ES2084725T3 - Nuevos derivados de ciclobutano. - Google Patents
Nuevos derivados de ciclobutano.Info
- Publication number
- ES2084725T3 ES2084725T3 ES91108303T ES91108303T ES2084725T3 ES 2084725 T3 ES2084725 T3 ES 2084725T3 ES 91108303 T ES91108303 T ES 91108303T ES 91108303 T ES91108303 T ES 91108303T ES 2084725 T3 ES2084725 T3 ES 2084725T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- compounds
- cyclobutane derivatives
- formula
- new cyclobutane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical class C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 1,4-DIHYDRO-1-METHYLNICOTINOYL Chemical class 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003016 phosphoric acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A DERIVADOS DE CICLOBUTANO REPRESENTADOS POR LA SIGUIENTE FORMULA GENERAL (1) Y SALES FISIOLOGICAMENTE ACEPTABLES DE LOS MISMOS: EN DONDE B REPRESENTA UN DERIVADO BASICO DE ACIDO NUCLEICO, R ELEVADO 1 Y R (AL CUADRADO) INDEPENDIENTEMENTE REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO DE DIALQUILAMINOACILO, UN GRUPO DE 1,4-DIHIDRO-1-METILNICOTINOILO O UN GRUPO DE ACIDO FOSFORICO SUSTITUIDO, SIEMPRE Y CUANDO BIEN R ELEVADO 1 O R (AL CUADRADO) SEA UN GRUPO DISTINTO DE UN ATOMO DE HIDROGENO. LOS COMPUESTOS DE LA INVENCION PRESENTAN UNA ALTA ABSORBENCIA ORAL Y SON METABOLIZADOS EN VIVO EN LOS COMPUESTOS DE LA FORMULA (1A). SEGUN ESTO, SE ESPERA QUE LOS COMPUESTOS DE LA INVENCION SEAN UTILES COMO AGENTES ANTIVIRICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13268690 | 1990-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084725T3 true ES2084725T3 (es) | 1996-05-16 |
Family
ID=15087157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91108303T Expired - Lifetime ES2084725T3 (es) | 1990-05-24 | 1991-05-23 | Nuevos derivados de ciclobutano. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5324730A (es) |
EP (1) | EP0458312B1 (es) |
KR (1) | KR0159945B1 (es) |
AU (1) | AU642738B2 (es) |
CA (1) | CA2043099A1 (es) |
DE (1) | DE69118016T2 (es) |
ES (1) | ES2084725T3 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2042931A1 (en) * | 1990-05-24 | 1991-11-25 | Robert Zahler | Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines |
CA2052315A1 (en) * | 1990-10-09 | 1992-04-10 | Masashi Nagai | Cyclobutane derivatives |
US7495006B2 (en) * | 2004-12-10 | 2009-02-24 | Emory University | 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
WO2010061931A1 (ja) * | 2008-11-27 | 2010-06-03 | 国立大学法人香川大学 | シクロブチルプリン誘導体、血管新生促進剤、管腔形成促進剤、神経細胞成長促進剤および医薬品 |
US10910081B2 (en) | 2018-12-17 | 2021-02-02 | Micron Technology, Inc. | Management of test resources to perform reliability testing of memory components |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816447A (en) * | 1981-08-26 | 1989-03-28 | Merck & Co., Inc. | Anti-viral guanine compounds |
JPS62208295A (ja) * | 1986-03-07 | 1987-09-12 | Nippon Kayaku Co Ltd | ヒポキサンチン塩基を有する新規化合物およびその製造法 |
JPS63264527A (ja) * | 1987-04-21 | 1988-11-01 | Nippon Kayaku Co Ltd | 抗エイズウイルス剤 |
IL86381A0 (en) * | 1987-05-19 | 1988-11-15 | Nippon Kayaku Kk | Oxetanocins and pharmaceutical compositions containing the same |
US4855466A (en) * | 1987-12-28 | 1989-08-08 | E. R. Squibb & Sons, Inc. | Purinyl cyclobutanes |
US5041447A (en) * | 1988-03-23 | 1991-08-20 | Nippon Kayaku Kabushiki Kaisha | Oxetanocin-related compounds and pharmaceutical compositions containing them |
US5723609A (en) * | 1988-03-30 | 1998-03-03 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl purines |
AU622926B2 (en) * | 1988-09-09 | 1992-04-30 | Nippon Kayaku Kabushiki Kaisha | Pyrimidine or purine cyclobutane derivatives |
IL92096A0 (en) * | 1988-10-25 | 1990-07-12 | Abbott Lab | Carboxylic nucleoside analogs |
EP0427799B1 (en) * | 1989-01-24 | 1994-11-30 | Gensia, Inc. | Method and compounds for aica riboside delivery and for lowering blood glucose |
US4992368A (en) * | 1989-04-20 | 1991-02-12 | Nippon Kayaku Kabushiki Kaisha | Novel process for producing oxetanocin G |
US4960910A (en) * | 1989-06-13 | 1990-10-02 | Nippon Kayaku Kabushiki Kaisha | Oxetane derivatives |
JPH03173896A (ja) * | 1989-09-08 | 1991-07-29 | Nippon Kayaku Co Ltd | 新規オキセタノシン誘導体、その塩およびその用途 |
-
1991
- 1991-05-22 US US07/704,085 patent/US5324730A/en not_active Expired - Fee Related
- 1991-05-23 ES ES91108303T patent/ES2084725T3/es not_active Expired - Lifetime
- 1991-05-23 DE DE69118016T patent/DE69118016T2/de not_active Expired - Fee Related
- 1991-05-23 CA CA002043099A patent/CA2043099A1/en not_active Abandoned
- 1991-05-23 EP EP91108303A patent/EP0458312B1/en not_active Expired - Lifetime
- 1991-05-23 AU AU77312/91A patent/AU642738B2/en not_active Ceased
- 1991-05-24 KR KR1019910008434A patent/KR0159945B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2043099A1 (en) | 1991-11-25 |
AU7731291A (en) | 1991-11-28 |
EP0458312B1 (en) | 1996-03-20 |
EP0458312A1 (en) | 1991-11-27 |
DE69118016D1 (de) | 1996-04-25 |
US5324730A (en) | 1994-06-28 |
KR910020021A (ko) | 1991-12-19 |
DE69118016T2 (de) | 1996-08-01 |
AU642738B2 (en) | 1993-10-28 |
KR0159945B1 (ko) | 1999-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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