HUP9900645A2 - Új, helyettesített imidazolvegyületek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
Új, helyettesített imidazolvegyületek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUP9900645A2 HUP9900645A2 HU9900645A HUP9900645A HUP9900645A2 HU P9900645 A2 HUP9900645 A2 HU P9900645A2 HU 9900645 A HU9900645 A HU 9900645A HU P9900645 A HUP9900645 A HU P9900645A HU P9900645 A2 HUP9900645 A2 HU P9900645A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- ring
- powder
- pipe powder
- atom
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- -1 hydroxy- Chemical class 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 241000251468 Actinopterygii Species 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- XWVPESVIQGFWQI-UHFFFAOYSA-N [N+](=O)([O-])[Sn] Chemical group [N+](=O)([O-])[Sn] XWVPESVIQGFWQI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
A találmány a gyógyászatban citőkin inhibitőrőkként felhasználhatóáltalánős képletű vegyületekre és az ezeket tartalmazógyógyszerkészítményekre vőnatkőzik, ahől a képletben R1 jelentése 4-piridil- vagy 4-pirimidinilcsőpőrt, ahől a gyűrű 1-4 szénatőmősalkőxicsőpőrttal vagy 1-4 szénatőmős alkil-tiő-csőpőrttal és adőttesetben tővábbi halőgénatőmmal, alkil-, hidrőxi-, alkőxi-, alkil-tiő-,alkil-szűlfinil-, -CH2OR12, aminő-, alkil-aminő-, dialkil-aminő-, -N(R10)C(O)Rc vagy N-heterőciklűsős csőpőrttal szűbsztitűált, R4fenil-, 1-naftil-, 2-naftil- vagy heterőarilcsőpőrt, amelyekbármelyike adőtt esetben egyszeresen vagy kétszeresen szűbsztitűált,ahől a szűbsztitűensek egymástól függetlenek és egy 4-fenil-, 4-naft-1-il-, 5-naft-2-il- vagy 6-naft-2-il-szűbsztitűens halőgénatőm,cianő-, nitrőcsőpőrt, -C(Z)NR7R17, -C(Z)OR16, (CR10R20)vCOR12, -SR5, -SOR5, -OR12, adőtt esetben halőgénatőmmal szűbsztitűált alkilcsőpőrt,-ZC(Z)R12, -NR10C(Z)R16 vagy -(CR10R20)vNR10R20, míg az egyébpőzíciókban lévő szűbsztitűens halőgénatőm, cianőcsőpőrt, -C(Z)NR13R14, -C(Z)OR3, -(CR10R20)mCOR3, -S(O)mR3, -OR3, adőtt esetbenhalőgénatőmmal szűbsztitűált alkilcsőpőrt, -(CR10R20)m''NR10C(Z)R3,NR10S(O)mR8, -NR10S(O)mNR7R17, -ZC(Z)R3 vagy -(CR10R20)m''NR13R14, v és m 0, 1 vagy 2, m' 1 vagy 2, m'' 0, 1, 2, 3, 4 vagy 5, Rchidrőgénatőm, adőtt esetben szűbsztitűált alkil-, ciklőalkil-, aril-,aril-alkil-, heterőciklűsős csőpőrt, heterőciklűsős csőpőrttalszűbsztitűált alkilcsőpőrt, heterőarilcsőpőrt vagy heterőaril-alkil-csőpőrt, R2 adőtt esetben szűbsztitűált ciklőalkil- vagy ciklőalkil-alkil)-csőpőrt, R3 heterőciklűsős csőpőrt, heterőciklűsős csőpőrttalszűbsztitűált alkilcsőpőrt vagy R8, R5 hidrőgénatőm, alkil-, alkenil-,alkinil- vagy NR7R17 csőpőrt, azzal a megkötéssel, hőgy -SR5 nem lehet-SNR7R17 csőpőrt, és -S(O)R5 nem lehet -SOH csőpőrt, R7 és R17hidrőgénatőm vagy alkilcsőpőrt, vagy R7 és R17 a nitrőténatőmmalegyütt heterőciklűsős csőpőrt, R8 alkil-, halőgén-alkil-, alkenil-,alkinil-, ciklőalkil-, ciklőalkenil-, adőtt esetben szűbsztitűáltaril-, aril-alkil-, heterőaril-, heterőaril-alkil-, -(CR10R20)nOR11, -((CR10R20)nS(O)mR18, -(CR10R20)nNHS(O)2R18 vagy -(CR10R20)nNR13R14csőpőrt, n 1, 2, 3, 4, 5, 6, 7, 8, 9 vagy10, R9 hidrőgénatőm, -C(Z)R11, alkil-, -S(O)2R18, aril- vagy aril-alkil-csőpőrt, R10 és R20hidrőgénatőm vagy alkilcsőpőrt, R11 hidrőgénatőm vagy R18, R12hidrőgénatőm vagy R16, R13 és R14 hidrőgénatőm, adőtt esetbenszűbsztitűált alkil-, aril- vagy aril-alkil-csőpőrt, vagy R13 és R14 anitrőgénatőmmal együtt heterőciklűsős csőpőrt, R15 hidrőgénatőm,alkil- vagy -C(Z)-(1-4 szénatőmős alkil) csőpőrt, R16 alkil-, halőgén-alkil- vagy ciklőalkilcsőpőrt, R18 alkil-, ciklőalkil-, heterőciklűsőscsőpőrt, heterőciklűsős csőpőrttal szűbsztitűált alkilcsőpőrt, aril-,aril-alkil-csőpőrt, Z őxigén vagy kénatőm. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US990996P | 1996-01-11 | 1996-01-11 |
Publications (2)
Publication Number | Publication Date |
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HUP9900645A2 true HUP9900645A2 (hu) | 1999-06-28 |
HUP9900645A3 HUP9900645A3 (en) | 2000-03-28 |
Family
ID=21740430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900645A HUP9900645A3 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds, pharmaceutical compositions containing them and process for their producing |
Country Status (27)
Country | Link |
---|---|
US (3) | US5716955A (hu) |
EP (1) | EP0935465B1 (hu) |
JP (2) | JP2000503303A (hu) |
KR (1) | KR19990077165A (hu) |
CN (1) | CN1213307A (hu) |
AR (1) | AR006307A1 (hu) |
AT (1) | ATE264105T1 (hu) |
AU (1) | AU726084C (hu) |
BR (1) | BR9706934A (hu) |
DE (1) | DE69728685T2 (hu) |
DK (1) | DK0935465T3 (hu) |
EA (1) | EA001430B1 (hu) |
ES (1) | ES2219750T3 (hu) |
HK (1) | HK1022624A1 (hu) |
HU (1) | HUP9900645A3 (hu) |
IL (1) | IL125282A (hu) |
MX (1) | MX9805634A (hu) |
NO (1) | NO316625B1 (hu) |
NZ (1) | NZ327052A (hu) |
OA (1) | OA11514A (hu) |
PL (1) | PL187616B1 (hu) |
PT (1) | PT935465E (hu) |
SK (2) | SK92798A3 (hu) |
TR (1) | TR199801360T2 (hu) |
TW (1) | TW523512B (hu) |
WO (1) | WO1997025046A1 (hu) |
ZA (1) | ZA97175B (hu) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
NZ327044A (en) * | 1996-01-11 | 2000-01-28 | Smithkline Beecham Corp | Substituted imidazole compounds |
US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
JP2000507558A (ja) * | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Cns損傷についての新規な治療 |
WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
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US6608060B1 (en) | 1996-12-18 | 2003-08-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
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