JP4803969B2 - 植物抽出物を含有する粒剤の製造方法 - Google Patents
植物抽出物を含有する粒剤の製造方法 Download PDFInfo
- Publication number
- JP4803969B2 JP4803969B2 JP2004108574A JP2004108574A JP4803969B2 JP 4803969 B2 JP4803969 B2 JP 4803969B2 JP 2004108574 A JP2004108574 A JP 2004108574A JP 2004108574 A JP2004108574 A JP 2004108574A JP 4803969 B2 JP4803969 B2 JP 4803969B2
- Authority
- JP
- Japan
- Prior art keywords
- plant extract
- granule
- extract
- plant
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008187 granular material Substances 0.000 title claims description 128
- 239000000419 plant extract Substances 0.000 title claims description 80
- 238000004519 manufacturing process Methods 0.000 title claims description 22
- 239000003814 drug Substances 0.000 claims description 86
- 229940079593 drug Drugs 0.000 claims description 65
- 238000000034 method Methods 0.000 claims description 62
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 60
- 238000004898 kneading Methods 0.000 claims description 55
- 238000005469 granulation Methods 0.000 claims description 54
- 230000003179 granulation Effects 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 33
- 241000411851 herbal medicine Species 0.000 claims description 29
- 239000000284 extract Substances 0.000 claims description 26
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 22
- 238000001125 extrusion Methods 0.000 claims description 22
- 241000736199 Paeonia Species 0.000 claims description 21
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 21
- 229940041616 menthol Drugs 0.000 claims description 21
- 239000011812 mixed powder Substances 0.000 claims description 20
- 239000011248 coating agent Substances 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 9
- 239000007931 coated granule Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 241001071795 Gentiana Species 0.000 claims description 8
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 8
- 244000025221 Humulus lupulus Species 0.000 claims description 8
- 229940048730 senega Drugs 0.000 claims description 8
- 241000269333 Caudata Species 0.000 claims description 7
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 7
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 7
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 7
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 7
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 7
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 7
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 7
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 7
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 7
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 7
- 240000006927 Foeniculum vulgare Species 0.000 claims description 7
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims description 7
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 7
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 7
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 7
- 229940010454 licorice Drugs 0.000 claims description 7
- 235000011960 Brassica ruvo Nutrition 0.000 claims description 6
- 235000002767 Daucus carota Nutrition 0.000 claims description 6
- 244000000626 Daucus carota Species 0.000 claims description 6
- 241000286209 Phasianidae Species 0.000 claims description 6
- 239000009538 yokuinin Substances 0.000 claims description 6
- 241000237502 Ostreidae Species 0.000 claims description 5
- 235000020636 oyster Nutrition 0.000 claims description 5
- 241000218657 Picea Species 0.000 claims description 4
- 235000008632 Santalum album Nutrition 0.000 claims description 3
- 240000000513 Santalum album Species 0.000 claims description 3
