KR910004573A - 이미다졸 유도체, 그의 제조방법 및 그를 함유하는 항궤양제 - Google Patents

이미다졸 유도체, 그의 제조방법 및 그를 함유하는 항궤양제 Download PDF

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KR910004573A
KR910004573A KR1019900012311A KR900012311A KR910004573A KR 910004573 A KR910004573 A KR 910004573A KR 1019900012311 A KR1019900012311 A KR 1019900012311A KR 900012311 A KR900012311 A KR 900012311A KR 910004573 A KR910004573 A KR 910004573A
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fluorine
butyl
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butoxy
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KR960011377B1 (ko
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스스무 오까베
미쓰오 미사끼
도미오 야마까와
히또시 마쓰꾸라
유다까 노무라
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닛뽕 케미파 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C33/00—Parts of bearings; Special methods for making bearings or parts thereof
    • F16C33/72—Sealings
    • F16C33/76—Sealings of ball or roller bearings
    • F16C33/78—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members
    • F16C33/7816—Details of the sealing or parts thereof, e.g. geometry, material
    • F16C33/782—Details of the sealing or parts thereof, e.g. geometry, material of the sealing region
    • F16C33/7823—Details of the sealing or parts thereof, e.g. geometry, material of the sealing region of sealing lips
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C33/00—Parts of bearings; Special methods for making bearings or parts thereof
    • F16C33/72—Sealings
    • F16C33/76—Sealings of ball or roller bearings
    • F16C33/78—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members
    • F16C33/784—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted to a groove in the inner surface of the outer race and extending toward the inner race
    • F16C33/7843—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted to a groove in the inner surface of the outer race and extending toward the inner race with a single annular sealing disc
    • F16C33/7853—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted to a groove in the inner surface of the outer race and extending toward the inner race with a single annular sealing disc with one or more sealing lips to contact the inner race
    • F16C33/7856—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted to a groove in the inner surface of the outer race and extending toward the inner race with a single annular sealing disc with one or more sealing lips to contact the inner race with a single sealing lip
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C33/00—Parts of bearings; Special methods for making bearings or parts thereof
    • F16C33/72—Sealings
    • F16C33/76—Sealings of ball or roller bearings
    • F16C33/78—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members
    • F16C33/7869—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted with a cylindrical portion to the inner surface of the outer race and having a radial portion extending inward
    • F16C33/7873—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted with a cylindrical portion to the inner surface of the outer race and having a radial portion extending inward with a single sealing ring of generally L-shaped cross-section
    • F16C33/7876—Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members mounted with a cylindrical portion to the inner surface of the outer race and having a radial portion extending inward with a single sealing ring of generally L-shaped cross-section with sealing lips
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F16J15/3204—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip
    • F16J15/322—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip supported in a direction perpendicular to the surfaces
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F16J15/3268—Mounting of sealing rings
    • F16J15/3276—Mounting of sealing rings with additional static sealing between the sealing, or its casing or support, and the surface on which it is mounted
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C19/00—Bearings with rolling contact, for exclusively rotary movement
    • F16C19/22—Bearings with rolling contact, for exclusively rotary movement with bearing rollers essentially of the same size in one or more circular rows, e.g. needle bearings
    • F16C19/24—Bearings with rolling contact, for exclusively rotary movement with bearing rollers essentially of the same size in one or more circular rows, e.g. needle bearings for radial load mainly
    • F16C19/26—Bearings with rolling contact, for exclusively rotary movement with bearing rollers essentially of the same size in one or more circular rows, e.g. needle bearings for radial load mainly with a single row of rollers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C2361/00—Apparatus or articles in engineering in general
    • F16C2361/61—Toothed gear systems, e.g. support of pinion shafts

Abstract

내용 없음.

