JP2538516B2 - 顔面前癌状態又は脂漏性面疾患の治療剤 - Google Patents

顔面前癌状態又は脂漏性面疾患の治療剤

Info

Publication number
JP2538516B2
JP2538516B2 JP6028600A JP2860094A JP2538516B2 JP 2538516 B2 JP2538516 B2 JP 2538516B2 JP 6028600 A JP6028600 A JP 6028600A JP 2860094 A JP2860094 A JP 2860094A JP 2538516 B2 JP2538516 B2 JP 2538516B2
Authority
JP
Japan
Prior art keywords
seborrheic
therapeutic agent
precancerous
surface disease
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP6028600A
Other languages
English (en)
Other versions
JPH06298643A (ja
Inventor
リチャード ソーンフェルト カール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEREJII PHARM Inc
Original Assignee
SEREJII PHARM Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEREJII PHARM Inc filed Critical SEREJII PHARM Inc
Publication of JPH06298643A publication Critical patent/JPH06298643A/ja
Application granted granted Critical
Publication of JP2538516B2 publication Critical patent/JP2538516B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

【発明の詳細な説明】
【０００１】
【産業上の利用分野】本発明は、顔面前癌状態又は脂漏
性面疾患の治療剤に関する。
【０００２】
【従来の技術】米国特許第 4,292,326（Nazarro-Porro,
1981年９月29日）, 第 4,386,104（Nazarro-Porro,1983
年５月31日）は、ニキビとメラニン細胞性色素沈着過度
の皮膚病との治療にジカルボン酸の使用を開示してい
る。
【０００３】
【発明が解決しようとする課題】本発明は、顔面前癌状
態又は脂漏性皮膚炎を治療することができる治療剤を提
供することを目的とする。
【０００４】
【課題を解決するための手段】本発明に係る顔面前癌状
態又は脂漏性面疾患の治療剤は、７〜13個の炭素原子を
有し、酸の部分以外においてはヒドロキシル又はケトの
群を有しない、直鎖のモノ又はジカルボン酸、そのアル
キルエステル及びポリオール, オリゴサッカライド又は
ポリサッカライドから生成されたエステルからなる群か
ら選ばれた化合物を治療に有効な量だけ含むことを特徴
とする。
【０００５】
【作用】本発明の治療剤では、これを皮膚の病変部に塗
布する。そうすると病変部の皮膚は正常に回復するか、
または病状は軽快する。
【０００６】
【実施例】本発明者の知見によれば治療に用いるモノま
たはジカルボン酸は分子内に４乃至18個の炭素原子を含
むものである。これらの酸で好ましいものは、非環状な
飽和の脂肪酸であり、特に直鎖のものが好ましい。これ
らのうち７乃至13個の炭素原子を有するものが最も好ま
しい。例をあげるとアゼライン（１，９ノナンジカルボ
ン）酸、スベリン（１，８オクタンジカルボン）酸、セ
バシン（１，10デカンジカルボン）酸、ピメリン（１，
７ヘプタンジカルボン）酸等である。
【０００７】またこれらの酸のモノまたはジメルカプト
誘導体を含み、また例えばナトリウム，エステルのよう
な塩も同様に含まれる。エステルの中にはアルキルエス
テル，ポリオールから作られるエステル，オリゴ及びポ
リサッカライドからのエステルも含まれる。このポリオ
ールの例としてはグリセリン、ポリエチレングリコー
ル、ポリプロピレングリコール等があり、オリゴ及びポ
リサッカライドの例としては蔗糖、乳糖、澱粉等があ
る。ジカルボン酸の中にはモノエステルとジエステルと
の両方が含まれる。好ましいエステルとしては、特にジ
カルボン酸に対してはモノグリセライドとモノ蔗糖エス
テルとがある。
【０００８】これらの化合物は一般に、皮膚科医向け製
剤として適用される。これらは種々の既知の混合物，ま
たは組合せとして局所的にて適用され、病気に冒された
部位（病変部）に活性部分を行きわたらせるようにして
使用される。これらの例として、クリーム、ローショ
ン、溶液、軟膏等がある。
【０００９】製剤中のモノまたはジカルボン酸の濃度は
厳密なものではなく、広い範囲にて変化できる。酸の濃
度は各製剤中溶解度の上限ぎりぎりでもよい。多くの場
合、最良の結果は約 0.1％〜40％重量の範囲内にて得ら
れ、好ましくは約３％〜20％重量である。製剤には付加
的成分を任意に加えてもよく、これは生物学的に活性な
ものでも不活性なものでもよい。不活性な成分の例とし
ては湿潤剤、表面活性剤、皮膚軟膏剤、溶剤、角質溶解
剤、経皮吸収促進剤等がある。
【００１０】「特許請求の範囲」における「治療に有効
な量」という言葉は、病変部に繰り返しある期間に亘っ
て塗布した際に、病変の状態に実質的な改善または変化
をもたらした量を意味している。この量は治療中の状
態、病変の進行度合、製剤の種類と濃度等によって変化
する。なおその際の適当な量は、当業者またはルーチン
の実験にて決定できる者にとっては容易に判明される。
この組成物は一般に局所的に病変部位に塗布される。即
ち臨床的に障害が明白である部位に局所的に塗布され
る。
【００１１】以下、本発明の製剤例、及び実際に治療を
施した例について説明する。 〔製剤例〕 １ポンドのCetaphilクリームと90グラムのアゼライン酸
とを別々にとり夫々が液化するまで熱する（約２時
間）。Cetaphilクリームは水、エチルアルコール、プロ
ピレンアルコール、ラウリル硫酸ナトリウム、ステアリ
ルアルコール、メチルパラベン、プロピルパラベン、ブ
チルパラベンの非処方混合物として市場にて入手でき、
Owen研究所（サンアントニオ, テキサス）から得られ
る。クリームと酸とを液化した後、酸をクリーム中にて
徐々にかきまぜて滑らかな均一なクリームに仕上げる。
【００１２】〔治療例〕 太陽による顔面前癌状態と脂漏性皮膚炎とを治療，防止
するために、72才の男性医師と66才, 67才の２人の女性
との計３人の患者に製剤Ａを９ケ月〜11ケ月半の間に亘
って１日１回塗布した。３人共これらの状態の改善に加
えて、この製剤は皮膚の組織を改善し、顔面の皮膚の柔
軟性を増すことが見られた。そして検査の結果この変化
が確認され、２人の回復は写真によって立証された。
【００１３】なお上述した記載は、元来本発明の目的の
ために書かれたものであり、上述した例にはないが、製
剤とその使用法との両者には本発明の精神と範囲とを逸
脱しない限り、多くの変化は存在し得ることは当業者に
とっては容易に理解される。
【００１４】
【発明の効果】以上詳述した如く本発明の治療方法では
顔面前癌状態又は脂漏性面疾患を短期間にて、完全に治
療することができる。

Claims (2)

    (57)【特許請求の範囲】
  1. 【請求項１】 ７〜13個の炭素原子を有し、酸の部分以
    外においてはヒドロキシル又はケトの群を有しない、直
    鎖のモノ又はジカルボン酸、そのアルキルエステル及び
    ポリオール, オリゴサッカライド又はポリサッカライド
    から生成されたエステルからなる群から選ばれた化合物
    を治療に有効な量だけ含むことを特徴とする顔面前癌状
    態又は脂漏性面疾患の治療剤。
  2. 【請求項２】 前記化合物はアゼライン酸である請求項
    １記載の顔面前癌状態又は脂漏性面疾患の治療剤。
JP6028600A 1987-07-02 1994-02-25 顔面前癌状態又は脂漏性面疾患の治療剤 Expired - Fee Related JP2538516B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6907187A 1987-07-02 1987-07-02
US069071 1988-03-08
US160042 1988-03-08
US07/160,042 US4885282A (en) 1987-07-02 1988-03-08 Treatment of hyperhidrosis, ichthyosis and wrinkling

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP63164788A Division JP2608762B2 (ja) 1987-07-02 1988-06-30 多汗症の治療剤

Publications (2)

Publication Number Publication Date
JPH06298643A JPH06298643A (ja) 1994-10-25
JP2538516B2 true JP2538516B2 (ja) 1996-09-25

Family

ID=26749652

Family Applications (3)

Application Number Title Priority Date Filing Date
JP63164788A Expired - Lifetime JP2608762B2 (ja) 1987-07-02 1988-06-30 多汗症の治療剤
JP6028599A Expired - Lifetime JPH085785B2 (ja) 1987-07-02 1994-02-25 魚鱗癬の治療剤
JP6028600A Expired - Fee Related JP2538516B2 (ja) 1987-07-02 1994-02-25 顔面前癌状態又は脂漏性面疾患の治療剤