- 239000007902 hard capsule Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 241000406668 Loxodonta cyclotis Species 0.000 claims description 2
- 238000000748 compression moulding Methods 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 2
- 240000000171 Crataegus monogyna Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 description 46
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 21
- 239000002994 raw material Substances 0.000 description 19
- 239000000843 powder Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 15
- 235000013399 edible fruits Nutrition 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 11
- 239000003172 expectorant agent Substances 0.000 description 9
- 230000003419 expectorant effect Effects 0.000 description 9
- 230000000202 analgesic effect Effects 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 241001092040 Crataegus Species 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 239000003960 organic solvent Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 235000004789 Rosa xanthina Nutrition 0.000 description 6
- 229940124584 antitussives Drugs 0.000 description 6
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 6
- 239000006188 syrup Substances 0.000 description 6
- 235000020357 syrup Nutrition 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 5
- 241000208173 Apiaceae Species 0.000 description 5
- 235000008694 Humulus lupulus Nutrition 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 240000004371 Panax ginseng Species 0.000 description 5
- 235000002789 Panax ginseng Nutrition 0.000 description 5
- 241000220222 Rosaceae Species 0.000 description 5
- 230000000954 anitussive effect Effects 0.000 description 5
- 230000001754 anti-pyretic effect Effects 0.000 description 5
- 239000003908 antipruritic agent Substances 0.000 description 5
- 239000000812 cholinergic antagonist Substances 0.000 description 5
- 229940124579 cold medicine Drugs 0.000 description 5
- 229940066493 expectorants Drugs 0.000 description 5
- 238000004080 punching Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 235000015961 tonic Nutrition 0.000 description 5
- 230000001256 tonic effect Effects 0.000 description 5
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 241001071804 Gentianaceae Species 0.000 description 4
- 230000002921 anti-spasmodic effect Effects 0.000 description 4
- 229960001948 caffeine Drugs 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 239000007771 core particle Substances 0.000 description 4
- 235000008434 ginseng Nutrition 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000007873 sieving Methods 0.000 description 4
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 3
- 241000208838 Asteraceae Species 0.000 description 3
- 241000132011 Atractylodes lancea Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 3
- 241000207923 Lamiaceae Species 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 3
- 235000009827 Prunus armeniaca Nutrition 0.000 description 3
- 244000018633 Prunus armeniaca Species 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- NTCYWJCEOILKNG-ROLPUNSJSA-N [(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-dimethylazanium;chloride Chemical compound Cl.CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 NTCYWJCEOILKNG-ROLPUNSJSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 229940035676 analgesics Drugs 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000002221 antipyretic Substances 0.000 description 3
- 239000003434 antitussive agent Substances 0.000 description 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 3
- 239000007963 capsule composition Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 229960000520 diphenhydramine Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004503 fine granule Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000004083 gastrointestinal agent Substances 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 229940051020 methylephedrine hydrochloride Drugs 0.000 description 3
- 229960004708 noscapine Drugs 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 244000284152 Carapichea ipecacuanha Species 0.000 description 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 2
- 244000183685 Citrus aurantium Species 0.000 description 2
- 241000221017 Euphorbiaceae Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000218228 Humulus Species 0.000 description 2
- 241000218195 Lauraceae Species 0.000 description 2
- 241001673966 Magnolia officinalis Species 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 240000007695 Nandina domestica Species 0.000 description 2
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 2
- 240000005001 Paeonia suffruticosa Species 0.000 description 2
- 241001106477 Paeoniaceae Species 0.000 description 2
- DYWNLSQWJMTVGJ-KUSKTZOESA-N Phenylpropanolamine hydrochloride Chemical compound Cl.C[C@H](N)[C@H](O)C1=CC=CC=C1 DYWNLSQWJMTVGJ-KUSKTZOESA-N 0.000 description 2
- 241000013557 Plantaginaceae Species 0.000 description 2
- 244000274050 Platycodon grandiflorum Species 0.000 description 2
- 235000006753 Platycodon grandiflorum Nutrition 0.000 description 2
- 241000734672 Polygala senega Species 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 241000405911 Rehmannia glutinosa Species 0.000 description 2
- 235000008081 Rheum officinale Nutrition 0.000 description 2
- 240000004980 Rheum officinale Species 0.000 description 2
- 241001107098 Rubiaceae Species 0.000 description 2
- 241001093501 Rutaceae Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000208292 Solanaceae Species 0.000 description 2
- 239000000150 Sympathomimetic Substances 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 241000234299 Zingiberaceae Species 0.000 description 2
- 244000126002 Ziziphus vulgaris Species 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 239000003159 antacid agent Substances 0.000 description 2
- 239000000043 antiallergic agent Substances 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 229940125715 antihistaminic agent Drugs 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 229940124575 antispasmodic agent Drugs 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- SBNKFTQSBPKMBZ-UHFFFAOYSA-N ethenzamide Chemical compound CCOC1=CC=CC=C1C(N)=O SBNKFTQSBPKMBZ-UHFFFAOYSA-N 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 229940127227 gastrointestinal drug Drugs 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000008141 laxative Substances 0.000 description 2
- 229940125722 laxative agent Drugs 0.000 description 2
- 239000000395 magnesium oxide Substances 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- FGSJNNQVSUVTPW-UHFFFAOYSA-N methoxyphenamine hydrochloride Chemical compound Cl.CNC(C)CC1=CC=CC=C1OC FGSJNNQVSUVTPW-UHFFFAOYSA-N 0.000 description 2
- 229960000659 methoxyphenamine hydrochloride Drugs 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 2
- 229960002305 phenylpropanolamine hydrochloride Drugs 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940127230 sympathomimetic drug Drugs 0.000 description 2
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 229960000716 tonics Drugs 0.000 description 2
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- AJZJIYUOOJLBAU-CEAXSRTFSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;n,n,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1.C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 AJZJIYUOOJLBAU-CEAXSRTFSA-N 0.000 description 1
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 description 1
- PMGQWSIVQFOFOQ-BDUVBVHRSA-N (e)-but-2-enedioic acid;(2r)-2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine Chemical compound OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCOC(C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PMGQWSIVQFOFOQ-BDUVBVHRSA-N 0.000 description 1
- FWLKKPKZQYVAFR-LVEZLNDCSA-N (e)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole Chemical compound OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.N=1C2=CC=CC=C2N(CCOCC)C=1N1CCCN(C)CC1 FWLKKPKZQYVAFR-LVEZLNDCSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 description 1
- QOLHOCYZKJILAV-UHFFFAOYSA-N 5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid;n,n-dimethyl-1-phenothiazin-10-ylpropan-2-amine Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1.C1=C(O)C(C(=O)O)=CC(CC=2C=C(C(O)=CC=2)C(O)=O)=C1 QOLHOCYZKJILAV-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000544270 Angelica acutiloba Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- FBMORZZOJSDNRQ-GLQYFDAESA-N Atractylenolide III Chemical compound C=C([C@@H]1C2)CCC[C@]1(C)C[C@@]1(O)C2=C(C)C(=O)O1 FBMORZZOJSDNRQ-GLQYFDAESA-N 0.000 description 1
- 241000984231 Atractylodes chinensis Species 0.000 description 1
- 241001106067 Atropa Species 0.000 description 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
- 241000202722 Bupleurum falcatum Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 241001561395 Citrus natsudaidai Species 0.000 description 1
- 241000555678 Citrus unshiu Species 0.000 description 1
- 241000533367 Cnidium officinale Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 241000218203 Coptis japonica Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241001034916 Corydalis turtschaninovii Species 0.000 description 1
- 235000008440 Crataegus cuneata Nutrition 0.000 description 1
- 244000160089 Crataegus cuneata Species 0.000 description 1
- 235000017159 Crataegus pinnatifida Nutrition 0.000 description 1
- 241000657480 Crataegus pinnatifida Species 0.000 description 1
- 235000014375 Curcuma Nutrition 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 1
- 240000009138 Curcuma zedoaria Species 0.000 description 1
- 241000490050 Eleutherococcus Species 0.000 description 1
- 241001632410 Eleutherococcus senticosus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001465251 Ephedra sinica Species 0.000 description 1
- 241000218670 Ephedraceae Species 0.000 description 1
- BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 240000001972 Gardenia jasminoides Species 0.000 description 1
- 235000002873 Gentiana lutea Nutrition 0.000 description 1
- 240000003409 Gentiana lutea Species 0.000 description 1
- 241001135871 Gentiana scabra Species 0.000 description 1
- 241000208150 Geraniaceae Species 0.000 description 1
- 244000105059 Geranium thunbergii Species 0.000 description 1
- 235000005491 Geranium thunbergii Nutrition 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 240000000691 Houttuynia cordata Species 0.000 description 1
- 235000013719 Houttuynia cordata Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 241001365031 Isodon japonicus Species 0.000 description 1
- BFSMWENDZZIWPW-UHFFFAOYSA-N Isopropamide iodide Chemical compound [I-].C=1C=CC=CC=1C(C(N)=O)(CC[N+](C)(C(C)C)C(C)C)C1=CC=CC=C1 BFSMWENDZZIWPW-UHFFFAOYSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241000146029 Lindera aggregata Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 240000004580 Magnolia hypoleuca Species 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- 241001149162 Mallotus japonicus Species 0.000 description 1
- HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 description 1
