HUP0400460A2 - Kortikotropin-feloldó faktor (CRF) receptor antagonista triciklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Kortikotropin-feloldó faktor (CRF) receptor antagonista triciklusos vegyületek és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400460A2 HUP0400460A2 HU0400460A HUP0400460A HUP0400460A2 HU P0400460 A2 HUP0400460 A2 HU P0400460A2 HU 0400460 A HU0400460 A HU 0400460A HU P0400460 A HUP0400460 A HU P0400460A HU P0400460 A2 HUP0400460 A2 HU P0400460A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- haloalkyl
- alkynyl
- alkenyl
- Prior art date
Links
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 title abstract 3
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 title abstract 3
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 8
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 nitro- Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004149 thio group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- External Artificial Organs (AREA)
Abstract
A találmány (I) általános képletű vegyületekre - amelyek képletében Raril- vagy heteroarilcsoport, amelyek mindegyike adott esetben akövetkező csoportból kiválasztott 1-4 szubsztituenst hordozhat:halogénatom, alkil-, alkoxi-, halogén-alkil-, alkenil-, alkinil-,halogén-alkoxi-, mono- vagy dialkil-amino-, nitro-, ciano- és/vagy -R5csoport; R1 hidrogén-, halogénatom, alkil-, alkenil-, alkinil-,halogén-alkil-, halogén-alkoxi-, amino- vagy cianocsoport; R2hidrogénatom vagy -C(H)n(R6)q(CH2)pZR7 csoport; R3 hidrogénatom,alkenil-, alkinil- vagy -[CH(R6)(CH2)p]mZR7 csoport; R4 hidrogén-,halogénatom, alkil- vagy halogén-alkil-csoport; R5 adott esetben egyvagy több kettős kötést tartalmazó 3-7 szénatomos cikloalkilcsoport;arilcsoport; vagy 5-6 tagú heterociklilcsoport; amely csoportokmindegyike adott esetben a következő csoportból kiválasztott egy vagytöbb szubsztituenst hordozhat: halogénatom, alkil-, alkoxi-, halogén-alkil-, alkenil-, alkinil-, halogén-alkoxi-, mono- vagy dialkil-amino-, nitro- és/vagy cianocsoport; R6 hidrogénatom, alkenil-,alkinil- vagy -(CH2)pZR7 csoport; R7 alkilcsoport, ami adott esetben akövetkező csoportból kiválasztott egy vagy több szubsztituensthordozhat: halogénatom, halogén-alkil-, alkenil-, alkinil-, halogén-alkoxi-, alkoxi-, mono- vagy dialkil-amino-, nitro-, ciano- és/vagy -R5 csoport; Y szén- vagy nitrogénatom; m és a értéke egymástólfüggetlenül 0 vagy 1; p értéke 0, 1, 2, 3 vagy 4; q értéke 1 vagy 2;és Z kötés, oxi-, imino- vagy tiocsoport és sztereoizomereikre,prodrugjaikra, valamint gyógyászatilag elfogadható sóikra ésszolvátjaikra, továbbá a vegyületeket tartalmazógyógyszerkészítményekre és a vegyületek kortikotropin-releasing faktor(CRF) által mediált állapotok kezelésében történő felhasználásáravonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0117395.4A GB0117395D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| PCT/US2002/022394 WO2003008414A1 (en) | 2001-07-17 | 2002-07-15 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0400460A2 true HUP0400460A2 (hu) | 2005-01-28 |
Family
ID=9918654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400460A HUP0400460A2 (hu) | 2001-07-17 | 2002-07-15 | Kortikotropin-feloldó faktor (CRF) receptor antagonista triciklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1425281B1 (hu) |
| JP (1) | JP2004537555A (hu) |
| KR (1) | KR20040027880A (hu) |
| CN (1) | CN1541217A (hu) |
| AT (1) | ATE316972T1 (hu) |
| AU (1) | AU2002354916B2 (hu) |
| BR (1) | BR0211220A (hu) |
| CA (1) | CA2452009A1 (hu) |
| DE (1) | DE60209014T2 (hu) |
| ES (1) | ES2256506T3 (hu) |
| GB (1) | GB0117395D0 (hu) |
| HU (1) | HUP0400460A2 (hu) |
| IL (1) | IL159521A0 (hu) |
| MX (1) | MXPA04000492A (hu) |
| NO (1) | NO20040203L (hu) |
| NZ (1) | NZ530508A (hu) |
| PL (1) | PL367965A1 (hu) |
| RU (1) | RU2004104464A (hu) |
| WO (1) | WO2003008414A1 (hu) |
| ZA (1) | ZA200309942B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2255610T3 (es) | 2001-04-30 | 2006-07-01 | Glaxo Group Limited | Antagonistas de los receptores de crf. |
| JP2004530702A (ja) | 2001-05-21 | 2004-10-07 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆ受容体アンタゴニストとしてのトリ−およびテトラアザ−アセナフチレン誘導体 |
| DE602008003055D1 (de) * | 2007-05-31 | 2010-12-02 | Nerviano Medical Sciences Srl | Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken |
| HUE026518T2 (hu) | 2009-06-08 | 2016-06-28 | Takeda Pharmaceuticals Co | Dihidro-pirrolo-naftiridinon-vegyületek mint JAK inhibitorok |
| RU2498986C2 (ru) * | 2011-07-20 | 2013-11-20 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| CN106279011A (zh) * | 2016-08-16 | 2017-01-04 | 成都百事兴科技实业有限公司 | 一种2,4‑二羟基‑6‑甲基烟酸乙酯的制备方法 |
| KR102462991B1 (ko) * | 2020-11-02 | 2022-11-04 | 한국해양과학기술원 | 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605642A (en) * | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| IL142893A0 (en) * | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
| NZ511267A (en) * | 1998-11-12 | 2002-12-20 | Neurocrine Biosciences Inc | Tricyclic heterocyclic CRF receptor antagonists and their use in treatment |
-
2001
- 2001-07-17 GB GBGB0117395.4A patent/GB0117395D0/en not_active Ceased
-
2002
- 2002-07-15 ES ES02752340T patent/ES2256506T3/es not_active Expired - Lifetime
- 2002-07-15 KR KR10-2004-7000714A patent/KR20040027880A/ko not_active Application Discontinuation
- 2002-07-15 WO PCT/US2002/022394 patent/WO2003008414A1/en active IP Right Grant
- 2002-07-15 BR BR0211220-5A patent/BR0211220A/pt not_active IP Right Cessation
- 2002-07-15 JP JP2003513973A patent/JP2004537555A/ja active Pending
- 2002-07-15 CA CA002452009A patent/CA2452009A1/en not_active Abandoned
- 2002-07-15 DE DE60209014T patent/DE60209014T2/de not_active Expired - Fee Related
- 2002-07-15 NZ NZ530508A patent/NZ530508A/en unknown
- 2002-07-15 IL IL15952102A patent/IL159521A0/xx unknown
- 2002-07-15 HU HU0400460A patent/HUP0400460A2/hu unknown
- 2002-07-15 CN CNA02815746XA patent/CN1541217A/zh active Pending
- 2002-07-15 AU AU2002354916A patent/AU2002354916B2/en not_active Ceased
- 2002-07-15 EP EP02752340A patent/EP1425281B1/en not_active Expired - Lifetime
- 2002-07-15 PL PL02367965A patent/PL367965A1/xx not_active Application Discontinuation
- 2002-07-15 RU RU2004104464/04A patent/RU2004104464A/ru not_active Application Discontinuation
- 2002-07-15 AT AT02752340T patent/ATE316972T1/de not_active IP Right Cessation
- 2002-07-15 MX MXPA04000492A patent/MXPA04000492A/es active IP Right Grant
-
2003
- 2003-12-23 ZA ZA200309942A patent/ZA200309942B/xx unknown
-
2004
- 2004-01-16 NO NO20040203A patent/NO20040203L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0211220A (pt) | 2004-07-13 |
| RU2004104464A (ru) | 2005-08-10 |
| CA2452009A1 (en) | 2003-01-30 |
| ES2256506T3 (es) | 2006-07-16 |
| AU2002354916B2 (en) | 2006-10-19 |
| EP1425281B1 (en) | 2006-02-01 |
| NZ530508A (en) | 2005-11-25 |
| EP1425281A1 (en) | 2004-06-09 |
| ATE316972T1 (de) | 2006-02-15 |
| PL367965A1 (en) | 2005-03-07 |
| NO20040203L (no) | 2004-03-16 |
| IL159521A0 (en) | 2004-06-01 |
| ZA200309942B (en) | 2004-05-25 |
| WO2003008414A1 (en) | 2003-01-30 |
| CN1541217A (zh) | 2004-10-27 |
| DE60209014T2 (de) | 2006-07-13 |
| KR20040027880A (ko) | 2004-04-01 |
| DE60209014D1 (de) | 2006-04-13 |
| GB0117395D0 (en) | 2001-09-05 |
| JP2004537555A (ja) | 2004-12-16 |
| MXPA04000492A (es) | 2005-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |