AR081823A1 - DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd - Google Patents
DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3KdInfo
- Publication number
- AR081823A1 AR081823A1 ARP110101269A ARP110101269A AR081823A1 AR 081823 A1 AR081823 A1 AR 081823A1 AR P110101269 A ARP110101269 A AR P110101269A AR P110101269 A ARP110101269 A AR P110101269A AR 081823 A1 AR081823 A1 AR 081823A1
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- Argentina
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- alkyl
- nrc5rd5
- alkynyl
- alkenyl
- independently selected
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
Abstract
La presente provee derivados fusionados que modulan la actividad de fosfoinositida 3-quinasas (PI3Ks) y son de utilidad en el tratamiento de enfermedades relacionadas con la actividad de PI3K que incluyen, por ejemplo, trastornos inflamatorios, trastornos con inmunobase, cáncer y otras enfermedades.Reivindicación 1: Un compuesto de la fórmula (1) o una de sus sales farmacéuticamente aceptables; en donde V es CR2 o N; X es CR3 o N; Y es CR4 o N; siempre que al menos dos de V, X e Y sean distintos de N; W es CH o N; Z es un enlace, O, S o NRA; siempre que, cuando Z es un enlace, entonces Ar sea un grupo azaheteroarilo bicíclico, que está unido a Z un átomo de nitrógeno, en donde dicho grupo azaheteroarilo bicíclico está sustituido con n grupos RD seleccionados de modo independiente; L es un enlace, alquileno C1-4, NRB, O ó S; Q es alquilo C1-6, alquenilo C2-6, alquinilo C2-6 o Cy; en donde dicho alquilo C1-6, alquenilo C2-6 y alquinilo C2-6 están cada uno opcionalmente sustituidos con 1, 2, 3, 4 ó 5 grupos RC seleccionados de modo independiente; Cy es cicloalquilo, heterocicloalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido con 1, 2, 3, 4 ó 5 grupos RC seleccionados de modo independiente; cada RC está seleccionado, de modo independiente, de halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, halosulfanilo, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo, heterocicloalquilalquilo, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, C(=NRe)Rb, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb y S(O)2NRcRd; en donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo están cada uno opcionalmente sustituidos con 1, 2, 3, 4 ó 5 sustituyentes seleccionados, de modo independiente, de halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, halosulfanilo, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, C(=NRg)NRc2Rd2, NRc2C(=NRg)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2 y S(O)2NRc2Rd2; R1 está seleccionado, de modo independiente, de H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6 y alquinilo C2-6; en donde dicho alquilo C1-6, haloalquilo C1-6, alquenilo C2-6 y alquinilo C2-6 están cada uno opcionalmente sustituidos con 1, 2, 3 ó 4 sustituyentes seleccionados, de modo independiente, de halo, OH, CN, NR11R12, alcoxi C1-6, haloalcoxi C1-6, tio, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, carbamilo, alquil C1-6-carbamilo, di(alquil C1-6)carbamilo, carboxi, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilamino, alquil C1-6-sulfonilamino, aminosulfonilo, alquil C1-6-aminosulfonilo, di(alquil C1-6)aminosulfonilo, aminosulfonilamino, alquil C1-6-aminosulfonilamino, di(alquil C1-6)aminosulfonilamino, aminocarbonilamino, alquil C1-6-aminocarbonilamino y di(alquil C1-6)aminocarbonilamino; cada R11 y R12 está seleccionado, de modo independiente, de H y alquilo C1-6; o cualquier R11 y R12 junto con el átomo de N al que están unidos forman un grupo heterocicloalquilo de 3, 4, 5, 6 ó 7 miembros, que está opcionalmente sustituido con 1, 2, 3 ó 4 sustituyentes seleccionados, de modo independiente, de alquilo C1-6; R2, R3, R4 o R5 están seleccionados cada uno, de modo independiente, de H, OH, NO2, CN, halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, amino, alquil C1-6-amino, di(alquil C1-6)amino, tio, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, carbamilo, alquil C1-6-carbamilo, di(alquil C1-6)carbamilo, carboxi, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilamino, alquil C1-6-sulfonilamino, aminosulfonilo, alquil C1-6-aminosulfonilo, di(alquil C1-6)aminosulfonilo, aminosulfonilamino, alquil C1-6-aminosulfonilamino, di(alquil C1-6)aminosulfonilamino, aminocarbonilamino, alquil C1-6-aminocarbonilamino y di(alquil C1-6)aminocarbonilamino; Ar es heteroarilo, sustituido con n grupos RD seleccionados de modo independiente; cada RD está seleccionado, de modo independiente, de -(alquil C1-4)r-Cy1, halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, halosulfanilo, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(=NRe)NRc1Rd1, NRc1C(=NRe)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1 y S(O)2NRc1Rd1; RA está seleccionado de H, alquilo C1-6, alquenilo C2-6 y alquinilo C2-6; RB está seleccionado de H, alquilo C1-6, alquenilo C2-6 y alquinilo C2-6; en donde dicho alquilo C1-6, alquenilo C2-6 y alquinilo C2-6 están cada uno opcionalmente sustituidos con 1, 2, 3 ó 4 sustituyentes seleccionados, de modo independiente, de halo, OH, CN, NR11R12, alcoxi C1-6, haloalcoxi C1-6, tio, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, carbamilo, alquil C1-6-carbamilo, di(alquil C1-6)carbamilo, carboxi, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilamino, alquil C1-6-sulfonilamino, aminosulfonilo, alquil C1-6-aminosulfonilo, di(alquil C1-6)aminosulfonilo, aminosulfonilamino, alquil C1-6-aminosulfonilamino, di(alquil C1-6)aminosulfonilamino, aminocarbonilamino, alquil C1-6-aminocarbonilamino y di(alquil C1-6)aminocarbonilamino; cada Cy1 es, de modo independiente, arilo, heteroarilo, cicloalquilo o heterocicloalquilo, cada uno opcionalmente sustituido con 1, 2, 3, 4 ó 5 sustituyentes seleccionados, de modo independiente, de OH, NO2, CN, halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, amino, alquil C1-6-amino, di(alquil C1-6)amino, tio, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, carbamilo, alquil C1-6-carbamilo, di(alquil C1-6)carbamilo, carboxi, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilamino, alquil C1-6-sulfonilamino, aminosulfonilo, alquil C1-6-aminosulfonilo, di(alquil C1-6)aminosulfonilo, aminosulfonilamino, alquil C1-6-aminosulfonilamino, di(alquil C1-6)aminosulfonilamino, aminocarbonilamino, alquil C1-6-aminocarbonilamino y di(alquil C1-6)aminocarbonilamino; cada Ra, Rc y Rd está seleccionado, de modo independiente, de H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, en donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con 1, 2, 3, 4 ó 5 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, haloalquilo C1-6, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(=NRf)NRc5Rd5, NRc5C(=NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5 y S(O)2NRc5Rd5; cada Rb está seleccionado, de modo independiente, de alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, en donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con 1, 2, 3, 4 ó 5 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, haloalquilo C1-6, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(=NRf)NRc5Rd5, NRc5C(=NRf)NRC5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5 y S(O)2NRc5Rd5; o cualquier Rc y Rd junto con el átomo de N al que están unidos forman un grupo heterocicloalquilo de 3, 4, 5, 6 ó 7 miembros o un grupo heteroarilo, cada uno opcionalmente sustituido con 1, 2 ó 3 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, haloalquilo C1-6, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(=NRf)NRc5Rd5, NRc5C(=NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5 y S(O)2NRc5Rd5; cada Re, Rf y Rg está seleccionado, de modo independiente, de H, alquilo C1-6, CN, ORa5, SRb5, S(O)2Rb5, C(O)Rb5, S(O)2NRc5Rd5 y C(O)NRc5Rd5; cada Ra1, Rc1 y Rd1 está seleccionado, de modo independiente, de H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, en donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con 1, 2, 3, 4 ó 5 sustituyentes seleccionados, de modo independiente, de OH, NO2, CN, halo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, amino, alquil C1-6-amino, di(alquil C1-6)amino, tio, alquil C1-6-tio, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, carbamilo, alquil C1-6-carbamilo, di(alquil C1-6)carbamilo, carboxi, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilamino, alquil C1-6-sulfonilamino, aminosulfonilo, alquil C1-6-aminosulfonilo, di(alquil C1-6)aminosulfonilo, aminosulfonilamino, alquil C1-6-aminosulfonilamino, di(alquil C1-6)aminosulfonilamino, aminocarbonilamino, alquil C1-6-aminocarbonilamino y di(alquil C1-6)-aminocarbonil
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US32414310P | 2010-04-14 | 2010-04-14 | |
US201061425085P | 2010-12-20 | 2010-12-20 |
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AR081823A1 true AR081823A1 (es) | 2012-10-24 |
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ARP110101269A AR081823A1 (es) | 2010-04-14 | 2011-04-13 | DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd |
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EP (1) | EP2558463A1 (es) |
JP (1) | JP5816678B2 (es) |
AR (1) | AR081823A1 (es) |
CA (1) | CA2796311A1 (es) |
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EP2558463A1 (en) | 2013-02-20 |
WO2011130342A1 (en) | 2011-10-20 |
JP2013523889A (ja) | 2013-06-17 |
US20110281884A1 (en) | 2011-11-17 |
JP5816678B2 (ja) | 2015-11-18 |
CA2796311A1 (en) | 2011-10-20 |
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