NO20053827L - Nye forbindelser. - Google Patents

Nye forbindelser.

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Publication number
NO20053827L
NO20053827L NO20053827A NO20053827A NO20053827L NO 20053827 L NO20053827 L NO 20053827L NO 20053827 A NO20053827 A NO 20053827A NO 20053827 A NO20053827 A NO 20053827A NO 20053827 L NO20053827 L NO 20053827L
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NO
Norway
Prior art keywords
sup
sub
alkyl
optionally substituted
nitrogen
Prior art date
Application number
NO20053827A
Other languages
English (en)
Other versions
NO20053827D0 (no
Inventor
Anthony Howard Ingall
Martin Edward Cooper
Simon David Guile
Rukhsana Tasneem
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20053827D0 publication Critical patent/NO20053827D0/no
Publication of NO20053827L publication Critical patent/NO20053827L/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)

Abstract

Sammendrag Oppfinnelsen angår thienopyridazinoner av formel (I): hvor: R1 er C1-6 alkyl, C2-6 alkenyl eller C3-6 cykloakyl som er eventuelt substituert med C1-6 alkyl, hvor hver av de ovennevnte er eventuelt substituert med et eller flere halogenatomer; R2 er C1-6 alkyl; R3 er en gruppe CO-G eller SO2-G hvor G er en 5- eller 6-leddet ring som inneholder et nitrogenatom og et annet heteroatom valgt fra oksygen og svovel som er i nabostilling til nitrogenatomet og er eventuelt substituert med opptil 3 grupper valgt fra hydroksyl og C1-4 alkyl; Q er CR5R6 hvor R5 og R6 er som definert i beskrivelsen; og R4 er et 5- til 10-leddet mono- eller bi-cyklisk aromatisk ringsystem, som inneholder 0 til 4 heteroatomer som er uavhengig valgt fra nitrogen, oksygen og svovel, hvor ring-systemet er eventuelt substituert som beskrevet i beskrivelsen, og farmasøytisk akseptable salter og solvater derav. Fremgangsmåter for deres fremstilling, farmasøytiske preparater som inneholder dem og deres anvendelse i terapi, spesielt ved modulering av autoimmun sykdom, er også beskrevet.
NO20053827A 2003-01-17 2005-08-15 Nye forbindelser. NO20053827L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0300120A SE0300120D0 (sv) 2003-01-17 2003-01-17 Novel compounds
PCT/SE2004/000051 WO2004065393A1 (en) 2003-01-17 2004-01-15 Novel compounds

Publications (2)

Publication Number Publication Date
NO20053827D0 NO20053827D0 (no) 2005-08-15
NO20053827L true NO20053827L (no) 2005-10-17

Family

ID=20290155

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053827A NO20053827L (no) 2003-01-17 2005-08-15 Nye forbindelser.

Country Status (23)

Country Link
US (2) US7064126B2 (no)
EP (1) EP1587809B1 (no)
JP (1) JP4589298B2 (no)
KR (1) KR20050092759A (no)
CN (1) CN100358900C (no)
AT (1) ATE375352T1 (no)
AU (1) AU2004205617B2 (no)
BR (1) BRPI0406780A (no)
CA (1) CA2512736A1 (no)
DE (1) DE602004009407T2 (no)
ES (1) ES2293208T3 (no)
HK (1) HK1081958A1 (no)
IL (1) IL169363A (no)
IS (1) IS2503B (no)
MX (1) MXPA05007494A (no)
NO (1) NO20053827L (no)
NZ (1) NZ541216A (no)
PL (1) PL378223A1 (no)
RU (1) RU2331646C2 (no)
SE (1) SE0300120D0 (no)
UA (1) UA80175C2 (no)
WO (1) WO2004065393A1 (no)
ZA (1) ZA200505273B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
JP2006515880A (ja) * 2003-01-17 2006-06-08 アストラゼネカ・アクチエボラーグ 自己免疫疾患の調節におけるチエノピリダジノンとその使用
CA2550361C (en) 2003-12-19 2014-04-29 Prabha Ibrahim Compounds and methods for development of ret modulators
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7846941B2 (en) 2005-05-17 2010-12-07 Plexxikon, Inc. Compounds modulating c-kit and c-fms activity and uses therefor
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CN101528752A (zh) * 2006-10-16 2009-09-09 辉瑞产品公司 治疗性吡唑基噻吩并吡啶
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
AU2007336811A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
CN101808994B (zh) 2007-07-17 2013-05-15 普莱希科公司 用于激酶调节的化合物和方法以及其适应症
MA33028B1 (fr) 2009-04-03 2012-02-01 Plexxikon Inc Compositions et utilisations associees
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CN102695417A (zh) 2009-11-06 2012-09-26 普莱希科公司 用于激酶调节的化合物和方法及其适应症
BR112013020041B1 (pt) 2011-02-07 2021-11-23 Plexxikon, Inc Compostos e composições para a modulação de quinases e uso dos mesmos
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9200005B2 (en) 2013-03-13 2015-12-01 AbbVie Deutschland GmbH & Co. KG Inhibitor compounds of phosphodiesterase type 10A
BR112016008060A8 (pt) * 2013-10-21 2020-03-17 Genosco composto, formulação farmacêutica, processo para preparar um composto de fórmula (i), método para preparação de um composto, uso do composto ou sal farmaceuticamente aceitável do mesmo

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620860A1 (de) * 1986-06-21 1987-12-23 Basf Ag Substituierte acrylsaeureester und fungizide, die diese verbindungen enthalten
US6469014B1 (en) * 1997-05-28 2002-10-22 Astrazeneca Ab Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
SE9702001D0 (sv) 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
CN1284079A (zh) 1997-12-05 2001-02-14 阿斯特拉曾尼卡英国有限公司 新化合物
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
JP2002523511A (ja) * 1998-08-28 2002-07-30 アストラゼネカ・アクチエボラーグ 新規化合物
GB0117583D0 (en) 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
JP2006515880A (ja) 2003-01-17 2006-06-08 アストラゼネカ・アクチエボラーグ 自己免疫疾患の調節におけるチエノピリダジノンとその使用

Also Published As

Publication number Publication date
IL169363A0 (en) 2007-07-04
DE602004009407D1 (de) 2007-11-22
DE602004009407T2 (de) 2008-07-24
IS2503B (is) 2009-04-15
RU2005121493A (ru) 2006-02-20
US20060223809A1 (en) 2006-10-05
ATE375352T1 (de) 2007-10-15
BRPI0406780A (pt) 2006-01-17
CN1761670A (zh) 2006-04-19
US20060052380A1 (en) 2006-03-09
ES2293208T3 (es) 2008-03-16
JP4589298B2 (ja) 2010-12-01
NO20053827D0 (no) 2005-08-15
AU2004205617B2 (en) 2007-03-08
UA80175C2 (en) 2007-08-27
JP2006515373A (ja) 2006-05-25
KR20050092759A (ko) 2005-09-22
PL378223A1 (pl) 2006-03-20
EP1587809B1 (en) 2007-10-10
NZ541216A (en) 2008-05-30
CA2512736A1 (en) 2004-08-05
ZA200505273B (en) 2006-04-26
WO2004065393A1 (en) 2004-08-05
CN100358900C (zh) 2008-01-02
US7064126B2 (en) 2006-06-20
RU2331646C2 (ru) 2008-08-20
SE0300120D0 (sv) 2003-01-17
AU2004205617A1 (en) 2004-08-05
IS7982A (is) 2005-08-15
EP1587809A1 (en) 2005-10-26
IL169363A (en) 2011-02-28
MXPA05007494A (es) 2005-09-21
HK1081958A1 (en) 2006-05-26

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