BRPI0417928A - composto, composição farmacêutica, métodos para o tratamento ou a prevenção de uma condição mediada pelo receptor de bradicinina b1, e de dor em um mamìfero, e, uso de um composto - Google Patents
composto, composição farmacêutica, métodos para o tratamento ou a prevenção de uma condição mediada pelo receptor de bradicinina b1, e de dor em um mamìfero, e, uso de um compostoInfo
- Publication number
- BRPI0417928A BRPI0417928A BRPI0417928-5A BRPI0417928A BRPI0417928A BR PI0417928 A BRPI0417928 A BR PI0417928A BR PI0417928 A BRPI0417928 A BR PI0417928A BR PI0417928 A BRPI0417928 A BR PI0417928A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- compound
- bradykinin
- pain
- prevention
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA O TRATAMENTO OU A PREVENçãO DE UMA CONDIçãO MEDIADA PELO RECEPTOR DE BRADICININA B1, E DE DOR EM UM MAMìFERO, E, USO DE UM COMPOSTO". Derivados de ><244>-hidróxi-amida de fórmula geral (I) na qual Y é CH ou N; R¬ 1¬ é são agonistas inversos ou antagonistas de bradicinina B1 úteis no tratamento ou na prevenção de sintomas tais como dor e inflamação associados com a rota de bradicinina B1. R¬ 2a¬ é selecionado de (1) um grupo selecionado de R¬ a¬, (2) (CH~ 2~)~ n~NR¬ b¬C(O)R¬ a¬, (3) (CH~ 2~)~ n~NR¬ b¬SO~ 2~R¬ d¬, (4) (CH~ 2~)~ n~NR¬ b¬CO~ 2~R¬ a¬, (5) (CH~ 2~)~ k~-heterociclo opcionalmente substituído com 1 a 3 grupos independentemente selecionados de halogênio, nitro, ciano, OR¬ a¬, SR¬ a¬, C~ 1-4~ alquila e C~ 1-3~ halo-aquila, no qual o citado heterociclo é (a) um anel heteroaromático de 5 membros possuindo um heteroátomo de anel selecionado de N, O e S e opcionalmente possuindo até 3 átomos de nitrogênio adicionais no anel no qual o citado anel é opcionalmente benzo-fusionado; ou (b) um anel heteroaromático de 6 membros contendo de 1 a 3 átomos de nitrogênio e seus N-óxidos. No qual o citado anel é opcionalmente benzo-fusionado, (6) (CH~ 2~)~ k~CO~ 2~R¬ a¬ e (7) (CH~ 2~)~ k~C(O)NR¬ b¬R¬ c¬. R¬ 2b¬ é OH ou um grupo selecionado de R¬ 2a¬ ou R¬ 2a¬ e R¬ 2b¬ juntos com o átomo de carbono no qual estão ligados formam um anel carbocíclico de 3 a 7 membros opcionalmente substituído com 1 a 4 grupos selecionados de halogênio, OR¬ a~, C~ 1-4~ alquila e C~ 1-4~halo-alquila.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53164303P | 2003-12-22 | 2003-12-22 | |
US53963704P | 2004-01-28 | 2004-01-28 | |
US62495804P | 2004-11-04 | 2004-11-04 | |
PCT/US2004/042691 WO2005063690A1 (en) | 2003-12-22 | 2004-12-17 | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417928A true BRPI0417928A (pt) | 2007-04-17 |
Family
ID=34743689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417928-5A BRPI0417928A (pt) | 2003-12-22 | 2004-12-17 | composto, composição farmacêutica, métodos para o tratamento ou a prevenção de uma condição mediada pelo receptor de bradicinina b1, e de dor em um mamìfero, e, uso de um composto |
Country Status (16)
Country | Link |
---|---|
US (1) | US7790754B2 (pt) |
EP (1) | EP1706372B1 (pt) |
JP (1) | JP4585522B2 (pt) |
KR (1) | KR20060115753A (pt) |
AT (1) | ATE468322T1 (pt) |
AU (1) | AU2004309357B2 (pt) |
BR (1) | BRPI0417928A (pt) |
CA (1) | CA2550372C (pt) |
DE (1) | DE602004027301D1 (pt) |
EC (1) | ECSP066658A (pt) |
IL (1) | IL176381A0 (pt) |
IS (1) | IS8510A (pt) |
MA (1) | MA28288A1 (pt) |
MX (1) | MXPA06007203A (pt) |
NO (1) | NO20063394L (pt) |
WO (1) | WO2005063690A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
AU2005310238A1 (en) * | 2004-10-29 | 2006-06-08 | Merck Sharp & Dohme Corp. | N-(pyridin-3-yl)-2-phenylbutanamides as androgen receptor modulators |
WO2006052514A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Asymmetric hydrogenation of enamides |
AU2006255642A1 (en) * | 2005-06-03 | 2006-12-14 | Merck Sharp & Dohme Corp. | 1-Hydroxycycloalkanecarboxamide derivatives as bradykinin antagonists |
US20090088458A1 (en) * | 2005-08-02 | 2009-04-02 | Meissner Robert S | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators |
MX2008013238A (es) * | 2006-04-12 | 2008-10-21 | Merck & Co Inc | Antagonistas de los canales de calcio de tipo t de piridil amida. |
WO2008059335A1 (en) | 2006-11-13 | 2008-05-22 | Pfizer Products Inc. | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof |
WO2009009041A2 (en) * | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
US8637513B2 (en) * | 2007-10-24 | 2014-01-28 | Merck Sharp & Dohme Corp. | Heterocycle phenyl amide T-type calcium channel antagonists |
EP2396301A2 (en) | 2009-02-13 | 2011-12-21 | Jerini AG | Small molecule bradykinin b1 receptor antagonists |
EP2459182B1 (en) * | 2009-07-30 | 2017-09-06 | University of Zürich | Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event |
JP6499076B2 (ja) | 2012-08-30 | 2019-04-10 | アセネックス インコーポレイテッド | タンパク質チロシンキナーゼ調節因子としてのn−(3−フルオロベンジル)−2−(5−(4−モルホリノフェニル)ピリジン−2−イル)アセトアミド |
CN113200841B (zh) * | 2021-04-21 | 2022-05-20 | 嘉兴学院 | 一种基于Heck偶联合成消旋萘普生的新工艺 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH075579B2 (ja) * | 1986-09-01 | 1995-01-25 | 吉富製薬株式会社 | アミノチアゾ−ル化合物 |
GB8726179D0 (en) * | 1987-11-09 | 1987-12-16 | Fujisawa Pharmaceutical Co | Heterocyclic derivatives |
DE60007697T2 (de) * | 1999-07-21 | 2004-12-09 | F. Hoffmann-La Roche Ag | Triazolderivate |
DE10008329A1 (de) * | 2000-02-23 | 2001-08-30 | Merck Patent Gmbh | Aminosulfonylbiphenylderivate |
DE10014645A1 (de) * | 2000-03-24 | 2001-09-27 | Merck Patent Gmbh | Substituierte Biphenylderivate |
FR2822827B1 (fr) * | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant |
AR038377A1 (es) * | 2002-02-08 | 2005-01-12 | Merck & Co Inc | Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo) |
WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
-
2004
- 2004-12-17 DE DE602004027301T patent/DE602004027301D1/de active Active
- 2004-12-17 EP EP04814829A patent/EP1706372B1/en active Active
- 2004-12-17 CA CA002550372A patent/CA2550372C/en not_active Expired - Fee Related
- 2004-12-17 WO PCT/US2004/042691 patent/WO2005063690A1/en active Application Filing
- 2004-12-17 MX MXPA06007203A patent/MXPA06007203A/es not_active Application Discontinuation
- 2004-12-17 KR KR1020067012382A patent/KR20060115753A/ko not_active Application Discontinuation
- 2004-12-17 BR BRPI0417928-5A patent/BRPI0417928A/pt not_active Application Discontinuation
- 2004-12-17 AU AU2004309357A patent/AU2004309357B2/en not_active Ceased
- 2004-12-17 AT AT04814829T patent/ATE468322T1/de not_active IP Right Cessation
- 2004-12-17 JP JP2006547200A patent/JP4585522B2/ja not_active Expired - Fee Related
- 2004-12-17 US US10/583,675 patent/US7790754B2/en not_active Expired - Fee Related
-
2006
- 2006-06-15 IS IS8510A patent/IS8510A/xx unknown
- 2006-06-18 IL IL176381A patent/IL176381A0/en unknown
- 2006-06-20 EC EC2006006658A patent/ECSP066658A/es unknown
- 2006-07-10 MA MA29175A patent/MA28288A1/fr unknown
- 2006-07-21 NO NO20063394A patent/NO20063394L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR20060115753A (ko) | 2006-11-09 |
WO2005063690A1 (en) | 2005-07-14 |
CA2550372C (en) | 2009-09-29 |
AU2004309357B2 (en) | 2010-10-07 |
ECSP066658A (es) | 2006-10-25 |
JP2007520472A (ja) | 2007-07-26 |
US20080318976A1 (en) | 2008-12-25 |
MXPA06007203A (es) | 2006-08-18 |
AU2004309357A1 (en) | 2005-07-14 |
JP4585522B2 (ja) | 2010-11-24 |
CA2550372A1 (en) | 2005-07-14 |
MA28288A1 (fr) | 2006-11-01 |
NO20063394L (no) | 2006-09-12 |
US7790754B2 (en) | 2010-09-07 |
EP1706372A1 (en) | 2006-10-04 |
DE602004027301D1 (de) | 2010-07-01 |
IS8510A (is) | 2006-06-15 |
IL176381A0 (en) | 2006-10-05 |
EP1706372B1 (en) | 2010-05-19 |
ATE468322T1 (de) | 2010-06-15 |
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