MX2009011810A - Tiazoles y pirazoles utiles como inhibidores de cinasa. - Google Patents

Tiazoles y pirazoles utiles como inhibidores de cinasa.

Info

Publication number
MX2009011810A
MX2009011810A MX2009011810A MX2009011810A MX2009011810A MX 2009011810 A MX2009011810 A MX 2009011810A MX 2009011810 A MX2009011810 A MX 2009011810A MX 2009011810 A MX2009011810 A MX 2009011810A MX 2009011810 A MX2009011810 A MX 2009011810A
Authority
MX
Mexico
Prior art keywords
thiazoles
kinase inhibitors
compounds
pyrazoles useful
useful
Prior art date
Application number
MX2009011810A
Other languages
English (en)
Inventor
Michael Mortimore
Julian Golec
John Studley
Christopher Davis
Daniel Robinson
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009011810A publication Critical patent/MX2009011810A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La presente invención se refiere a compuestos útiles como inhibidores de proteínas cinasas Aurora. La invención también provee composiciones farmacéuticamente aceptables que comprenden esos compuestos y métodos para usar los compuestos y composiciones en el tratamiento de varias enfermedades, condiciones y trastornos. La invención también provee procesos para la preparación de compuestos de la invención.
MX2009011810A 2007-05-02 2008-05-02 Tiazoles y pirazoles utiles como inhibidores de cinasa. MX2009011810A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91557007P 2007-05-02 2007-05-02
PCT/US2008/062327 WO2008137619A2 (en) 2007-05-02 2008-05-02 Thiazoles and pyrazoles useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009011810A true MX2009011810A (es) 2010-01-14

Family

ID=39865531

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011810A MX2009011810A (es) 2007-05-02 2008-05-02 Tiazoles y pirazoles utiles como inhibidores de cinasa.

Country Status (9)

Country Link
US (2) US8268811B2 (es)
EP (1) EP2152694A2 (es)
JP (2) JP5389785B2 (es)
CN (1) CN101679378A (es)
AU (1) AU2008247592A1 (es)
CA (1) CA2685876A1 (es)
MX (1) MX2009011810A (es)
NZ (1) NZ580884A (es)
WO (1) WO2008137619A2 (es)

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MX2009009590A (es) 2007-03-09 2009-11-10 Vertex Pharma Aminopirimidinas utiles como inhibidores de proteinas cinasas.
NZ580343A (en) 2007-04-13 2012-03-30 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
MX2009011812A (es) 2007-05-02 2010-01-14 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
AU2008247592A1 (en) 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
AR067762A1 (es) 2007-07-31 2009-10-21 Vertex Pharma Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
BR112014003997A2 (pt) 2011-08-25 2017-03-21 Hoffmann La Roche composto, método para inibição da atividade de pak1 em uma célula e paciente, método para o tratamento ou melhoria da gravidade do câncer ou de um distúrbio hiperproliferativo em um paciente, utilização do composto e composição
JP2015504876A (ja) 2011-12-22 2015-02-16 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト セリン／トレオニンキナーゼ阻害剤としての２，４−ジアミン−ピリミジン誘導体
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SG11201408679XA (en) 2012-06-26 2015-01-29 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
WO2017156493A1 (en) 2016-03-11 2017-09-14 Denali Therapeutics Inc. Compounds, compositions, and methods
SG11201507203RA (en) 2013-03-12 2015-10-29 Vertex Pharma Dna-pk inhibitors
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
CN108771681B (zh) 2013-10-17 2021-06-15 沃泰克斯药物股份有限公司 作为dna-pk抑制剂的化合物及其氘化衍生物的共晶
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WO2017087905A1 (en) 2015-11-20 2017-05-26 Denali Therapeutics Inc. Compound, compositions, and methods
IL299412A (en) 2016-06-16 2023-02-01 Denali Therapeutics Inc Pyrimidine-2-ylamino-1H-pyrazoles as LRRK2 inhibitors for use in the treatment of neurodegenerative disorders
JP2019529475A (ja) 2016-09-27 2019-10-17 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法
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Also Published As

Publication number Publication date
JP2010526096A (ja) 2010-07-29
WO2008137619A2 (en) 2008-11-13
US8785444B2 (en) 2014-07-22
US8268811B2 (en) 2012-09-18
EP2152694A2 (en) 2010-02-17
CN101679378A (zh) 2010-03-24
CA2685876A1 (en) 2008-11-13
US20100317641A1 (en) 2010-12-16
NZ580884A (en) 2012-02-24
JP2013231083A (ja) 2013-11-14
AU2008247592A1 (en) 2008-11-13
JP5389785B2 (ja) 2014-01-15
US20130116228A1 (en) 2013-05-09
WO2008137619A3 (en) 2009-03-19

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