KR870006024A - 니자티딘의 제조방법 - Google Patents

니자티딘의 제조방법 Download PDF

Info

Publication number
KR870006024A
KR870006024A KR860010822A KR860010822A KR870006024A KR 870006024 A KR870006024 A KR 870006024A KR 860010822 A KR860010822 A KR 860010822A KR 860010822 A KR860010822 A KR 860010822A KR 870006024 A KR870006024 A KR 870006024A
Authority
KR
South Korea
Prior art keywords
nizatidine
prepare
methyl
formula
solmethanamine
Prior art date
Application number
KR860010822A
Other languages
English (en)
Other versions
KR890002427B1 (ko
Inventor
그리넬 잭슨 빌리
앤드류 슬람스키 브루스
Original Assignee
메리 앤 터커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메리 앤 터커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 터커
Publication of KR870006024A publication Critical patent/KR870006024A/ko
Application granted granted Critical
Publication of KR890002427B1 publication Critical patent/KR890002427B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

니자티딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 일반식(II)의 1-알콕시-N-메틸-2-니트로에텐아민을 구조식(III)의 4-[[(2-아미노에틸)티오]메틸]-N,N-디메틸-2-티아졸메탄아민과 반응시켜 구조식(I)의 니자티딘을 제조하는 방법.
    상기식에서, R은 C1-C4알킬이다.
  2. 제 1 항에 있어서, R이 메틸 또는 에틸이고, 반응을 물중에서 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860010822A 1985-12-18 1986-12-17 니자티딘의 제조방법 KR890002427B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81013685A 1985-12-18 1985-12-18
US810136 1985-12-18

Publications (2)

Publication Number Publication Date
KR870006024A true KR870006024A (ko) 1987-07-08
KR890002427B1 KR890002427B1 (ko) 1989-07-03

Family

ID=25203102

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860010822A KR890002427B1 (ko) 1985-12-18 1986-12-17 니자티딘의 제조방법

Country Status (14)

Country Link
EP (1) EP0230127A1 (ko)
JP (1) JPS62155268A (ko)
KR (1) KR890002427B1 (ko)
CN (1) CN86108424A (ko)
AU (1) AU582932B2 (ko)
CA (1) CA1277325C (ko)
DK (1) DK605386A (ko)
FI (1) FI865117A (ko)
HU (1) HU196385B (ko)
IL (1) IL80961A0 (ko)
NZ (1) NZ218647A (ko)
PH (1) PH21924A (ko)
PT (1) PT83938B (ko)
ZA (1) ZA869438B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
KR100980612B1 (ko) * 2008-09-02 2010-09-07 한국항공우주연구원 유량조절밸브
CN101462969B (zh) * 2009-01-09 2012-04-25 福建深纳生物工程有限公司 1-甲氨基-1-甲氧基-2-硝基乙烯的合成方法
CN102329282A (zh) * 2011-07-15 2012-01-25 海南灵康制药有限公司 一种尼扎替丁化合物及其制法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
PT78063A (en) * 1983-02-07 1984-03-01 Lilly Co Eli Improvements in or relating to the process of synthesis of nizatidine

Also Published As

Publication number Publication date
AU582932B2 (en) 1989-04-13
JPS62155268A (ja) 1987-07-10
FI865117A (fi) 1987-06-19
EP0230127A1 (en) 1987-07-29
KR890002427B1 (ko) 1989-07-03
CA1277325C (en) 1990-12-04
ZA869438B (en) 1988-07-27
CN86108424A (zh) 1987-08-05
DK605386D0 (da) 1986-12-16
AU6660386A (en) 1987-06-25
FI865117A0 (fi) 1986-12-16
HU196385B (en) 1988-11-28
PT83938B (pt) 1989-06-30
HUT45033A (en) 1988-05-30
PH21924A (en) 1988-04-08
IL80961A0 (en) 1987-03-31
NZ218647A (en) 1989-02-24
DK605386A (da) 1987-06-19
PT83938A (en) 1987-01-01

Similar Documents

Publication Publication Date Title
KR850000406A (ko) 4-클로로-2-페닐이미다졸-5-아세트산유도체의 제조방법
KR840005083A (ko) 항고혈압제로서 유용한 아미노산유도체의 제조방법
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
KR830000214A (ko) 펩타이드 유도체의 제법
KR830006198A (ko) 시클로헥산 유도체의 제조방법
KR870006024A (ko) 니자티딘의 제조방법
KR830007545A (ko) 프로스타글란딘의 제조방법
KR830009044A (ko) 3,5-디-3급부틸-4-하이드록시페닐-치환 복소환 화합물의 제조방법
KR840007591A (ko) 니자티딘의 합성법
KR830010075A (ko) 말초 혈관 확장 작용을 갖는 화합물의 제조방법
KR870001137A (ko) 1,1-(3-에틸페닐) 페닐에틸렌 및 그제법
KR880003926A (ko) 구아디노 티아졸 화합물의 제조방법
KR870010025A (ko) 티아졸리딘 유도체의 제조방법
KR860008996A (ko) 구아니디노 티아졸 화합물의 제조방법
KR880002849A (ko) 구아니디노 티아졸 화합물의 제조 방법
KR830009090A (ko) 1-벤질-4-[4-(2-피리미디닐아미노)벤질]-2,3-디옥소피페라진 유도체의 제조방법
KR830007673A (ko) 아미노-페니실린 유도체의 제조방법
KR890008119A (ko) 티아졸 유도체의 제조방법
KR890016032A (ko) 푸란 유도체의 제조방법
KR840000467A (ko) 살리칠산 유도체의 제법
KR870002051A (ko) L-페닐 알라닌 에스테르의 제조 방법
KR870010062A (ko) 세파로스포린 유도체의 제조방법
KR880006185A (ko) 신규 α-클로로케톤 유도체 및 그 제조법
KR900000348A (ko) N-술파모일-3-[(2-구아니디노티아졸-4-일)메틸티오]프로피온아미딘의 제조방법
KR860006483A (ko) 시타라빈 유도체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee