HRP20110203T4 - Poboljšana protutijela selektivna za protofibrile i njihova primjena - Google Patents
Poboljšana protutijela selektivna za protofibrile i njihova primjena Download PDFInfo
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- HRP20110203T4 HRP20110203T4 HRP20110203TT HRP20110203T HRP20110203T4 HR P20110203 T4 HRP20110203 T4 HR P20110203T4 HR P20110203T T HRP20110203T T HR P20110203TT HR P20110203 T HRP20110203 T HR P20110203T HR P20110203 T4 HRP20110203 T4 HR P20110203T4
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- Croatia
- Prior art keywords
- antibody
- mixture
- heavy chain
- protofibrils
- antibody according
- Prior art date
Links
- 230000035772 mutation Effects 0.000 claims abstract 7
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 7
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 3
- 201000010374 Down Syndrome Diseases 0.000 claims 3
- 201000002832 Lewy body dementia Diseases 0.000 claims 3
- 201000004810 Vascular dementia Diseases 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 102220465380 NF-kappa-B inhibitor beta_S23A_mutation Human genes 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000010384 proximity ligation assay Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 102000009109 Fc receptors Human genes 0.000 abstract 1
- 108010087819 Fc receptors Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Claims (27)
1. Protutijelo ili njegov fragment koji je selektivan i ima visoki afinitet za humane Aβ protofibrile, pri čemu to protutijelo ili njegov fragment u svojih šest CDR regija ima sljedeće konsenzus sekvence:
VH-CDR1 SFGMH
VH-CDR2 YISSGSSTIYYGDTVKG
VH-CDR3 EGGYYYGRSYYTMDY
VL-CDR1 RSSQSIVHSNGNTYLE
VL-CDR2 KVSNRFS
VL-CDR3 FQGSHVPPT
2. Protutijelo prema zahtjevu 1, pri čemu je spomenuto protutijelo monoklonsko.
3. Protutijelo prema zahtjevu 1 ili 2, pri čemu je aminokiselinski prolin na položaju 331 u humanom IgG1 promijenjen u serin ili drugu polarnu aminokiselinu.
4. Protutijelo prema bilo kojem od zahtjeva 1 do 3, pri čemu je spomenuto protutijelo klase IgG.
5. Protutijelo prema zahtjevu 4, pri čemu je spomenuto protutijelo iz IgG1 ili IgG4 podklase.
6. Protutijelo prema zahtjevu 5, pri čemu je spomenuto protutijelo himer iz IgG1 i IgG4 podklasa, gdje je konstantna regija teškog lanca CH2 ili dio CH2 iz IgG4 i gdje su regije CH1 i CH3 iz IgG1.
7. Protutijelo prema bilo kojem od zahtjeva 1 do 6, pri čemu spomenuto protutijelo sadrži kompletnu aminokiselinsku sekvencu teškog lanca prema Tablici 31 i kompletnu aminokiselinsku sekvencu lakog lanca prema Tablici 42.
8. Protutijelo koje se veže za humane Aβ protofibrile, pri čemu to protutijelo sadrži teški lanac i laki lanac, pri čemu teški lanac sadrži aminokiselinsku sekvencu 158RHA u Tablici 27 i laki lanac sadrži aminokiselinsku sekvencu 158RKA u Tablici 38.
9. Protutijelo prema bilo kojem od zahtjeva 1-6, pri čemu spomenuto protutijelo sadrži mutacije u teškom lancu (VH) prema Tablici spomenute mutacije su izabrane između E do D na Kabatovom položaju do P na Kabatovom položaju 74 i S do T na Kabatovom položaju 82A, i/ili mutacije u lakom lancu (VK) prema Tablici spomenute mutacije su izabrane između V do L na Kabatovom položaju 3 i P do G na Kabatovom položaju 100, ili kombinacije ovih VH i VK mutacija.
10. Protutijelo prema bilo kojem od zahtjeva 1-6, pri čemu spomenuto protutijelo sadrži kompletnu sekvencu teškog lanca prema Tablici 31 i kompletnu sekvencu lakog lanca prema Tablici 42, s izuzetkom da je u teški lanac uvedena mutacija S23A.
11. Protutijelo prema bilo kojem od zahtjeva 1 do 10, pri čemu je spomenuto protutijelo humano ili humanizirano ili mutirano da bi se smanjila antigenost kod ljudi.
12. Protutijelo prema bilo kojem od zahtjeva 1, 2, 4, 5 ili 6, pri čemu je spomenuto protutijelo mišje protutijelo.
13. Protutijelo prema zahtjevu 12, pri čemu spomenuto protutijelo sadrži kompletnu sekvencu lakog lanca kodiranu sa DNK sekvencom 158 VK prema Tablici 11 i kompletnu sekvencu teškog lanca kodiranu sa DNK sekvencom 158 VH prema Tablici 15.
14. Smjesa koja sadrži protutijelo prema bilo kojem od zahtjeva 1 to 13 i farmaceutski prihvatljivi pufer.
15. Smjesa prema zahtjevu 14, koja dalje sadrži antibakterijsko sredstvo.
16. Smjesa prema zahtjevu 14 ili 15, pri čemu je smjesa liofilizirana.
17. Smjesa prema zahtjevu 16, pri čemu je smjesa liofilizirana zajedno s pomoćnom tvari za povećanje stabilnosti protutijela tijekom liofilizacije.
18. Smjesa prema zahtjevu 17, pri čemu je pomoćna tvar manitol ili trehaloza.
19. Postupak otkrivanja Aβ protofibrila in vitro, koji obuhvaća korake:
- dodavanje protutijela prema bilo kojem od zahtjeva 1-13 biološkom uzorku koji sadrži ili je suspektan na sadržaj Aβ protofibrile.
