ATE334988T1 - Thieno 2,3-döpyrimidinediones als inhibitoren von t-zellen-proliferation - Google Patents
Thieno 2,3-döpyrimidinediones als inhibitoren von t-zellen-proliferationInfo
- Publication number
- ATE334988T1 ATE334988T1 AT02745634T AT02745634T ATE334988T1 AT E334988 T1 ATE334988 T1 AT E334988T1 AT 02745634 T AT02745634 T AT 02745634T AT 02745634 T AT02745634 T AT 02745634T AT E334988 T1 ATE334988 T1 AT E334988T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- döpyrimidinediones
- thieno
- inhibitors
- cell proliferation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0117583.5A GB0117583D0 (en) | 2001-07-19 | 2001-07-19 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE334988T1 true ATE334988T1 (de) | 2006-08-15 |
Family
ID=9918788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02745634T ATE334988T1 (de) | 2001-07-19 | 2002-07-16 | Thieno 2,3-döpyrimidinediones als inhibitoren von t-zellen-proliferation |
Country Status (9)
Country | Link |
---|---|
US (2) | US7361660B2 (de) |
EP (1) | EP1412362B1 (de) |
JP (1) | JP2004537557A (de) |
AT (1) | ATE334988T1 (de) |
DE (1) | DE60213609T2 (de) |
ES (1) | ES2268059T3 (de) |
GB (1) | GB0117583D0 (de) |
HK (1) | HK1065542A1 (de) |
WO (1) | WO2003008422A1 (de) |
Families Citing this family (65)
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SE9801399D0 (sv) | 1998-04-21 | 1998-04-21 | Astra Pharma Prod | Method and apparatus for filling containers |
GB0117583D0 (en) * | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
SE0300120D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300119D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
JP2006515880A (ja) * | 2003-01-17 | 2006-06-08 | アストラゼネカ・アクチエボラーグ | 自己免疫疾患の調節におけるチエノピリダジノンとその使用 |
CA2550361C (en) | 2003-12-19 | 2014-04-29 | Prabha Ibrahim | Compounds and methods for development of ret modulators |
US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
US7846941B2 (en) | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
AU2006202209B2 (en) * | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
EP1888123B1 (de) * | 2005-06-08 | 2013-01-09 | Janssen Biotech, Inc. | Zelltherapie für augendegeneration |
MY153898A (en) | 2005-06-22 | 2015-04-15 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US20070122448A1 (en) * | 2005-11-28 | 2007-05-31 | Alireza Rezania | Compositions and methods to create a vascularized environment for cellular transplantation |
US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
ES2725601T3 (es) | 2006-04-28 | 2019-09-25 | Lifescan Inc | Diferenciación de células madre embriónicas humanas |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
CA2676044C (en) * | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
DK3192865T3 (da) | 2007-07-01 | 2021-06-28 | Janssen Biotech Inc | Enkelt pluripotent stamcelle-kultur |
CN101808994B (zh) | 2007-07-17 | 2013-05-15 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
US20100255580A1 (en) | 2007-07-18 | 2010-10-07 | Lifesccan, Inc. | Differentiation of Human Embryonic Stem Cells |
US9096832B2 (en) | 2007-07-31 | 2015-08-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
CA2706560C (en) * | 2007-11-27 | 2017-02-28 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
BR122017025207B1 (pt) | 2008-02-21 | 2021-03-16 | Centocor Ortho Biotech Inc | superfície que faz parte de um recipiente ou matriz destinada para uso em uma cultura de células ou análises, desprovida de uma camada de células alimentadoras e desprovida de uma camada adsorvente |
US20090220995A1 (en) | 2008-02-28 | 2009-09-03 | Sachs David H | Multiple administrations of umbilicus derived cells |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
PL2310492T3 (pl) | 2008-06-30 | 2015-12-31 | Janssen Biotech Inc | Różnocowanie pluripotencjalnych komórek macierzystych |
AU2009274517B2 (en) | 2008-07-25 | 2015-03-26 | The University Of Georgia Research Foundation, Inc. | Compositions for Mesoderm derived ISL1+ Multipotent cells (IMPs), epicardial progenitor cells (EPCs) and multipotent CXCR4+CD56+ cells (C56Cs) and methods of use |
US20110305672A1 (en) | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
US20100028307A1 (en) * | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
KR101712085B1 (ko) | 2008-10-31 | 2017-03-03 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 췌장 내분비 계통으로의 분화 |
JP2012507289A (ja) | 2008-10-31 | 2012-03-29 | ヤンセン バイオテツク,インコーポレーテツド | ヒト胚性幹細胞の膵内分泌系への分化 |
AU2009316583B2 (en) * | 2008-11-20 | 2016-04-21 | Janssen Biotech, Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
WO2010059775A1 (en) | 2008-11-20 | 2010-05-27 | Centocor Ortho Biotech Inc. | Pluripotent stem cell culture on micro-carriers |
MA33028B1 (fr) | 2009-04-03 | 2012-02-01 | Plexxikon Inc | Compositions et utilisations associees |
ES2693088T3 (es) | 2009-07-20 | 2018-12-07 | Janssen Biotech, Inc. | Diferenciación de células madre embriónicas humanas |
GB2485113B (en) * | 2009-07-20 | 2016-12-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage |
GB2484873B (en) | 2009-07-20 | 2014-04-30 | Janssen Biotech Inc | Differentiation of pancreatic endoderm cells. |
CN102695417A (zh) | 2009-11-06 | 2012-09-26 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
WO2011079018A2 (en) * | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
US9150833B2 (en) | 2009-12-23 | 2015-10-06 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
CN107189979B (zh) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
ES2728900T3 (es) | 2010-05-12 | 2019-10-29 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas |
BR112013003160A2 (pt) | 2010-08-12 | 2016-06-28 | Janssen Biotech Inc | tratamento de diabetes com células precursoras endócrinas pancráticas |
RU2673946C1 (ru) | 2010-08-31 | 2018-12-03 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
RU2620938C2 (ru) | 2010-08-31 | 2017-05-30 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
BR112013004514A2 (pt) | 2010-08-31 | 2016-06-07 | Janssen Biotech Inc | diferenciação das células-tronco embrionárias humanas |
US9404087B2 (en) | 2010-12-15 | 2016-08-02 | Kadimastem Ltd. | Insulin producing cells derived from pluripotent stem cells |
BR112013020041B1 (pt) | 2011-02-07 | 2021-11-23 | Plexxikon, Inc | Compostos e composições para a modulação de quinases e uso dos mesmos |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
SG10201608914WA (en) | 2011-12-22 | 2016-12-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
CN104160018A (zh) | 2012-03-07 | 2014-11-19 | 詹森生物科技公司 | 用于扩增和维持多能干细胞的成分确定的培养基 |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
EP3450543A1 (de) | 2012-06-08 | 2019-03-06 | Janssen Biotech, Inc. | Differenzierung humaner embryonaler stammzellen in endokrine pankreaszellen |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
EP4219683A1 (de) | 2012-12-31 | 2023-08-02 | Janssen Biotech, Inc. | Differenzierung humaner embryonaler stammzellen in endokrine pankreaszellen mittels hb9-regulatoren |
KR20150103203A (ko) | 2012-12-31 | 2015-09-09 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포 내로의 분화를 위한 인간 만능 세포의 현탁 및 클러스터링 |
AU2013368221B2 (en) | 2012-12-31 | 2018-11-01 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
DK3677271T3 (da) | 2013-03-13 | 2023-05-22 | Univ Miami | Fremgangsmåde til isolering og oprensning af microvesikler fra cellekultur-supernatanter og biologiske fluider |
US10006006B2 (en) | 2014-05-16 | 2018-06-26 | Janssen Biotech, Inc. | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
US11679133B2 (en) | 2015-11-30 | 2023-06-20 | Kadimastem Ltd. | Methods for differentiating and purifying pancreatic endocrine cells |
MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
MX2023001927A (es) | 2020-08-21 | 2023-03-09 | Univ Miami | Composiciones y metodos de tratamiento usando microvesiculas de celulas madre mesenquimaticas derivadas de medula osea. |
WO2023205158A1 (en) | 2022-04-19 | 2023-10-26 | University Of Miami | Compositions comprising microvesicles for use in the prevention and treatment of graft versus host disease |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6469014B1 (en) * | 1997-05-28 | 2002-10-22 | Astrazeneca Ab | Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy |
SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
DE19738855C2 (de) * | 1997-09-05 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht |
CN1284079A (zh) | 1997-12-05 | 2001-02-14 | 阿斯特拉曾尼卡英国有限公司 | 新化合物 |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
JP2002523511A (ja) * | 1998-08-28 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
GB0117583D0 (en) * | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
SE0300120D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300119D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
JP2006515880A (ja) | 2003-01-17 | 2006-06-08 | アストラゼネカ・アクチエボラーグ | 自己免疫疾患の調節におけるチエノピリダジノンとその使用 |
-
2001
- 2001-07-19 GB GBGB0117583.5A patent/GB0117583D0/en not_active Ceased
-
2002
- 2002-07-16 DE DE60213609T patent/DE60213609T2/de not_active Expired - Fee Related
- 2002-07-16 WO PCT/GB2002/003250 patent/WO2003008422A1/en active IP Right Grant
- 2002-07-16 AT AT02745634T patent/ATE334988T1/de not_active IP Right Cessation
- 2002-07-16 JP JP2003513981A patent/JP2004537557A/ja active Pending
- 2002-07-16 EP EP02745634A patent/EP1412362B1/de not_active Expired - Lifetime
- 2002-07-16 ES ES02745634T patent/ES2268059T3/es not_active Expired - Lifetime
- 2002-07-16 US US10/483,161 patent/US7361660B2/en not_active Expired - Fee Related
-
2004
- 2004-10-26 HK HK04108389A patent/HK1065542A1/xx not_active IP Right Cessation
-
2008
- 2008-02-28 US US12/039,204 patent/US20080153855A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003008422A1 (en) | 2003-01-30 |
EP1412362A1 (de) | 2004-04-28 |
DE60213609T2 (de) | 2007-08-16 |
US20080153855A1 (en) | 2008-06-26 |
DE60213609D1 (de) | 2006-09-14 |
ES2268059T3 (es) | 2007-03-16 |
US20040171623A1 (en) | 2004-09-02 |
GB0117583D0 (en) | 2001-09-12 |
EP1412362B1 (de) | 2006-08-02 |
HK1065542A1 (en) | 2005-02-25 |
US7361660B2 (en) | 2008-04-22 |
JP2004537557A (ja) | 2004-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |