IE812500L - Piperidine derivatives - Google Patents

Piperidine derivatives

Info

Publication number
IE812500L
IE812500L IE812500A IE250081A IE812500L IE 812500 L IE812500 L IE 812500L IE 812500 A IE812500 A IE 812500A IE 250081 A IE250081 A IE 250081A IE 812500 L IE812500 L IE 812500L
Authority
IE
Ireland
Prior art keywords
radical
hydrogen atom
alkyl
halogen atoms
piperidine derivatives
Prior art date
Application number
IE812500A
Other versions
IE51707B1 (en
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Priority to CA000388595A priority Critical patent/CA1173039A/en
Priority to FI813330A priority patent/FI77850C/en
Priority to JP56170536A priority patent/JPS5872565A/en
Priority to IE2500/81A priority patent/IE51707B1/en
Priority to DK469381A priority patent/DK157853C/en
Priority to PT73875A priority patent/PT73875B/en
Priority to AU76769/81A priority patent/AU545739B2/en
Priority to NO813577A priority patent/NO153890C/en
Priority to ES506500A priority patent/ES506500A0/en
Priority to GR66337A priority patent/GR75364B/el
Priority to NZ198748A priority patent/NZ198748A/en
Priority to ZA817373A priority patent/ZA817373B/en
Publication of IE812500L publication Critical patent/IE812500L/en
Publication of IE51707B1 publication Critical patent/IE51707B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Piperidine derivatives of the general formula: <IMG> wherein R represents a hydrogen atom, or a (C1-4)alkyl hydroxy(C1-4)alkyl, or (C1-4)alkoxycarbonyl radical or a benzyl radical optionally carrying a substituent selected from halogen atoms and (C1-4)alkoxy radicals or the phenethyl radical, or the 3-phenylpropyl radical, and X represents one or more hydrogen or halogen atoms or (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl or methylenedioxy radicals, or alternatively X forms with the phenyl nucleus a naphthyl radical, with the proviso that when R represents a hydrogen atom X is other than a hydrogen atom, are new compounds useful as medicaments and, more particularly, as antidepressants. They may be prepared by reaction of a 4-hydroxypiperidine with a benzyl halide. [CA1173039A]
IE2500/81A 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them IE51707B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA000388595A CA1173039A (en) 1981-10-23 1981-10-23 4-benzyloxypiperidine compounds
FI813330A FI77850C (en) 1981-10-23 1981-10-23 Process for the preparation of 4-benzyloxy or 4-naphthylmethoxypipe ridin derivatives which have antidepressant effect.
JP56170536A JPS5872565A (en) 1981-10-23 1981-10-23 Piperidine derivative and application to medicine
IE2500/81A IE51707B1 (en) 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them
DK469381A DK157853C (en) 1981-10-23 1981-10-23 ANALOGY PROCEDURE FOR THE PREPARATION OF 4-BENZYLOXYPIPERIDE INGREDIATES
PT73875A PT73875B (en) 1981-10-23 1981-10-23 PROCESS FOR THE PREPARATION OF THERAPEUTICALLY APPLICABLE PIPERIDINE DERIVATIVES
AU76769/81A AU545739B2 (en) 1981-10-23 1981-10-23 Piperidine derivatives
NO813577A NO153890C (en) 1981-10-23 1981-10-23 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS.
ES506500A ES506500A0 (en) 1981-10-23 1981-10-23 PIPERIDINE DERIVATIVES PREPARATION PROCEDURE
GR66337A GR75364B (en) 1981-10-23 1981-10-23
NZ198748A NZ198748A (en) 1981-10-23 1981-10-23 Piperidine derivatives and pharmaceutical compositions
ZA817373A ZA817373B (en) 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
CA000388595A CA1173039A (en) 1981-10-23 1981-10-23 4-benzyloxypiperidine compounds
FI813330A FI77850C (en) 1981-10-23 1981-10-23 Process for the preparation of 4-benzyloxy or 4-naphthylmethoxypipe ridin derivatives which have antidepressant effect.
JP56170536A JPS5872565A (en) 1981-10-23 1981-10-23 Piperidine derivative and application to medicine
IE2500/81A IE51707B1 (en) 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them
DK469381A DK157853C (en) 1981-10-23 1981-10-23 ANALOGY PROCEDURE FOR THE PREPARATION OF 4-BENZYLOXYPIPERIDE INGREDIATES
PT73875A PT73875B (en) 1981-10-23 1981-10-23 PROCESS FOR THE PREPARATION OF THERAPEUTICALLY APPLICABLE PIPERIDINE DERIVATIVES
AU76769/81A AU545739B2 (en) 1981-10-23 1981-10-23 Piperidine derivatives
NO813577A NO153890C (en) 1981-10-23 1981-10-23 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS.
ES506500A ES506500A0 (en) 1981-10-23 1981-10-23 PIPERIDINE DERIVATIVES PREPARATION PROCEDURE
GR66337A GR75364B (en) 1981-10-23 1981-10-23
NZ198748A NZ198748A (en) 1981-10-23 1981-10-23 Piperidine derivatives and pharmaceutical compositions
ZA817373A ZA817373B (en) 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IE812500L true IE812500L (en) 1983-04-21
IE51707B1 IE51707B1 (en) 1987-02-18

Family

ID=27582840

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2500/81A IE51707B1 (en) 1981-10-23 1981-10-23 Piperidine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (12)

Country Link
JP (1) JPS5872565A (en)
AU (1) AU545739B2 (en)
CA (1) CA1173039A (en)
DK (1) DK157853C (en)
ES (1) ES506500A0 (en)
FI (1) FI77850C (en)
GR (1) GR75364B (en)
IE (1) IE51707B1 (en)
NO (1) NO153890C (en)
NZ (1) NZ198748A (en)
PT (1) PT73875B (en)
ZA (1) ZA817373B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02148948U (en) * 1989-05-17 1990-12-18
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
JPH0535676U (en) * 1991-06-06 1993-05-14 株式会社カネマス Pack for reconstitution of dried seaweed

Also Published As

Publication number Publication date
AU7676981A (en) 1983-04-28
DK157853B (en) 1990-02-26
ES8206476A1 (en) 1982-08-16
IE51707B1 (en) 1987-02-18
JPS5872565A (en) 1983-04-30
DK469381A (en) 1983-04-24
NO153890C (en) 1986-06-11
PT73875B (en) 1983-01-25
AU545739B2 (en) 1985-08-01
NO813577L (en) 1983-04-25
ZA817373B (en) 1983-03-30
GR75364B (en) 1984-07-13
JPS6135177B2 (en) 1986-08-12
FI813330L (en) 1983-04-24
ES506500A0 (en) 1982-08-16
PT73875A (en) 1981-11-01
FI77850B (en) 1989-01-31
DK157853C (en) 1990-08-06
NO153890B (en) 1986-03-03
FI77850C (en) 1989-05-10
NZ198748A (en) 1984-08-24
CA1173039A (en) 1984-08-21

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Legal Events

Date Code Title Description
MM4A Patent lapsed