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP63164788A Expired - Lifetime JP2608762B2 (ja) 1987-07-02 1988-06-30 多汗症の治療剤
JP6028599A Expired - Lifetime JPH085785B2 (ja) 1987-07-02 1994-02-25 魚鱗癬の治療剤

Country Status (4)

Country Link
US (1) US4885282A (ja)
EP (2) EP0297436B1 (ja)
JP (3) JP2608762B2 (ja)
DE (3) DE3853558T2 (ja)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885282A (en) * 1987-07-02 1989-12-05 Thornfeldt Carl R Treatment of hyperhidrosis, ichthyosis and wrinkling
DE3811081A1 (de) * 1988-03-30 1989-10-12 Schering Ag Verwendung von topisch applizierbaren praeparaten zur behandlung der altershaut
IT1232161B (it) * 1989-07-31 1992-01-25 Sigma Tau Ind Farmaceuti Uso dell'acido sebacico e di suoi derivati nell'alimentazione enterale e parentaerale e composizioni farmaceutiche contenenti tali composti
JP2558188B2 (ja) * 1991-06-10 1996-11-27 花王株式会社 入浴剤組成物
GB9213472D0 (en) * 1992-06-25 1992-08-12 Unilever Plc Cosmetic composition
GB9220670D0 (en) * 1992-09-30 1992-11-11 Unilever Plc Cosmetic composition
DE4434775A1 (de) * 1994-09-29 1996-04-04 Beiersdorf Ag Dermatologische Zubereitungen mit einem Gehalt an Fettsäureglyceriden gegen Superinfektionen
DE4435290A1 (de) * 1994-10-01 1996-04-04 Beiersdorf Ag Dermatologische Zubereitungen mit einem Gehalt an Fettsäuren und Fettsäureglyceriden gegen Superinfektionen
UY24246A1 (es) * 1995-06-06 1996-06-14 Neutrogena Corp Vehiculos tropicos que contienen acido azelaico solubilizado y estabilizado
US5609587A (en) * 1995-08-03 1997-03-11 The Procter & Gamble Company Diaper having a lotioned topsheet comprising a liquid polyol polyester emollient and an immobilizing agent
US5624676A (en) * 1995-08-03 1997-04-29 The Procter & Gamble Company Lotioned tissue paper containing an emollient and a polyol polyester immobilizing agent
US5705164A (en) * 1995-08-03 1998-01-06 The Procter & Gamble Company Lotioned tissue paper containing a liquid polyol polyester emollient and an immobilizing agent
US5607760A (en) * 1995-08-03 1997-03-04 The Procter & Gamble Company Disposable absorbent article having a lotioned topsheet containing an emollient and a polyol polyester immobilizing agent
JP3854326B2 (ja) * 1995-10-27 2006-12-06 株式会社ノエビア コラゲナーゼ阻害剤
US5621008A (en) * 1995-10-27 1997-04-15 Avon Products, Inc. N-acyl-ethylene-triacetic acids
DE19543696A1 (de) * 1995-11-23 1997-05-28 Beiersdorf Ag Gegen Bakterien, Mycota und Viren wirksame Wirkstoffkombinationen auf der Basis von Partialglyceriden und dialkylsubstituierte Essigsäuren
JP3583239B2 (ja) * 1996-01-25 2004-11-04 花王株式会社 皮膚外用剤
US5932229A (en) * 1996-04-25 1999-08-03 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions
US5834513A (en) * 1996-04-25 1998-11-10 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions
US5847003A (en) * 1996-06-04 1998-12-08 Avon Products, Inc. Oxa acids and related compounds for treating skin conditions
FR2755369B1 (fr) * 1996-11-04 1998-12-04 Oreal Composition moussante pour le nettoyage de la peau sous la forme d'un gel transparent
FR2755368B1 (fr) * 1996-11-04 1999-03-19 Oreal Composition rincable pour le soin de la peau
FR2755366B1 (fr) * 1996-11-04 1998-12-04 Oreal Composition rincable pour le soin de la peau
FR2755370B1 (fr) * 1996-11-04 1998-12-04 Oreal Composition nettoyante sous la forme d'un gel transparent rincable
KR20000053244A (ko) 1996-11-12 2000-08-25 도브 타마킨 피부질환의 치료방법
TWI234467B (en) * 1997-06-04 2005-06-21 Univ Michigan Composition for inhibiting photoaging of skin
US20050058709A1 (en) * 1997-06-04 2005-03-17 Fisher Gary J. Methods for inhibiting photoaging of human skin using orally-administered agent
US6780403B1 (en) * 1999-07-26 2004-08-24 Kao Corporation Deodorants
WO2001008681A1 (en) * 1999-08-02 2001-02-08 First Horizon Pharmaceutical Corporation Methods of administration of glycopyrrolate compositions
US6447789B1 (en) 1999-10-13 2002-09-10 Terrie E. Banks Facial cleanser and method of treating skin conditions
US6734210B2 (en) 2000-02-24 2004-05-11 Rolland F. Hebert Therapeutically improved salts of azelaic acid
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
DE10039783A1 (de) * 2000-08-16 2002-02-28 Cognis Deutschland Gmbh Kosmetische Zubereitungen
US7226605B2 (en) * 2001-07-27 2007-06-05 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Botulinum toxin in the treatment or prevention of acne
US20030224027A1 (en) * 2002-05-29 2003-12-04 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions with ammonium malonates
US20030224023A1 (en) * 2002-05-29 2003-12-04 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions with hydroxy amine salts of malonic acid
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
ES2532906T5 (es) 2002-10-25 2022-03-23 Foamix Pharmaceuticals Ltd Espuma cosmética y farmacéutica
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20040185073A1 (en) * 2003-03-17 2004-09-23 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions containing salts of malonic acid
US20040185074A1 (en) * 2003-03-17 2004-09-23 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Odor control in amine salt containing cosmetic compositions
US20040202689A1 (en) * 2003-03-17 2004-10-14 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Terpenoid fragrance components stabilized with malonic acid salts
US20040185015A1 (en) * 2003-03-17 2004-09-23 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Sunscreen cosmetic compositions storage stabilized with malonate salts
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
ATE520390T1 (de) 2004-12-27 2011-09-15 Beiersdorf Ag Glycopyrrolat in kosmetischen zubereitungen
JP3955868B2 (ja) * 2004-12-27 2007-08-08 株式会社キングジム 書類等の綴じ具
DE102005029387B4 (de) * 2005-06-23 2018-12-27 Beiersdorf Ag Wirkstoffkombinationen aus Glycopyrroniumbromid und Polyglyceryl(3)-Methylglucosedistearat
BRPI0612428A2 (pt) 2005-05-09 2010-11-09 Foamix Ltd composição farmacêutica higroscópica, veìculo farmacêutico espumoso e composição farmacêutica espumosa
US8236333B2 (en) 2005-10-19 2012-08-07 Unirem, Inc. Active agent delivery and/or odor retentive composition and methods of use thereof
WO2007140791A1 (en) * 2006-06-08 2007-12-13 Astion Pharma A/S Treatment of cutaneous neurogenic inflammation
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009090558A2 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8729108B2 (en) * 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
BR112012007473A2 (pt) 2009-10-02 2019-05-07 Foamix Ltd composições tópicas de tetraciclina e respectivo método de uso
AU2014223172B2 (en) 2013-02-28 2016-09-08 Journey Medical Corporation Glycopyrrolate salts
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
AU2014297993A1 (en) 2013-07-30 2016-02-04 Glaxosmithkline Intellectual Property Development Limited Topical compositions for treatment of excessive sweating and methods of use thereof
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS522979B2 (ja) * 1972-09-29 1977-01-25
US4294852A (en) * 1973-11-01 1981-10-13 Johnson & Johnson Skin treating compositions
DE2608221B1 (de) * 1976-02-28 1977-07-21 Beiersdorf Ag Kosmetisches mittel zur glaettung der haut
US4386104A (en) * 1977-04-19 1983-05-31 Nazzaro Porro Marcella Process for the treatment of acne
IT1114950B (it) * 1977-12-30 1986-02-03 Porro Marcella Composizioni per il trattamento e la terapia di acne
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
JPS56131512A (en) * 1980-03-19 1981-10-15 Kanebo Keshohin Kk Scrubbing skin cleaner
FR2492815A1 (fr) * 1980-10-23 1982-04-30 Sori Soc Rech Ind Nouveau derive d'acide cinnamoyl-cinnamique, son procede de preparation et son application en therapeutique
JPS58103319A (ja) * 1981-12-14 1983-06-20 Pola Chem Ind Inc 皮膚塗布用組成物
JPS59501986A (ja) * 1982-11-04 1984-11-29 レツドケン　ラボラトリ−ズ　インコ−ポレイテイツド 化粧品製剤
GB8600822D0 (en) * 1986-01-15 1986-02-19 Unilever Plc Treatment of skin disorders
US4713394A (en) * 1986-01-17 1987-12-15 Thornfeldt Carl R Treatment of nonacne inflammatory and infectious dermatoses and hair loss
DE3623862A1 (de) * 1986-07-11 1988-01-21 Schering Ag Verwendung von dicarbonsaeuren mit 7 - 13 kohlenstoffatomen oder physiologisch vertraeglichen salzen davon zur topischen behandlung von rosazea
ZA879063B (en) * 1986-12-22 1989-04-26 Hoffmann La Roche Use of 13-cis retinoic acid
AU618517B2 (en) * 1986-12-23 1992-01-02 Eugene J. Van Scott Additives enhancing topical actions of therapeutic agents
US4885282A (en) * 1987-07-02 1989-12-05 Thornfeldt Carl R Treatment of hyperhidrosis, ichthyosis and wrinkling
JPH0745401A (ja) * 1993-07-30 1995-02-14 Matsushita Electric Ind Co Ltd 正特性サーミスタの製造方法