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- DJDFFEBSKJCGHC-UHFFFAOYSA-N Naphazoline Chemical compound Cl.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 DJDFFEBSKJCGHC-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 244000248557 Ophiopogon japonicus Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 1
- 241001474977 Palla Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000218180 Papaveraceae Species 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 241001499733 Plantago asiatica Species 0.000 description 1
- 241000131460 Plectranthus Species 0.000 description 1
- 241001080798 Polygala tenuifolia Species 0.000 description 1
- 241000208977 Polygalaceae Species 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 235000010401 Prunus avium Nutrition 0.000 description 1
- 241001290151 Prunus avium subsp. avium Species 0.000 description 1
- 240000008296 Prunus serotina Species 0.000 description 1
- 235000014441 Prunus serotina Nutrition 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000219100 Rhamnaceae Species 0.000 description 1
- 241000960945 Rheum coreanum Species 0.000 description 1
- 235000008090 Rheum palmatum Nutrition 0.000 description 1
- 240000001745 Rheum palmatum Species 0.000 description 1
- 235000000656 Rosa multiflora Nutrition 0.000 description 1
- 244000050053 Rosa multiflora Species 0.000 description 1
- 241000109329 Rosa xanthina Species 0.000 description 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 description 1
- 235000002911 Salvia sclarea Nutrition 0.000 description 1
- 244000182022 Salvia sclarea Species 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 241000758724 Schisandraceae Species 0.000 description 1
- 241000242847 Scopolia japonica Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 241000967294 Swertia japonica Species 0.000 description 1
- 208000012931 Urologic disease Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 244000131415 Zanthoxylum piperitum Species 0.000 description 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- -1 aliphatic alcohols Chemical class 0.000 description 1
- MANKSFVECICGLK-UHFFFAOYSA-K aloxiprin Chemical compound [OH-].[Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O MANKSFVECICGLK-UHFFFAOYSA-K 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229960000985 ambroxol hydrochloride Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- SGRYPYWGNKJSDL-UHFFFAOYSA-N amlexanox Chemical compound NC1=C(C(O)=O)C=C2C(=O)C3=CC(C(C)C)=CC=C3OC2=N1 SGRYPYWGNKJSDL-UHFFFAOYSA-N 0.000 description 1
- 229960003731 amlexanox Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 description 1
- YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 description 1
- 229960004335 azelastine hydrochloride Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- FXNFHKRTJBSTCS-UHFFFAOYSA-N baicalein Chemical compound C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 description 1
- 229940092732 belladonna alkaloid Drugs 0.000 description 1
- 229940108858 belladonna total alkaloid Drugs 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229960002335 bromhexine hydrochloride Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 229960000428 carbinoxamine Drugs 0.000 description 1
- OJFSXZCBGQGRNV-UHFFFAOYSA-N carbinoxamine Chemical compound C=1C=CC=NC=1C(OCCN(C)C)C1=CC=C(Cl)C=C1 OJFSXZCBGQGRNV-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 229960002689 clemastine fumarate Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 1
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
- 229960001140 cyproheptadine Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229960001985 dextromethorphan Drugs 0.000 description 1
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 1
