HUP0400989A2 - Helyettesített 2-piridin-ciklohexán-1,4-diamin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Helyettesített 2-piridin-ciklohexán-1,4-diamin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400989A2 HUP0400989A2 HU0400989A HUP0400989A HUP0400989A2 HU P0400989 A2 HUP0400989 A2 HU P0400989A2 HU 0400989 A HU0400989 A HU 0400989A HU P0400989 A HUP0400989 A HU P0400989A HU P0400989 A2 HUP0400989 A2 HU P0400989A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- aryl
- cycloalkyl
- heteroaryl
- hydrogen atom
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
A találmány (I) általános képletű helyettesített 2-piridin-ciklohexán-l,4-diamin-származékokra, ezek előállítására, az e vegyületekettartalmazó gyógyszerekre és a helyettesített 2-piridin-ciklohexán-l,4-diamin-származékoknak gyógyszerek előállítására történőfelhasználására vonatkozik. A képletben R1 és R2 jelentése egymástólfüggetlenül hidrogénatom; vagy adott esetben helyettesített alkil-,cikloalkil-, aril- vagy heteroarilcsoport; vagy R1 és R2 együtt gyűrűtképez; R3 jelentése hidrogénatom; vagy adott esetben helyettesítettalkil-, cikloalkil-, aril- vagy heteroarilcsoport; vagy SH, OH, F, Cl,I, Br, CN, NO2, OR26, NR27R28; R26 jelentése adott esetbenhelyettesített alkil-, cikloalkil-, aril- vagy heteroarilcsoport; R27és R28 jelentése egymástól függetlenül hidrogénatom; adott esetbenhelyettesített alkil-, cikloalkil-, aril- vagy heteroarilcsoport; vagyR27 és R28 együtt gyűrűt képez; R4 jelentése hidrogénatom; alkil-csoport; vagy C(X)R7, C(X)NR7R8, C(X)OR9, C(X)SR9, S(O)2R9 (ahol Xjelentése oxigén- vagy kénatom); R7 jelentése hidrogénatom; adottesetben helyettesített alkil-, cikloalkil-, aril- vagyheteroarilcsoport; R8 jelentése hidrogénatom; alkilcsoport; vagy R7 ésR8 együtt gyűrűt képez; R9 jelentése adott esetben helyettesítettalkil-, cikloalkíl-, aril- vagy heteroarilcsoport; R5 jelentése adottesetben helyettesített cikloalkil-, aril- vagy heteroarilcsoport;CHR11R12 -CHR11-CH2R12, -CHR11-CH2-CH2R12, -CHR11-CH2-CH2-CH2R12, -C(Y)R12, -C(Y)-CH2R12, -C(Y)-CH2-CH2R vagy -C(Y)-CH2-CH2-CH2R12 (aholY jelentése O, S vagy H2); Rll jelentése hidrogénatom; adott esetbenhelyettesített alkil- vagy alkoxi-karbonil-csoport; és Rl2 jelentésehidrogénatom; vagy adott esetben helyettesített cikloalkil-, aril-vagy heteroarilcsoport; vagy R4 és R5 együtt heterociklust képez. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123163A DE10123163A1 (de) | 2001-05-09 | 2001-05-09 | Substituierte Cyclohexan-1,4-diaminderivate |
| PCT/EP2002/005078 WO2002090330A1 (de) | 2001-05-09 | 2002-05-08 | Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0400989A2 true HUP0400989A2 (hu) | 2004-08-30 |
| HUP0400989A3 HUP0400989A3 (en) | 2011-08-29 |
| HU229288B1 HU229288B1 (en) | 2013-10-28 |
Family
ID=7684562
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400888A HU228253B1 (en) | 2001-05-09 | 2002-05-08 | Substituted cyclohexane-1,4-diamine derivatives, process for their preparation and pharmaceutical compositions containing them |
| HU0400989A HU229288B1 (en) | 2001-05-09 | 2002-05-08 | Substituted 2-pyridine-cyclohexane-1,4-diamine derivatives |
| HU0400963A HUP0400963A2 (hu) | 2001-05-09 | 2002-05-09 | Antidiarrheás és perifériális analgetikus hatású helyettesített ciklohexán-1,4-diamin-származékok felhasználása gyógyszerkészítmények előállítására |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400888A HU228253B1 (en) | 2001-05-09 | 2002-05-08 | Substituted cyclohexane-1,4-diamine derivatives, process for their preparation and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400963A HUP0400963A2 (hu) | 2001-05-09 | 2002-05-09 | Antidiarrheás és perifériális analgetikus hatású helyettesített ciklohexán-1,4-diamin-származékok felhasználása gyógyszerkészítmények előállítására |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20040229872A1 (hu) |
| EP (3) | EP1392641B1 (hu) |
| JP (3) | JP2004533439A (hu) |
| KR (2) | KR20040002943A (hu) |
| CN (2) | CN1533374B (hu) |
| AR (1) | AR035883A1 (hu) |
| AT (2) | ATE359260T1 (hu) |
| AU (3) | AU2002312883B2 (hu) |
| BR (2) | BR0209580A (hu) |
| CA (3) | CA2446463C (hu) |
| CO (2) | CO5540300A2 (hu) |
| CY (2) | CY1106468T1 (hu) |
| CZ (2) | CZ20032995A3 (hu) |
| DE (3) | DE10123163A1 (hu) |
| DK (2) | DK1392641T3 (hu) |
| EC (2) | ECSP034830A (hu) |
| ES (2) | ES2284876T3 (hu) |
| HK (2) | HK1062911A1 (hu) |
| HU (3) | HU228253B1 (hu) |
| IL (4) | IL158782A0 (hu) |
| MX (3) | MXPA03010201A (hu) |
| NO (2) | NO326784B1 (hu) |
| NZ (2) | NZ529334A (hu) |
| PE (1) | PE20021094A1 (hu) |
| PL (3) | PL212887B1 (hu) |
| PT (2) | PT1392641E (hu) |
| RU (2) | RU2321579C2 (hu) |
| SI (2) | SI1392641T1 (hu) |
| SK (2) | SK286617B6 (hu) |
| WO (3) | WO2002090330A1 (hu) |
| ZA (2) | ZA200309521B (hu) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| DE50312412D1 (en) | 2002-11-12 | 2010-03-25 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
| CA2506415A1 (en) | 2002-11-19 | 2004-06-03 | Achillion Pharmaceuticals, Inc. | Substituted aryl thioureas and releated compounds; inhibitors of viral replication |
| US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004023501A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004023506A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006035787A1 (de) | 2006-07-28 | 2008-03-13 | Tesa Ag | Verfahren zum Stanzen von bei Raumtemperatur nicht tackigen hitzeaktivierbaren Klebmassen |
| WO2008089307A2 (en) * | 2007-01-18 | 2008-07-24 | Lexicon Pharmaceuticals, Inc. | Delta 5 desaturase inhibitors for the treatment of pain, inflammation and cancer |
| BRPI0813176A2 (pt) * | 2007-06-15 | 2014-12-30 | Mission Pharma Co | Moléculas e composições par ainibir fator edema e adenilil ciclase |
| US20090215725A1 (en) * | 2008-02-26 | 2009-08-27 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| DK2260042T3 (da) | 2008-03-27 | 2011-10-31 | Gruenenthal Gmbh | Substituerede spirocykliske cyklohexan-derivater |
| MX2010010337A (es) | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Derivados de espiro(5.5)undecano. |
| ES2663398T3 (es) | 2008-03-27 | 2018-04-12 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
| AR071066A1 (es) | 2008-03-27 | 2010-05-26 | Gruenenthal Chemie | Derivados de (hetero) aril-ciclohexano |
| CL2009000732A1 (es) | 2008-03-27 | 2009-05-15 | Gruenethal Gmbh | Compuestos derivados de hidroximetil ciclohexilaminas sustituidos; composicion farmaceutica que contiene a dicho compuesto y sus uso como moduladores del receptor de opiodes u y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso del alcohol, hipertension, anorexia, obesidad y diarrea. |
| WO2009118174A1 (de) * | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Substituierte cyclohexyldiamine |
| AU2009275218C1 (en) | 2008-07-21 | 2015-02-05 | Purdue Pharma L.P. | Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the uses thereof |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| MX338041B (es) | 2009-09-25 | 2016-03-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especificos de lisina y su uso. |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| KR101794020B1 (ko) | 2010-04-19 | 2017-11-06 | 오리존 지노믹스 에스.에이. | 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도 |
