MX2009004141A - Composiciones y metodos para modular receptores de c-kit y pdgfr. - Google Patents
Composiciones y metodos para modular receptores de c-kit y pdgfr.Info
- Publication number
- MX2009004141A MX2009004141A MX2009004141A MX2009004141A MX2009004141A MX 2009004141 A MX2009004141 A MX 2009004141A MX 2009004141 A MX2009004141 A MX 2009004141A MX 2009004141 A MX2009004141 A MX 2009004141A MX 2009004141 A MX2009004141 A MX 2009004141A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- raf
- kit
- pdgfr
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
Abstract
La presente invención proporciona compuestos y composiciones farmacéuticas de los mismos, las cuales son útiles como inhibidores de quinasa de proteína, así como a métodos para utilizar dichos compuestos para tratar, disminuir o prevenir una condición asociada con actividad de quinasa anormal o desregulada. En algunas modalidades, la presente invención proporciona métodos para utilizar dichos compuestos para tratar, disminuir o prevenir enfermedades o trastornos, que implican la activación anormal de la quinasa c-kit, PDGFR, PDGFR, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2, BRK, KDR, c-raf o b-raf, o formas mutantes de la misma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86243006P | 2006-10-20 | 2006-10-20 | |
PCT/US2007/081538 WO2008051757A1 (en) | 2006-10-20 | 2007-10-16 | Compositions and methods for modulating c-kit and pdgfr receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009004141A true MX2009004141A (es) | 2009-05-01 |
Family
ID=39027274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009004141A MX2009004141A (es) | 2006-10-20 | 2007-10-16 | Composiciones y metodos para modular receptores de c-kit y pdgfr. |
Country Status (25)
Country | Link |
---|---|
US (2) | US7678792B2 (es) |
EP (1) | EP2076513A1 (es) |
JP (1) | JP2010506948A (es) |
KR (1) | KR101079520B1 (es) |
CN (1) | CN101528744A (es) |
AR (1) | AR063343A1 (es) |
AU (1) | AU2007309279B2 (es) |
BR (1) | BRPI0718162A2 (es) |
CA (1) | CA2667010A1 (es) |
CL (1) | CL2007003005A1 (es) |
CO (1) | CO6170361A2 (es) |
CR (1) | CR10717A (es) |
EA (1) | EA200900573A1 (es) |
EC (1) | ECSP099353A (es) |
IL (1) | IL197875A0 (es) |
MA (1) | MA30888B1 (es) |
MX (1) | MX2009004141A (es) |
NI (1) | NI200900061A (es) |
NO (1) | NO20091949L (es) |
PE (1) | PE20081262A1 (es) |
SM (1) | SMP200900027B (es) |
TN (1) | TN2009000145A1 (es) |
TW (1) | TW200825081A (es) |
WO (1) | WO2008051757A1 (es) |
ZA (1) | ZA200902711B (es) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US8221804B2 (en) | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
BRPI0718696A2 (pt) | 2006-11-09 | 2013-12-31 | Alcon Res Ltd | Matriz de polímero insolúvel em água para liberação de fármaco. |
TWI498115B (zh) * | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
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US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
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WO2002028853A1 (fr) | 2000-10-02 | 2002-04-11 | Tanabe Seiyaku Co., Ltd. | Compose de benzylamine, son procede de production et produit intermediaire correspondant |
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US20090312349A1 (en) * | 2004-12-23 | 2009-12-17 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
US20090312321A1 (en) | 2006-05-15 | 2009-12-17 | Irm Llc | Compositions and methods for fgf receptor kinases inhibitors |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
JP5357763B2 (ja) * | 2006-11-06 | 2013-12-04 | トレロ ファーマシューティカルズ, インコーポレイテッド | イミダゾ[1,2−b]ピリダジン誘導体およびピラゾロ[1,5−a]ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用 |
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AU2007309279B2 (en) | 2011-03-24 |
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ZA200902711B (en) | 2010-05-26 |
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SMP200900027B (it) | 2010-01-19 |
KR101079520B1 (ko) | 2011-11-03 |
CA2667010A1 (en) | 2008-05-02 |
CN101528744A (zh) | 2009-09-09 |
CR10717A (es) | 2009-07-02 |
PE20081262A1 (es) | 2008-10-29 |
TN2009000145A1 (en) | 2010-10-18 |
CO6170361A2 (es) | 2010-06-18 |
EA200900573A1 (ru) | 2009-10-30 |
ECSP099353A (es) | 2009-06-30 |
BRPI0718162A2 (pt) | 2013-11-26 |
AR063343A1 (es) | 2009-01-21 |
NO20091949L (no) | 2009-05-19 |
JP2010506948A (ja) | 2010-03-04 |
MA30888B1 (fr) | 2009-11-02 |
US7678792B2 (en) | 2010-03-16 |
WO2008051757A1 (en) | 2008-05-02 |
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