MX9706913A - Compuestos de bis-aminacido-hidroxietilamina-sulfonamida inhibidoresde proteasan retroviral, composiciones que los contienen y ek uso de los mismos. - Google Patents

Compuestos de bis-aminacido-hidroxietilamina-sulfonamida inhibidoresde proteasan retroviral, composiciones que los contienen y ek uso de los mismos.

Info

Publication number
MX9706913A
MX9706913A MX9706913A MX9706913A MX9706913A MX 9706913 A MX9706913 A MX 9706913A MX 9706913 A MX9706913 A MX 9706913A MX 9706913 A MX9706913 A MX 9706913A MX 9706913 A MX9706913 A MX 9706913A
Authority
MX
Mexico
Prior art keywords
amino acid
protease inhibitors
bis
retroviral
retroviral protease
Prior art date
Application number
MX9706913A
Other languages
English (en)
Inventor
Daniel P Getman
Gary A Decrescenzo
John N Freskos
Michael Vazquez
James A Sikorski
Balekudru Devadas
Srinivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of MX9706913A publication Critical patent/MX9706913A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se descubren compuestos de bis-aminoácidos hidroxietilamina-sulfonamida de la formula (I) que so efectivos como inhibidores de proteasa retroviral, y en particular como inhibidores de proteasa de VIH, dichos inhibidores de proteasa retroviral y, muy particularmente, compuestos novedosos, composiciones y el uso de dichos compuestos para preparar dichas composiciones para inhibir proteasas retrovirales, tales como protesa de virus de inmunodeficiencia humana (VIH), que previenen profilácticamente infeccion retroviral o la diseminacion de un retrovirus, y el tratamiento de una infeccion retroviral.
MX9706913A 1995-03-10 1996-03-07 Compuestos de bis-aminacido-hidroxietilamina-sulfonamida inhibidoresde proteasan retroviral, composiciones que los contienen y ek uso de los mismos. MX9706913A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40245095A 1995-03-10 1995-03-10
US08/479,071 US6150556A (en) 1995-03-10 1995-06-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002685 WO1996028464A1 (en) 1995-03-10 1996-03-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
MX9706913A true MX9706913A (es) 1997-11-29

Family

ID=27017890

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706913A MX9706913A (es) 1995-03-10 1996-03-07 Compuestos de bis-aminacido-hidroxietilamina-sulfonamida inhibidoresde proteasan retroviral, composiciones que los contienen y ek uso de los mismos.

Country Status (23)

Country Link
US (2) US6150556A (es)
EP (2) EP0813543B1 (es)
JP (1) JPH11501921A (es)
KR (1) KR100428499B1 (es)
CN (1) CN1178954C (es)
AT (1) ATE304550T1 (es)
AU (1) AU704360B2 (es)
BR (1) BR9607543A (es)
CA (1) CA2215025A1 (es)
CZ (1) CZ294966B6 (es)
DE (1) DE69635183T2 (es)
DK (1) DK0813543T3 (es)
EA (1) EA000578B1 (es)
EE (1) EE04376B1 (es)
ES (1) ES2249779T3 (es)
HU (1) HUP9802647A3 (es)
MX (1) MX9706913A (es)
NO (3) NO325230B1 (es)
NZ (1) NZ305544A (es)
PL (2) PL185108B1 (es)
SK (2) SK285930B6 (es)
UA (1) UA55384C2 (es)
WO (1) WO1996028464A1 (es)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US7339078B2 (en) * 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) * 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
CZ20012435A3 (cs) * 1999-01-13 2002-02-13 Dupont Pharmaceuticals Company Sulfonamidy bis-aminokyselin obsahující N-koncově substituovanou benzylovou skupinu pouľitelné jako inhibitory HIV proteáz
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
US6391919B1 (en) 2000-01-12 2002-05-21 Bristol-Myers Squibb Pharma Company Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
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CN101230067B (zh) * 2001-02-14 2011-06-15 泰博特克药品有限公司 广谱的2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
AR035819A1 (es) 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
AU2002310818B2 (en) * 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
US6562848B1 (en) 2001-09-18 2003-05-13 Bristol-Myers Squibb Company Bis-amino acid sulfonamides as HIV protease inhibitors
KR100942743B1 (ko) 2001-12-21 2010-02-16 티보텍 파마슈티칼즈 리미티드 광범위 스펙트럼 헤테로사이클릭 치환된 페닐 포함설폰아미드 ｈｉｖ 프로테아제 저해제
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
KR101019648B1 (ko) 2002-05-17 2011-03-07 티보텍 파마슈티컬즈 광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드ｈｉｖ 프로테아제 저해제
CN1688586B (zh) 2002-08-14 2012-05-09 泰博特克药品有限公司 取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂
US20060128634A1 (en) * 2002-11-14 2006-06-15 Carini David J Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
US6943170B2 (en) * 2002-11-14 2005-09-13 Bristol-Myers Squibb Company N-cycloalkylglycines as HIV protease inhibitors
CN1845725A (zh) * 2003-08-06 2006-10-11 尼马尔·穆利耶 包含水溶性药物的药物组合物
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
DK1725566T3 (da) 2003-12-23 2009-10-05 Tibotec Pharm Ltd Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat
AU2007318026B2 (en) 2006-11-03 2013-04-18 Merck Sharp & Dohme (Holdings) Pty Ltd Canine Lyme disease vaccine
JP5745855B2 (ja) * 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
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US20150113867A1 (en) 2013-10-24 2015-04-30 Basf Se Use of an alkoxylated polytetrahydrofuran to reduce fuel consumption
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Also Published As

Publication number Publication date
PL185543B1 (pl) 2003-05-30
ATE304550T1 (de) 2005-09-15
EP1076062A1 (en) 2001-02-14
CZ294966B6 (cs) 2005-04-13
KR19980702908A (ko) 1998-09-05
SK285930B6 (sk) 2007-11-02
UA55384C2 (uk) 2003-04-15
AU704360B2 (en) 1999-04-22
AU5356196A (en) 1996-10-02
SK122297A3 (en) 1998-02-04
HUP9802647A3 (en) 2000-10-30
EP0813543B1 (en) 2005-09-14
NO20075806L (no) 1997-11-05
KR100428499B1 (ko) 2004-11-16
WO1996028464A1 (en) 1996-09-19
DE69635183T2 (de) 2006-06-29
DE69635183D1 (de) 2005-10-20
CA2215025A1 (en) 1996-09-19
SK285958B6 (sk) 2007-12-06
PL185108B1 (pl) 2003-02-28
US6316496B1 (en) 2001-11-13
PL322163A1 (en) 1998-01-19
EA199700220A1 (ru) 1998-02-26
CZ282597A3 (cs) 1998-02-18
NO20075810L (no) 1997-11-05
DK0813543T3 (da) 2006-01-16
HUP9802647A2 (hu) 1999-02-01
CN1178954C (zh) 2004-12-08
ES2249779T3 (es) 2006-04-01
EE04376B1 (et) 2004-10-15
JPH11501921A (ja) 1999-02-16
NO325230B1 (no) 2008-03-03
NO974149D0 (no) 1997-09-09
NZ305544A (en) 1999-04-29
EE9700200A (et) 1998-02-16
US6150556A (en) 2000-11-21
CN1196732A (zh) 1998-10-21
NO974149L (no) 1997-11-05
BR9607543A (pt) 1997-12-23
EP0813543A1 (en) 1997-12-29
EA000578B1 (ru) 1999-12-29

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