| WO2012013727A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| US9181198B2 (en) | 2010-07-29 | 2015-11-10 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| CN107266345B (zh) | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
| RS58475B1 (sr) | 2011-10-20 | 2019-04-30 | Oryzon Genomics Sa | Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori |
| TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU172460B (hu) * | 1975-10-03 | 1978-09-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 5,6-digidro-3h-pirimidin-4-ona |
| US4065573A (en) * | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4113866A (en) * | 1977-04-01 | 1978-09-12 | The Upjohn Company | Analgetic compounds, compositions and process of treatment |
| US4447454A (en) * | 1977-04-01 | 1984-05-08 | The Upjohn Company | Analgetic compounds, compositions and process of treatment |
| US5877277A (en) | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
| US4906655A (en) | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| US5153226A (en) | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| FR2687147A1 (fr) | 1992-02-11 | 1993-08-13 | Union Pharma Scient Appl | Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5620955A (en) | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
| US5565568A (en) | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
| CA2203428A1 (en) | 1995-08-21 | 1997-02-27 | Philip Arthur Hipskind | 2-acylaminopropanamides as growth hormone secretagogues |
| NZ333038A (en) | 1996-08-22 | 2000-10-27 | Warner Lambert Co | Non-peptide bombesin receptor antagonists |
| ES2175925T3 (es) * | 1998-01-19 | 2002-11-16 | Pfizer | Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1. |
| US20020169101A1 (en) | 1999-05-10 | 2002-11-14 | Gonzalez Maria Isabel | Treatment of sexual dysfunction |
| GB0006289D0 (en) | 2000-03-15 | 2000-05-03 | Smithkline Beecham Plc | New use |
| GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| US20020028799A1 (en) | 2000-07-06 | 2002-03-07 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
| US6991916B2 (en) | 2000-07-14 | 2006-01-31 | Pfizer Inc. | Compounds for the treatment of sexual dysfunction |
| US6849622B2 (en) * | 2000-10-06 | 2005-02-01 | Tanabe Seiyaku Co., Ltd. | Aliphatic nitrogenous five-membered ring compounds |
| US20020055759A1 (en) | 2000-11-06 | 2002-05-09 | Shibuya Terry Y. | Bioactive surgical suture |
| AU2002225730A1 (en) | 2000-11-16 | 2002-05-27 | Smith Kline Beecham Corporation | Compounds |
| IL155814A0 (en) | 2000-11-17 | 2003-12-23 | Warner Lambert Co | Treatment of sexual dysfunction using bombesin antagonist |
| US20040087561A1 (en) | 2000-11-17 | 2004-05-06 | Gonzalez Maria Isabel | Treatment of sexual dysfunction |
| WO2002040008A2 (en) | 2000-11-17 | 2002-05-23 | Warner-Lambert Company Llc | Treatment of sexual dysfunction with non peptide bombesin receptor antagonists |
| GB2369117A (en) | 2000-11-17 | 2002-05-22 | Warner Lambert Co | Bombesin receptor antagonists |
| GB2369118A (en) | 2000-11-17 | 2002-05-22 | Warner Lambert Co | Bombesin receptor antagonists |
| US20030119714A1 (en) | 2000-12-15 | 2003-06-26 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
-
2001
- 2001-05-09 DE DE10123163A patent/DE10123163A1/de not_active Withdrawn
-
2002
- 2002-05-08 RU RU2003134147/04A patent/RU2321579C2/ru not_active IP Right Cessation
- 2002-05-08 PT PT02738038T patent/PT1392641E/pt unknown
- 2002-05-08 KR KR10-2003-7014530A patent/KR20040002943A/ko not_active Application Discontinuation
- 2002-05-08 HU HU0400888A patent/HU228253B1/hu not_active IP Right Cessation
- 2002-05-08 MX MXPA03010201A patent/MXPA03010201A/es active IP Right Grant
- 2002-05-08 PL PL368851A patent/PL212887B1/pl unknown
