MX2011010347A - Derivados sustituidos de azoantraceno, composiciones farmaceuticas y metodos de uso de los mismos. - Google Patents

Derivados sustituidos de azoantraceno, composiciones farmaceuticas y metodos de uso de los mismos.

Info

Publication number
MX2011010347A
MX2011010347A MX2011010347A MX2011010347A MX2011010347A MX 2011010347 A MX2011010347 A MX 2011010347A MX 2011010347 A MX2011010347 A MX 2011010347A MX 2011010347 A MX2011010347 A MX 2011010347A MX 2011010347 A MX2011010347 A MX 2011010347A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
methods
receptor
human glp
substituted azoanthracene
Prior art date
Application number
MX2011010347A
Other languages
English (en)
Inventor
Robert Carl Andrews
Mustafa Guzel
Dharma Rao Polisetti
Daniel P Christen
Adnan M M Mjalli
Thomas Scott Yokum
Christopher Behme
Stephen Thomas Davis
James Quada
Jennifer L R Freeman
Kalpathy Santhosh
Muralidhar Bondlela
Ravindra Reddy Yarragunta
Devi Reddy Gohimukkula
Original Assignee
Transtech Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transtech Pharma Inc filed Critical Transtech Pharma Inc
Publication of MX2011010347A publication Critical patent/MX2011010347A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems

Abstract

La presente invención se dirige a derivados sustituidos de azoantraceno, o sales farmacéuticamente aceptables de los mismos, que modulan el receptor de GLP-1 humano y que pueden ser útiles en el tratamiento de enfermedades, trastornos, o padecimientos en los que la modulación del receptor de GLP-1 humano es favorable, tal como la diabetes mellitus tipo 2. La invención también se dirige a composiciones farmacéuticas que comprenden estos compuestos, y al uso de estos compuestos y composiciones en el tratamiento de tales enfermedades, trastornos o padecimientos en los cuales la modulación del receptor de GLP-1 humano es conveniente.
MX2011010347A 2009-03-30 2010-03-30 Derivados sustituidos de azoantraceno, composiciones farmaceuticas y metodos de uso de los mismos. MX2011010347A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16452309P 2009-03-30 2009-03-30
US30934810P 2010-03-01 2010-03-01
PCT/US2010/029172 WO2010114824A1 (en) 2009-03-30 2010-03-30 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2011010347A true MX2011010347A (es) 2011-11-29

Family

ID=42828657

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011010347A MX2011010347A (es) 2009-03-30 2010-03-30 Derivados sustituidos de azoantraceno, composiciones farmaceuticas y metodos de uso de los mismos.

Country Status (18)

Country Link
US (3) US8383644B2 (es)
EP (1) EP2413693B1 (es)
JP (1) JP5755217B2 (es)
KR (1) KR101732978B1 (es)
CN (1) CN102378574B (es)
AU (1) AU2010232750B2 (es)
BR (1) BRPI1013579A2 (es)
CA (1) CA2757084C (es)
DK (1) DK2413693T3 (es)
EA (1) EA023430B1 (es)
ES (1) ES2553645T3 (es)
HK (1) HK1164050A1 (es)
IL (1) IL214822A (es)
MA (1) MA33219B1 (es)
MX (1) MX2011010347A (es)
SG (1) SG174205A1 (es)
TN (1) TN2011000437A1 (es)
WO (1) WO2010114824A1 (es)

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TW202206412A (zh) 2020-05-28 2022-02-16 美商維特衛治療有限責任公司 製備（ｓ）－２－胺基－３－（４－（２，３－二甲基吡啶－４－基）苯基）丙酸甲酯及其鹽酸鹽的方法
TW202206420A (zh) 2020-05-28 2022-02-16 美商維特衛治療有限責任公司 用於製備glp-1受體促效劑的中間體和方法
WO2021238965A1 (zh) 2020-05-28 2021-12-02 杭州中美华东制药有限公司 (s)-2-氨基-3-(4-(2,3-二甲基吡啶-4-基)苯基丙酸甲酯及其盐的制备方法
US20230348484A1 (en) * 2020-05-28 2023-11-02 Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Method for preparing glp-1 receptor agonist free base
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Also Published As

Publication number Publication date
DK2413693T3 (en) 2015-11-16
EP2413693B1 (en) 2015-09-09
US20110160198A1 (en) 2011-06-30
US20130096150A1 (en) 2013-04-18
JP2012522060A (ja) 2012-09-20
CN102378574B (zh) 2013-11-20
SG174205A1 (en) 2011-10-28
US20150148539A1 (en) 2015-05-28
CN102378574A (zh) 2012-03-14
EP2413693A1 (en) 2012-02-08
EP2413693A4 (en) 2012-08-22
EA201171197A8 (ru) 2014-10-30
MA33219B1 (fr) 2012-04-02
CA2757084C (en) 2017-08-29
AU2010232750B2 (en) 2015-10-29
KR101732978B1 (ko) 2017-05-08
BRPI1013579A2 (pt) 2020-11-03
IL214822A0 (en) 2011-11-30
WO2010114824A8 (en) 2011-10-06
JP5755217B2 (ja) 2015-07-29
US9175003B2 (en) 2015-11-03
ES2553645T3 (es) 2015-12-10
IL214822A (en) 2016-08-31
KR20120006506A (ko) 2012-01-18
EA201171197A1 (ru) 2012-04-30
CA2757084A1 (en) 2010-10-07
HK1164050A1 (en) 2012-09-21
US8383644B2 (en) 2013-02-26
US8987295B2 (en) 2015-03-24
WO2010114824A1 (en) 2010-10-07
TN2011000437A1 (en) 2013-03-27
EA023430B1 (ru) 2016-06-30
AU2010232750A1 (en) 2011-09-08

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