RS51073B - Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata - Google Patents
Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamataInfo
- Publication number
- RS51073B RS51073B YUP-2009/0404A YUP20090404A RS51073B RS 51073 B RS51073 B RS 51073B YU P20090404 A YUP20090404 A YU P20090404A RS 51073 B RS51073 B RS 51073B
- Authority
- RS
- Serbia
- Prior art keywords
- formula
- compound
- hexahydrofuro
- furan
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Proces za pripremanje jedinjenja sa formulom (6)njegovih adicijskih soli, polimorfnih i/ili pseudopolimorfnih formi, naznačen time, da pomenuti proces obuhvata korake:(i) uvođenja izobutilamino grupe ujedinjenje sa formulom (1');sa ciljem dobivanja jedinjenj a sa formulom (2');(ii) uvođenja p-nitrofenilsulfonilne grupe ujedinjenje sa formulom (2') sa ciljem da se dobije jedinjenje sa formulom (3');(iii) reduciranja nitro ostatka iz jedinjenja sa formulom (3') sa ciljem da se dobije jedinjenje sa formulom (4');(iv) otklanjanja zaštite sa jedinjenja sa formulom (4') sa ciljem da se dobije jedinjenje sa formulom (5);spajanja jedinjenja sa formulom (5) sa derivatom (3R,3aS,6aR)-heksahidrofuro [2,3-b] furan-3-il, koji je dobiven aktivisanjem (3R,3aS,6aR)-heksahidrofuro [2,3-b] furan-3-ol ili njegovih prekursora uz pomoć karbamoilcije uz korišćenje agensa za spajanje sa ciljem dobivanja jedinjenja sa formulom (6)gde pomenuti prekursor (3R, 3aS, 6aR)-heksahidrofuro [2, 3-b] furan-3-ol obuhvata jedinjenja gde kiseonik iz alkoholne funkcije je zaštićen sa O-zaštitnim grupama, izabranima iz t-butil etera, acetata, benzilnih grupa, benzilnih etera, allila, silil zaštitnih grupa, alkoksialkilnih grupa tetrahidropiranila.Prijava sadrži još 13 patentnih zahteva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104949 | 2003-12-23 | ||
US56818304P | 2004-05-04 | 2004-05-04 | |
PCT/EP2004/053692 WO2005063770A1 (en) | 2003-12-23 | 2004-12-23 | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
Publications (1)
Publication Number | Publication Date |
---|---|
RS51073B true RS51073B (sr) | 2010-10-31 |
Family
ID=43827001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2009/0404A RS51073B (sr) | 2003-12-23 | 2004-12-23 | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata |
Country Status (5)
Country | Link |
---|---|
US (1) | US7772411B2 (sr) |
JP (1) | JP4818124B2 (sr) |
ME (1) | ME01059B (sr) |
RS (1) | RS51073B (sr) |
UA (1) | UA85567C2 (sr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2217548A1 (en) * | 2007-10-26 | 2010-08-18 | Concert Pharmaceuticals Inc. | Deuterated darunavir |
US8592487B2 (en) * | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
TWI482775B (zh) * | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備(3r,3as,6ar)-六氫呋喃并〔2,3-b〕呋喃-3-基(1s,2r)-3-〔〔(4-胺基苯基)磺醯基〕(異丁基)胺基〕-1-苯甲基-2-羥基丙基胺基甲酸酯之方法 |
EP2358198A4 (en) * | 2008-10-24 | 2012-11-14 | Concert Pharmaceuticals Inc | HYDROXYETHYLAMINO SULFONAMIDE DERIVATIVES |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
WO2010127272A2 (en) * | 2009-04-30 | 2010-11-04 | Concert Pharmaceuticals, Inc. | Hydroxyethylamino sulfonamide derivatives |
WO2011005502A2 (en) | 2009-06-23 | 2011-01-13 | Biolex Therapeutics, Inc. | Methods and compositions for the cryopreservation of duckweed |
WO2011017395A1 (en) * | 2009-08-04 | 2011-02-10 | Glaxosmithkline Llc | Chemical compounds |
WO2011051978A2 (en) | 2009-10-30 | 2011-05-05 | Lupin Limited | A novel process for preparation of darunavir and darunavir ethanolate of fine particle size |
AU2011210349A1 (en) | 2010-01-28 | 2012-07-05 | Mapi Pharma Limited | Process for the preparation of darunavir and darunavir intermediates |
WO2012107889A1 (en) | 2011-02-10 | 2012-08-16 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous darunavir |
