HK1254190A1 - 通用供體幹細胞和相關方法 - Google Patents
通用供體幹細胞和相關方法Info
- Publication number
- HK1254190A1 HK1254190A1 HK18113328.6A HK18113328A HK1254190A1 HK 1254190 A1 HK1254190 A1 HK 1254190A1 HK 18113328 A HK18113328 A HK 18113328A HK 1254190 A1 HK1254190 A1 HK 1254190A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cells
- related methods
- universal donor
- donor stem
- universal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158999P | 2015-05-08 | 2015-05-08 | |
| PCT/US2016/031551 WO2016183041A2 (en) | 2015-05-08 | 2016-05-09 | Universal donor stem cells and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1254190A1 true HK1254190A1 (zh) | 2019-07-12 |
Family
ID=57249476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18113328.6A HK1254190A1 (zh) | 2015-05-08 | 2018-10-18 | 通用供體幹細胞和相關方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US10968426B2 (zh) |
| EP (1) | EP3294342A4 (zh) |
| JP (2) | JP2018515139A (zh) |
| CN (1) | CN107921148A (zh) |
| AU (3) | AU2016261600B2 (zh) |
| CA (1) | CA2988854A1 (zh) |
| HK (1) | HK1254190A1 (zh) |
| WO (1) | WO2016183041A2 (zh) |
Families Citing this family (108)
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| CA2781149A1 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| CN107249318A (zh) * | 2014-12-10 | 2017-10-13 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| CN107208055B (zh) * | 2015-01-17 | 2021-06-15 | 浙江大学 | 引起免疫原性反应降低的被修饰细胞 |
| US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| CN108699557A (zh) * | 2015-12-04 | 2018-10-23 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| GB201619876D0 (en) * | 2016-11-24 | 2017-01-11 | Cambridge Entpr Ltd | Controllable transcription |
| KR102030364B1 (ko) * | 2016-12-02 | 2019-10-10 | 가톨릭대학교 산학협력단 | 멀티플렉스 CRISPR-Cas9 시스템을 이용한 HLA 결핍 세포주로부터 제조된 인공항원제시세포 및 이의 용도 |
| CN107760680B (zh) * | 2016-12-28 | 2020-09-22 | 北京微旋基因技术有限公司 | 特异性靶向TIM-3基因的sgRNA和特异性敲除TIM-3基因的方法 |
| BR112019014257A2 (pt) * | 2017-01-13 | 2020-04-28 | Univ California | método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina |
| EP3601528A4 (en) * | 2017-03-20 | 2021-05-05 | Washington University | CELLS AND METHODS OF USE AND PRODUCTION OF THEM |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| WO2018191490A1 (en) * | 2017-04-13 | 2018-10-18 | The Trustees Of The University Of Pennsylvania | Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy |
| AU2018367896B2 (en) | 2017-05-12 | 2023-06-01 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
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| WO2019002633A1 (en) | 2017-06-30 | 2019-01-03 | Cellectis | CELLULAR IMMUNOTHERAPY FOR REPETITIVE ADMINISTRATION |
| WO2019006330A1 (en) * | 2017-06-30 | 2019-01-03 | Indiana University Research And Technology Corporation | COMPOSITIONS AND METHODS FOR DETECTING REACTIVITY TO ALS |
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| EP3754018A4 (en) * | 2018-02-16 | 2021-11-24 | Kyoto University | LOW ANTIGENIC CELL PRODUCTION PROCESS |
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| CN112041334A (zh) * | 2018-04-27 | 2020-12-04 | 西雅图儿童医院（Dba西雅图儿童研究所） | 人foxp3在经基因编辑的t细胞中的表达 |
| CA3091688A1 (en) * | 2018-04-27 | 2019-10-31 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Expression of foxp3 in edited cd34+ cells |
| BR112020022879A2 (pt) | 2018-05-11 | 2021-02-23 | Crispr Therapeutics Ag | métodos e composições para tratamento de câncer |
| CN112166186A (zh) * | 2018-05-23 | 2021-01-01 | 新加坡国立大学 | 用于t细胞恶性肿瘤的免疫治疗的嵌合抗原受体和cd2的基因编辑 |
| EP3805370A4 (en) * | 2018-05-30 | 2022-04-27 | Kangstem Biotech Co., Ltd. | MESENCHYMATE STEM CELL DERIVED FROM HLA GENE DELETED HUMAN INDUCED PLURIPOTENT STEM CELL AND METHOD FOR PREPARING IT |
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| AU2019305585A1 (en) * | 2018-07-17 | 2021-01-28 | The Regents Of The University Of California | Cells differentiated from immunoengineered pluripotent cells |
| BR112021000639A2 (pt) * | 2018-07-17 | 2021-04-13 | The Regents Of The University Of California | Célula-tronco pluripotente induzida hipoimunogênica (hip) isolada, célula car-t hipoimune isolada, método de tratamento de um paciente com câncer por meio da administração de uma composição, população pura de células car-t hipoimunes, e método de produção de células car-t hipoimunes isoladas |
| CN110819592A (zh) * | 2018-08-13 | 2020-02-21 | 赛元生物科技(杭州)有限公司 | 一种通用供体干细胞及其制备方法 |
| US20200080107A1 (en) | 2018-09-07 | 2020-03-12 | Crispr Therapeutics Ag | Universal donor cells |
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| US20220333082A1 (en) | 2019-07-10 | 2022-10-20 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
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| EP3294342A2 (en) | 2018-03-21 |
| US12031155B2 (en) | 2024-07-09 |
| WO2016183041A2 (en) | 2016-11-17 |
| AU2016261600A1 (en) | 2018-01-04 |
| US10968426B2 (en) | 2021-04-06 |
| US20220112459A1 (en) | 2022-04-14 |
| US20190309259A1 (en) | 2019-10-10 |
| WO2016183041A3 (en) | 2017-01-05 |
| US11492591B2 (en) | 2022-11-08 |
| AU2021221859B2 (en) | 2024-06-13 |
| US20230323288A1 (en) | 2023-10-12 |
| AU2024203322A1 (en) | 2024-06-06 |
| AU2021221859A9 (en) | 2021-10-14 |
| US11618881B2 (en) | 2023-04-04 |
| JP2018515139A (ja) | 2018-06-14 |
| US20240141288A1 (en) | 2024-05-02 |
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