DK0815124T3 - Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser - Google Patents

Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser

Info

Publication number
DK0815124T3
DK0815124T3 DK96911230T DK96911230T DK0815124T3 DK 0815124 T3 DK0815124 T3 DK 0815124T3 DK 96911230 T DK96911230 T DK 96911230T DK 96911230 T DK96911230 T DK 96911230T DK 0815124 T3 DK0815124 T3 DK 0815124T3
Authority
DK
Denmark
Prior art keywords
retroviral
inhibitors
retroviral proteases
protease
heterocyclic carbonylamino
Prior art date
Application number
DK96911230T
Other languages
Danish (da)
English (en)
Inventor
Michael L Vazquez
John N Freskos
Daniel P Getman
James A Sikorski
David L Brown
Srinivasan Nagarajan
Gary A Decrescenzo
Balekudru Devadas
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0815124T3 publication Critical patent/DK0815124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK96911230T 1995-03-10 1996-03-07 Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser DK0815124T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
DK0815124T3 true DK0815124T3 (da) 2003-03-17

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96911230T DK0815124T3 (da) 1995-03-10 1996-03-07 Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser

Country Status (20)

Country Link
US (3) US5972989A (es)
EP (1) EP0815124B1 (es)
JP (1) JP4124818B2 (es)
CN (2) CN1530372A (es)
AT (1) ATE229033T1 (es)
AU (1) AU717598B2 (es)
BR (1) BR9607625A (es)
CA (1) CA2215022A1 (es)
CZ (1) CZ297676B6 (es)
DE (1) DE69625183T2 (es)
DK (1) DK0815124T3 (es)
ES (1) ES2190793T3 (es)
HU (1) HUP9800518A3 (es)
MX (1) MX9706946A (es)
NO (1) NO974147L (es)
NZ (1) NZ306027A (es)
PL (1) PL184771B1 (es)
PT (1) PT815124E (es)
RU (1) RU2174519C2 (es)
WO (1) WO1996028465A1 (es)

Families Citing this family (24)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
JP4124818B2 (ja) * 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US6407134B1 (en) * 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
TR199902751T2 (xx) * 1997-05-08 2000-02-21 Smithkline Beecham Corporation Proteaz inhibit�rleri.
US6538006B1 (en) 1998-07-08 2003-03-25 Pharmacia Corporation Retroviral protease inhibitors
KR100650303B1 (ko) 1999-01-28 2006-11-28 아지노모토 가부시키가이샤 α-아미노케톤류의 제조방법
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
AU2002302363B2 (en) * 2001-02-14 2008-05-01 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
PL367084A1 (en) * 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
AP1652A (en) 2001-05-11 2006-08-11 Tibotec Pharm Ltd Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors.
EA009556B1 (ru) 2001-12-21 2008-02-28 Тиботек Фармасьютикалз Лтд. Гетероциклические замещённые фенилсодержащие сульфонамиды широкого спектра действия в качестве ингибиторов протеазы вич
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
DK1517899T3 (da) * 2002-05-17 2007-12-03 Tibotec Pharm Ltd Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor
PL375307A1 (en) * 2002-08-14 2005-11-28 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
KR101090102B1 (ko) * 2003-09-30 2011-12-07 티보텍 파마슈티컬즈 벤조옥사졸 설폰아미드 화합물 및 그의 중간체를 제조하는방법
DE602004021640D1 (de) 2003-12-23 2009-07-30 Tibotec Pharm Ltd Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester
UA85567C2 (en) 2003-12-23 2009-02-10 Тиботек Фармасьютикелз Лтд. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
WO2007015805A1 (en) * 2005-07-20 2007-02-08 Eli Lilly And Company 1-amino linked compounds
CN101674822A (zh) * 2006-08-18 2010-03-17 塞阔伊亚药品公司 抑制细胞色素p450的组合物和方法
JP5745855B2 (ja) * 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
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JP4124818B2 (ja) * 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター

Also Published As

Publication number Publication date
CN1149223C (zh) 2004-05-12
CN1183102A (zh) 1998-05-27
CZ297676B6 (cs) 2007-03-07
US5972989A (en) 1999-10-26
EP0815124B1 (en) 2002-12-04
HUP9800518A2 (hu) 1998-06-29
CN1530372A (zh) 2004-09-22
BR9607625A (pt) 1999-06-15
US6063795A (en) 2000-05-16
WO1996028465A1 (en) 1996-09-19
AU717598B2 (en) 2000-03-30
PT815124E (pt) 2003-04-30
PL184771B1 (pl) 2002-12-31
AU5417896A (en) 1996-10-02
NO974147L (no) 1997-11-04
MX9706946A (es) 1997-11-29
DE69625183D1 (en) 2003-01-16
RU2174519C2 (ru) 2001-10-10
NZ306027A (en) 1999-03-29
HUP9800518A3 (en) 1998-09-28
ATE229033T1 (de) 2002-12-15
NO974147D0 (no) 1997-09-09
CZ282397A3 (cs) 1998-02-18
DE69625183T2 (de) 2003-10-09
CA2215022A1 (en) 1996-09-19
US6214861B1 (en) 2001-04-10
JP4124818B2 (ja) 2008-07-23
PL322179A1 (en) 1998-01-19
EP0815124A1 (en) 1998-01-07
ES2190793T3 (es) 2003-08-16
JPH11501920A (ja) 1999-02-16

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