JP5441287B2 - 心血管事象を予防するための必須脂肪酸 - Google Patents
心血管事象を予防するための必須脂肪酸 Download PDFInfo
- Publication number
- JP5441287B2 JP5441287B2 JP2000599384A JP2000599384A JP5441287B2 JP 5441287 B2 JP5441287 B2 JP 5441287B2 JP 2000599384 A JP2000599384 A JP 2000599384A JP 2000599384 A JP2000599384 A JP 2000599384A JP 5441287 B2 JP5441287 B2 JP 5441287B2
- Authority
- JP
- Japan
- Prior art keywords
- dha
- epa
- ethyl ester
- fatty acids
- essential fatty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明による治療の有効性は例えば、実質的に以下のごとく設計されたプロトコルを3.5年間継続した臨床試験で、梗塞後死亡率がこのような治療によって予想以上の極めて有意な減少を示したという事実によって証明される:
1 “対照”グループ1は、梗塞患者に常用の標準療法で治療した;
2 “処理”グループ2は、“対照”グループに与えた療法に加えて、85%のEPA+DHA(1g/日)を投与した;
3 “処理”グループ3は、“対照”グループに与えた療法に加えて、ビタミンEを投与した;
4 “処理”グループ4は、“対照”グループに与えた療法に加えて、ビタミンEと85%のEPA+DHA(1g/日)とを投与した。
以下の組成を有しており1カプセルあたり1gの有効成分(EPA+DHA、85%力価)を含有するカプセルを公知の製薬技術に従って調製する。
EPA−エチルエステル 525mg/カプセル
DHA−エチルエステル 315mg/カプセル
d−アルファトコフェロール 4IU/カプセル
ゼラチン 246mg/カプセル
グリセロール 118mg/カプセル
赤色酸化鉄 2.27mg/カプセル
黄色酸化鉄 1.27mg/カプセル
ポリ不飽和脂肪酸のエチルエステル 1000mg
エチルエステル中の
ω−3ポリ不飽和エステル
(エイコサペンタエン酸(EPA)、
ドコサヘキサエン酸(DHA))の含量 850mg
d−1−α トコフェロール 0.3mg
ゼラチンスクシネート 233mg
グリセロール 67mg
p−オキシ安息香酸ナトリウム 1.09mg
プロピルp−オキソ安息香酸ナトリウム 0.54mg
Claims (4)
- エイコサペンタエン酸エチルエステル(EPA)とドコサヘキサエン酸エチルエステル(DHA)とを含有する必須脂肪酸混合物を含み、前記混合物中のEPA+DHAの含量が約84%−約100重量%であり、心筋梗塞の病歴のある患者の突然死による死亡率を約40%低下させるための経口投与用医薬組成物。
- 前記混合物中のEPA+DHAの含量が約85重量%であることを特徴とする請求項1に記載の医薬組成物。
- 約0.7g−約1.5g/日の用量で経口投与されることを特徴とする請求項1又は2に記載の医薬組成物。
- EPA+DHA混合物のEPA/DHA比が約0.9−約1.5であることを特徴とする請求項1乃至3のいずれか1項に記載の医薬組成物。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI99A000313 | 1999-02-17 | ||
IT1999MI000313A IT1308613B1 (it) | 1999-02-17 | 1999-02-17 | Acidi grassi essenziali nella prevenzione di eventi cardiovascolari. |
IT99A000313 | 1999-02-17 | ||
PCT/EP2000/000957 WO2000048592A1 (en) | 1999-02-17 | 2000-02-07 | Essential fatty acids in the prevention of cardiovascular events |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010014742A Division JP2010116414A (ja) | 1999-02-17 | 2010-01-07 | 心血管事象を予防するための必須脂肪酸 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002537252A JP2002537252A (ja) | 2002-11-05 |
JP5441287B2 true JP5441287B2 (ja) | 2014-03-12 |
Family
ID=11381919
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000599384A Expired - Lifetime JP5441287B2 (ja) | 1999-02-17 | 2000-02-07 | 心血管事象を予防するための必須脂肪酸 |
JP2010014742A Pending JP2010116414A (ja) | 1999-02-17 | 2010-01-07 | 心血管事象を予防するための必須脂肪酸 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010014742A Pending JP2010116414A (ja) | 1999-02-17 | 2010-01-07 | 心血管事象を予防するための必須脂肪酸 |
Country Status (26)
Country | Link |
---|---|
US (2) | US7462643B1 (ja) |
EP (2) | EP1247523A1 (ja) |
JP (2) | JP5441287B2 (ja) |
KR (2) | KR20070098954A (ja) |
CN (1) | CN1230159C (ja) |
AT (1) | ATE216230T1 (ja) |
AU (1) | AU775078B2 (ja) |
BR (1) | BR0008153A (ja) |
CA (1) | CA2362271C (ja) |
CZ (1) | CZ301307B6 (ja) |
DE (1) | DE60000133C5 (ja) |
DK (1) | DK1152755T3 (ja) |
EA (1) | EA004312B1 (ja) |
ES (1) | ES2174814T3 (ja) |
HK (1) | HK1044720B (ja) |
HU (1) | HUP0200111A3 (ja) |
ID (1) | ID30205A (ja) |
IL (2) | IL144377A0 (ja) |
IT (1) | IT1308613B1 (ja) |
NO (1) | NO328797B1 (ja) |
NZ (1) | NZ513093A (ja) |
PL (1) | PL209078B1 (ja) |
PT (1) | PT1152755E (ja) |
SK (1) | SK286523B6 (ja) |
WO (1) | WO2000048592A1 (ja) |
ZA (1) | ZA200106029B (ja) |
Families Citing this family (41)
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IT1308613B1 (it) * | 1999-02-17 | 2002-01-09 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella prevenzione di eventi cardiovascolari. |
ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
ITMI20020269A1 (it) * | 2002-02-12 | 2003-08-12 | Victorix Assets Ltd | Uso di steri etilici di acidi poliinsaturi omega-3 in pazienti con insufficienza cardiaca |
GB0210212D0 (en) * | 2002-05-03 | 2002-06-12 | Univ Southampton | Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability |
US8729124B2 (en) | 2002-03-05 | 2014-05-20 | Pronova Biopharma Norge As | Use of EPA and DHA in secondary prevention |
CA2485116C (en) | 2002-05-03 | 2013-02-05 | Pronova Biocare As | Use of epa and dha in secondary prevention |
ITMI20022511A1 (it) * | 2002-11-26 | 2004-05-27 | Victorix Assets Ltd | Uso di composizioni farmaceutiche contenenti esteri etilici di acidi poliinsaturi omega-3 nella orevenzione della fibrillazione atriale. |
ATE499146T1 (de) | 2005-03-11 | 2011-03-15 | Recon Oil Ind Private Ltd | Synergistisch hitzestabiles ölmedium mit eicosapentaensäure (epa) und docosahexaensäure (dha) |
CA2570763C (en) * | 2005-07-08 | 2011-08-23 | Mochida Pharmaceutical Co., Ltd. | Composition for preventing onset of cardiovascular events |
JP5134916B2 (ja) * | 2005-07-08 | 2013-01-30 | 持田製薬株式会社 | 心血管イベント発症予防用組成物 |
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CN101365438A (zh) | 2006-02-07 | 2009-02-11 | 持田制药株式会社 | 预防中风复发的组合物 |
ES2500063T3 (es) | 2006-05-31 | 2014-09-29 | Mochida Pharmaceutical Co., Ltd. | Composición para prevenir la aparición de acontecimiento cardiovascular en paciente con riesgo múltiple |
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JPWO2010018856A1 (ja) * | 2008-08-13 | 2012-01-26 | 持田製薬株式会社 | カンナビノイド受容体関連疾患の予防/改善または治療剤 |
EP2475309A4 (en) * | 2009-09-08 | 2015-07-29 | Atrium Medical Corp | HERNIAPFLASTER |
RU2014146265A (ru) | 2009-12-30 | 2015-07-10 | Басф Фарма (Калланиш) Лимитед | Способ хроматографического разделения с псевдодвижущимся слоем |
US8715648B2 (en) | 2011-02-16 | 2014-05-06 | Pivotal Therapeutics Inc. | Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics |
US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
US8952000B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
KR101681907B1 (ko) * | 2012-02-27 | 2016-12-12 | 주식회사 케어사이드 | 혈액 순환 촉진 및 피부 질환 개선용 조성물 |
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MY189576A (en) | 2012-03-30 | 2022-02-17 | Micelle Biopharma Inc | Omega-3 fatty acid ester compositions |
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US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
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EP3118186B1 (fr) | 2013-12-11 | 2022-02-09 | Novasep Process | Installation chromatographique de production d acides gras polyinsatures |
BR112016015718B1 (pt) | 2014-01-07 | 2021-12-07 | Novasep Process Solutions | Processo de purificação de aminoácidos aromáticos |
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-
1999
- 1999-02-17 IT IT1999MI000313A patent/IT1308613B1/it active
-
2000
- 2000-02-07 EP EP20020076100 patent/EP1247523A1/en not_active Withdrawn
- 2000-02-07 PT PT00907510T patent/PT1152755E/pt unknown
- 2000-02-07 EA EA200100895A patent/EA004312B1/ru not_active IP Right Cessation
- 2000-02-07 SK SK1080-2001A patent/SK286523B6/sk not_active IP Right Cessation
- 2000-02-07 DE DE60000133.4T patent/DE60000133C5/de not_active Expired - Lifetime
- 2000-02-07 KR KR1020077019755A patent/KR20070098954A/ko not_active Application Discontinuation
- 2000-02-07 KR KR1020017010387A patent/KR100823051B1/ko active IP Right Review Request
- 2000-02-07 DK DK00907510T patent/DK1152755T3/da active
- 2000-02-07 JP JP2000599384A patent/JP5441287B2/ja not_active Expired - Lifetime
- 2000-02-07 NZ NZ513093A patent/NZ513093A/xx not_active IP Right Cessation
- 2000-02-07 CN CNB008050732A patent/CN1230159C/zh not_active Expired - Lifetime
- 2000-02-07 EP EP00907510A patent/EP1152755B1/en not_active Expired - Lifetime
- 2000-02-07 US US09/869,333 patent/US7462643B1/en not_active Expired - Fee Related
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