HRP20240149T1 - Bispecifična molekula za vezanje antigena, koji vežu cd3 i cd20, i njihove upotrebe - Google Patents
Bispecifična molekula za vezanje antigena, koji vežu cd3 i cd20, i njihove upotrebe Download PDFInfo
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- HRP20240149T1 HRP20240149T1 HRP20240149TT HRP20240149T HRP20240149T1 HR P20240149 T1 HRP20240149 T1 HR P20240149T1 HR P20240149T T HRP20240149T T HR P20240149TT HR P20240149 T HRP20240149 T HR P20240149T HR P20240149 T1 HRP20240149 T1 HR P20240149T1
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- 239000000427 antigen Substances 0.000 title claims 29
- 102000036639 antigens Human genes 0.000 title claims 29
- 108091007433 antigens Proteins 0.000 title claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 101100495232 Homo sapiens MS4A1 gene Proteins 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 238000009175 antibody therapy Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims 1
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 1
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Claims (16)
1. Bispecifična molekula za vezanje antigena koji obuhvaća prvu domenu za vezanje antigena koja specifično veže humani CD3, i drugu domenu za vezanje antigena koja specifično veže humani CD20, gdje prva domena za vezanje antigena obuhvaća varjabilno područje teškog lanca (HCVR) koje sadrži područja koja određuju komplementarnost A1-HCDR1, A1-HCDR2 i A1-HCDR3, i varjabilno područje lakog lanca (LCVR) koje sadrži područje koje određuje komplementarnost A1-LCDR1, A1-LCDR2 i A1-LCDR3, gdje se područje koje određuje komplementarnost nalazi u okviru para HCVR/LCVR koji čine aminokiselinske sekvence izabrane iz SEQ ID NOs: 1250/1258, 1266/1274 ili 1282/1290, gdje bispecifična molekula za vezanje antigena izaziva proliferaciju mononukleranih stanica periferne krvi čovjeka i cinomolgusa in vitro.
2. Bispecifična molekula koja veže antigen prema zahtjevu 1, gdje drugu domenu za vezanje antigena koji specifično veže humani CD20 obuhvaća HCVR koji čine područje koje određuje komplementarnost A2-HCDR1, A2-HCDR2 i A2-HCDR3 koji se nalaze u okviru HCVR koji sadrži SEQ ID NO:1242, i LCVR koji čine područje koje određuje komplementarnost A2-LCDR1, A2-LCDR2 i A2-LCDR3 koji se nalaze u okviru LCVR koji sadrži aminokiselinske sekvence SEQ ID NO: 1258, 1274 ili 1290.
3. Bispecifična molekula za vezanje antigena prema zahtjevu 2, gdje:
A1-HCDR1, A1-HCDR2 i A1-HCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1268, 1270 i 1272;
A1-LCDR1, A1-LCDR2 i A1-LCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1276, 1278 i 1280;
A2-HCDR1, A2-HCDR2 i A2-HCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1244, 1246 i 1248; i
A2-LCDR1, A2-LCDR2 i A2-LCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1276, 1278 i 1280.
4. Bispecifična molekula za vezanje antigena prema zahtjevu 2, gdje:
A1-HCDR1, A1-HCDR2 i A1-HCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1284, 1286 i 1288;
A1-LCDR1, A1-LCDR2 i A1-LCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1292, 1294 i 1296;
A2-HCDR1, A2-HCDR2 i A2-HCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1244, 1246 i 1248; i
A2-LCDR1, A2-LCDR2 i A2-LCDR3 sadrže aminokiselinske sekvence, tim redom, SEQ ID NOs: 1292, 1294 i 1296.
5. Bispecifična molekula za vezanje antigena prema zahtjevu 2, gdje prva domena za vezanje antigena obuhvaća varjabilno područje teškog lanca (HCVR) koje sadrži aminokiselinsku sekvencu SEQ ID NO:1250, i varjabilno područje teškog lanca (LCVR) koji sadrži aminokiselinu sekvencu SEQ ID NO:1258; i gdje druga domena za vezanje antigena obuhvaća HCVR koji sadrži aminokiselinsku sekvencu SEQ ID NO:1242, i LCVR sadrži aminokiselinu sekvencu SEQ ID NO:1258.
6. Bispecifična molekula za vezanje antigena prema zahtjevu 2, gdje prva domena za vezanje antigena obuhvaća varjabilno područje teškog lanca (HCVR) koje sadrži aminokiselinsku sekvencu SEQ ID NO:1266, i varjabilno područje lakog lanca (LCVR) koje sadrži aminokiselinu sekvencu SEQ ID NO:1274; i gdje druga domena za vezanje antigena obuhvaća HCVR koji sadrži aminokiselinu sekvencu SEQ ID NO:1242, i LCVR koji sadrži aminokiselinsku sekvencu SEQ ID NO:1274.
7. Bispecifična molekula za vezanje antigena prema zahtjevu 2, gdje prva domena koja veže antigen obuhvaća varijabilno područje teškog lanca (HCVR) koje sadrži aminokiselinsku sekvencu SEQ ID NO:1282, i varijabilno područje lakog lanca (LCVR) koji sadrži aminokiselinsku sekvencu SEQ ID NO:1290; i gdje druga domena za vezanje antigena obuhvaća HCVR koji sadrži aminokiselinsku sekvencu SEQ ID NO:1242, i LCVR koji sadrži aminokiselinsku sekvencu SEQ ID NO:1290.
8. Bispecifična molekula za vezanje antigena prema bilo kojem od zahtjeva 1 do 7 koji je bispecifično antitijelo.
9. Bispecifična molekula za vezanje antigena prema zahtjevu 8 koji obuhvaća konstantno područje teškog lanca izotipa IgG1 ili IgG4.
10. Farmaceutski sastav koji sadrži bispecifičnu molekulu za vezanje antigena prema bilo kojem od zahtjeva 1 do 9 i farmaceutski prihvatljiv nosač ili razblaživač.
11. Bispecifična molekula za vezanje antigena prema bilo kojem od zahtjeva 1 do 9, ili farmaceutski sastav prema zahtjevu 10, za upotrebu u liječenju raka B-stanica subjekta.
12. Bispecifična molekula za vezanje antigena ili farmaceutski sastav za upotrebu prema zahtjevu 11, gdje je rak B-ćelija izabrana iz grupe koju čine:
folikularni limfom, B stanična kronična limfocitna leukemija. B stanični limfoblasni limfom, Hodgkinsov limfom, ne-Hodgkinsov limfom, difuzni limfom velikih B stanica, limfom marginalne zone, limfom opne stanica, leukemija dlakastih stanica i Burkittov limfom.
13. Bispecifična molekula za vezanje antigena ili farmaceutski sastav za upotrebu prema zahtjevu 11 ili zahtjevu 12, pri čemu je subjekt pogođen tumorom koji je otporan na, ili nepotpuno reagira na samu anti-CD20 monospecifičnu terapiju.
14. Bispecifična molekula za vezanje antigena ili farmaceutski sastav za upotrebu prema bilo kojem od patentnih zahtjeva 11 do 13, gdje je subjekt primio terapiju anti-CD20 monospecifičnog antitijela bar 1 dan do 1 godine prije davanja bispecifične molekule za vezanje antigena ili farmaceutskog sastava.
15. Bispecifična molekula za vezanje antigena ili farmaceutski sastav za upotrebu prema zahtjevu 14, gdje anti-CD20 monospecifična terapija sadrži ili se sastoji od anti-CD20 mono-specifičnih antitijela.
16. Bispecifična molekula za vezanje antigena ili farmaceutski sastav za upotrebu prema zahtjevu 15, gdje je anti-CD20 mono-specifično antitijelo rituksimab.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261704029P | 2012-09-21 | 2012-09-21 | |
US201361753461P | 2013-01-17 | 2013-01-17 | |
US201361763110P | 2013-02-11 | 2013-02-11 | |
US201361827098P | 2013-05-24 | 2013-05-24 | |
EP20186993.0A EP3778641B1 (en) | 2012-09-21 | 2013-09-19 | Bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof |
Publications (1)
Publication Number | Publication Date |
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HRP20240149T1 true HRP20240149T1 (hr) | 2024-04-12 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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HRP20230844TT HRP20230844T1 (hr) | 2012-09-21 | 2013-09-19 | Anti-cd3 antitijela, bispecifične molekule koje vežu antigen koji veže cd3 i cd20, i njihove upotrebe |
HRP20240149TT HRP20240149T1 (hr) | 2012-09-21 | 2013-09-19 | Bispecifična molekula za vezanje antigena, koji vežu cd3 i cd20, i njihove upotrebe |
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HRP20230844TT HRP20230844T1 (hr) | 2012-09-21 | 2013-09-19 | Anti-cd3 antitijela, bispecifične molekule koje vežu antigen koji veže cd3 i cd20, i njihove upotrebe |
Country Status (34)
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US (4) | US9657102B2 (hr) |
EP (3) | EP4309740A3 (hr) |
JP (5) | JP6923292B2 (hr) |
KR (2) | KR102163136B1 (hr) |
CN (3) | CN110041429B (hr) |
AR (1) | AR092612A1 (hr) |
AU (3) | AU2013318059C1 (hr) |
BR (1) | BR112015005380B1 (hr) |
CA (2) | CA3135724A1 (hr) |
CL (3) | CL2015000713A1 (hr) |
CO (1) | CO7400860A2 (hr) |
DK (2) | DK3778641T3 (hr) |
EA (1) | EA033400B1 (hr) |
ES (2) | ES2968913T3 (hr) |
FI (2) | FI2897981T3 (hr) |
HK (1) | HK1212996A1 (hr) |
HR (2) | HRP20230844T1 (hr) |
HU (2) | HUE063215T2 (hr) |
IL (2) | IL237301B (hr) |
JO (3) | JOP20200236A1 (hr) |
LT (2) | LT2897981T (hr) |
MX (2) | MX2015003206A (hr) |
MY (1) | MY179577A (hr) |
NZ (2) | NZ742078A (hr) |
PH (2) | PH12015500328B1 (hr) |
PL (2) | PL3778641T3 (hr) |
PT (2) | PT3778641T (hr) |
RS (2) | RS65123B1 (hr) |
SG (3) | SG10202111095XA (hr) |
SI (2) | SI3778641T1 (hr) |
TW (4) | TW202039579A (hr) |
UY (1) | UY35042A (hr) |
WO (1) | WO2014047231A1 (hr) |
ZA (1) | ZA201501097B (hr) |
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