HUP9902460A2 - Új helyettesített imidazolszármazékok, alkalmazásuk, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Új helyettesített imidazolszármazékok, alkalmazásuk, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9902460A2 HUP9902460A2 HU9902460A HUP9902460A HUP9902460A2 HU P9902460 A2 HUP9902460 A2 HU P9902460A2 HU 9902460 A HU9902460 A HU 9902460A HU P9902460 A HUP9902460 A HU P9902460A HU P9902460 A2 HUP9902460 A2 HU P9902460A2
- Authority
- HU
- Hungary
- Prior art keywords
- cr10r20
- alkyl
- heterocyclic
- nr13r14
- substituted
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- -1 4-quinazolinyl Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical class 0.000 abstract 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- ALRLPDGCPYIVHP-UHFFFAOYSA-N 1-nitropyrene Chemical class C1=C2C([N+](=O)[O-])=CC=C(C=C3)C2=C2C3=CC=CC2=C1 ALRLPDGCPYIVHP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
- 150000001768 cations Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
A találmány a gyógyászatban citőkin inhibitőrőkként felhasználható (I)általánős képletű vegyületekre és az ezeket tartalmazógyógyszerkészítményekre vőnatkőzik, ahől a képletben R1 4-piridil-,pirimidinil-, kinőlil-, izőkinőlil-, 4-kinazőlinil-, 1-imidazőlil-vagy 1-benzimidazőlilcsőpőrt, ahől a heterőaril-gyűrű -YRa általánősképletű csőpőrttal és adőtt esetben tővábbi helyettesítővelszűbsztitűált; Y jelentése őxigén- vagy kénatőm; Ra adőtt esetbenszűbsztitűált aril-, aril-alkil-, heterőciklűsős, heterőciklűsőscsőpőrttal szűbsztitűált alkil-, heterőaril- vagy heterőaril-alkil-csőpőrt; Rb hidrőgénatőm, alkil-, ciklőalkil-, aril-, aril-alkil-,heterőciklűsős, heterőciklűsős csőpőrttal szűbsztitűált alkil-,heterőaril- vagy heterőaril-alkil-csőpőrt; R4 fenil-, 1-naftil-, 2-naftil- vagy heterőarilcsőpőrt, amelyek bármelyike adőtt esetbenegyszeresen vagy kétszeresen szűbsztitűált, ahől a szűbsztitűensekegymástól függetlenek és egy 4-fenil-, 4-naft-1-il-, 5-naft-2-il- vagy6-naft-2-il-szűbsztitűens halőgénatőm, cianő-, nitrőcsőpőrt, -C(Z)NR7R17, -C(Z)OR16, -(CR10R20)vCOR12, -SR5, -SOR5, -OR12, adőttesetben halőgénatőmmal szűbsztitűált alkilcsőpőrt, -ZC(Z)R12, -NR10C(Z)R16 vagy -(CR10R20)vNR10R20, míg az egyéb pőzíciókban lévőszűbsztitűens halőgénatőm, cianőcsőpőrt, -C(Z)nR13R14, -C(Z)OR3, -(CR10R20)m''COR3, -S(O)mR3, -OR3, adőtt esetben halőgénatőmszűbsztitűált alkilcsőpőrt, -(CR10R20)m''NR10C(Z)R3, -NR10S(O)m'R8, -NR10S(O)m'NR7R17, -ZC(Z)R3 vagy -(CR10R20)m''NR13R14; v 0, 1 vagy 2; m0, 1 vagy 2; m' 1 vagy 2; m'' 0, 1, 2, 3, 4 vagy 5; R2 -(CR10R20)n'OR9, heterőciklűsős csőpőrt, adőtt esetben heterőciklűsőscsőpőrttal szűbsztitűált alkilcsőpőrt, halőgén-alkil-, alkenil-,alkinil-, ciklőalkil-, ciklőalkil-alkil-, ciklőalkenil-, ciklőalkenil-alkil-, aril-, aril-alkil-, heterőaril-, heterőaril-alkil-, -(CR10R20)nOR11, -(CR10R20)nS(O)mR18, -(CR10R20)nNHS(O)2R18, -(CR10R20)nNR13R14, -(CR10R20)nNO2, -(CR10R20)nCN, -(CR10R20)nSO2R18, -(CR10R20)nS(O)m'NR13R14, -(CR10R20)nC(Z)R11, -(CR10R20)nOC(Z)R11, -(CR10R20)nC(Z)OR11, -(CR10R20)nC(Z)NR13R14, -(CR10R20)nC(Z)NR11OR9, -(CR10R20)nNR10C(Z)R11, -(CR10R20)nNR10C(Z)N13R14, -(CR10R20)nN(OR6)C(Z)NR13R14, -(CR10R20)nN(OR6)C(Z)R11, -(CR10R20)nC(=NOR6)R11, -(CR10R20)nNR10C=NR19)NR13R14, -(CR10R20)nOC(Z)NR13R14, -(CR10R20)nNR10C(Z)NR13R14, -(CR10R20)nNR10C(Z)OR10, 5-(R18)-1,2,4-őxadiazől-3-il- vagy 4-(R12)-5-(R18R19)-4,5-dihidrő- 1,2,4-őxadiazől-3-il-csőpőrt; n 1, 2, 3, 4, 5,6, 7, 8, 9 vagy 10; n' 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 vagy 10; Z őxigén-vagy kénatőm; R3 heterőciklűsős vagy heterőciklűsős csőpőrttalszűbsztitűált alkilcsőpőrt vagy R8; R5 hidrőgénatőm, alkil-, alkenil-,alkinilcsőpőrt vagy -NR7R17; R6 hidrőgénatőm, katiőn, alkil-,ciklőalkil-, aril-, aril-alkil-, heterőaril-, heterő
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US990796P | 1996-01-11 | 1996-01-11 | |
US1495296P | 1996-04-05 | 1996-04-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9902460A2 true HUP9902460A2 (hu) | 1999-11-29 |
HUP9902460A3 HUP9902460A3 (en) | 2000-03-28 |
Family
ID=26680002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902460A HUP9902460A3 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds, their use, method for their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (3) | US5977103A (hu) |
EP (1) | EP0900083B1 (hu) |
JP (1) | JP2000503302A (hu) |
KR (1) | KR19990077164A (hu) |
CN (1) | CN1213306A (hu) |
AT (1) | ATE247470T1 (hu) |
AU (1) | AU715900B2 (hu) |
BR (1) | BR9706973A (hu) |
CA (1) | CA2242327A1 (hu) |
CZ (1) | CZ216498A3 (hu) |
DE (1) | DE69724246T2 (hu) |
ES (1) | ES2205167T3 (hu) |
HU (1) | HUP9902460A3 (hu) |
IL (1) | IL125223A0 (hu) |
MX (1) | MX9805631A (hu) |
NO (1) | NO983189L (hu) |
NZ (1) | NZ327044A (hu) |
PL (1) | PL187516B1 (hu) |
TR (1) | TR199801361T2 (hu) |
TW (1) | TW505637B (hu) |
WO (1) | WO1997025045A1 (hu) |
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ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US5977103A (en) * | 1996-01-11 | 1999-11-02 | Smithkline Beecham Corporation | Substituted imidazole compounds |
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US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
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WO2000026209A1 (en) * | 1998-11-03 | 2000-05-11 | Novartis Ag | Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles |
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US6288089B1 (en) * | 1998-12-21 | 2001-09-11 | Michael Zawada | Use of kinase inhibitors for treating neurodegenerative diseases |
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-
1997
- 1997-01-10 US US09/101,531 patent/US5977103A/en not_active Expired - Fee Related
- 1997-01-10 US US08/780,954 patent/US5756499A/en not_active Expired - Fee Related
- 1997-01-10 BR BR9706973A patent/BR9706973A/pt not_active Application Discontinuation
- 1997-01-10 PL PL97327735A patent/PL187516B1/pl not_active IP Right Cessation
- 1997-01-10 CZ CZ982164A patent/CZ216498A3/cs unknown
- 1997-01-10 WO PCT/US1997/000500 patent/WO1997025045A1/en not_active Application Discontinuation
- 1997-01-10 AU AU15774/97A patent/AU715900B2/en not_active Ceased
- 1997-01-10 EP EP97902002A patent/EP0900083B1/en not_active Expired - Lifetime
- 1997-01-10 TR TR1998/01361T patent/TR199801361T2/xx unknown
- 1997-01-10 NZ NZ327044A patent/NZ327044A/xx unknown
- 1997-01-10 KR KR1019980705302A patent/KR19990077164A/ko not_active Application Discontinuation
- 1997-01-10 IL IL12522397A patent/IL125223A0/xx unknown
- 1997-01-10 CN CN97192882A patent/CN1213306A/zh active Pending
- 1997-01-10 ES ES97902002T patent/ES2205167T3/es not_active Expired - Lifetime
- 1997-01-10 JP JP9525452A patent/JP2000503302A/ja not_active Ceased
- 1997-01-10 CA CA002242327A patent/CA2242327A1/en not_active Abandoned
- 1997-01-10 HU HU9902460A patent/HUP9902460A3/hu not_active Application Discontinuation
- 1997-01-10 DE DE69724246T patent/DE69724246T2/de not_active Expired - Fee Related
- 1997-01-10 AT AT97902002T patent/ATE247470T1/de not_active IP Right Cessation
- 1997-08-22 TW TW086112053A patent/TW505637B/zh active
-
1998
- 1998-04-17 US US09/062,542 patent/US5864036A/en not_active Expired - Fee Related
- 1998-07-10 NO NO983189A patent/NO983189L/no not_active Application Discontinuation
- 1998-07-10 MX MX9805631A patent/MX9805631A/es not_active IP Right Cessation
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NZ327044A (en) | 2000-01-28 |
WO1997025045A1 (en) | 1997-07-17 |
EP0900083A4 (en) | 1999-08-25 |
HUP9902460A3 (en) | 2000-03-28 |
KR19990077164A (ko) | 1999-10-25 |
NO983189L (no) | 1998-09-10 |
CA2242327A1 (en) | 1997-07-17 |
US5977103A (en) | 1999-11-02 |
CZ216498A3 (cs) | 1999-08-11 |
TR199801361T2 (xx) | 1998-10-21 |
ATE247470T1 (de) | 2003-09-15 |
MX9805631A (es) | 1998-11-30 |
DE69724246T2 (de) | 2004-06-03 |
EP0900083A1 (en) | 1999-03-10 |
PL187516B1 (pl) | 2004-07-30 |
BR9706973A (pt) | 1999-04-06 |
CN1213306A (zh) | 1999-04-07 |
AU715900B2 (en) | 2000-02-10 |
PL327735A1 (en) | 1998-12-21 |
EP0900083B1 (en) | 2003-08-20 |
US5864036A (en) | 1999-01-26 |
US5756499A (en) | 1998-05-26 |
JP2000503302A (ja) | 2000-03-21 |
ES2205167T3 (es) | 2004-05-01 |
TW505637B (en) | 2002-10-11 |
IL125223A0 (en) | 1999-03-12 |
AU1577497A (en) | 1997-08-01 |
DE69724246D1 (de) | 2003-09-25 |
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