- 229960001193 diclofenac sodium Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940124568 digestive agent Drugs 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 229960000325 emedastine Drugs 0.000 description 1
- 229960002534 ephedrine hydrochloride Drugs 0.000 description 1
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 description 1
- 229960002548 epinastine hydrochloride Drugs 0.000 description 1
- 229960000514 ethenzamide Drugs 0.000 description 1
- YRSGDLIATOURQO-UHFFFAOYSA-N ethyl 4-acetyl-5-oxohexanoate Chemical compound CCOC(=O)CCC(C(C)=O)C(C)=O YRSGDLIATOURQO-UHFFFAOYSA-N 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 229960001545 hydrotalcite Drugs 0.000 description 1
- 229910001701 hydrotalcite Inorganic materials 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229960001543 isopropamide iodide Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- YNQQEYBLVYAWNX-WLHGVMLRSA-N ketotifen fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 YNQQEYBLVYAWNX-WLHGVMLRSA-N 0.000 description 1
- 229960003630 ketotifen fumarate Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000001809 melena Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229960005042 mequitazine Drugs 0.000 description 1
- 229960005192 methoxamine Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 229960004186 naphazoline nitrate Drugs 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000010330 ougon Substances 0.000 description 1
- BAINIUMDFURPJM-UHFFFAOYSA-N oxatomide Chemical compound O=C1NC2=CC=CC=C2N1CCCN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 BAINIUMDFURPJM-UHFFFAOYSA-N 0.000 description 1
- 229960002698 oxatomide Drugs 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 229960004811 pemirolast potassium Drugs 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 238000011170 pharmaceutical development Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
- 229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- NMMVKSMGBDRONO-UHFFFAOYSA-N potassium;9-methyl-3-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one Chemical compound [K+].CC1=CC=CN(C2=O)C1=NC=C2C1=NN=N[N-]1 NMMVKSMGBDRONO-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229960003101 pranoprofen Drugs 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- 229960002244 promethazine hydrochloride Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229960000581 salicylamide Drugs 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008485 shosaiko-to Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- JWBPVFVNISJVEM-UHFFFAOYSA-M sodium caffeine benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1.CN1C(=O)N(C)C(=O)C2=C1N=CN2C JWBPVFVNISJVEM-UHFFFAOYSA-M 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960000337 tetryzoline Drugs 0.000 description 1
- 229960005342 tranilast Drugs 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
PHARM TECH JAPAN, Vol.16,No.6, May,2000, pp.40-49
項1.植物抽出物を含む混合末に、練合液として水、エタノール及びメントールを添加して練合した後、押出し造粒により製粒する工程を有する植物抽出物含有粒剤の製造方法。
項2. 練合液として、水、及びメントールを含有するエタノールを用いることを特徴とする項1記載の植物抽出物含有粒剤の製造方法。
項3. 植物抽出物が、アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サイシン、サンキライ、サンザシ、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン、及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物である、項1または2に記載する植物抽出物含有粒剤の製造方法。
項4. 植物抽出物が、シャクヤクの抽出物である、項1または2に記載する植物抽出物含有粒剤の製造方法。
項5. 項1乃至4のいずれかに記載する方法によって製造される植物抽出物含有粒剤。
項6. アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サンキライ、サンザシ、サイシン、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物を少なくとも2重量%の割合で含み、かつ適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
項7. シャクヤクの抽出物を少なくとも2重量%の割合で含む混合末、水、エタノール、及びメントールを原料として用いて調製される、適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
項8. 項5乃至7のいずれかに記載される植物抽出物含有粒剤を内部に含むカプセル剤、または被膜粒剤。
項9. 項5乃至7のいずれかに記載される植物抽出物含有粒剤を用いて調製される錠剤。
