HUP9902414A2 - 2,6,9-triszubsztituált purin-származékok, mint ciklin-függő kináz-2 és -IkB-alfa purin-inhibitorok, valamint ezeket tartalmazó gyógyszerkészítmények - Google Patents

2,6,9-triszubsztituált purin-származékok, mint ciklin-függő kináz-2 és -IkB-alfa purin-inhibitorok, valamint ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9902414A2
HUP9902414A2 HU9902414A HUP9902414A HUP9902414A2 HU P9902414 A2 HUP9902414 A2 HU P9902414A2 HU 9902414 A HU9902414 A HU 9902414A HU P9902414 A HUP9902414 A HU P9902414A HU P9902414 A2 HUP9902414 A2 HU P9902414A2
Authority
HU
Hungary
Prior art keywords
group
purine
ikb
alpha
optionally
Prior art date
Application number
HU9902414A
Other languages
English (en)
Inventor
Cheri Lynn Blum
Robert T. Lum
Richard Mackman
Steven R. Schow
Michael M. Wick
Original Assignee
Cv Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics, Inc. filed Critical Cv Therapeutics, Inc.
Publication of HUP9902414A2 publication Critical patent/HUP9902414A2/hu
Publication of HUP9902414A3 publication Critical patent/HUP9902414A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

A találmány szerinti 2,6,9-triszubsztituált purinkészítmény (I)általános képletében R1 jelentése halogénatom vagy R1'-X általános képletű csoport, ahol X jelentése NH, O, S vagy S(O)2, R1' jelentése alkilcsoport, cikloalkilcsoport,cikloheteroalkilcsoport, arilcsoport, heterociklusos csoport,heteroarilcsoport, aralkilcsoport, heteroaralkilcsoport,heteroalkilcsoport, alkil-alkenil-csoport, alkil-alkinil-csoport,alkil-cikloalkil-csoport vagy alkil-cikloheteroalkil-csoport, amelyekadott esetben szubsztituálva lehetnek, R2 jelentése hidrogénatom vagy szénhidrogéncsoport, R3 jelentése halogénatom, hidroxilcsoport, tiocsoport, alkoxicsoport,alkil-tio-csoport, adott esetben mono- vagy diszubsztituáltaminocsoport, vagy adott esetben szubsztituált nitrogéntartalmú gyűrű.A találmány kiterjed a fenti purinkészítményt tartalmazó, asejtszaporodást gátló gyógyszerkészítményekre. Ó
HU9902414A 1996-08-02 1997-08-01 2,6,9-trisubstituted purine derivatives as purine inhibitors of cyclin dependent kinase 2 and ikb-alpha, and pharmaceutical compositions thereof HUP9902414A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/692,012 US5866702A (en) 1996-08-02 1996-08-02 Purine inhibitors of cyclin dependent kinase 2
PCT/US1997/013386 WO1998005335A1 (en) 1996-08-02 1997-08-01 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IλB-$g(a)

Publications (2)

Publication Number Publication Date
HUP9902414A2 true HUP9902414A2 (hu) 2001-04-28
HUP9902414A3 HUP9902414A3 (en) 2002-04-29

Family

ID=24778922

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902414A HUP9902414A3 (en) 1996-08-02 1997-08-01 2,6,9-trisubstituted purine derivatives as purine inhibitors of cyclin dependent kinase 2 and ikb-alpha, and pharmaceutical compositions thereof

Country Status (26)

Country Link
US (1) US5866702A (hu)
EP (1) EP1021186B1 (hu)
JP (1) JP2000515550A (hu)
KR (1) KR100403336B1 (hu)
CN (1) CN1161356C (hu)
AT (1) ATE298572T1 (hu)
AU (1) AU731778B2 (hu)
BR (1) BR9710801A (hu)
CA (1) CA2262454C (hu)
CZ (1) CZ299381B6 (hu)
DE (1) DE69733674T2 (hu)
DK (1) DK1021186T3 (hu)
ES (1) ES2242981T3 (hu)
GE (1) GEP20022786B (hu)
HK (1) HK1020884A1 (hu)
HU (1) HUP9902414A3 (hu)
IL (1) IL128323A (hu)
NO (1) NO323775B1 (hu)
NZ (1) NZ334061A (hu)
PL (1) PL189775B1 (hu)
PT (1) PT1021186E (hu)
RU (1) RU2220968C2 (hu)
SI (1) SI1021186T1 (hu)
TR (1) TR199900683T2 (hu)
UA (1) UA71890C2 (hu)
WO (1) WO1998005335A1 (hu)

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