HUP0500573A2 - Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0500573A2
HUP0500573A2 HU0500573A HUP0500573A HUP0500573A2 HU P0500573 A2 HUP0500573 A2 HU P0500573A2 HU 0500573 A HU0500573 A HU 0500573A HU P0500573 A HUP0500573 A HU P0500573A HU P0500573 A2 HUP0500573 A2 HU P0500573A2
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Hungary
Prior art keywords
hydroxy
hydrogen atom
group
selective estrogen
triphenyl
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HU0500573A
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English (en)
Inventor
Robert Kaltenbach
Simon Robinson
George Trainor
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Bristol-Myers Squibb Pharma Company
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Application filed by Bristol-Myers Squibb Pharma Company filed Critical Bristol-Myers Squibb Pharma Company
Publication of HUP0500573A2 publication Critical patent/HUP0500573A2/hu

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    • A61P5/30—Oestrogens
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    • C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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Abstract

A találmány tárgyát szelektív ösztrogén modulátor hatású általánosképletű trifenil-etilén-származékok - ahol Rl általános képletűcsoport; R2, R3, R4 hidrogénatom, alkilcsoport, halogénatom, vagy R2és R3 hozzájuk kapcsolódó atomokkal együtt egy 6- vagy 7-tagú gyűrűtalkotnak; R5 hidrogénatom, hidroxi-, ciano-, nitro-, alkilcsoport,halogénatom; R6 hidrogénatom, hidroxi-, ciano-, alkilcsoport; R7hidrogénatom, aril-, alkil-, hidroxicsoport; R8 aril-, alkil-,hidroxicsoport; X oxigénatom vagy iminocsoport - különösen 3-{4-[6-(3-metoxi-fenil)-8,9-dihidro-7H-benzociklohepten-5-i1]-fenil}-akrilsav éssóik és ezeket tartalmazó főleg daganatos megbetegedések gyógyításáraszolgáló gyógyszerkészítmények képezik.
HU0500573A 2001-08-11 2002-08-09 Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények HUP0500573A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31146601P 2001-08-11 2001-08-11
PCT/US2002/025394 WO2003016270A2 (en) 2001-08-11 2002-08-09 Selective estrogen receptor modulators

Publications (1)

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HUP0500573A2 true HUP0500573A2 (hu) 2005-11-28

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HU0500573A HUP0500573A2 (hu) 2001-08-11 2002-08-09 Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények

Country Status (11)

