MX9706946A - Inhibidores de la proteasa retroviral de la hidroxietilaminosulfonamida de aminoacidos heterociclicocarbonilicos y uso de los mismos. - Google Patents

Inhibidores de la proteasa retroviral de la hidroxietilaminosulfonamida de aminoacidos heterociclicocarbonilicos y uso de los mismos.

Info

Publication number
MX9706946A
MX9706946A MX9706946A MX9706946A MX9706946A MX 9706946 A MX9706946 A MX 9706946A MX 9706946 A MX9706946 A MX 9706946A MX 9706946 A MX9706946 A MX 9706946A MX 9706946 A MX9706946 A MX 9706946A
Authority
MX
Mexico
Prior art keywords
protease inhibitors
amino acid
retroviral
retroviral protease
hydroxyethylamino sulfonamide
Prior art date
Application number
MX9706946A
Other languages
English (en)
Inventor
Daniel P Getman
Gary A Decrescenzo
John N Freskos
Michael L Vazquez
James A Sikorski
Balekudru Devadas
Srinivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of MX9706946A publication Critical patent/MX9706946A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Compuestos selectos de hidroxietilaminosulfonamida de aminoácidos heterociclocarbonílicos son eficaces como inhibidores y, en particular, como inhibidores de la proteasa del HIV, y la presente invencion se refiere a tales inhibidores y, muy particularmente, se refiere novedoso y selectos compuestos, la composicion y el uso de los mismos en la preparacion de composiciones y medicamentos para inhibir las proteasas retrovirales, tales como la proteasa del virus de inmunodeficiencia humana (HIV), evitar profilácticamente la infeccion profiláctica o la propagacion de un retrovirus, y el tratamiento de una infeccion retroviral.
MX9706946A 1995-03-10 1996-03-07 Inhibidores de la proteasa retroviral de la hidroxietilaminosulfonamida de aminoacidos heterociclicocarbonilicos y uso de los mismos. MX9706946A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
MX9706946A true MX9706946A (es) 1997-11-29

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706946A MX9706946A (es) 1995-03-10 1996-03-07 Inhibidores de la proteasa retroviral de la hidroxietilaminosulfonamida de aminoacidos heterociclicocarbonilicos y uso de los mismos.

Country Status (20)

Country Link
US (3) US5972989A (es)
EP (1) EP0815124B1 (es)
JP (1) JP4124818B2 (es)
CN (2) CN1530372A (es)
AT (1) ATE229033T1 (es)
AU (1) AU717598B2 (es)
BR (1) BR9607625A (es)
CA (1) CA2215022A1 (es)
CZ (1) CZ297676B6 (es)
DE (1) DE69625183T2 (es)
DK (1) DK0815124T3 (es)
ES (1) ES2190793T3 (es)
HU (1) HUP9800518A3 (es)
MX (1) MX9706946A (es)
NO (1) NO974147L (es)
NZ (1) NZ306027A (es)
PL (1) PL184771B1 (es)
PT (1) PT815124E (es)
RU (1) RU2174519C2 (es)
WO (1) WO1996028465A1 (es)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US6407134B1 (en) * 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
RU2174519C2 (ru) * 1995-03-10 2001-10-10 Джи. Ди. Сирл Энд Ко. Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9815469A (pt) * 1997-05-08 2001-03-06 Smithkline Beecham Corp Inibidores de protease
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
JP4482783B2 (ja) 1999-01-28 2010-06-16 味の素株式会社 α−アミノケトン類の製造方法
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
CZ304273B6 (cs) 2001-02-14 2014-02-12 Tibotec Pharmaceuticals Ltd. 2-(Substitovaná-amino)benzothiazolsulfonamidová sloučenina, způsob její přípravy a farmaceutická kompozice s jejím obsahem
NZ528954A (en) * 2001-04-09 2005-04-29 Tibotec Pharm Ltd Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
PL209029B1 (pl) 2001-05-11 2011-07-29 Tibotec Pharm Ltd Pochodne 2-aminobenzoksazolo-sulfonamidów jako inhibitory proteazy HIV, oraz kompozycje zawierające te związki
BR0215260A (pt) 2001-12-21 2004-12-07 Tibotec Pharm Ltd Inibidores de hiv protease de sulfonamida contendo fenila substituìda heterocìclica de amplo espectro
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
IL165043A0 (en) 2002-05-17 2005-12-18 Tibotec Pharm Ltd broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
MXPA05001792A (es) 2002-08-14 2005-04-25 Tibotec Pharm Ltd Oxindolsulfonamida sustituida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro.
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
CA2537877C (en) * 2003-09-30 2015-03-17 Tibotec Pharmaceuticals Ltd. Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
CA2549460C (en) 2003-12-23 2014-08-05 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
EP1910317B1 (en) * 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino linked compounds
JP2010501583A (ja) 2006-08-18 2010-01-21 セコイア、ファーマシューティカルズ、インコーポレイテッド シトクロムｐ４５０を阻害するための組成物および方法
JP5745855B2 (ja) 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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Also Published As

Publication number Publication date
CZ282397A3 (cs) 1998-02-18
HUP9800518A2 (hu) 1998-06-29
JPH11501920A (ja) 1999-02-16
CN1183102A (zh) 1998-05-27
RU2174519C2 (ru) 2001-10-10
US6214861B1 (en) 2001-04-10
EP0815124B1 (en) 2002-12-04
AU717598B2 (en) 2000-03-30
CN1149223C (zh) 2004-05-12
US5972989A (en) 1999-10-26
CA2215022A1 (en) 1996-09-19
CZ297676B6 (cs) 2007-03-07
JP4124818B2 (ja) 2008-07-23
EP0815124A1 (en) 1998-01-07
ATE229033T1 (de) 2002-12-15
DE69625183T2 (de) 2003-10-09
PL322179A1 (en) 1998-01-19
US6063795A (en) 2000-05-16
DK0815124T3 (da) 2003-03-17
DE69625183D1 (en) 2003-01-16
WO1996028465A1 (en) 1996-09-19
ES2190793T3 (es) 2003-08-16
HUP9800518A3 (en) 1998-09-28
NZ306027A (en) 1999-03-29
BR9607625A (pt) 1999-06-15
PL184771B1 (pl) 2002-12-31
CN1530372A (zh) 2004-09-22
PT815124E (pt) 2003-04-30
NO974147D0 (no) 1997-09-09
AU5417896A (en) 1996-10-02
NO974147L (no) 1997-11-04

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