WO2013011485A1 (en) | 2011-07-20 | 2013-01-24 | Ranbaxy Laboratories Limited | Process for the preparation of sulfonamides useful as retroviral protease inhibitors |
EP2804869B1 (en) | 2012-01-18 | 2019-06-12 | Aurobindo Pharma Limited | Novel solvates of darunavir |
EP2867210A1 (en) * | 2012-07-02 | 2015-05-06 | Pharmathen S.A. | A process for the preparation of solifenacin or a salt thereof |
ES2848216T3 (es) | 2012-07-24 | 2021-08-05 | Laurus Labs Ltd | Un proceso para la preparación de Darunavir |
US9551373B2 (en) | 2014-06-27 | 2017-01-24 | The Boeing Company | Apparatus for fuel tank spark containment |
US20160075643A1 (en) | 2014-09-16 | 2016-03-17 | Zcl Chemicals Limited | Novel process to prepare intermediates of hiv-protease inhibitors thereof |
JP6435907B2 (ja) * | 2015-02-16 | 2018-12-12 | 住友化学株式会社 | ヘキサヒドロフロフラノール誘導体の製造方法 |
EP3303343A1 (en) | 2015-06-05 | 2018-04-11 | Amneal Pharmaceuticals Company GmbH | Process for the preparation of darunavir |
EP3518935A1 (en) | 2016-09-27 | 2019-08-07 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
EP3532478B1 (en) | 2016-10-27 | 2021-05-26 | Gilead Sciences, Inc. | Crystalline form of darunavir free base |
PL3541819T3 (pl) * | 2016-11-17 | 2021-06-14 | Janssen Sciences Ireland Unlimited Company | Uproszczona procedura wytwarzania darunawiru |
CN113896658A (zh) * | 2021-09-24 | 2022-01-07 | 上药康丽(常州)药业有限公司 | 一种利用微通道反应器合成地瑞那韦中间体的方法 |
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EP0129856A3 (de) | 1983-06-21 | 1985-12-18 | Lobenstein & Ludwig | Verfahren und Vorrichtung zur Herstellung von Presslingen aus zerkleinerten Produktionsruckständen und Abfällen |
EP0656887B1 (en) | 1992-08-25 | 1998-10-28 | G.D. Searle & Co. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
EP0715618B1 (en) | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
DE69637380T2 (de) | 1995-01-20 | 2009-09-17 | G.D. Searle Llc, Chicago | Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen |
US5929284A (en) | 1995-02-03 | 1999-07-27 | Kaneka Corporation | Processes for producing α-halo ketones, α-halohydrins and epoxides |
US5756533A (en) | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
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US5705500A (en) | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
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KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
EP2194038A3 (en) | 1999-12-23 | 2010-09-01 | Ampac Fine Chemicals LLC | Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
US6455738B1 (en) | 2000-07-13 | 2002-09-24 | Rhodia Chimie | Process for the sulfonation of an aromatic compound |
KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
AU2002310818B2 (en) | 2001-05-11 | 2007-12-13 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors |
ATE453648T1 (de) | 2001-09-10 | 2010-01-15 | Tibotec Pharm Ltd | Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol |
KR100927304B1 (ko) | 2001-12-27 | 2009-11-18 | 다이이찌 세이야꾸 가부시기가이샤 | β-아밀로이드 단백 생산·분비 저해제 |
AU2002362189A1 (en) * | 2001-12-28 | 2003-07-24 | Ajinomoto Co., Inc. | Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same |
ES2638412T3 (es) | 2002-05-16 | 2017-10-20 | Janssen Sciences Ireland Uc | Formas pseudopolimórficas de un inhibidor de la proteasa del HIV |
-
2004
- 2004-12-23 US US10/596,732 patent/US7772411B2/en active Active
- 2004-12-23 UA UAA200604501A patent/UA85567C2/ru unknown
- 2004-12-23 RS YUP-2009/0404A patent/RS51073B/sr unknown
- 2004-12-23 ME MEP-2009-274A patent/ME01059B/me unknown
- 2004-12-23 JP JP2006546183A patent/JP4818124B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
UA85567C2 (en) | 2009-02-10 |
JP2007520468A (ja) | 2007-07-26 |
US7772411B2 (en) | 2010-08-10 |
ME01059B (me) | 2012-10-20 |
JP4818124B2 (ja) | 2011-11-16 |
US20070060642A1 (en) | 2007-03-15 |
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