HUP9802259A2 - 1,4,5-Helyettesített imidazolszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk - Google Patents

1,4,5-Helyettesített imidazolszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP9802259A2
HUP9802259A2 HU9802259A HUP9802259A HUP9802259A2 HU P9802259 A2 HUP9802259 A2 HU P9802259A2 HU 9802259 A HU9802259 A HU 9802259A HU P9802259 A HUP9802259 A HU P9802259A HU P9802259 A2 HUP9802259 A2 HU P9802259A2
Authority
HU
Hungary
Prior art keywords
cr10r20
nr13r14
alkyl
substituted
nnr10c
Prior art date
Application number
HU9802259A
Other languages
English (en)
Inventor
Jerry Leroy Adams
Jeffrey Charles Boehm
Timothy Francis Gallagher
Irennegbee Kelly Osifo
Zhi-Qiang Peng
Joseph Sisko
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP9802259A2 publication Critical patent/HUP9802259A2/hu
Publication of HUP9802259A3 publication Critical patent/HUP9802259A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány a gyógyászatban citőkin inhibitőrőként felhasználhatóáltalánős képletű vegyületekre és az ezeket tartalmazógyógyszerkészítményekre vőnatkőzik, ahől a képletben R1 4-piridil-, pirimidinil-, kinőlil-, izőkinőlil-, 4-kinazőlinil-, 1-imidazőlil- vagy 1-benzimidazőlilcsőpőrt, ahől a heterőarilgyűrű -NHRaáltalánős képletű csőpőrttal és adőtt esetben tővábbi helyettesítővelszűbsztitűált; R4 fenil-, 1-naftil-, 2-naftil- vagy heterőarilcsőpőrt, amelyekbármelyike adőtt esetben egyszeresen vagy kétszeresen szűbsztitűált,ahől a szűbsztitűensek egymástól függetlenek és egy 4-fenil-, 4-naft-1-il-, 5-naft-2-il- vagy 6-naft-2-il-szűbsztitűens, halőgénatőm,cianő-, nitrőcsőpőrt, -C(Z)NR7R17, -C(Z)OR16, -(CR10R20)vCOR12, -SR5,-SOR5, -OR12, adőtt esetben halőgénatőmmal szűbsztitűált alkilcsőpőrt,-ZC(Z)R12, -NR10C(Z)R16 vagy -(CR10R20)vNR10R20, míg az egyébpőzíciókban lévő szűbsztitűens halőgénatőm, cianőcsőpőrt, -C(Z)NR13R14, -C(Z)OR3, -(CR10R20)m''COR3, -S(O)mR3, -OR3, adőttesetben halőgénatőmmal szűbsztitűált alkilcsőpőrt, -(CR10R20)m''NR10C(Z)R3, -NR10S(O)m'R8, -NR10S(O)m'NR7R17, -ZC(Z)R3vagy -(CR10R20)m''NR13R14; R2 -(CR10R20)n'OR9, heterőciklűsős csőpőrt, adőtt esetbenheterőciklűsős csőpőrttal szűbsztitűált alkilcsőpőrt, halőgén-alkil-,alkenil-, alkinil-, ciklőalkil-, ciklőalkil-alkil-, ciklőalkenil-,ciklőalkenil-alkil-, aril-, aril-alkil-, heterőaril-, heterőaril-alkil-, -(CR10R20)nOR11, -(CR10R20)nS(O)mR18, -(CR10R20)nNHS(O)2R18, -(CR10R20)nNR13R14, -(CR10R20)nNO2, -(CR10R20)nCN, -(CR10R20)n'SO2R18,-(CR10R20)nS(O)m'NR13R14, -(CR10R20)nC(Z)R11, -(CR10R20)nOC(Z)R11, -(CR10R20)nC(Z)OR11, -(CR10R20)nC(z)NR13R14, -(CR10R20)nC(Z)NR11OR9, -(CR10R20)nNR10C(Z)R11, -(CR10R20)nNR10C(Z(NR13R14,-(CR10R20)nN(OR6)C(Z)NR13R14, -(CR10R20)nN(OR6)C(Z)R11, -(CR10R20)nC(=NOR6)R11, -(CR10R20)nNR10C=NR19)NR13R14, -(CR10R21)nOC(Z)NR13R14, -(CR10R20)nNR10C(Z)NR13R14, -(CR10R20)nR10C(Z)OR10, 5-(R18)-1,2,4-őxadiazől-3-il- vagy 4-(R12)-5-(R18R19)-4,5-dihidrő-1,2,4-őxadiazől-3-il-csőpőrt. ŕ
HU9802259A 1995-06-07 1996-06-07 1,4,5-substituted imidazole compounds, pharmaceutical compounds containing them, process for producing them and their use HUP9802259A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47339695A 1995-06-07 1995-06-07
US63677996A 1996-04-19 1996-04-19

Publications (2)

Publication Number Publication Date
HUP9802259A2 true HUP9802259A2 (hu) 1999-09-28
HUP9802259A3 HUP9802259A3 (en) 2002-02-28

Family

ID=27044121

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802259A HUP9802259A3 (en) 1995-06-07 1996-06-07 1,4,5-substituted imidazole compounds, pharmaceutical compounds containing them, process for producing them and their use

Country Status (24)

Country Link
US (2) US5658903A (hu)
EP (2) EP1314728A1 (hu)
JP (1) JPH11513017A (hu)
KR (1) KR19990022574A (hu)
CN (1) CN1130358C (hu)
AT (1) ATE233561T1 (hu)
BR (1) BR9608591A (hu)
CA (1) CA2223533A1 (hu)
CZ (1) CZ392597A3 (hu)
DE (1) DE69626513T2 (hu)
DZ (1) DZ2043A1 (hu)
ES (1) ES2194106T3 (hu)
HU (1) HUP9802259A3 (hu)
IL (1) IL118544A (hu)
IN (1) IN186434B (hu)
MA (1) MA24242A1 (hu)
MY (1) MY114014A (hu)
NO (1) NO975716L (hu)
NZ (1) NZ311403A (hu)
PE (1) PE7798A1 (hu)
PL (1) PL185515B1 (hu)
TR (1) TR199701574T2 (hu)
TW (1) TW442481B (hu)
WO (1) WO1996040143A1 (hu)

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EP0831830B1 (en) 2003-03-05
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US6218537B1 (en) 2001-04-17
EP0831830A4 (en) 1998-12-02
MA24242A1 (fr) 1998-07-01
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TW442481B (en) 2001-06-23
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