- mjerenje koncentracije kompleksa nastalog između spomenutog Aβ protofibrila i spomenutog protutijela.
20. Postupak prema zahtjevu 19, gdje je spomenuti postupak otkrivanja imunološki test.
21. Postupak prema zahtjevu 19, gdje je spomenuti postupak otkrivanja test blizinske ligacije.
22. Protutijelo prema bilo kojem od zahtjeva 1-13 za primjenu u postupku dijagnosticiranja Alzheimerove bolesti, a postupak obuhvaća:
- dodavanje protutijela definiranog prema bilo kojem od zahtjeva 1-13 uzorku uzetom od subjekta; i
- mjerenje koncentracije kompleksa nastalog između spomenutog protutijela i eventualno prisutnih Aβ protofibrila u spomenutom uzorku.
23. Protutijelo prema bilo kojem od zahtjeva 1-13 za primjenu u postupku dijagnosticiranja Downovog sindroma, demencije s Levijevim tijelima ili vaskularne demencije, a postupak sadrži:
- dodavanje protutijela definiranog prema bilo kojem od zahtjeva 1-13 uzorku uzetom od subjekta; i
- mjerenje koncentracije kompleksa nastalog između spomenutog protutijela i eventualno prisutnih Aβ protofibrila u spomenutom uzorku.
24. Primjena protutijela prema bilo kojem od zahtjeva 1-13 ili smjese prema bilo kojem od zahtjeva 14-18 za dobivanje lijeka za liječenje Alzheimerove bolesti.
25. Primjena protutijela prema bilo kojem od zahtjeva 1-13 ili smjese prema bilo kojem od zahtjeva 14-18 za dobivanje lijeka za liječenje Downovog sindroma, demencije s Levijevim tijelima ili vaskularne demencije.
26. Protutijelo prema bilo kojem od zahtjeva 1-13 ili smjesa prema bilo kojem od zahtjeva 14-18 za primjenu u liječenju Alzheimerove bolesti.
27. Protutijelo prema bilo kojem od zahtjeva 1-13 ili smjesa prema bilo kojem od zahtjeva 14-18 za primjenu u liječenju Downovog sindroma, demencije s Levijevim tijelima ili vaskularne demencije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0600662 | 2006-03-23 | ||
| SE0602591 | 2006-11-30 | ||
| PCT/SE2007/000292 WO2007108756A1 (en) | 2006-03-23 | 2007-03-23 | Improved protofibril selective antibodies and the use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20110203T1 HRP20110203T1 (hr) | 2011-04-30 |
| HRP20110203T4 true HRP20110203T4 (hr) | 2014-05-09 |
Family
ID=38522718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20110203TT HRP20110203T4 (hr) | 2006-03-23 | 2011-03-21 | Poboljšana protutijela selektivna za protofibrile i njihova primjena |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8025878B2 (hr) |
| EP (2) | EP2325209A3 (hr) |
| JP (1) | JP5033868B2 (hr) |
| KR (1) | KR101413615B1 (hr) |
| CN (1) | CN101421303B (hr) |
| AT (1) | ATE492561T1 (hr) |
| AU (1) | AU2007227813B2 (hr) |
| BR (1) | BRPI0709050B1 (hr) |
| CA (1) | CA2630344C (hr) |
| CY (1) | CY1111337T1 (hr) |
| DE (1) | DE602007011415D1 (hr) |
| DK (1) | DK2004688T4 (hr) |
| HK (1) | HK1120056A1 (hr) |
| HR (1) | HRP20110203T4 (hr) |
| IL (1) | IL191331A (hr) |
| MX (1) | MX2008012223A (hr) |
| MY (1) | MY169492A (hr) |
| NO (1) | NO347079B1 (hr) |
| NZ (1) | NZ567888A (hr) |
| PL (1) | PL2004688T5 (hr) |
| RS (1) | RS51723B2 (hr) |
| RU (1) | RU2429244C2 (hr) |
| SI (1) | SI2004688T2 (hr) |
| WO (1) | WO2007108756A1 (hr) |
| ZA (1) | ZA200805805B (hr) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1309341A2 (en) | 2000-07-07 | 2003-05-14 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| BRPI0619249A2 (pt) | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| KR101413615B1 (ko) | 2006-03-23 | 2014-07-18 | 바이오악틱 뉴로사이언스 에이비 | 인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도 |
| ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
| ES2429407T3 (es) | 2006-06-08 | 2013-11-14 | Chugai Seiyaku Kabushiki Kaisha | Agente preventivo o remedio para enfermedades inflamatorias |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| TW200844110A (en) | 2007-01-11 | 2008-11-16 | Univ Marburg Philipps | Diagnosis and treatment of alzheimer's disease and other neurodementing diseases |
| EP2486928A1 (en) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
| CN101883790B (zh) | 2007-10-05 | 2015-09-09 | 基因技术公司 | 抗淀粉样蛋白β抗体在眼病中的用途 |
| JP5616230B2 (ja) | 2007-11-16 | 2014-10-29 | ザ ロックフェラー ユニバーシティー | ベータ−アミロイドタンパク質のプロトフィブリルの形態に特異的な抗体 |
| RU2531521C2 (ru) * | 2007-12-05 | 2014-10-20 | Чугаи Сейяку Кабусики Кайся | Антитело против nr10 и его применение |
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- 2009-01-06 HK HK09100098.2A patent/HK1120056A1/xx active IP Right Maintenance
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2011
- 2011-03-15 CY CY20111100288T patent/CY1111337T1/el unknown
- 2011-03-21 HR HRP20110203TT patent/HRP20110203T4/hr unknown
- 2011-08-26 US US13/219,012 patent/US9034334B2/en active Active
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