Description

이미다졸 유도체, 그의 제조방법 및 그를 함유하는 항궤양제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(I)의 이미다졸 유도체
    [상기 식중, R1은 수소 또는 탄소수 1∼6의 알킬기이고, R2는 수소 1개가 탄소수 1∼4인 알콕시기로 치환된 탄소수 2∼6 알킬기이며, R3, R4, R5및 R6각각은 독립적으로 수소, 할로겐, 탄소수 1∼6 알킬기, 탄소수 1∼6의 알콕시기, 탄소수 1∼6의 불소-치환 알킬기 또는 탄소수 1∼6의 불소-치환 알콕시기이다.]
  2. 제1항에 있어서, R1이 수소, 메틸, 에틸, n-프로필, i-프로필, n-부틸, i-부틸, t-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실 또는 i-헥실인 이미다졸 유도체.
  3. 제1항에 있어서, 알킬기 R2의 말단 탄소원자가 알콕시기로 치환된 이미다졸 유도체.
  4. 제1항에 있어서, R2중의 탄소수 1∼4의 알콕시기가 메톡시, 에톡시, n-프로폭시, i-프로폭시, n-부톡시, i-부톡시 또는 t-부톡시이고, 탄소수 2∼6의 알킬기 R2가 에틸, n-프로필, i-프로필, n-부틸,i-부틸, t-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실 또는 i-헥실인 이미다졸 유도체.
  5. 제1항에 있어서, R3, R4, R5및 R6이 각각 독립적으로 수소, 불소, 염소, 브롬, 요오드, 메틸, 에틸, n-프로필, i-프로필, n-부틸, i-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실, i-헥실, 불소-치환 메틸, 불소-치환에틸, 불소-치환n-프로필, 불소-치환i-프로필, 불소-치환n-부틸, 불소-치환i-부틸, 불소-치환t-부틸, 불소-치환n-펜틸, 불소-치환n-헥실, 불소-치환 i-헥실, 메톡시, 에톡시, n-프로폭시, i-프로폭시, n-부톡시, i-부톡시, t-부톡시, 펜틸옥시, 헥실옥시, 불소-치환 메톡시, 불소-치환 에톡시, 불소-치환n-프로폭시, 불소-치환i-프로폭시, 불소-치환 n-부톡시, 불소-치환 펜틸옥시 또는 불소-치환 헥실옥시인 이미다졸 유도체.
  6. 하기 일반식(II)의 화합물을 2-메트캅토이미다졸과 반응시켜서 하기 일반식(III)의 이미다졸 유도체를 제조하고, 하기 일반식(III)의 이미다졸 유도체를 산화시키는 단계들로 이루어진 하기 일반식(I)의 이미다졸 유도체의 제조방법.
    [상기 식중, R1은 수소 또는 탄소수 1∼6의 알킬기이고, R2는 탄소수 1∼4의 알콕시기로 치환된 탄소수 2∼6의 알킬기이며, R3, R4, R5및 R6각각은 독립적으로 수소, 할로겐, 탄소수 1∼6의 알킬기, 탄소수 1∼6의 알콕시기, 탄소수 1∼6의 불소-치환 알킬기 또는 탄소수 1∼6의 불소-치환 알콕시기이고, X는 이탈기이다.]
  7. 제6항에 있어서, R1이 수소, 메틸, 에틸n-프로필, i-프로필, n-부틸, i-부틸, t-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실 또는 i-헥실인 방법.
  8. 제6항에 있어서, 알킬기 R2의 말단 탄소원자가 알콕시기로 치환된 방법.
  9. 제6항에 있어서, R2중의 탄소수 1∼4의 알콕시기가 메톡시, 에톡시, n-프로폭시, i-프로폭시, n-부톡시, i-부톡시 또는 t-부톡시이고, 탄소수 2∼6의 알킬기 R2가 에틸, n-프로필, i-프로필, n-부틸, i-부틸, t-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실 또는 i-헥실인 방법.
  10. 제6항에 있어서, R3, R4, R5및 R6이 각각 독립적으로 수소, 불소, 염소, 브롬, 요오드, 메틸, 에틸, n-프로필, i-프로필, n-부틸, i-부틸, t-부틸, n-펜틸, i-펜틸, 네오펜틸, n-헥실, i-헥실, 불소-치환 메틸, 불소-치환에틸, 불소-치환n-브로필, 불소-치환i-프로필, 불소-치환n-부틸, 불소-치환 i-부틸, 불소-치환t-부틸, 불소-치환n-펜틸 , 불소-치환i-펜틸, 불소-치환 네오펜틸, 불소-치환n-헥실, 불소-치환 i-헥실, 메톡시, 에톡시, n-프로폭시, i-프로폭시, n-부톡시, i-부톡시, t-부톡시, 펜틸옥시, 헥실옥시, 불소-치환 메톡시, 불소-치환 에톡시, 불소-치환n-프로폭시, 불소-치환i-프로폭시, 불소-치환n-부톡시, 불소-치환 i-부톡시, 불소-치환 t-부톡시, 불소-치환 펜틸옥시 또는 불소-치환 헥실옥시인 방법.
  11. 하기 일반식(I)의 이미다졸 유도체를 유효 성분으로서 함유하는 항궤양제.
    [상기 식중, R1은 수소 또는 탄소수 1~6의 알킬기이고, R2는 수소 1개가탄소수 1∼4의 알콕시기로 치환된 탄소수 2∼6의 알킬기이며, R3, R4, R5및 R6각각은 독립적으로 수소, 할로겐, 탄소수 1∼6의 알킬기, 탄소수 1∼6의 알콕시기, 탄소수 1∼6의 불소-치환 알킬기 또는 1∼6의 불소-치환 알콕시기이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012311A 1989-08-10 1990-08-10 이미다졸유도체,그의제조방법및그를함유하는항궤양제 KR960011377B1 (ko)

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JPH0770083A (ja) * 1993-07-05 1995-03-14 Nippon Chemiphar Co Ltd イミダゾール誘導体を有効成分とする血圧降下剤
JP3046924B2 (ja) * 1995-03-27 2000-05-29 株式会社アラクス イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬
CN103874697A (zh) 2011-08-03 2014-06-18 协和发酵麒麟株式会社 二苯并氧杂*衍生物

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EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤

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RU2026293C1 (ru) 1995-01-09
PL286432A1 (en) 1991-04-22
US5091403A (en) 1992-02-25
AU630839B2 (en) 1992-11-05
RU2069212C1 (ru) 1996-11-20
ATE102610T1 (de) 1994-03-15
MX171158B (ko) 1993-10-05
JPH03163065A (ja) 1991-07-15
EP0412529B1 (en) 1994-03-09
ZA906247B (en) 1991-06-26
CA2022903A1 (en) 1991-02-11
PL163654B1 (pl) 1994-04-29
DE69007203T2 (de) 1994-07-28
HU206686B (en) 1992-12-28
NO179004C (no) 1996-07-17
DD297159A5 (de) 1992-01-02
EP0412529A1 (en) 1991-02-13
DE69007203D1 (de) 1994-04-14
ES2062223T3 (es) 1994-12-16
NO903514L (no) 1991-02-11
KR960011377B1 (ko) 1996-08-22
AU6085190A (en) 1991-02-14
NO179004B (no) 1996-04-09
FI903967A0 (fi) 1990-08-10
NO903514D0 (no) 1990-08-09
HU904946D0 (en) 1991-01-28
HUT54663A (en) 1991-03-28
DK0412529T3 (da) 1994-04-05
JP2794640B2 (ja) 1998-09-10

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