- 2002-05-08 BR BR0209580-7A patent/BR0209580A/pt not_active Application Discontinuation
- 2002-05-08 ES ES02738038T patent/ES2284876T3/es not_active Expired - Lifetime
- 2002-05-08 SK SK1378-2003A patent/SK286617B6/sk not_active IP Right Cessation
- 2002-05-08 MX MXPA03010134A patent/MXPA03010134A/es active IP Right Grant
- 2002-05-08 DE DE50210707T patent/DE50210707D1/de not_active Expired - Lifetime
- 2002-05-08 CN CN028137531A patent/CN1533374B/zh not_active Expired - Fee Related
- 2002-05-08 AU AU2002312883A patent/AU2002312883B2/en not_active Ceased
- 2002-05-08 AT AT02738038T patent/ATE359260T1/de active
- 2002-05-08 KR KR1020037014568A patent/KR100895778B1/ko not_active IP Right Cessation
- 2002-05-08 CN CNB028135571A patent/CN1307158C/zh not_active Expired - Fee Related
- 2002-05-08 BR BR0209579-3A patent/BR0209579A/pt active Search and Examination
- 2002-05-08 NZ NZ529334A patent/NZ529334A/en not_active IP Right Cessation
- 2002-05-08 HU HU0400989A patent/HU229288B1/hu not_active IP Right Cessation
- 2002-05-08 CA CA2446463A patent/CA2446463C/en not_active Expired - Fee Related
- 2002-05-08 JP JP2002587399A patent/JP2004533439A/ja active Pending
- 2002-05-08 SK SK1379-2003A patent/SK287319B6/sk not_active IP Right Cessation
- 2002-05-08 DK DK02738038T patent/DK1392641T3/da active
- 2002-05-08 PL PL366662A patent/PL220595B1/pl unknown
- 2002-05-08 EP EP02738038A patent/EP1392641B1/de not_active Expired - Lifetime
- 2002-05-08 AU AU2002341195A patent/AU2002341195B2/en not_active Ceased
- 2002-05-08 IL IL15878202A patent/IL158782A0/xx unknown
- 2002-05-08 CZ CZ20032995A patent/CZ20032995A3/cs unknown
- 2002-05-08 EP EP02750900A patent/EP1385825B1/de not_active Expired - Lifetime
- 2002-05-08 SI SI200230571T patent/SI1392641T1/sl unknown
- 2002-05-08 NZ NZ529147A patent/NZ529147A/en not_active IP Right Cessation
- 2002-05-08 WO PCT/EP2002/005078 patent/WO2002090330A1/de active IP Right Grant
- 2002-05-08 PT PT02750900T patent/PT1385825E/pt unknown
- 2002-05-08 WO PCT/EP2002/005051 patent/WO2002090317A1/de active IP Right Grant
- 2002-05-08 RU RU2003134145/04A patent/RU2287523C2/ru not_active IP Right Cessation
- 2002-05-08 DK DK02750900T patent/DK1385825T3/da active
- 2002-05-08 IL IL15878402A patent/IL158784A0/xx unknown
- 2002-05-08 CZ CZ20033005A patent/CZ20033005A3/cs unknown
- 2002-05-08 JP JP2002587410A patent/JP2004528374A/ja active Pending
- 2002-05-08 CA CA2446461A patent/CA2446461C/en not_active Expired - Fee Related
- 2002-05-08 DE DE50209929T patent/DE50209929D1/de not_active Expired - Lifetime
- 2002-05-08 ES ES02750900T patent/ES2291486T3/es not_active Expired - Lifetime
- 2002-05-08 SI SI200230627T patent/SI1385825T1/sl unknown
- 2002-05-08 AT AT02750900T patent/ATE370120T1/de active
- 2002-05-09 HU HU0400963A patent/HUP0400963A2/hu unknown
- 2002-05-09 JP JP2002586920A patent/JP2005515959A/ja not_active Withdrawn
- 2002-05-09 EP EP02769145A patent/EP1385493A1/de not_active Withdrawn
- 2002-05-09 PL PL02366631A patent/PL366631A1/xx not_active Application Discontinuation
- 2002-05-09 CA CA002446735A patent/CA2446735A1/en not_active Abandoned
- 2002-05-09 PE PE2002000388A patent/PE20021094A1/es not_active Application Discontinuation
- 2002-05-09 WO PCT/EP2002/005122 patent/WO2002089783A1/de not_active Application Discontinuation
- 2002-05-09 MX MXPA03010195A patent/MXPA03010195A/es unknown
- 2002-05-10 AR ARP020101704A patent/AR035883A1/es unknown
-
2003
- 2003-11-05 NO NO20034931A patent/NO326784B1/no not_active IP Right Cessation
- 2003-11-05 NO NO20034930A patent/NO328600B1/no not_active IP Right Cessation
- 2003-11-06 IL IL158784A patent/IL158784A/en not_active IP Right Cessation
