LT3424920T - (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai - Google Patents

(s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai

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Publication number
LT3424920T
LT3424920T LTEP18188034.5T LT18188034T LT3424920T LT 3424920 T LT3424920 T LT 3424920T LT 18188034 T LT18188034 T LT 18188034T LT 3424920 T LT3424920 T LT 3424920T
Authority
LT
Lithuania
Prior art keywords
methyl
bipyrimidin
propan
carboxamide
quinoline
Prior art date
Application number
LTEP18188034.5T
Other languages
English (en)
Inventor
Kwame NTI-ADDAE
Simon Adam O`NEIL
Yuegang Zhang
Praveen Mudunuri
John Gregg Van Alsten
Bin Song
Kathy Stavropoulos
Mark STROHMEIER
Michael Waldo
Mettachit Navamal
Irina Nikolaevna Kadiyala
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of LT3424920T publication Critical patent/LT3424920T/lt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C59/235—Saturated compounds containing more than one carboxyl group
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
LTEP18188034.5T 2013-10-17 2014-10-17 (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai LT3424920T (lt)

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US201361892002P 2013-10-17 2013-10-17

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LT3424920T true LT3424920T (lt) 2020-08-10

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LTEP14799578.1T LT3057953T (lt) 2013-10-17 2014-10-17 (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai
LTEP18188034.5T LT3424920T (lt) 2013-10-17 2014-10-17 (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai

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LTEP14799578.1T LT3057953T (lt) 2013-10-17 2014-10-17 (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai

Country Status (26)

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US (2) US10039761B2 (lt)
EP (2) EP3424920B1 (lt)
JP (2) JP6408569B2 (lt)
KR (1) KR102411227B1 (lt)
CN (2) CN105814036B (lt)
AU (2) AU2014337154B2 (lt)
BR (1) BR112016008452B1 (lt)
CA (1) CA2927631C (lt)
CL (1) CL2016000916A1 (lt)
DK (2) DK3057953T3 (lt)
ES (2) ES2705342T3 (lt)
HR (2) HRP20181841T1 (lt)
HU (2) HUE041877T2 (lt)
IL (1) IL245117B (lt)
LT (2) LT3057953T (lt)
MX (1) MX361488B (lt)
PE (1) PE20161022A1 (lt)
PL (2) PL3424920T3 (lt)
PT (2) PT3057953T (lt)
RS (2) RS60426B1 (lt)
RU (2) RU2018143803A (lt)
SG (1) SG11201602962PA (lt)
SI (2) SI3057953T1 (lt)
UA (1) UA120915C2 (lt)
WO (1) WO2015058067A1 (lt)
ZA (1) ZA201602777B (lt)

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CN109563018A (zh) * 2016-06-13 2019-04-02 心悦生医股份有限公司 苯甲酸钠的共晶及其用途
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CA3060597A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
ES2929309T3 (es) 2017-05-18 2022-11-28 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor PGE2
WO2019143677A1 (en) 2018-01-17 2019-07-25 Vertex Pharmaceuticals Incorporated Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
CN112300126A (zh) * 2019-07-31 2021-02-02 山东轩竹医药科技有限公司 杂环类dna-pk抑制剂
CN112574179B (zh) * 2019-09-29 2022-05-10 山东轩竹医药科技有限公司 Dna-pk抑制剂
CN114478399A (zh) * 2020-10-27 2022-05-13 华东理工大学 嘧菌酯低共熔混合物及其制备方法和应用

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IL245117B (en) 2019-10-31
EP3424920B1 (en) 2020-04-15
PT3424920T (pt) 2020-07-07
ZA201602777B (en) 2018-07-25
SI3424920T1 (sl) 2020-08-31
HRP20201011T1 (hr) 2020-10-16
HRP20181841T1 (hr) 2019-01-11
EP3424920A1 (en) 2019-01-09
RS57969B1 (sr) 2019-01-31
JP6763919B2 (ja) 2020-09-30
US20180325897A1 (en) 2018-11-15
RU2016118771A (ru) 2017-11-22
PT3057953T (pt) 2018-11-27
SG11201602962PA (en) 2016-05-30
PL3057953T3 (pl) 2019-01-31
PL3424920T3 (pl) 2020-11-16
EP3057953A1 (en) 2016-08-24
US10716789B2 (en) 2020-07-21
AU2014337154B2 (en) 2018-06-28
IL245117A0 (en) 2016-06-30
RU2018143803A (ru) 2019-01-17
CA2927631A1 (en) 2015-04-23
WO2015058067A1 (en) 2015-04-23
CN108771681A (zh) 2018-11-09
US20160339024A1 (en) 2016-11-24
BR112016008452A2 (lt) 2017-08-01
MX2016004992A (es) 2016-07-19
RS60426B1 (sr) 2020-07-31
CL2016000916A1 (es) 2016-11-11
MX361488B (es) 2018-12-07
DK3057953T3 (en) 2018-11-19

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