(1)植物抽出物含有粒剤の製造方法、及びそれによって得られる粒剤
本発明は、植物抽出物を含有する粒剤の、押出し造粒による製造方法を提供するものである。
本剤(顆粒剤の場合は20.0g、散剤の場合は10.0g)を正確に量り、前記のふるい及び受器を重ね合わせた用器の上段のふるいに入れ、上蓋をした後、3分間水平に揺り動かしながら時々軽くたたいてふるった後、各々のふるい及び受器の残留物の重量を量る。ただし、この試験に用いるふるいの枠の内径は75mmとする。
前述する植物抽出物(図1の「薬物」に相当)と他の原料成分(図1の「他の原料」に相当)とを調合して調合末とした後、練合機等により所定時間混合して混合末を調製する工程である。
前述の(1)「調合」及び「混合」工程で得られた混合末を練合する工程である。この練合は、上記で調製した混合末に練合液を加え、練合機等を用いてこの混合物を練合(混練)することによって実施することができる。
前述の(2)「練合」工程で得られた練合物を製粒機(造粒機)にいれて製粒(造粒)する工程である。製粒は「押出し造粒」機構によってなされるものであればよく、製粒機(造粒機)の種類は問わない。例えば、スクリューの回転によって円板上のパンチング板から練合物を強制的に押出す方式の所謂「押出し造粒機」も、また押出し羽根の回転によって円筒状のパンチング板から練合物を押出す方式の「製粒機」も、いずれも基本的には練合物をパンチング板から押出す機構を有するため、本発明において製粒機(造粒機)として使用することができる。
前述の(3)「製粒」工程で得られた生粒剤を乾燥する工程である。乾燥工程は、具体的には、上記工程で得られた生粒剤を複数枚のトレーに広げて、通気乾燥機で行う方法や流動層乾燥機を使用する方法で行うことができる。但し、この方法に限定されない。
前述の(4)「乾燥」工程で得られた乾燥粒剤の粒子径を整える工程である。調粒工程は、具体的には、上記工程で得られた乾燥粒剤をスピードミルなどの解砕機で調粒し、所望の粒度域にある粒子を篩過機で集めることによって実施することができる。
本発明はまた、前述する植物抽出物を少なくとも2重量%の割合で含み、且つ適正水分量が0.5〜10重量%である植物抽出物含有粒剤を提供する。
下記の処方からなる顆粒剤を、図2に示すフローチャートに従って押出し造粒法により作成した。なお、下記のシャクヤク抽出物としては、シャクヤク(芍薬根)の乾燥物の粗切物を水で抽出し、抽出液を濃縮して得られた軟エキス(シャクヤク抽出物1gは、シャクヤク(根)4gに相当する)を用いた。
<処方>
シャクヤク抽出物 0.325 kg ( 6.5%)
メタケイ酸アルミン酸マグネシウム 1.000 (20.0%)
乳糖 3.675 (73.5%)
合 計 5.000 kg (100.0%)。
練合物の塊100gを840μmの篩上に置いて手で40回タッピングして、残存した量(xg)をパーセント(x%)として算出する。
乾燥顆粒20gを、12号[1400μm]、18号[850μm]、30号[500μm]、42号[355μm]、60号[250μm]、83号[180μm]、100号[150μm]、140号[106μm]ふるい(各ふるい直径75mm)及び受器を重ね合わせた用器の上段のふるいに入れ、振盪器で5分間ふるって、各ふるいの上に残留した乾燥顆粒の量(g)を測定する。30号[500μm]及び42号[355μm]ふるいの上に残留した乾燥顆粒の総量(g)を各ふるい及び受器に残留した乾燥顆粒の総量(約20g)で割ってパーセントを算出し、下記の基準に従って評価する。
◎:75%以上100%以下、○:50%以上75%未満、△:25%以上50%未満、
×:0%以上25%未満。
上記粒度の測定により30号[500μm]のふるいに残留した乾燥顆粒を100mL容量の容器にとり、その量(重量と容積)を測定し、比重(g/mL)を算出する。
生成した全乾燥顆粒を、18号[850μm]、30号[500μm]、42号[355μm]ふるい(各ふるい直径30cm)及び受器を重ね合わせた用器の上段のふるいに入れ、振盪器で5分間ふるって、各ふるいの上に残留した乾燥顆粒の量(g)を測定する。30号[500μm]及び42号[355μm]ふるいの上に残留した乾燥顆粒の総量(kg)を、原料の重量(kg)で割って、パーセントを算出する。
30号[500μm]ふるいに残留した乾燥顆粒100gを回転式強度試験器により10分間回転して摩耗させた後、500μmのふるい上に残存した量を求め、パーセント表示する。
○:整粒機が途中でストップしない。
×:まったく製粒できなかった。
表2の処方からなる顆粒剤を、試験例1と同様に、図2に示すフローチャートに従って押出し造粒法により作成した。そして、試験例1と同様にして、各試験体の造粒性を評価し、また粒度(%)と得率(%)を求めた。結果を表3に合わせて示す。
塩酸メチルエフェドリン 0.6
マレイン酸クロルフェニラミン 0.0075
ノスカピン 0.048
アセトアミノフェン 0.45
エテンザミド 0.75
カフェイン 0.075
カンゾウエキス 0.4(原生薬換算1.6g)
キキョウエキス 0.2(原生薬換算0.8g)
乳 糖 残 部
合 計 5.0 g。
炭酸水素ナトリウム 2.0
酸化マグネシウム 0.6
センブリエキス 0.3(原生薬換算1.2g)
ゲンチアナエキス 0.3(原生薬換算1.5g)
乳 糖 残 部
合 計 4.0 g。
Claims (7)
- 植物抽出物を含む混合末に、練合液として水、エタノール及びメントールを添加して練合した後、押出し造粒により製粒する工程を有する、植物抽出物含有粒剤の製造方法。
- 練合液として、水、及びメントール含有エタノールを用いることを特徴とする請求項1記載の植物抽出物含有粒剤の製造方法。
- 植物抽出物が、アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サンキライ、サンザシ、サイシン、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物である、請求項1または2に記載する植物抽出物含有粒剤の製造方法。
- 植物抽出物が、シャクヤクの抽出物である、請求項1または2に記載する生薬・植物抽出物含有粒剤の製造方法。
- 請求項1乃至4のいずれかに記載する製粒工程に加えて、製粒工程で得られた植物抽出物含有粒剤をカプセル基材に充填する工程を有する硬カプセル剤の製造方法。
- 請求項1乃至4のいずれかに記載する製粒工程に加えて、製粒工程で得られた植物抽出物含有粒剤をコーティング剤で被覆する工程を有する被膜粒剤の製造方法。
- 請求項1乃至4のいずれかに記載する製粒工程に加えて、製粒工程で得られた植物抽出物含有粒剤に滑沢剤を加えて圧縮成型する工程を有する錠剤の製造方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004108574A JP4803969B2 (ja) | 2004-03-31 | 2004-03-31 | 植物抽出物を含有する粒剤の製造方法 |
PCT/JP2004/013895 WO2005099732A1 (ja) | 2004-03-31 | 2004-09-24 | 植物抽出物を含有する粒剤の製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004108574A JP4803969B2 (ja) | 2004-03-31 | 2004-03-31 | 植物抽出物を含有する粒剤の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005289911A JP2005289911A (ja) | 2005-10-20 |
JP4803969B2 true JP4803969B2 (ja) | 2011-10-26 |
Family
ID=35149768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004108574A Expired - Lifetime JP4803969B2 (ja) | 2004-03-31 | 2004-03-31 | 植物抽出物を含有する粒剤の製造方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP4803969B2 (ja) |
