KR870007118A - 광학적으로 순수한 화합물 및 그의 제조 방법 - Google Patents

광학적으로 순수한 화합물 및 그의 제조 방법 Download PDF

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Publication number
KR870007118A
KR870007118A KR860011720A KR860011720A KR870007118A KR 870007118 A KR870007118 A KR 870007118A KR 860011720 A KR860011720 A KR 860011720A KR 860011720 A KR860011720 A KR 860011720A KR 870007118 A KR870007118 A KR 870007118A
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South Korea
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propyl
hydrochloride
weight
water
volume
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KR860011720A
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KR940008302B1 (ko
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베르너 산드베르크 루네
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안더스 뢴너
아스트라 레케메델 악티에볼라크
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Application filed by 안더스 뢴너, 아스트라 레케메델 악티에볼라크 filed Critical 안더스 뢴너
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

광학적으로 순수한 화합물 및 그의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일수화물 형태임을 특징으로 하는 S-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염.
  2. 제1항에 있어서, 실제로 광학적으로 순수함을 특징으로 하는 화합물.
  3. 제1항에 있어서, 대응하는 R-(+)-에난티오머를 0.5중량%미만 함유량을 특징으로하는 화합물.
  4. S-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염을 물 중에 용해시키고, 여기에 45℃내지 비점 온도까지 가열시킨 아세톤을 첨가한 후, S-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염의 일 수화물을 단리시킴을 특징으로 하는, 실제로 광학적으로 순수한 S-(-)-1-프로필 2',6'-피페콜옥실리디드 염산염의 제조 방법.
  5. 제4항에 있어서, S-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염을 그의 중량의 1-3배에 해당하는 양의 물 중에 용해시키고, 여기에 아세톤을 물 용적의 5-15배 용적으로 첨가한 후, 용액을 여과시키고, 최종 생성물을 단리시킴을 특징으로 하는 방법.
  6. 제5항에 있어서, 물의 중량을 S-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염의 중량과 동량으로하고, 아세톤의 용적을 첨가한 물 용적의 10배로 함을 특징으로 하는 방법.
  7. 제1항에 의한 화합물을 함유함을 특징으로 하는 국부 마취용 약제.
  8. 국부 마취 유도 용도의 제1항에 의한 화합물.
  9. 국부 마취를 필요로 하는 인체를 포함한 포유 동물에 제1항에 의한 화합물을 마취량으로 투여하는것으로 되는, 국부 마취 유도 방법.
  10. 제1항에 의한 화합물의 국부 마취 효과를 갖는 약제 제조 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860011720A 1986-01-03 1986-12-31 광학적으로 순수한 s-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염의 제조방법 KR940008302B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8600017A SE451840B (sv) 1986-01-03 1986-01-03 Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
SE8600017-1 1986-01-03

Publications (2)

Publication Number Publication Date
KR870007118A true KR870007118A (ko) 1987-08-14
KR940008302B1 KR940008302B1 (ko) 1994-09-12

Family

ID=20363001

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860011720A KR940008302B1 (ko) 1986-01-03 1986-12-31 광학적으로 순수한 s-(-)-1-프로필-2',6'-피페콜옥실리디드 염산염의 제조방법

Country Status (29)

Country Link
US (1) US4870086A (ko)
EP (1) EP0239710B1 (ko)
JP (1) JPH07598B2 (ko)
KR (1) KR940008302B1 (ko)
AR (1) AR242561A1 (ko)
AT (1) ATE56956T1 (ko)
AU (1) AU592392B2 (ko)
BG (1) BG62066B2 (ko)
CA (1) CA1276154C (ko)
CY (1) CY1680A (ko)
DE (1) DE3674582D1 (ko)
DK (1) DK171378B1 (ko)
EG (1) EG17867A (ko)
ES (1) ES2036179T3 (ko)
FI (1) FI83075C (ko)
GR (1) GR3002516T3 (ko)
HK (1) HK5493A (ko)
IE (1) IE59061B1 (ko)
LU (1) LU88843I2 (ko)
LV (1) LV5765B4 (ko)
MY (1) MY101132A (ko)
NL (1) NL960005I2 (ko)
NO (2) NO170330C (ko)
NZ (1) NZ218615A (ko)
PH (1) PH22924A (ko)
PT (1) PT84041B (ko)
SE (1) SE451840B (ko)
SG (1) SG117292G (ko)
ZA (1) ZA868600B (ko)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
SI21560B (sl) * 1990-06-07 2005-04-30 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
ES2082703B1 (es) * 1993-11-04 1996-12-16 Inst Investigacion Desarrollo Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
US5834490A (en) * 1993-11-04 1998-11-10 Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A. Cyclopropyl derivatives, preparation method there-of and applications
AU695479B2 (en) * 1994-09-23 1998-08-13 Darwin Discovery Limited Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
SE9501808D0 (sv) * 1995-05-16 1995-05-16 Astra Ab New process
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
SE9800139D0 (sv) 1998-01-21 1998-01-21 Astra Ab New use
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
US7683175B2 (en) * 2005-06-06 2010-03-23 Navinta, Llc Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
WO2007123405A1 (en) * 2006-04-25 2007-11-01 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
DK2234974T3 (da) * 2008-01-15 2012-06-25 Pharmathen Sa Fremgangsmåde til fremstilling af (S)-1-alkyl-2',6'-pipecoloxylidid-forbindelse
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法

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US2248018A (en) * 1939-03-30 1941-07-01 Winthrop Chem Co Inc 4-aryl-piperidine-ketones and a process of preparing them
GB775749A (en) * 1955-04-06 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
US2799679A (en) * 1955-04-28 1957-07-16 Bofors Ab Process of preparing amides of heterocyclic carboxylic acids
GB775750A (en) * 1955-04-28 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine mono-carboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
GB800565A (en) * 1956-01-23 1958-08-27 Bofors Ab Method of producing n-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides
GB824542A (en) * 1957-05-15 1959-12-02 Bofors Ab Method of producing n-alkyl-piperidine-alpha-monocarboxylic acid amides
GB869978A (en) * 1958-03-13 1961-06-07 Bofors Ab Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides
GB949729A (en) * 1960-11-15 1964-02-19 Bofors Ab Substituted-piperidine carboxylic acid amide salts and their preparation
SE341404B (ko) * 1967-05-18 1971-12-27 Sterling Drug Inc
CH491915A (de) * 1967-06-28 1970-06-15 Geigy Ag J R Verfahren zur Herstellung von neuen Piperidinderivaten
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Also Published As

Publication number Publication date
NO1997009I1 (no) 1997-08-18
MY101132A (en) 1991-07-31
AR242561A1 (es) 1993-04-30
IE870004L (en) 1987-07-03
ES2036179T3 (es) 1993-05-16
SE8600017L (sv) 1987-07-04
FI83075B (fi) 1991-02-15
EP0239710B1 (en) 1990-09-26
LV5765A4 (lv) 1996-12-20
NO170330B (no) 1992-06-29
KR940008302B1 (ko) 1994-09-12
ZA868600B (en) 1987-08-26
SE8600017D0 (sv) 1986-01-03
LU88843I2 (fr) 1997-03-14
JPS62158251A (ja) 1987-07-14
PH22924A (en) 1989-01-24
NZ218615A (en) 1989-07-27
BG62066B2 (bg) 1999-01-29
CA1276154C (en) 1990-11-13
ATE56956T1 (de) 1990-10-15
LV5765B4 (lv) 1997-06-20
AU592392B2 (en) 1990-01-11
SG117292G (en) 1993-01-29
GR3002516T3 (en) 1993-01-25
CY1680A (en) 1993-10-10
JPH07598B2 (ja) 1995-01-11
DK287A (da) 1987-07-04
PT84041B (pt) 1989-09-14
DK171378B1 (da) 1996-10-07
NO864858L (no) 1987-07-06
FI870003A0 (fi) 1987-01-02
DE3674582D1 (de) 1990-10-31
AU6644986A (en) 1987-07-09
FI870003A (fi) 1987-07-04
SE451840B (sv) 1987-11-02
EP0239710A1 (en) 1987-10-07
NL960005I2 (nl) 1997-10-01
IE59061B1 (en) 1993-12-15
HK5493A (en) 1993-01-29
NL960005I1 (nl) 1996-09-02
US4870086A (en) 1989-09-26
DK287D0 (da) 1987-01-02
EG17867A (en) 1991-03-30
PT84041A (en) 1987-01-01
FI83075C (fi) 1991-05-27
NO170330C (no) 1992-10-07
NO864858D0 (no) 1986-12-03

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