EA200501148A1 - Пиридилоксиметильные и бензизоксазольные азабициклические производные - Google Patents

Пиридилоксиметильные и бензизоксазольные азабициклические производные

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Publication number
EA200501148A1
EA200501148A1 EA200501148A EA200501148A EA200501148A1 EA 200501148 A1 EA200501148 A1 EA 200501148A1 EA 200501148 A EA200501148 A EA 200501148A EA 200501148 A EA200501148 A EA 200501148A EA 200501148 A1 EA200501148 A1 EA 200501148A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkoxy
hydrogen
alkyl
disorders
pyridyloxymethyl
Prior art date
Application number
EA200501148A
Other languages
English (en)
Other versions
EA009527B1 (ru
Inventor
Джин Майкл Брайт
Майкл Аарон Бродней
Бишоп Влодеки
Original Assignee
Пфайзер Продактс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Продактс, Инк. filed Critical Пфайзер Продактс, Инк.
Publication of EA200501148A1 publication Critical patent/EA200501148A1/ru
Publication of EA009527B1 publication Critical patent/EA009527B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
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    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P35/00Antineoplastic agents
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    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Аминометилпиридилоксиметил/бензизоксазолзамещенное азабициклическое соединение формулы (I)фармацевтическая композиция, содержащая его, и способ лечения одного или более расстройств ЦНС или других расстройств, включая одновременное лечение таких расстройств как шизофрения и депрессия. Или его (R)- или (S)-энантиомер, или его цис- или транс-изомер, или его или любого из вышеуказанного фармацевтически приемлемая соль, сольват или пролекарство, где m равно 0 или 1; Z представляет собойгде Rпредставляет собой водород или (C-C)алкокси; Rпредставляет собой водород, гидрокси или (C-C)алкокси и Rпредставляет собой (C-C)алкокси; X представляет собой кислород или NR, где R представляет собой водород или (C-C)алкил; Y представляет собой метилен, при этом n равно 0, 1 или 2; или кислород, азот или серу, при этом n равно 2, 3 или 4; каждый из Rи Rнезависимо представляет собой водород, галоген или группу (C-C)алкил, (C-C)алкокси или (C-C)алкокси(C-C)алкил, причем любая из этих групп может быть незамещенной или замещенной одним или более галогенами.
EA200501148A 2003-03-12 2004-02-23 Пиридилоксиметильные и бензизоксазольные азабициклические производные EA009527B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45392503P 2003-03-12 2003-03-12
PCT/IB2004/000499 WO2004081007A1 (en) 2003-03-12 2004-02-23 Pyridyloxymethyl and benzisoxazole azabicyclic derivatives

Publications (2)

Publication Number Publication Date
EA200501148A1 true EA200501148A1 (ru) 2006-04-28
EA009527B1 EA009527B1 (ru) 2008-02-28

Family

ID=32990837

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501148A EA009527B1 (ru) 2003-03-12 2004-02-23 Пиридилоксиметильные и бензизоксазольные азабициклические производные

Country Status (31)

Country Link
US (1) US7345038B2 (ru)
EP (1) EP1608648B1 (ru)
JP (2) JP3910627B2 (ru)
KR (2) KR100767854B1 (ru)
CN (1) CN100389115C (ru)
AP (1) AP2005003390A0 (ru)
AR (1) AR043537A1 (ru)
AU (2) AU2004220327B2 (ru)
BR (1) BRPI0408248A (ru)
CA (1) CA2518740C (ru)
EA (1) EA009527B1 (ru)
EC (1) ECSP056011A (ru)
GT (1) GT200400041A (ru)
HK (1) HK1085725A1 (ru)
HR (1) HRP20050798A2 (ru)
IL (1) IL170290A (ru)
MA (1) MA27747A1 (ru)
MX (1) MXPA05009660A (ru)
NL (1) NL1025710C2 (ru)
NO (1) NO20054095L (ru)
OA (1) OA13038A (ru)
PA (1) PA8597501A1 (ru)
PE (1) PE20041057A1 (ru)
PL (1) PL378749A1 (ru)
RS (1) RS20050692A (ru)
TN (1) TNSN05224A1 (ru)
TW (1) TW200502234A (ru)
UA (1) UA78437C2 (ru)
UY (1) UY28225A1 (ru)
WO (1) WO2004081007A1 (ru)
ZA (1) ZA200506373B (ru)

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US6994726B2 (en) * 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
AP2006003620A0 (en) 2003-10-15 2006-06-30 Osi Pharm Inc Imidazopyrazine tyroshine kinase inhibitors
CA2555172A1 (en) * 2004-01-29 2005-09-09 Pfizer Products Inc. Combinations of an atypical antipsychotic and an aminomethylpyridyloxymethyl/benzisoxazole azabicyclic derivatives for treating cns disorders
MXPA06011423A (es) 2004-04-02 2007-01-23 Osi Pharm Inc Inhibidores de proteina cinasa heterobiciclica sustituida en el anillo 6,6-biciclico.
MY139689A (en) 2004-07-20 2009-10-30 Osi Pharm Inc Imidazotriazines as protein kinase inhibitors
WO2006027692A2 (en) * 2004-09-10 2006-03-16 Pfizer Products Inc. Methods of treating cognitive disorders using pyridyloxymethyl and benzisoxazole azabicyclic derivatives
US8575164B2 (en) * 2005-12-19 2013-11-05 OSI Pharmaceuticals, LLC Combination cancer therapy
EP2250173A1 (en) * 2008-01-18 2010-11-17 OSI Pharmaceuticals, Inc. Imidazopyrazinol derivatives for the treatment of cancers
JP2011520970A (ja) * 2008-05-19 2011-07-21 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換されたイミダゾピラジン類およびイミダゾトリアジン類
CA2752826A1 (en) 2009-04-20 2010-10-28 OSI Pharmaceuticals, LLC Preparation of c-pyrazine-methylamines
JP2012526138A (ja) * 2009-05-07 2012-10-25 オーエスアイ・ファーマシューティカルズ,エルエルシー 副腎皮質癌を治療するためのosi−906の使用
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2016115282A1 (en) * 2015-01-13 2016-07-21 Vanderbilt University Benzoisoxazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
WO2023083445A1 (en) 2021-11-10 2023-05-19 Symrise Ag Compositions comprising trpm8 agonistic cooling agents

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Also Published As

Publication number Publication date
KR100767854B1 (ko) 2007-10-17
MA27747A1 (fr) 2006-02-01
PA8597501A1 (es) 2005-05-24
TW200502234A (en) 2005-01-16
PL378749A1 (pl) 2006-05-15
ZA200506373B (en) 2006-10-25
HRP20050798A2 (en) 2006-02-28
WO2004081007A1 (en) 2004-09-23
RS20050692A (en) 2007-11-15
CA2518740C (en) 2011-01-11
AU2010203303A1 (en) 2010-08-12
CA2518740A1 (en) 2004-09-23
MXPA05009660A (es) 2005-10-20
ECSP056011A (es) 2006-01-27
US7345038B2 (en) 2008-03-18
IL170290A (en) 2011-02-28
JP2007051155A (ja) 2007-03-01
JP3910627B2 (ja) 2007-04-25
TNSN05224A1 (fr) 2007-06-11
AU2004220327B2 (en) 2010-06-24
NL1025710C2 (nl) 2005-10-10
EP1608648A1 (en) 2005-12-28
JP2006519830A (ja) 2006-08-31
UA78437C2 (en) 2007-03-15
HK1085725A1 (en) 2006-09-01
OA13038A (en) 2006-11-10
BRPI0408248A (pt) 2006-03-01
NO20054095L (no) 2005-09-26
PE20041057A1 (es) 2005-01-22
CN1759116A (zh) 2006-04-12
EP1608648B1 (en) 2012-07-18
KR20050113221A (ko) 2005-12-01
NO20054095D0 (no) 2005-09-02
NL1025710A1 (nl) 2004-09-14
AR043537A1 (es) 2005-08-03
AU2004220327A1 (en) 2004-09-23
GT200400041A (es) 2005-03-23
EA009527B1 (ru) 2008-02-28
UY28225A1 (es) 2004-11-08
AP2005003390A0 (en) 2005-09-30
US20050026922A1 (en) 2005-02-03
KR20070074667A (ko) 2007-07-12
CN100389115C (zh) 2008-05-21

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