MX2021009533A - Composiciones y metodos para usar anticuerpos bispecificos para unirse al complemento y a un antigeno objetivo. - Google Patents
Composiciones y metodos para usar anticuerpos bispecificos para unirse al complemento y a un antigeno objetivo.Info
- Publication number
- MX2021009533A MX2021009533A MX2021009533A MX2021009533A MX2021009533A MX 2021009533 A MX2021009533 A MX 2021009533A MX 2021009533 A MX2021009533 A MX 2021009533A MX 2021009533 A MX2021009533 A MX 2021009533A MX 2021009533 A MX2021009533 A MX 2021009533A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- target antigen
- sub
- compositions
- methods
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 9
- 102000036639 antigens Human genes 0.000 title abstract 9
- 108091007433 antigens Proteins 0.000 title abstract 9
- 230000000295 complement effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
De acuerdo con ciertas modalidades, la presente descripción proporciona moléculas biespecíficas de unión a antígeno que comprenden un primer dominio de unión a antígeno que se une específicamente a un antígeno objetivo y un segundo dominio de unión a antígeno que se une a un componente del complemento. En ciertas modalidades, las moléculas biespecíficas de unión a antígeno de la presente descripción son capaces de unirse al antígeno objetivo con una EC50 de aproximadamente 10 nM o menos y/o son capaces de promover la deposición del complemento en el antígeno objetivo con una EC50 de aproximadamente 10 nM. En ciertas modalidades, las moléculas biespecíficas de unión a antígeno de la descripción son útiles para tratar enfermedades en las que se desea la inhibición o reducción del crecimiento de un agente infeccioso o una célula cancerosa y/o es terapéuticamente beneficiosa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962804358P | 2019-02-12 | 2019-02-12 | |
PCT/US2020/017889 WO2020167919A1 (en) | 2019-02-12 | 2020-02-12 | Compositions and methods for using bispecific antibodies to bind complement and a target antigen |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021009533A true MX2021009533A (es) | 2021-11-12 |
Family
ID=69771250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021009533A MX2021009533A (es) | 2019-02-12 | 2020-02-12 | Composiciones y metodos para usar anticuerpos bispecificos para unirse al complemento y a un antigeno objetivo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220153819A1 (es) |
EP (1) | EP3923978A1 (es) |
JP (1) | JP2022519631A (es) |
KR (1) | KR20210126641A (es) |
CN (1) | CN113412121A (es) |
AU (1) | AU2020223205A1 (es) |
CA (1) | CA3127696A1 (es) |
IL (1) | IL285404A (es) |
MA (1) | MA54945A (es) |
MX (1) | MX2021009533A (es) |
WO (1) | WO2020167919A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024500093A (ja) * | 2020-12-10 | 2024-01-04 | ウーシー バイオロジクス アイルランド リミテッド | P-カドヘリンに対する抗体及びその使用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
WO2002072600A2 (en) | 2001-01-26 | 2002-09-19 | Inhibitex, Inc. | Monoclonal antibodies to the clfa protein and method of use in treating or preventing infections |
EP2468769A1 (en) | 2004-04-21 | 2012-06-27 | The Brigham and Women's Hospital, Inc. | Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof |
ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
BR112013031485B1 (pt) | 2011-06-10 | 2022-06-14 | Medimmune, Llc | Anticorpo monoclonal isolado ou fragmento de ligação a antígeno do mesmo, composição farmacêutica, usos e método in vitro para bloqueio ou prevenção da ligação de p. aeruginosa a células epiteliais |
WO2013096948A1 (en) * | 2011-12-23 | 2013-06-27 | Lydon Nicholas B | Immunoglobulins and variants directed against pathogenic microbes |
US9988439B2 (en) * | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
MX2017006312A (es) | 2014-11-17 | 2017-08-21 | Regeneron Pharma | Metodos para el tratamiento tumoral utilizando el anticuerpo biespecifico cd3xcd20. |
TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
AU2017278193B9 (en) | 2016-06-10 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Anti-GITR antibodies and uses thereof |
-
2020
- 2020-02-12 WO PCT/US2020/017889 patent/WO2020167919A1/en active Search and Examination
- 2020-02-12 AU AU2020223205A patent/AU2020223205A1/en not_active Abandoned
- 2020-02-12 KR KR1020217028365A patent/KR20210126641A/ko not_active Application Discontinuation
- 2020-02-12 EP EP20710016.5A patent/EP3923978A1/en not_active Withdrawn
- 2020-02-12 CA CA3127696A patent/CA3127696A1/en active Pending
- 2020-02-12 CN CN202080012874.2A patent/CN113412121A/zh active Pending
- 2020-02-12 JP JP2021545677A patent/JP2022519631A/ja not_active Abandoned
- 2020-02-12 US US17/430,117 patent/US20220153819A1/en active Pending
- 2020-02-12 MA MA054945A patent/MA54945A/fr unknown
- 2020-02-12 MX MX2021009533A patent/MX2021009533A/es unknown
-
2021
- 2021-08-05 IL IL285404A patent/IL285404A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020167919A1 (en) | 2020-08-20 |
JP2022519631A (ja) | 2022-03-24 |
MA54945A (fr) | 2021-12-22 |
KR20210126641A (ko) | 2021-10-20 |
IL285404A (en) | 2021-09-30 |
EP3923978A1 (en) | 2021-12-22 |
CN113412121A (zh) | 2021-09-17 |
US20220153819A1 (en) | 2022-05-19 |
CA3127696A1 (en) | 2020-08-20 |
AU2020223205A1 (en) | 2021-08-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201891428A1 (ru) | Комбинация антител к pd-1 и биспецифических антител к cd20/cd3 для лечения злокачественной опухоли | |
AU2018282038A1 (en) | Anti TRBC1 antigen binding domains | |
AU2017297138A8 (en) | Anti-PD-1 antibodies, method for producing same and method for using same | |
MX2023003418A (es) | Moleculas multiespecificas de union a antigenos y usos de estas. | |
MD3353212T2 (ro) | Anticorpi bispecifici anti-CD3 optimizați și utilizările acestora | |
NZ750132A (en) | Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases | |
WO2019160751A3 (en) | Methods for treating cancer with anti-pd-1 antibodies | |
NZ595235A (en) | Compositions and methods for increasing muscle growth | |
EA201490957A1 (ru) | Лечение гематологических злокачественных заболеваний с помощью анти-cxcr4 антитела | |
NZ594682A (en) | Fully human antibodies specific to cadm1 | |
EA020130B9 (ru) | Специфичное к антигену са6 антитело, содержащий его цитотоксический конъюгат и способы применения конъюгата | |
RU2014114119A (ru) | Биспецифические анти-egfr/анти igf-1r-антитела | |
MX2020012309A (es) | Moleculas de union a gp41 optimizadas y usos de las mismas. | |
MX2021010116A (es) | Anticuerpo anti-pd-l1 y uso de este. | |
MX2022007790A (es) | Terapia para el tratamiento del cancer. | |
WO2021022304A3 (en) | Bispecific anti lrrc15 and cd3epsilon antibodies | |
MX2021009533A (es) | Composiciones y metodos para usar anticuerpos bispecificos para unirse al complemento y a un antigeno objetivo. | |
MX2023006969A (es) | Moleculas de union a gucy2c y sus usos. | |
MX2020008289A (es) | Moleculas biespecificas de union al antigeno y metodos de uso. | |
MX2022006714A (es) | Métodos de tratamiento del mieloma múltiple con anticuerpos anti-bcma x anti-cd3 bisespecíficos. | |
WO2021231651A8 (en) | Sars-cov2 neutralizing single domain antibody constructs | |
MX2022013876A (es) | Constructos de anticuerpos triespecificos precursores y metodos de uso de los mismos. | |
PE20130460A1 (es) | Composiciones y metodos para el diagnostico y tratamiento de tumores | |
EP4028056A4 (en) | METHODS OF TREATING CANCER USING PD-1 AXIS INHIBITORS AND ANTI-PERIOSTIN ANTIBODIES | |
PH12020500375A1 (en) | Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof |