JP2005289911A - 植物抽出物を含有する粒剤の製造方法 - Google Patents
植物抽出物を含有する粒剤の製造方法 Download PDFInfo
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- JP2005289911A JP2005289911A JP2004108574A JP2004108574A JP2005289911A JP 2005289911 A JP2005289911 A JP 2005289911A JP 2004108574 A JP2004108574 A JP 2004108574A JP 2004108574 A JP2004108574 A JP 2004108574A JP 2005289911 A JP2005289911 A JP 2005289911A
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- plant extract
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- plant
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Abstract
【解決手段】押出し造粒法において、練合工程に使用する練合液として、水、エタノール、及びメントールを用いる。
【選択図】なし
Description
PHARM TECH JAPAN, Vol.16,No.6, May,2000, pp.40-49
項1.植物抽出物を含む混合末に、練合液として水、エタノール及びメントールを添加して練合した後、押出し造粒により製粒する工程を有する植物抽出物含有粒剤の製造方法。
項2. 練合液として、水、及びメントールを含有するエタノールを用いることを特徴とする項1記載の植物抽出物含有粒剤の製造方法。
項3. 植物抽出物が、アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サイシン、サンキライ、サンザシ、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン、及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物である、項1または2に記載する植物抽出物含有粒剤の製造方法。
項4. 植物抽出物が、シャクヤクの抽出物である、項1または2に記載する植物抽出物含有粒剤の製造方法。
項5. 項1乃至4のいずれかに記載する方法によって製造される植物抽出物含有粒剤。
項6. アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サンキライ、サンザシ、サイシン、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物を少なくとも2重量%の割合で含み、かつ適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
項7. シャクヤクの抽出物を少なくとも2重量%の割合で含む混合末、水、エタノール、及びメントールを原料として用いて調製される、適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
項8. 項5乃至7のいずれかに記載される植物抽出物含有粒剤を内部に含むカプセル剤、または被膜粒剤。
項9. 項5乃至7のいずれかに記載される植物抽出物含有粒剤を用いて調製される錠剤。
(1)植物抽出物含有粒剤の製造方法、及びそれによって得られる粒剤
本発明は、植物抽出物を含有する粒剤の、押出し造粒による製造方法を提供するものである。
本剤(顆粒剤の場合は20.0g、散剤の場合は10.0g)を正確に量り、前記のふるい及び受器を重ね合わせた用器の上段のふるいに入れ、上蓋をした後、3分間水平に揺り動かしながら時々軽くたたいてふるった後、各々のふるい及び受器の残留物の重量を量る。ただし、この試験に用いるふるいの枠の内径は75mmとする。
前述する植物抽出物(図1の「薬物」に相当)と他の原料成分(図1の「他の原料」に相当)とを調合して調合末とした後、練合機等により所定時間混合して混合末を調製する工程である。
前述の(1)「調合」及び「混合」工程で得られた混合末を練合する工程である。この練合は、上記で調製した混合末に練合液を加え、練合機等を用いてこの混合物を練合(混練)することによって実施することができる。
前述の(2)「練合」工程で得られた練合物を製粒機(造粒機)にいれて製粒(造粒)する工程である。製粒は「押出し造粒」機構によってなされるものであればよく、製粒機(造粒機)の種類は問わない。例えば、スクリューの回転によって円板上のパンチング板から練合物を強制的に押出す方式の所謂「押出し造粒機」も、また押出し羽根の回転によって円筒状のパンチング板から練合物を押出す方式の「製粒機」も、いずれも基本的には練合物をパンチング板から押出す機構を有するため、本発明において製粒機(造粒機)として使用することができる。