WO (1) | WO2005099732A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7648718B2 (en) * | 2005-01-25 | 2010-01-19 | University-Industry Cooperation Group Of Kyung Hee University | Composition comprising the extract of crude drug complex having neuroprotective activity for preventing and treating stroke and neurodegenerative diseases |
CN101909602B (zh) * | 2007-12-27 | 2012-06-13 | 大鹏药品工业株式会社 | 口服粉粒状抗肿瘤剂 |
JP6062168B2 (ja) * | 2011-07-01 | 2017-01-18 | 武田薬品工業株式会社 | 生薬由来成分を含有する製剤及びその製造方法 |
CN102356836B (zh) * | 2011-09-14 | 2013-01-16 | 上海交通大学 | 紫苏营养保健咀嚼片及其制备方法 |
CN102335143A (zh) * | 2011-10-10 | 2012-02-01 | 广西润达制药股份有限公司 | 金刚藤颗粒(无糖型)新工艺 |
CN102973693B (zh) * | 2011-10-27 | 2014-10-29 | 成都中医药大学 | 一种用于通便减肥的药物组合物及其制备方法和用途 |
CN105012805A (zh) * | 2015-08-05 | 2015-11-04 | 上海海虹实业(集团)巢湖今辰药业有限公司 | 一种乙肝解毒胶囊的制备及其检测方法 |
JP2019011318A (ja) * | 2017-06-30 | 2019-01-24 | 大鵬薬品工業株式会社 | 顆粒の製造方法 |
JP7451124B2 (ja) * | 2018-09-28 | 2024-03-18 | ロート製薬株式会社 | 内服組成物およびその吸湿抑制方法 |
KR102088136B1 (ko) * | 2019-08-21 | 2020-03-11 | 구태훈 | 단미약재 또는 복합약재 추출물을 고농도로 포함하는 펠렛 제제 및 이의 제조방법 |
CN111544303A (zh) * | 2020-06-24 | 2020-08-18 | 湖州市中医院 | 一种胶囊中药制作工艺及设备 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2726498B2 (ja) * | 1988-06-27 | 1998-03-11 | 第一製薬株式会社 | 経口固形製剤 |
JPH1045580A (ja) * | 1996-07-31 | 1998-02-17 | Asahi Breweries Ltd | 塩化カルニチン含有製剤の製造方法 |
JPH1129488A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | ピコスルファートナトリウムを含有する医薬組成物 |
JP4400941B2 (ja) * | 1998-10-15 | 2010-01-20 | 木村産業株式会社 | 漢方含有錠剤および漢方充填カプセル剤および生薬含有錠剤および生薬充填カプセル剤および漢方含有錠剤の製造方法および漢方充填カプセル剤の製造方法および生薬含有錠剤の製造方法および生薬充填カプセル剤の製造方法 |
EP1226818A1 (en) * | 2001-01-26 | 2002-07-31 | Pfizer Products Inc. | Pharmaceutical dosage forms with enhanced cohesive and compressibility properties |
-
2004
- 2004-03-31 JP JP2004108574A patent/JP4803969B2/ja not_active Expired - Lifetime
- 2004-09-24 WO PCT/JP2004/013895 patent/WO2005099732A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2005099732A1 (ja) | 2005-10-27 |
JP2005289911A (ja) | 2005-10-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102123972B1 (ko) | 두통을 치료하기 위한 약학적 조성물 및 그의 제조방법 | |
WO2009117953A1 (zh) | 一种具有抗抑郁、抗焦虑作用的药物组合物及其制备方法 | |
AU2007264289B2 (en) | Granule and preparation method thereof | |
JP4803969B2 (ja) | 植物抽出物を含有する粒剤の製造方法 | |
US20210052504A1 (en) | Pellet Formulation Containing Single Or Complex Herbal Extract At High Concentration And Manufacturing Method Therefor | |
CN102416139A (zh) | 一种用于治疗乳腺疾病的中药组合物 | |
CN1965836B (zh) | 口服固体制剂及其制备方法 | |
CN103610659A (zh) | 一种大蒜素药物组合物及其制备方法 | |
CN102085344B (zh) | 一种木香顺气缓释制剂及其制备方法 | |
Salome et al. | Formulation and evaluation of Cymbopogon citratus dried leaf-powder tablets | |
CN102793839A (zh) | 一种包含矫味的中药制剂及其制备方法 | |
CN101628059B (zh) | 一种药物组合物和含有该药物组合物的药物制剂 | |
CN104127510B (zh) | 小儿热速清颗粒矫味组合物及其颗粒剂和制法 | |
CN113521167B (zh) | 一种治疗帕金森病的中药组合物及其应用 | |
CN108601737A (zh) | 干法制粒物和含有该干法制粒物的固态制剂及它的制造方法 | |
WO2021078087A1 (zh) | 靶向定位释放的中药丸剂及其制备方法 | |
CN108704049B (zh) | 一种具有抗氧化功能的中药组合物及其保健食品的制备方法 | |
CN111358906B (zh) | 一种适用于外感症的中药组合物 | |
CN103961582B (zh) | 治疗肾炎的中药组合物及其制剂和制备方法 | |
CN100411657C (zh) | 一种青柏洁身泡藤颗粒制剂 | |
CN114569688A (zh) | 一种中华肝灵片及其制备方法 | |
CN100509048C (zh) | 金乌骨通片及其制备方法 | |
CN111643594A (zh) | 一种用于治疗阿片类药物相关性便秘的中药组合物、其制备方法和应用 | |
CN116139238B (zh) | 药物组合物及其制备方法 | |
CN111603501B (zh) | 一种用于原发性肝癌的中药组合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070326 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100721 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100921 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110719 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110809 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4803969 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140819 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |