1-YL (5-METHOXY-2- (2H- , 2,3-TRIAZOL-2-IL) PHENYL) METHANONE AND ITS USE AS ANTAGONISTS OF OREXIN RECEPTOR
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
WO2015083094A1 (en) 2013-12-04 2015-06-11 Actelion Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
US10188652B2 (en) 2014-10-23 2019-01-29 Eisai R&D Management Co., Ltd. Compositions and methods for treating insomnia
EP3369736A4 (en) * 2015-10-29 2019-04-24 University of Tsukuba MORPHINANE DERIVATIVE AND MEDICAL USE THEREOF
BR112018016446B1 (pt) 2016-02-12 2024-02-06 Eolas Therapeutics, Inc. Composto de piperidina halo-substituída, composição farmacêutica compreendendo dito composto e uso terapêutico dos mesmos
CA2960253A1 (en) 2016-03-10 2017-09-10 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
KR101671008B1 (ko) * 2016-04-13 2016-12-01 한국과학기술원 TNP(N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 식욕억제용 약학적 조성물
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
CN110117271A (zh) * 2018-02-06 2019-08-13 中国科学院上海药物研究所 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物
CN117126134A (zh) * 2022-05-20 2023-11-28 中国科学院上海药物研究所 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480714A (en) 1966-02-07 1969-11-25 Ciba Geigy Corp N-substituted isoquinolines as antiprotozoal agents
DD204917A1 (de) 1981-12-31 1983-12-14 Gerhard Kempter Verfahren zur herstellung phenylsubstituierter und benzkondensierter cycloalkylaminoacetanilide
DE3419642A1 (de) 1984-05-25 1985-11-28 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagenz zur vollenzymatischen bestimmung von harnstoff
JPS6153268A (ja) 1984-08-24 1986-03-17 Hokuriku Seiyaku Co Ltd アントラニルアミド誘導体
DD261158A1 (de) 1987-01-08 1988-10-19 Univ Halle Wittenberg Verfahren zur herstellung von 2-aminoalkyl-3,4-dihydro-4-oxo-7h-pyrrolo 2.3-d pyrimidinen
DD258817A1 (de) 1987-01-19 1988-08-03 Univ Halle Wittenberg Verfahren zur herstellung von 2-(aminoalkyl) -pyrimido-4,5'-5,4 pyrrolo 3,2-f 1,4 thiazepinderivaten
ES2104887T3 (es) 1991-01-11 1997-10-16 Glaxo Lab Sa Derivados de acridina.
JPH07267961A (ja) 1994-03-30 1995-10-17 Taisho Pharmaceut Co Ltd ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体
US6184381B1 (en) 1995-12-06 2001-02-06 Japan Science & Technology Corp. Process for preparing optically active compounds
EP1007074B1 (en) 1996-08-02 2003-12-17 The Scripps Research Institute Hypothalamus-specific polypeptides
JPH1095766A (ja) 1996-09-19 1998-04-14 Sanwa Kagaku Kenkyusho Co Ltd アセトアミド誘導体、及びその用途
AU716151B2 (en) 1996-11-27 2000-02-17 Pfizer Inc. Apo B-secretion/MTP inhibitory amides
AR016817A1 (es) 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
EP1075478B1 (en) 1998-05-08 2003-04-16 SmithKline Beecham plc Phenylurea and phenylthio urea derivatives
WO2000029399A1 (en) 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
GB9827467D0 (en) 1998-12-15 1999-02-10 Zeneca Ltd Chemical compounds
GB9914015D0 (en) 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
ES2226785T3 (es) 1999-02-12 2005-04-01 Smithkline Beecham Plc Derivados de fenilurea como antagonistas de los receptores de orexina.
DE60002984T2 (de) 1999-02-12 2004-03-11 Smithkline Beecham P.L.C., Brentford Neue verwendung von orexinrezeptorantagonisten
ATE282614T1 (de) 1999-02-12 2004-12-15 Smithkline Beecham Plc Phenylharnstoff und phenylthioharnstoffderivate
WO2000047576A1 (en) 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
GB9914025D0 (en) 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
WO2001002368A1 (en) 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
WO2001008720A2 (en) 1999-07-30 2001-02-08 The Board Of Trustees Of The Leland Stanford Junior University Hypocretin and hypocretin receptors in regulation of sleep and related disorders
US6319710B1 (en) 1999-08-23 2001-11-20 Decode Genetics Ehf. Human narcolepsy gene
US6410712B1 (en) 1999-10-25 2002-06-25 Decode Genetics Ehf. Human narcolepsy gene
WO2001040304A1 (en) 1999-12-01 2001-06-07 Smithkline Beecham Corporation Monkey orexin 2 receptor
WO2001040259A2 (en) 1999-12-02 2001-06-07 Smithkline Beecham Corporation Monkey orexin 1 receptor
US20020064814A1 (en) 1999-12-07 2002-05-30 Ellis Catherine E. Dog orexin 1 receptor
ES2234840T3 (es) 2000-03-14 2005-07-01 Actelion Pharmaceuticals Ltd. Derivados de 1,2,3,4- tetrahidroisoquinolina.
WO2001074162A1 (en) 2000-04-04 2001-10-11 The Regents Of The University Of California Treatment of sleep disorders with hypocretin-1
EP1288202A4 (en) 2000-05-11 2003-07-02 Banyu Pharma Co Ltd N-ACYLTETRAHYDROISOQUINOLINE DERIVATIVES
PT1289955E (pt) 2000-06-16 2005-08-31 Smithkline Beecham Plc Piperidinas para utilizacao como antagonistas dos receptores da orexina
ATE286897T1 (de) 2000-11-28 2005-01-15 Smithkline Beecham Plc Morpholinderivate als antagonisten an orexinrezeptoren
WO2002087606A2 (en) 2000-12-20 2002-11-07 Sri International Modulators of the hypocretin system and methods of screening therefor
WO2002051232A2 (en) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
CZ20032990A3 (cs) 2001-05-05 2004-04-14 Smithkline Beecham P. L. C. N-aroylové cyklické aminy
JP2004534026A (ja) 2001-05-05 2004-11-11 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー オレキシン受容体アンタゴニストとしてのｎ−アロイルサイクリックアミン誘導体
BR0210609A (pt) 2001-06-28 2004-07-20 Smithkline Beecham Plc Derivados de amina cìclica n-aroila como antagonistas do receptor da orexina
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
GB0124463D0 (en) 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0127145D0 (en) 2001-11-10 2002-01-02 Smithkline Beecham Compounds
GB0130388D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130341D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130335D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130393D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
NZ535885A (en) 2002-04-26 2007-05-31 Hoffmann La Roche Isoquinoline derivatives and their use as monoamine oxidase B inhibitors
US7662780B2 (en) 2002-08-29 2010-02-16 The Regents Of The University Of California Administering hypocretin to obese individuals
DE60309481T2 (de) 2002-09-18 2007-06-21 Glaxo Group Ltd., Greenford Cyclische n-aroylamine als orexinrezeptorantagonisten
GB0225938D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
GB0225884D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
GB0225944D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
AU2003299648A1 (en) 2002-12-12 2004-06-30 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-(1,3)-dioxanes
WO2004054510A2 (en) 2002-12-13 2004-07-01 Janssen Pharmaceutica N.V. Method for identifying modulators of human orexin-2 receptor
WO2004085403A1 (en) * 2003-03-26 2004-10-07 Actelion Pharmaceuticals Ltd Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists
WO2005118548A1 (en) * 2004-03-01 2005-12-15 Actelion Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
JP4582722B2 (ja) 2006-03-15 2010-11-17 アクテリオン ファーマシューティカルズ リミテッド 記憶機能を向上させるテトラヒドロイソキノリン誘導体
CA2647077A1 (en) 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists

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