前述の(3)「製粒」工程で得られた生粒剤を乾燥する工程である。乾燥工程は、具体的には、上記工程で得られた生粒剤を複数枚のトレーに広げて、通気乾燥機で行う方法や流動層乾燥機を使用する方法で行うことができる。但し、この方法に限定されない。
前述の(4)「乾燥」工程で得られた乾燥粒剤の粒子径を整える工程である。調粒工程は、具体的には、上記工程で得られた乾燥粒剤をスピードミルなどの解砕機で調粒し、所望の粒度域にある粒子を篩過機で集めることによって実施することができる。
本発明はまた、前述する植物抽出物を少なくとも2重量%の割合で含み、且つ適正水分量が0.5〜10重量%である植物抽出物含有粒剤を提供する。
下記の処方からなる顆粒剤を、図2に示すフローチャートに従って押出し造粒法により作成した。なお、下記のシャクヤク抽出物としては、シャクヤク(芍薬根)の乾燥物の粗切物を水で抽出し、抽出液を濃縮して得られた軟エキス(シャクヤク抽出物1gは、シャクヤク(根)4gに相当する)を用いた。
<処方>
シャクヤク抽出物 0.325 kg ( 6.5%)
メタケイ酸アルミン酸マグネシウム 1.000 (20.0%)
乳糖 3.675 (73.5%)
合 計 5.000 kg (100.0%)。
練合物の塊100gを840μmの篩上に置いて手で40回タッピングして、残存した量(xg)をパーセント(x%)として算出する。
乾燥顆粒20gを、12号[1400μm]、18号[850μm]、30号[500μm]、42号[355μm]、60号[250μm]、83号[180μm]、100号[150μm]、140号[106μm]ふるい(各ふるい直径75mm)及び受器を重ね合わせた用器の上段のふるいに入れ、振盪器で5分間ふるって、各ふるいの上に残留した乾燥顆粒の量(g)を測定する。30号[500μm]及び42号[355μm]ふるいの上に残留した乾燥顆粒の総量(g)を各ふるい及び受器に残留した乾燥顆粒の総量(約20g)で割ってパーセントを算出し、下記の基準に従って評価する。
◎:75%以上100%以下、○:50%以上75%未満、△:25%以上50%未満、
×:0%以上25%未満。
上記粒度の測定により30号[500μm]のふるいに残留した乾燥顆粒を100mL容量の容器にとり、その量(重量と容積)を測定し、比重(g/mL)を算出する。
生成した全乾燥顆粒を、18号[850μm]、30号[500μm]、42号[355μm]ふるい(各ふるい直径30cm)及び受器を重ね合わせた用器の上段のふるいに入れ、振盪器で5分間ふるって、各ふるいの上に残留した乾燥顆粒の量(g)を測定する。30号[500μm]及び42号[355μm]ふるいの上に残留した乾燥顆粒の総量(kg)を、原料の重量(kg)で割って、パーセントを算出する。
30号[500μm]ふるいに残留した乾燥顆粒100gを回転式強度試験器により10分間回転して摩耗させた後、500μmのふるい上に残存した量を求め、パーセント表示する。
○:整粒機が途中でストップしない。
×:まったく製粒できなかった。
表2の処方からなる顆粒剤を、試験例1と同様に、図2に示すフローチャートに従って押出し造粒法により作成した。そして、試験例1と同様にして、各試験体の造粒性を評価し、また粒度(%)と得率(%)を求めた。結果を表3に合わせて示す。
塩酸メチルエフェドリン 0.6
マレイン酸クロルフェニラミン 0.0075
ノスカピン 0.048
アセトアミノフェン 0.45
エテンザミド 0.75
カフェイン 0.075
カンゾウエキス 0.4(原生薬換算1.6g)
キキョウエキス 0.2(原生薬換算0.8g)
乳 糖 残 部
合 計 5.0 g。
炭酸水素ナトリウム 2.0
酸化マグネシウム 0.6
センブリエキス 0.3(原生薬換算1.2g)
ゲンチアナエキス 0.3(原生薬換算1.5g)
乳 糖 残 部
合 計 4.0 g。
Claims (9)
- 植物抽出物を含む混合末に、練合液として水、エタノール及びメントールを添加して練合した後、押出し造粒により製粒する工程を有する、植物抽出物含有粒剤の製造方法。
- 練合液として、水、及びメントールを含有するエタノールを用いることを特徴とする請求項1記載の植物抽出物含有粒剤の製造方法。
- 植物抽出物が、アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サンキライ、サンザシ、サイシン、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物である、請求項1または2に記載する植物抽出物含有粒剤の製造方法。
- 植物抽出物が、シャクヤクの抽出物である、請求項1または2に記載する生薬・植物抽出物含有粒剤の製造方法。
- 請求項1乃至4のいずれかに記載する方法によって製造される植物抽出物含有粒剤。
- アカメガシワ、ウイキョウ、ウヤク、エイジツ、エゾウコギ、エンゴサク、エンメイソウ、オウゴン、オウバク、オウヒ、オウレン、オンジ、ガジュツ、カンゾウ、キキョウ、キジツ、キョウニン、クコシ、ケイヒ、ゲンチアナ、ゲンノショウコ、コウジン、コウボク、ゴミン、サイコ、サンキライ、サンザシ、サイシン、サンシシ、サンショウ、ジオウ、シャクヤク、シャゼンソウ、ジュウヤク、ショウキョウ、セネガ、センキュウ、センブリ、ソウジュツ、ソヨウ、ダイオウ、タイソウ、チンピ、トウキ、トコン、ナンテンジツ、ニンジン、バクモンドウ、ビャクジュツ、ボタンピ、ホップ、マオウ、モッコウ、ヨクイニン、リュウタン及びロートコンよりなる群から選択される少なくとも1つの植物性生薬の抽出物を少なくとも2重量%の割合で含み、かつ適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