Also Published As

Publication number Publication date
JPH085785B2 (ja) 1996-01-24
JPS6429308A (en) 1989-01-31
EP0588379A3 (en) 1994-06-01
EP0297436B1 (en) 1995-04-12
JPH06298643A (ja) 1994-10-25
EP0297436A2 (en) 1989-01-04
DE297436T1 (de) 1989-08-03
JP2608762B2 (ja) 1997-05-14
DE3855489D1 (de) 1996-09-26
EP0297436A3 (en) 1991-05-15
DE3853558T2 (de) 1995-08-24
EP0588379A2 (en) 1994-03-23
US4885282A (en) 1989-12-05
DE3853558D1 (de) 1995-05-18
EP0588379B1 (en) 1996-08-21
DE3855489T2 (de) 1996-12-19
JPH06321779A (ja) 1994-11-22

Similar Documents

Publication Publication Date Title
JP2538516B2 (ja) 顔面前癌状態又は脂漏性面疾患の治療剤
CA2606530C (en) Phycotoxins and uses thereof
DE3205504C2 (de) Äußerlich anwendbares, Ibuprofen enthaltendes Arzneimittel
JP2001010960A (ja) 局所用亜鉛組成物および使用方法
JPH0222211A (ja) 老化皮膚を治療するための局所適用可能な製剤
JPH1045533A (ja) レチノール長鎖不飽和脂肪酸エステルを有する化粧品組成物
US5043356A (en) Composition and method for rejuvenating skin using vitamin A propionate
JP2951345B2 (ja) 化粧用および皮膚処置用組成物
DK173201B1 (da) Anvendelse af glycerylestere af monocarboxylsyrer til fremstilling af dermatologiske formuleringer og fremstilling af et fa
JP7421558B2 (ja) 組織修復に適用されるピルフェニドンを含有する半固体油性医薬組成物
JPS62215522A (ja) 非アクネ炎症性又は感染性皮膚疾患の治療剤
US5258391A (en) Phenyl alpha acyloxyalkanoic acids, derivatives and their therapeutic use
JP2001525803A (ja) ***機能不全治療用の薬剤の調製のためのミソプロストール及び／又はミソプロストール酸の用途
JPH0827081A (ja) Ｌ−カルニチン塩および化粧用および皮膚病処置用医薬組成物
CA2310049C (en) Use of a mixture of a diol and an alpha-hydroxy acid for the treatment of hyperkeratotic skin diseases
DE2748399C2 (de) Antimikrobielles Mittel zur örtlichen Anwendung
JPH04500824A (ja) 光老化の作用を回復させるための皮膚の治療方法
JPH06510770A (ja) 化粧および皮膚科学的調製物
JP2006298796A (ja) 小じわ改善用皮膚外用剤
WO1993015713A2 (en) Method and compositions for treating acne
WO2019221114A1 (ja) ベタニンまたはその類似化合物を含む皮膚組織修復剤
Birnbaum et al. Cutaneous erythema and blood pressure lowering effects of topically applied 16-vinylprostaglandins
DE3631169A1 (de) Prostacyclinderivate enthaltende mittel fuer die topische anwendung
Manna et al. The effect of povidone-iodine paint on fungal infection
HODGSON et al. A clinical comparison between triacetoxyanthracene and dithranol pastes in the treatment of chronic psoriasis

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees