ES2097023T3 - Derivados del acido succinoilamino-hidroxietilamino-sulfamico utiles como inhibidores de proteasas retrovirales. - Google Patents

Derivados del acido succinoilamino-hidroxietilamino-sulfamico utiles como inhibidores de proteasas retrovirales.

Info

Publication number
ES2097023T3
ES2097023T3 ES94901230T ES94901230T ES2097023T3 ES 2097023 T3 ES2097023 T3 ES 2097023T3 ES 94901230 T ES94901230 T ES 94901230T ES 94901230 T ES94901230 T ES 94901230T ES 2097023 T3 ES2097023 T3 ES 2097023T3
Authority
ES
Spain
Prior art keywords
succinoylamino
hydroxyethylamine
derivatives
protease inhibitors
retroviral protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901230T
Other languages
English (en)
Inventor
Michael L Vazquez
Richard A Mueller
John J Talley
Daniel P Getman
Crescenzo Gary A De
Eric T Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2097023T3 publication Critical patent/ES2097023T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LOS COMPUESTOS DERIVADOS DEL ACIDO SUCCINOILAMINO HIDROXIETILAMINO SULFAMICO SON EFECTIVOS COMO INHIBIDORES DE LA PROTEASA RETROVIRAL Y EN PARTICULAR COMO INHIBIDORES DE LA PROTEASA DEL VIH.
ES94901230T 1992-10-30 1993-10-29 Derivados del acido succinoilamino-hidroxietilamino-sulfamico utiles como inhibidores de proteasas retrovirales. Expired - Lifetime ES2097023T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96968392A 1992-10-30 1992-10-30

Publications (1)

Publication Number Publication Date
ES2097023T3 true ES2097023T3 (es) 1997-03-16

Family

ID=25515855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901230T Expired - Lifetime ES2097023T3 (es) 1992-10-30 1993-10-29 Derivados del acido succinoilamino-hidroxietilamino-sulfamico utiles como inhibidores de proteasas retrovirales.

Country Status (9)

Country Link
EP (1) EP0666841B1 (es)
AT (1) ATE148105T1 (es)
AU (1) AU5589294A (es)
CA (1) CA2141570A1 (es)
DE (1) DE69307726T2 (es)
DK (1) DK0666841T3 (es)
ES (1) ES2097023T3 (es)
GR (1) GR3023044T3 (es)
WO (1) WO1994010133A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4124818B2 (ja) * 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US5776971A (en) 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
US9855230B2 (en) 2014-09-09 2018-01-02 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH676988A5 (es) * 1987-01-21 1991-03-28 Sandoz Ag
DE3830825A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Hydrophile reninhemmer, ihre herstellung und verwendung
ATE164839T1 (de) * 1990-11-19 1998-04-15 Monsanto Co Retrovirale proteaseinhibitoren
EP0554400B1 (en) * 1990-11-19 1997-07-23 Monsanto Company Retroviral protease inhibitors

Also Published As

Publication number Publication date
EP0666841B1 (en) 1997-01-22
DK0666841T3 (da) 1997-02-10
GR3023044T3 (en) 1997-07-30
CA2141570A1 (en) 1994-05-11
ATE148105T1 (de) 1997-02-15
AU5589294A (en) 1994-05-24
DE69307726T2 (de) 1997-06-05
WO1994010133A1 (en) 1994-05-11
EP0666841A1 (en) 1995-08-16
DE69307726D1 (de) 1997-03-06

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