NO20061509L - Selektiv syntese av CF3-substituerte pyrimidiner - Google Patents

Selektiv syntese av CF3-substituerte pyrimidiner

Info

Publication number
NO20061509L
NO20061509L NO20061509A NO20061509A NO20061509L NO 20061509 L NO20061509 L NO 20061509L NO 20061509 A NO20061509 A NO 20061509A NO 20061509 A NO20061509 A NO 20061509A NO 20061509 L NO20061509 L NO 20061509L
Authority
NO
Norway
Prior art keywords
formula
substituted pyrimidines
selective synthesis
compound
hnr4r4
Prior art date
Application number
NO20061509A
Other languages
English (en)
Other versions
NO334383B1 (no
Inventor
Michael Joseph Luzzio
John Charles Kath
Daniel Tyler Richter
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20061509L publication Critical patent/NO20061509L/no
Publication of NO334383B1 publication Critical patent/NO334383B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Det er beskrevet en fremgangsmåte for å fremstille en forbindelse av formel (I), hvor X\ X^ og R^-R'' er som definert heri. Fremgangsmåten omfatter omsetning av en forbindelse av formel (II) med et amin av formel (III) (HNR^R'') i nærvær av en Lewis syre og en ikke-nukleofil base. 2,4-diaminopyrimidinenheten er en felles komponent i en rekke biologisk aktive, legemiddel-lignende molekyler og pyrimidinderivater er furmet å være nyttige i behandlingen av abnormal ceUevekst, så som kreft, i pattedyr.
NO20061509A 2003-09-05 2006-04-03 Fremgangsmåte for fremstilling av av CF3-substituerte pyrimidiner NO334383B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50073303P 2003-09-05 2003-09-05
PCT/IB2004/002744 WO2005023780A1 (en) 2003-09-05 2004-08-24 Selective synthesis of cf3-substituted pyrimidines

Publications (2)

Publication Number Publication Date
NO20061509L true NO20061509L (no) 2006-04-03
NO334383B1 NO334383B1 (no) 2014-02-24

Family

ID=34272990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061509A NO334383B1 (no) 2003-09-05 2006-04-03 Fremgangsmåte for fremstilling av av CF3-substituerte pyrimidiner

Country Status (24)

Country Link
US (1) US7122670B2 (no)
EP (1) EP1663991B1 (no)
JP (1) JP4842816B2 (no)
KR (1) KR100694732B1 (no)
CN (1) CN100465164C (no)
AR (1) AR045557A1 (no)
BR (1) BRPI0414059B8 (no)
CA (1) CA2537373C (no)
CO (1) CO5650237A2 (no)
CY (1) CY1106370T1 (no)
DE (1) DE602004004287T2 (no)
DK (1) DK1663991T3 (no)
ES (1) ES2276344T3 (no)
HK (1) HK1091824A1 (no)
IL (1) IL173363A (no)
MX (1) MXPA06002552A (no)
NO (1) NO334383B1 (no)
NZ (1) NZ544969A (no)
PL (1) PL1663991T3 (no)
PT (1) PT1663991E (no)
RU (1) RU2315759C2 (no)
TW (1) TWI283667B (no)
WO (1) WO2005023780A1 (no)
ZA (1) ZA200600747B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338545T3 (es) * 2002-12-20 2010-05-10 Pfizer Products Inc. Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
US20060205945A1 (en) * 2004-05-14 2006-09-14 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
JP4778717B2 (ja) * 2005-03-25 2011-09-21 富士フイルム株式会社 複素環式化合物の製造方法
DE102007010801A1 (de) 2007-03-02 2008-09-04 Bayer Cropscience Ag Diaminopyrimidine als Fungizide
CN101678215B (zh) 2007-04-18 2014-10-01 辉瑞产品公司 用于治疗异常细胞生长的磺酰胺衍生物
KR101294731B1 (ko) * 2007-06-04 2013-08-16 삼성디스플레이 주식회사 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법
EP2268621A1 (en) 2008-03-20 2011-01-05 Boehringer Ingelheim International GmbH Regioselective preparation of substituted pyrimidines
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
DE102009006643A1 (de) 2009-01-29 2010-08-05 Saltigo Gmbh Herstellung von halogenierten N-heteroaromatischen Polyhalogenderivaten
TW201100441A (en) * 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
US8729265B2 (en) 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) * 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
PL2646448T3 (pl) 2010-11-29 2017-12-29 OSI Pharmaceuticals, LLC Makrocykliczne inhibitory kinazy
US8546443B2 (en) 2010-12-21 2013-10-01 Boehringer Ingelheim International Gmbh Benzylic oxindole pyrimidines
ES2691673T3 (es) 2011-02-17 2018-11-28 Cancer Therapeutics Crc Pty Limited Inhibidores de Fak
DK2675794T3 (da) 2011-02-17 2019-05-06 Cancer Therapeutics Crc Pty Ltd Selektive fak-inhibitorer
WO2014126954A1 (en) 2013-02-13 2014-08-21 OSI Pharmaceuticals, LLC Regioselective synthesis of substituted pyrimidines
GB2538476B (en) * 2014-05-08 2019-03-20 Tosoh F Tech Inc 5-(Trifluoromethyl)pyrimidine derivatives and method for producing same
JP6391985B2 (ja) * 2014-05-16 2018-09-19 東ソー・ファインケム株式会社 ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6391988B2 (ja) * 2014-05-21 2018-09-19 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体
CN108440499A (zh) * 2018-03-22 2018-08-24 盐城师范学院 一种色瑞替尼及其关键中间体的制备方法
CN114213339B (zh) * 2021-12-20 2023-10-31 苏州康纯医药科技有限公司 一种表皮细胞生长因子受体突变抑制剂的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
UY27487A1 (es) * 2001-10-17 2003-05-30 Boehringer Ingelheim Pharma Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación

Also Published As

Publication number Publication date
ES2276344T3 (es) 2007-06-16
KR20060030918A (ko) 2006-04-11
IL173363A (en) 2010-05-31
JP2007504211A (ja) 2007-03-01
RU2006106727A (ru) 2006-06-27
HK1091824A1 (en) 2007-01-26
CA2537373C (en) 2009-10-20
CY1106370T1 (el) 2011-10-12
PT1663991E (pt) 2007-02-28
CN1845906A (zh) 2006-10-11
BRPI0414059A (pt) 2006-10-24
BRPI0414059B1 (pt) 2018-11-06
PL1663991T3 (pl) 2007-04-30
AU2004270480A1 (en) 2005-03-17
NO334383B1 (no) 2014-02-24
RU2315759C2 (ru) 2008-01-27
DE602004004287T2 (de) 2007-06-21
US7122670B2 (en) 2006-10-17
KR100694732B1 (ko) 2007-03-14
TW200514773A (en) 2005-05-01
EP1663991A1 (en) 2006-06-07
WO2005023780A1 (en) 2005-03-17
JP4842816B2 (ja) 2011-12-21
MXPA06002552A (es) 2006-06-20
DK1663991T3 (da) 2007-04-10
CN100465164C (zh) 2009-03-04
IL173363A0 (en) 2006-06-11
CO5650237A2 (es) 2006-06-30
NZ544969A (en) 2008-07-31
DE602004004287D1 (de) 2007-02-22
CA2537373A1 (en) 2005-03-17
TWI283667B (en) 2007-07-11
EP1663991B1 (en) 2007-01-10
US20050101620A1 (en) 2005-05-12
BRPI0414059B8 (pt) 2021-05-25
AR045557A1 (es) 2005-11-02
ZA200600747B (en) 2007-03-28

Similar Documents

Publication Publication Date Title
NO20061509L (no) Selektiv syntese av CF3-substituerte pyrimidiner
TW200740805A (en) Novel compounds
DE60019317D1 (de) Chinazolinderivate
CY1106677T1 (el) Παρασκευη ν1-(2’-πυριδυλ)-1, 2-προπανοδιαμινο σουλφαμικου οξεος και χρηση αυτου στη συνθεση βιολογικως δραστικων πιπεραζινων
NO333251B1 (no) Fremgangsmate for fremstilling av N-substituerte 2-cyanopyrrolidoner
AU2006258051A1 (en) Process for the synthesis of 5- (methyl-1H-imidazol-1-yl) -3- (tri fluorome th yl) -benzeneamine
NO20074055L (no) Prosesser for a fremstille 4-(fenoksy-5-metylpyrimidin-4-yloksy)piperidin-1-karboksylsyrederivater og relaterte forbindelser
AU2012319291B2 (en) Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein
DK1038875T3 (da) Imidazopyridine- derivativer og fremgangsmåde til fremstilling deraf
CA2499822A1 (en) Novel pyrimidineamide derivatives and the use thereof
JP4268871B2 (ja) ピリミジノン化合物及びその薬剤として許容される塩の製造方法
TW200604161A (en) Chemical process
US3898230A (en) Sydnone imine compounds
CA1037953A (en) 2,4-diamino-5-benzylpyrimidines
WO2005063720A1 (ja) アミド誘導体及び医薬
NO20055991L (no) Fremgangsmate for syntetisering av heterocykliske forbindelser
DK1182199T3 (da) Fremgangsmåde til fremstilling af amicsyre
JPH08104679A (ja) キナゾリン−４（３ｈ）−オン誘導体
TR200003877T2 (tr) İnsan CD23 üretiminin ve TNF salınmasının ihhibitörleri olan hiydroxamic acid türevleri
US5234925A (en) 2-aza-2-desamino analogues of 5,8-dideazafolic acid
GR3023144T3 (en) Inhibitors of pneumocystis carinii dihydrofolate reductase
PL352465A1 (en) Novel method of obtaining n-(1,1-dimethyl)-4-[[5'-ethoxy-4-cis[2-[4-morpholin]ethoxy]2'-oxospiro[cycloexane-1,3'-[3h]indol]-1'(2'h)yl]-sulphonyl]-3-methoxybenzamide and its salts
AU782818C (en) Process for producing substituted alkylamine derivative
JP4178793B2 (ja) キナゾリン−４−オン誘導体の製造法
PL363756A1 (en) Process for preparing fluconazole and its crystal modifications