DK1663991T3 - Selektiv syntese af CF3-substituerede pyrimidiner - Google Patents

Selektiv syntese af CF3-substituerede pyrimidiner

Info

Publication number
DK1663991T3
DK1663991T3 DK04769170T DK04769170T DK1663991T3 DK 1663991 T3 DK1663991 T3 DK 1663991T3 DK 04769170 T DK04769170 T DK 04769170T DK 04769170 T DK04769170 T DK 04769170T DK 1663991 T3 DK1663991 T3 DK 1663991T3
Authority
DK
Denmark
Prior art keywords
substituted pyrimidines
selective synthesis
selective
synthesis
pyrimidines
Prior art date
Application number
DK04769170T
Other languages
English (en)
Inventor
Daniel Tyler Richter
Michael Joseph Luzzio
John Charles Kath
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1663991T3 publication Critical patent/DK1663991T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK04769170T 2003-09-05 2004-08-24 Selektiv syntese af CF3-substituerede pyrimidiner DK1663991T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50073303P 2003-09-05 2003-09-05
PCT/IB2004/002744 WO2005023780A1 (en) 2003-09-05 2004-08-24 Selective synthesis of cf3-substituted pyrimidines

Publications (1)

Publication Number Publication Date
DK1663991T3 true DK1663991T3 (da) 2007-04-10

Family

ID=34272990

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04769170T DK1663991T3 (da) 2003-09-05 2004-08-24 Selektiv syntese af CF3-substituerede pyrimidiner

Country Status (24)

Country Link
US (1) US7122670B2 (da)
EP (1) EP1663991B1 (da)
JP (1) JP4842816B2 (da)
KR (1) KR100694732B1 (da)
CN (1) CN100465164C (da)
AR (1) AR045557A1 (da)
BR (1) BRPI0414059B8 (da)
CA (1) CA2537373C (da)
CO (1) CO5650237A2 (da)
CY (1) CY1106370T1 (da)
DE (1) DE602004004287T2 (da)
DK (1) DK1663991T3 (da)
ES (1) ES2276344T3 (da)
HK (1) HK1091824A1 (da)
IL (1) IL173363A (da)
MX (1) MXPA06002552A (da)
NO (1) NO334383B1 (da)
NZ (1) NZ544969A (da)
PL (1) PL1663991T3 (da)
PT (1) PT1663991E (da)
RU (1) RU2315759C2 (da)
TW (1) TWI283667B (da)
WO (1) WO2005023780A1 (da)
ZA (1) ZA200600747B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL379330A1 (pl) * 2002-12-20 2006-08-21 Pfizer Products Inc. Pochodne pirymidyny dla leczenia nienormalnego wzrostu komórek
US20060205945A1 (en) * 2004-05-14 2006-09-14 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
JP4778717B2 (ja) * 2005-03-25 2011-09-21 富士フイルム株式会社 複素環式化合物の製造方法
DE102007010801A1 (de) 2007-03-02 2008-09-04 Bayer Cropscience Ag Diaminopyrimidine als Fungizide
WO2008129380A1 (en) * 2007-04-18 2008-10-30 Pfizer Products Inc. Sulfonyl amide derivatives for the treatment of abnormal cell growth
KR101294731B1 (ko) * 2007-06-04 2013-08-16 삼성디스플레이 주식회사 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법
JP2011515372A (ja) * 2008-03-20 2011-05-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリミジン類の位置選択的製造法
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
DE102009006643A1 (de) 2009-01-29 2010-08-05 Saltigo Gmbh Herstellung von halogenierten N-heteroaromatischen Polyhalogenderivaten
TW201100441A (en) * 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
US8933227B2 (en) * 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
EP2464633A1 (en) * 2009-08-14 2012-06-20 Boehringer Ingelheim International GmbH Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
EP2646448B1 (en) 2010-11-29 2017-08-30 OSI Pharmaceuticals, LLC Macrocyclic kinase inhibitors
US8546443B2 (en) 2010-12-21 2013-10-01 Boehringer Ingelheim International Gmbh Benzylic oxindole pyrimidines
EP2675793B1 (en) 2011-02-17 2018-08-08 Cancer Therapeutics Crc Pty Limited Fak inhibitors
CN103534240B (zh) 2011-02-17 2015-12-09 癌症疗法Crc私人有限公司 选择性fak抑制剂
WO2014126954A1 (en) 2013-02-13 2014-08-21 OSI Pharmaceuticals, LLC Regioselective synthesis of substituted pyrimidines
JP6637880B2 (ja) * 2014-05-08 2020-01-29 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6391985B2 (ja) * 2014-05-16 2018-09-19 東ソー・ファインケム株式会社 ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6391988B2 (ja) * 2014-05-21 2018-09-19 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体
CN108440499A (zh) * 2018-03-22 2018-08-24 盐城师范学院 一种色瑞替尼及其关键中间体的制备方法
CN114213339B (zh) * 2021-12-20 2023-10-31 苏州康纯医药科技有限公司 一种表皮细胞生长因子受体突变抑制剂的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
EP2090571B1 (de) * 2001-10-17 2012-05-16 Boehringer Ingelheim Pharma GmbH & Co. KG Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
NZ544969A (en) 2008-07-31
CO5650237A2 (es) 2006-06-30
EP1663991A1 (en) 2006-06-07
RU2315759C2 (ru) 2008-01-27
CN1845906A (zh) 2006-10-11
DE602004004287D1 (de) 2007-02-22
PT1663991E (pt) 2007-02-28
DE602004004287T2 (de) 2007-06-21
CY1106370T1 (el) 2011-10-12
BRPI0414059B8 (pt) 2021-05-25
ZA200600747B (en) 2007-03-28
RU2006106727A (ru) 2006-06-27
KR100694732B1 (ko) 2007-03-14
BRPI0414059B1 (pt) 2018-11-06
NO20061509L (no) 2006-04-03
JP2007504211A (ja) 2007-03-01
TWI283667B (en) 2007-07-11
IL173363A0 (en) 2006-06-11
MXPA06002552A (es) 2006-06-20
JP4842816B2 (ja) 2011-12-21
TW200514773A (en) 2005-05-01
US7122670B2 (en) 2006-10-17
NO334383B1 (no) 2014-02-24
AU2004270480A1 (en) 2005-03-17
CA2537373A1 (en) 2005-03-17
KR20060030918A (ko) 2006-04-11
BRPI0414059A (pt) 2006-10-24
IL173363A (en) 2010-05-31
CN100465164C (zh) 2009-03-04
ES2276344T3 (es) 2007-06-16
HK1091824A1 (en) 2007-01-26
CA2537373C (en) 2009-10-20
AR045557A1 (es) 2005-11-02
WO2005023780A1 (en) 2005-03-17
EP1663991B1 (en) 2007-01-10
US20050101620A1 (en) 2005-05-12
PL1663991T3 (pl) 2007-04-30

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