- 2003-11-06 IL IL158782A patent/IL158782A/en not_active IP Right Cessation
- 2003-11-07 EC EC2003004830A patent/ECSP034830A/es unknown
- 2003-11-07 CO CO03098846A patent/CO5540300A2/es active IP Right Grant
- 2003-11-07 CO CO03098857A patent/CO5700725A2/es not_active Application Discontinuation
- 2003-11-07 EC EC2003004831A patent/ECSP034831A/es unknown
- 2003-11-10 US US10/704,524 patent/US20040229872A1/en not_active Abandoned
- 2003-11-10 US US10/704,200 patent/US6998409B2/en not_active Expired - Fee Related
- 2003-11-10 US US10/704,329 patent/US7276518B2/en not_active Expired - Fee Related
- 2003-12-08 ZA ZA200309521A patent/ZA200309521B/xx unknown
- 2003-12-08 ZA ZA2003/09522A patent/ZA200309522B/en unknown
-
2004
- 2004-08-03 HK HK04105744A patent/HK1062911A1/xx not_active IP Right Cessation
-
2005
- 2005-03-29 HK HK05102616.5A patent/HK1070049A1/xx not_active IP Right Cessation
-
2007
- 2007-05-07 AU AU2007202033A patent/AU2007202033B8/en not_active Ceased
- 2007-05-10 CY CY20071100630T patent/CY1106468T1/el unknown
- 2007-10-25 CY CY20071101374T patent/CY1108067T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0400989A2 (hu) | Helyettesített 2-piridin-ciklohexán-1,4-diamin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| SE0202133D0 (sv) | Novel compounds | |
| MXPA04000677A (es) | Tienopirimidindionas y su uso en modulacion de enfermedades autoinmunes. | |
| DE60236600D1 (de) | Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung | |
| HUP0400699A2 (hu) | Fenetanolaminszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0500443A2 (hu) | Himbacin analógok mint trombin receptor antagonisták és a vegyületeket tartalmazó gyógyszerkészítmények | |
| AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
| ATE311378T1 (de) | Benzopyran derivate | |
| HUP0201356A2 (hu) | Ösztrogén agonisták/antagonisták alkalmazása depresszió kezelésére vagy a kognitív funkció romlásának megelőzésére alkalmas gyógyászati készítmény előállítására | |
| ATE381554T1 (de) | Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen | |
| HUP0302193A2 (hu) | 1,4-Diazabiciklo[3.2.2]nonán-benzoxazol,-benzotiazol és -benzimidazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
| ATE482933T1 (de) | Sulfopyrrolderivate | |
| TNSN07395A1 (en) | Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives | |
| IS2472B (is) | Ný tetrahýdrópýridín, framleiðsluaðferð og lyfjasamsetningar sem innihalda þau | |
| HUP0500203A2 (hu) | Acil-3-karboxi-fenil-karbamid-származékok, eljárás ezek előállítására és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| DK0732332T3 (da) | Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf | |
| HUP0402585A2 (hu) | Új benzotiazin- benzotiadiazin-származékok, előállításuk, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények | |
| SG148023A1 (en) | New benzothiazine and benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them | |
| HUP0400207A2 (hu) | Helyettesített 4-amino-ciklohexanol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0000966A2 (hu) | Izoflavonszármazékok és ilyen vegyületeket hatóanyagként tartalmazó gyógyszerkészítmények | |
| HUP0400436A2 (hu) | Új triciklusos dihidrokinolin-vegyületek, eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítmények | |
| HUP0202293A2 (hu) | Új N-benzilpiperazin vegyületek, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0400744A2 (hu) | Piridoindolon származékok felhasználása rákellenes gyógyszerek előállítására | |
| DE60239491D1 (de) | Thiazolidindionderivate und diese enthaltende pharmazeutische zusammensetzung | |
| RS51051B (sr) | Heksaciklična jedinjenja |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |