MX2011008645A - Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa. - Google Patents

Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa.

Info

Publication number
MX2011008645A
MX2011008645A MX2011008645A MX2011008645A MX2011008645A MX 2011008645 A MX2011008645 A MX 2011008645A MX 2011008645 A MX2011008645 A MX 2011008645A MX 2011008645 A MX2011008645 A MX 2011008645A MX 2011008645 A MX2011008645 A MX 2011008645A
Authority
MX
Mexico
Prior art keywords
inhibitors
tetrahydrothiazolopyridine
phosphatidylinositol
kinase
compounds
Prior art date
Application number
MX2011008645A
Other languages
English (en)
Inventor
Robert Davies
Mark Ledeboer
Yusheng Liao
Jinwang Xu
Brian Ledford
David Messersmith
Arnaud Le Tiran
Tiansheng Wang
Kevin Cottrell
Alex Aronov
Upul Keerthi Bandarage
Elaine Krueger
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2011008645A publication Critical patent/MX2011008645A/es

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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente invención se refiere a los compuestos (I) útiles como inhibidores de PI3K, particularmente de PI3KY. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para el uso de las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos.
MX2011008645A 2009-02-17 2010-02-16 Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa. MX2011008645A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15305609P 2009-02-17 2009-02-17
PCT/US2010/024323 WO2010096389A1 (en) 2009-02-17 2010-02-16 Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase

Publications (1)

Publication Number Publication Date
MX2011008645A true MX2011008645A (es) 2011-09-30

Family

ID=42138747

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008645A MX2011008645A (es) 2009-02-17 2010-02-16 Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa.

Country Status (7)

Country Link
US (1) US8524906B2 (es)
EP (1) EP2398810A1 (es)
JP (1) JP2012518011A (es)
AU (1) AU2010216219A1 (es)
CA (1) CA2752596A1 (es)
MX (1) MX2011008645A (es)
WO (1) WO2010096389A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104870017B (zh) 2012-11-08 2020-08-14 理森制药股份公司 含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物
JP2017505346A (ja) 2014-02-12 2017-02-16 アイティーオス セラペウティクス 新規な３−（インドール−３−イル）−ピリジン誘導体、医薬組成物、および使用方法
MD20160118A2 (ro) 2014-05-15 2017-04-30 Iteos Therapeutics Derivaţi ai pirolidin-2,5-dionei, compoziţii farmaceutice şi metode de utilizare ca inhibitori ai IDO1
EP3271354A1 (en) 2015-03-17 2018-01-24 Pfizer Inc Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
US10544095B2 (en) 2015-08-10 2020-01-28 Pfizer Inc. 3-indol substituted derivatives, pharmaceutical compositions and methods for use
AU2017229445B2 (en) * 2016-03-10 2019-07-11 Astrazeneca Ab Novel inhibitors of phosphatidylinositol 3-kinase gamma
TW202043239A (zh) * 2019-01-24 2020-12-01 日商第一三共股份有限公司 具有取代基之脲化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
ES2365258T3 (es) 2006-06-26 2011-09-27 Ucb Pharma S.A. Derivados de tiazol condensados como inhibidores de quinasa.
BRPI0915717A2 (pt) 2008-07-02 2015-10-27 Wood Group Logging Services Inc ferramenta de avaliação de cascalho e métodos de uso
JPWO2010024258A1 (ja) 2008-08-29 2012-01-26 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体

Also Published As

Publication number Publication date
US8524906B2 (en) 2013-09-03
AU2010216219A1 (en) 2011-09-01
US20120039849A1 (en) 2012-02-16
JP2012518011A (ja) 2012-08-09
CA2752596A1 (en) 2010-08-26
EP2398810A1 (en) 2011-12-28
WO2010096389A1 (en) 2010-08-26

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