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US (3) US6927224B2 (hu)
EP (1) EP1417169A2 (hu)
JP (1) JP2005528320A (hu)
AU (1) AU2002323098A1 (hu)
BG (1) BG108561A (hu)
CZ (1) CZ2004220A3 (hu)
EE (1) EE200400061A (hu)
HU (1) HUP0500573A2 (hu)
PL (1) PL374215A1 (hu)
SK (1) SK602004A3 (hu)
WO (1) WO2003016270A2 (hu)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6180731A (ja) * 1984-09-28 1986-04-24 Toshiba Corp 管球の製造方法
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
CN1856461A (zh) 2003-07-28 2006-11-01 史密丝克莱恩比彻姆公司 作为***受体调节剂的亚环烷基化合物
WO2005033056A2 (en) * 2003-10-08 2005-04-14 Smithkline Beecham Corporation Triphenylethylene compounds as selective estrogen receptor modulators
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
NZ553834A (en) 2004-09-21 2010-03-26 Novogen Res Pty Ltd 7-hydroxy-3,4-diphenyl-chroman and chromene derivatives
US7208526B2 (en) * 2005-05-20 2007-04-24 Hoffmann-La Roche Inc. Styrylsulfonamides
EP2048126A1 (de) * 2007-10-11 2009-04-15 Bayer Schering Pharma AG Benzocycloheptanderivate als selektiv wirksame Estrogene
UA96076C2 (en) 2007-10-16 2011-09-26 Репрос Терапьютикс Инк. Use of trans-clomiphene
US20090215738A1 (en) * 2008-02-26 2009-08-27 Michael Charles Scally Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake
WO2010107474A1 (en) * 2009-03-16 2010-09-23 The Research Foundation Of State University Of New York Antiestrogens for breast cancer therapy
EA022551B1 (ru) 2010-06-10 2016-01-29 Серагон Фармасьютикалс, Инк. Модуляторы рецепторов эстрогена и их применение
WO2011159769A2 (en) 2010-06-17 2011-12-22 Aragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
DE102010030538A1 (de) * 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
GB2483736B (en) * 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
ES2773732T3 (es) 2010-11-01 2020-07-14 Mei Pharma Inc Composiciones de isoflavonoides y procedimientos para el tratamiento del cáncer
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CA2857057A1 (en) 2011-12-14 2013-06-20 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof
WO2013130832A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
US9499538B2 (en) * 2012-03-20 2016-11-22 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2014008159A1 (en) * 2012-07-03 2014-01-09 The University Of North Carolina At Chapel Hill Selective estrogen receptor degraders for treatment of tamoxifen resistant tumors
CN105121413B (zh) * 2013-03-14 2018-09-14 赛拉根医药股份有限公司 多环***受体调节剂及其用途
CN104211695B (zh) * 2013-06-04 2017-04-12 中国医学科学院医药生物技术研究所 一组胺甲酰基苯磺酰类化合物的用途
DK3253208T3 (da) 2015-02-02 2021-06-07 Mei Pharma Inc Kombinationsterapier til anvendelse i behandlingen af brystcancer
CN105061316B (zh) * 2015-07-17 2017-12-22 苏州大学 稠环类化合物、制备方法和用途
DK3355884T3 (da) 2015-10-01 2021-08-02 Olema Pharmaceuticals Inc Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler
AU2016352592B2 (en) 2015-11-10 2023-04-27 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen
CO2018009534A2 (es) 2016-02-15 2018-09-20 Sanofi Sa Nuevos compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
EP3541809A1 (en) 2016-11-17 2019-09-25 Sanofi Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
CA3071270A1 (en) * 2017-07-28 2019-01-31 Recurium Ip Holdings, Llc Acrylic acid analogs
US20210085796A1 (en) * 2017-07-28 2021-03-25 Yale University Anticancer drugs and methods of making and using same
US11034653B2 (en) * 2017-09-25 2021-06-15 Luoxin Pharmaceutical (Shanghai) Co., Ltd. Crystal form of estrogen receptor inhibitor and preparation method therefor
MA51670A (fr) * 2018-01-22 2020-12-02 Radius Pharmaceuticals Inc Composés modulant les récepteurs des oestrogènes
AU2019229258B2 (en) * 2018-02-27 2023-09-14 Artax Biopharma Inc. Chromene derivatives as inhibitors of TCR-Nck interaction
MX2021002665A (es) 2018-09-07 2021-07-16 Sanofi Sa Sales de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirroli din-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anulen-2-carboxilato de metilo y proceso de preparación de las mismas.
WO2023023531A1 (en) * 2021-08-20 2023-02-23 Biotheryx, Inc. Estrogen receptor degraders, pharmaceutical compositions, and therapeutic applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
DE69840126D1 (de) * 1997-08-15 2008-11-27 Univ Duke Verfahren zur prophylaxis oder behandlung von östrogen-abhängigen krankheiten
FR2778404B1 (fr) * 1998-05-06 2000-06-30 Hoechst Marion Roussel Inc Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
AU7896100A (en) 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
US6528681B2 (en) 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
US6417394B2 (en) * 2000-04-05 2002-07-09 Bristol Myers Squibb Pharma Company Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators

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US20050245602A1 (en) 2005-11-03
AU2002323098A1 (en) 2003-03-03
US6927224B2 (en) 2005-08-09
EP1417169A2 (en) 2004-05-12
JP2005528320A (ja) 2005-09-22
US7045540B2 (en) 2006-05-16
CZ2004220A3 (cs) 2004-06-16
US20030105148A1 (en) 2003-06-05
EE200400061A (et) 2004-04-15
US20050267183A1 (en) 2005-12-01
WO2003016270A3 (en) 2003-11-06
US7323587B2 (en) 2008-01-29
SK602004A3 (en) 2004-11-03
PL374215A1 (en) 2005-10-03
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