- シャクヤクの抽出物を少なくとも2重量%の割合で含む混合末、水、エタノール、及びメントールを原料として用いて調製される、適正水分量が0.5〜10重量%である植物抽出物含有粒剤。
- 請求項5乃至7のいずれかに記載される植物抽出物含有粒剤を内部に含むカプセル剤、または被膜粒剤。
- 請求項5乃至7のいずれかに記載される植物抽出物含有粒剤を用いて調製される錠剤。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0276826A (ja) * | 1988-06-27 | 1990-03-16 | Dai Ichi Seiyaku Co Ltd | 経口固形製剤 |
JPH1045580A (ja) * | 1996-07-31 | 1998-02-17 | Asahi Breweries Ltd | 塩化カルニチン含有製剤の製造方法 |
JPH1129488A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | ピコスルファートナトリウムを含有する医薬組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4400941B2 (ja) * | 1998-10-15 | 2010-01-20 | 木村産業株式会社 | 漢方含有錠剤および漢方充填カプセル剤および生薬含有錠剤および生薬充填カプセル剤および漢方含有錠剤の製造方法および漢方充填カプセル剤の製造方法および生薬含有錠剤の製造方法および生薬充填カプセル剤の製造方法 |
EP1226818A1 (en) * | 2001-01-26 | 2002-07-31 | Pfizer Products Inc. | Pharmaceutical dosage forms with enhanced cohesive and compressibility properties |
-
2004
- 2004-03-31 JP JP2004108574A patent/JP4803969B2/ja not_active Expired - Lifetime
- 2004-09-24 WO PCT/JP2004/013895 patent/WO2005099732A1/ja active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0276826A (ja) * | 1988-06-27 | 1990-03-16 | Dai Ichi Seiyaku Co Ltd | 経口固形製剤 |
JPH1045580A (ja) * | 1996-07-31 | 1998-02-17 | Asahi Breweries Ltd | 塩化カルニチン含有製剤の製造方法 |
JPH1129488A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | ピコスルファートナトリウムを含有する医薬組成物 |
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JP2008528481A (ja) * | 2005-01-25 | 2008-07-31 | ユニバーシティー−インダストリー コーペレーション グループ オブ キュン ヒー ユニバーシティー | 脳卒中及び神経変性疾患の予防及び治療ための神経保護活性を有する複合生薬材抽出物を含む組成物 |
WO2009084216A1 (ja) * | 2007-12-27 | 2009-07-09 | Taiho Pharmaceutical Co., Ltd. | 経口粉粒状抗腫瘍剤 |
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JP5356255B2 (ja) * | 2007-12-27 | 2013-12-04 | 大鵬薬品工業株式会社 | 経口粉粒状抗腫瘍剤 |
JP2014012705A (ja) * | 2007-12-27 | 2014-01-23 | Taiho Yakuhin Kogyo Kk | 経口粉粒状抗腫瘍剤 |
JP2013032346A (ja) * | 2011-07-01 | 2013-02-14 | Takeda Chem Ind Ltd | 生薬由来成分を含有する製剤及びその製造方法 |
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JP2021031488A (ja) * | 2019-08-21 | 2021-03-01 | テフン・ク | 単味薬材又は複合薬材の抽出物を高濃度で含むペレット製剤及びその製造方法 |
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