KR890002137A - 아지트로마이신 이수화물 - Google Patents
아지트로마이신 이수화물 Download PDFInfo
- Publication number
- KR890002137A KR890002137A KR1019880008463A KR880008463A KR890002137A KR 890002137 A KR890002137 A KR 890002137A KR 1019880008463 A KR1019880008463 A KR 1019880008463A KR 880008463 A KR880008463 A KR 880008463A KR 890002137 A KR890002137 A KR 890002137A
- Authority
- KR
- South Korea
- Prior art keywords
- azithromycin dihydrate
- dihydrate
- crystalline azithromycin
- hydrocarbon
- azithromycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 결정성 아지트로마이신 이수화물.
- 테트라하이드로푸란 및 (C5-C7) 지방족 탄화수소의 혼합물로 부터 적어도 2몰 당량의 물의 존재하에 결정화 하는 것을 포함하여, 결정성 아지트로마이신 이수화물을 제조하는 방법.
- 제2항에 있어서, 탄화수소가 헥산인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US87/01612 | 1987-07-09 | ||
PCT/US1987/001612 WO1989000576A1 (en) | 1987-07-09 | 1987-07-09 | Azithromycin dihydrate |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890002137A true KR890002137A (ko) | 1989-04-08 |
KR900006218B1 KR900006218B1 (ko) | 1990-08-25 |
Family
ID=22202456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880008463A KR900006218B1 (ko) | 1987-07-09 | 1988-07-08 | 아지트로 마이신 이수화물 |
Country Status (45)
Families Citing this family (76)
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HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
US5912331A (en) * | 1991-03-15 | 1999-06-15 | Merck & Co., Inc. | Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A |
US5985844A (en) * | 1992-03-26 | 1999-11-16 | Merck & Co., Inc. | Homoerythromycin A derivatives modified at the 4"-and 8A-positions |
US5189159A (en) * | 1992-04-02 | 1993-02-23 | Merck & Co., Inc. | 8a-AZA-8a-homoerythromycin cyclic iminoethers |
CA2081268A1 (en) * | 1991-10-25 | 1993-04-26 | Katsuhiro Imaki | Glycine derivative monosodium salt tetrahydrate |
US5215980A (en) * | 1992-01-17 | 1993-06-01 | Merck & Co., Inc. | 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof |
US5210235A (en) * | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
CN1034734C (zh) * | 1993-12-10 | 1997-04-30 | 北京市集才药物研究所 | 一种新的阿齐红霉素结晶及其制备方法 |
US5605889A (en) | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
CZ292360B6 (cs) | 1994-05-06 | 2003-09-17 | Pfizer Inc. | Dávkovací forma s řízeným uvolňováním obsahující azithromycin a způsob její výroby |
ES2122905B1 (es) * | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
ATE267835T1 (de) * | 1997-10-16 | 2004-06-15 | Pliva Pharm & Chem Works | Neue 9a-azalide |
US6861411B1 (en) | 1997-12-02 | 2005-03-01 | Pfizer, Inc. | Method of treating eye infections with azithromycin |
PT102130A (pt) * | 1998-03-13 | 1999-09-30 | Hovione Sociedade Quimica S A | Processo de preparacao de dihidrato de azitromicina |
TW546302B (en) * | 1998-05-08 | 2003-08-11 | Biochemie Sa | Improvements in macrolide production |
CA2245398C (en) | 1998-08-21 | 2002-01-29 | Apotex Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
EP1152765B1 (en) | 1998-11-30 | 2004-10-13 | Teva Pharmaceutical Industries Ltd. | Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof |
US7056893B2 (en) | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
JP3897983B2 (ja) * | 1999-05-18 | 2007-03-28 | ファイザー・プロダクツ・インク | マクロライド系抗生物質の新規結晶 |
US6703372B1 (en) * | 1999-06-29 | 2004-03-09 | Biochemie S.A. | Macrolides |
ES2177373B1 (es) * | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
US6586576B2 (en) | 2000-01-04 | 2003-07-01 | Teva Pharmaceutical Industries Ltd | Preparation method of azithromycin hydrates |
ES2162764B1 (es) * | 2000-05-17 | 2003-04-01 | Ercros Ind Sa | Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion. |
DE60026718T2 (de) | 2000-07-25 | 2006-11-16 | Laboratorio Silanes, S.A. De C.V. | Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a |
ES2172417B1 (es) * | 2000-07-31 | 2003-09-16 | Sint Quimica Sa | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
EP1313749B1 (en) * | 2000-08-23 | 2005-10-12 | Wockhardt Limited | Process for preparation of anhydrous azithromycin |
SK287814B6 (sk) * | 2000-11-27 | 2011-11-04 | Sandoz Ag | Azithromycin in the form of a monohydrate, a process for its preparation and pharmaceutical compositions comprising same |
IN190080B (ko) * | 2001-01-29 | 2003-06-07 | Alembic Ltd | |
KR100491183B1 (ko) | 2001-03-21 | 2005-05-25 | 한미약품 주식회사 | 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물 |
SI1390377T1 (sl) | 2001-05-22 | 2006-06-30 | Pfizer Prod Inc | Nova kristalna oblika azitromicina |
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CN1889931A (zh) * | 2003-12-04 | 2007-01-03 | 辉瑞产品公司 | 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾-冻凝方法 |
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CN101177441B (zh) * | 2007-12-05 | 2012-05-23 | 浙江耐司康药业有限公司 | 一种稳定的阿奇霉素一水合物结晶的制备方法 |
CN101624412B (zh) * | 2008-07-10 | 2012-07-04 | 刘力 | 大环内酯类衍生物及其制备和用途 |
PL2344129T3 (pl) | 2008-10-07 | 2018-07-31 | Horizon Orphan Llc | Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych |
JP2012505222A (ja) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 肺炎症を低減するためのレボフロキサシンの吸入 |
CN101418026B (zh) * | 2008-10-09 | 2011-05-18 | 南京工业大学 | 一种晶型和粒度可控的阿奇霉素结晶工艺 |
CN101787063B (zh) * | 2009-01-23 | 2012-12-19 | 刘力 | 抗感染药物及其制备和用途 |
EA201101319A1 (ru) | 2009-03-13 | 2012-04-30 | Да Волтерра | Композиции и способы элиминации грамотрицательных бактерий |
ES2739979T3 (es) | 2009-09-04 | 2020-02-05 | Horizon Orphan Llc | Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística |
CN102911219A (zh) * | 2011-08-03 | 2013-02-06 | 山东方明药业集团股份有限公司 | 一种阿齐霉素在水相直接结晶的方法 |
CN103159811A (zh) * | 2011-12-10 | 2013-06-19 | 山东方明药业集团股份有限公司 | 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法 |
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-
1987
- 1987-07-09 RU SU874742955A patent/RU2066324C1/ru active
- 1987-07-09 RO RO143593A patent/RO107257B1/ro unknown
- 1987-07-09 UA UA93004522A patent/UA27040C2/uk unknown
- 1987-07-09 MX MX1221388A patent/MX12213A/es unknown
- 1987-07-09 WO PCT/US1987/001612 patent/WO1989000576A1/en active IP Right Grant
-
1988
- 1988-05-11 IN IN418/DEL/88A patent/IN168879B/en unknown
- 1988-06-15 AP APAP/P/1988/000093A patent/AP44A/en active
- 1988-06-28 DE DE8888305921T patent/DE3868296D1/de not_active Expired - Lifetime
- 1988-06-28 ES ES198888305921T patent/ES2038756T3/es not_active Expired - Lifetime
- 1988-06-28 EP EP88305921A patent/EP0298650B1/en not_active Expired - Lifetime
- 1988-06-28 AT AT88305921T patent/ATE72446T1/de not_active IP Right Cessation
- 1988-07-04 IL IL86979A patent/IL86979A/xx not_active IP Right Cessation
- 1988-07-05 MY MYPI88000744A patent/MY103744A/en unknown
- 1988-07-05 BG BG84783A patent/BG47348A3/xx unknown
- 1988-07-06 JP JP63168637A patent/JPH0631300B2/ja not_active Expired - Lifetime
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- 1988-07-08 KR KR1019880008463A patent/KR900006218B1/ko not_active IP Right Cessation
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1990
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1992
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1993
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1994
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1995
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1998
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