HK1254190A1 - 通用供體幹細胞和相關方法 - Google Patents
通用供體幹細胞和相關方法Info
- Publication number
- HK1254190A1 HK1254190A1 HK18113328.6A HK18113328A HK1254190A1 HK 1254190 A1 HK1254190 A1 HK 1254190A1 HK 18113328 A HK18113328 A HK 18113328A HK 1254190 A1 HK1254190 A1 HK 1254190A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cells
- related methods
- universal donor
- donor stem
- universal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562158999P | 2015-05-08 | 2015-05-08 | |
PCT/US2016/031551 WO2016183041A2 (en) | 2015-05-08 | 2016-05-09 | Universal donor stem cells and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1254190A1 true HK1254190A1 (zh) | 2019-07-12 |
Family
ID=57249476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18113328.6A HK1254190A1 (zh) | 2015-05-08 | 2018-10-18 | 通用供體幹細胞和相關方法 |
Country Status (8)
Country | Link |
---|---|
US (7) | US10968426B2 (zh) |
EP (1) | EP3294342A4 (zh) |
JP (2) | JP2018515139A (zh) |
CN (1) | CN107921148A (zh) |
AU (3) | AU2016261600B2 (zh) |
CA (1) | CA2988854A1 (zh) |
HK (1) | HK1254190A1 (zh) |
WO (1) | WO2016183041A2 (zh) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2781149A1 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
CN107249318A (zh) * | 2014-12-10 | 2017-10-13 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
CN107208055B (zh) * | 2015-01-17 | 2021-06-15 | 浙江大学 | 引起免疫原性反应降低的被修饰细胞 |
US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
CN108699557A (zh) * | 2015-12-04 | 2018-10-23 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
GB201619876D0 (en) * | 2016-11-24 | 2017-01-11 | Cambridge Entpr Ltd | Controllable transcription |
KR102030364B1 (ko) * | 2016-12-02 | 2019-10-10 | 가톨릭대학교 산학협력단 | 멀티플렉스 CRISPR-Cas9 시스템을 이용한 HLA 결핍 세포주로부터 제조된 인공항원제시세포 및 이의 용도 |
CN107760680B (zh) * | 2016-12-28 | 2020-09-22 | 北京微旋基因技术有限公司 | 特异性靶向TIM-3基因的sgRNA和特异性敲除TIM-3基因的方法 |
BR112019014257A2 (pt) * | 2017-01-13 | 2020-04-28 | Univ California | método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina |
EP3601528A4 (en) * | 2017-03-20 | 2021-05-05 | Washington University | CELLS AND METHODS OF USE AND PRODUCTION OF THEM |
WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
WO2018191490A1 (en) * | 2017-04-13 | 2018-10-18 | The Trustees Of The University Of Pennsylvania | Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy |
AU2018367896B2 (en) | 2017-05-12 | 2023-06-01 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
WO2019002633A1 (en) | 2017-06-30 | 2019-01-03 | Cellectis | CELLULAR IMMUNOTHERAPY FOR REPETITIVE ADMINISTRATION |
WO2019006330A1 (en) * | 2017-06-30 | 2019-01-03 | Indiana University Research And Technology Corporation | COMPOSITIONS AND METHODS FOR DETECTING REACTIVITY TO ALS |
US10391156B2 (en) * | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
US20200237823A1 (en) * | 2017-10-19 | 2020-07-30 | Cellectis | Targeted gene integration of nk inhibitors genes for improved immune cells therapy |
EP3754018A4 (en) * | 2018-02-16 | 2021-11-24 | Kyoto University | LOW ANTIGENIC CELL PRODUCTION PROCESS |
CN112534044A (zh) * | 2018-02-16 | 2021-03-19 | 凯德药业股份有限公司 | 经修饰的多能干细胞及制备和使用方法 |
CN112041334A (zh) * | 2018-04-27 | 2020-12-04 | 西雅图儿童医院(Dba西雅图儿童研究所) | 人foxp3在经基因编辑的t细胞中的表达 |
CA3091688A1 (en) * | 2018-04-27 | 2019-10-31 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Expression of foxp3 in edited cd34+ cells |
BR112020022879A2 (pt) | 2018-05-11 | 2021-02-23 | Crispr Therapeutics Ag | métodos e composições para tratamento de câncer |
CN112166186A (zh) * | 2018-05-23 | 2021-01-01 | 新加坡国立大学 | 用于t细胞恶性肿瘤的免疫治疗的嵌合抗原受体和cd2的基因编辑 |
EP3805370A4 (en) * | 2018-05-30 | 2022-04-27 | Kangstem Biotech Co., Ltd. | MESENCHYMATE STEM CELL DERIVED FROM HLA GENE DELETED HUMAN INDUCED PLURIPOTENT STEM CELL AND METHOD FOR PREPARING IT |
WO2019237035A1 (en) * | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
AU2019305585A1 (en) * | 2018-07-17 | 2021-01-28 | The Regents Of The University Of California | Cells differentiated from immunoengineered pluripotent cells |
BR112021000639A2 (pt) * | 2018-07-17 | 2021-04-13 | The Regents Of The University Of California | Célula-tronco pluripotente induzida hipoimunogênica (hip) isolada, célula car-t hipoimune isolada, método de tratamento de um paciente com câncer por meio da administração de uma composição, população pura de células car-t hipoimunes, e método de produção de células car-t hipoimunes isoladas |
CN110819592A (zh) * | 2018-08-13 | 2020-02-21 | 赛元生物科技(杭州)有限公司 | 一种通用供体干细胞及其制备方法 |
US20200080107A1 (en) | 2018-09-07 | 2020-03-12 | Crispr Therapeutics Ag | Universal donor cells |
KR20210065141A (ko) * | 2018-09-21 | 2021-06-03 | 카파 테라퓨틱스 리미티드 | CRISPR/Cas 시스템을 기반으로 한 세포의 유전자 편집 방법 |
US11312963B2 (en) * | 2018-10-18 | 2022-04-26 | Synerk Inc. | Compositions and methods for inhibiting TIGIT gene expression |
UY38427A (es) | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
TW202028222A (zh) * | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
EP3894546A4 (en) * | 2018-12-16 | 2022-12-21 | Figene, LLC | THERAPEUTIC USES OF GENEDITED FIBROBLAST |
WO2020160489A1 (en) * | 2019-02-01 | 2020-08-06 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
WO2020168317A2 (en) * | 2019-02-15 | 2020-08-20 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
WO2020186237A1 (en) * | 2019-03-13 | 2020-09-17 | The Broad Institute, Inc. | Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof |
US20220249558A1 (en) | 2019-04-30 | 2022-08-11 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
SG11202112506SA (en) * | 2019-05-10 | 2021-12-30 | Univ California | Modified pluripotent cells |
JP2022540090A (ja) * | 2019-07-05 | 2022-09-14 | インテレクソン・ゲーエムベーハー | 個人のhlaパターンの決定、予後因子としての使用、標的遺伝子、及び治療薬 |
US20220333082A1 (en) | 2019-07-10 | 2022-10-20 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
CN114787358A (zh) * | 2019-07-18 | 2022-07-22 | 罗切斯特大学 | 细胞的细胞类型选择性免疫保护 |
JP2022543112A (ja) | 2019-08-01 | 2022-10-07 | サナ バイオテクノロジー,インコーポレイテッド | Dux4発現細胞およびそれらの使用 |
JP2022546317A (ja) | 2019-08-23 | 2022-11-04 | サナ バイオテクノロジー,インコーポレイテッド | Cd24発現細胞およびそれらの用途 |
JOP20220049A1 (ar) * | 2019-08-30 | 2023-01-30 | Janssen Biotech Inc | مشرعات وتركيبات car t خاصة بمركب نضج الخلايا البائية |
CA3150233A1 (en) | 2019-09-05 | 2021-03-11 | Alireza Rezania | UNIVERSAL DONOR CELLS |
CA3150235A1 (en) * | 2019-09-05 | 2021-03-11 | Alireza Rezania | UNIVERSAL DONOR CELLS |
US20230242909A1 (en) * | 2019-11-26 | 2023-08-03 | Disarm Therapeutics, Inc. | Methods and compositions for neuroprotection |
CN116234906A (zh) | 2020-01-13 | 2023-06-06 | 萨那生物技术股份有限公司 | 血型抗原的修饰 |
CN115298314A (zh) | 2020-01-17 | 2022-11-04 | 萨那生物技术股份有限公司 | 基因表达调控的安全开关 |
WO2021163191A1 (en) * | 2020-02-10 | 2021-08-19 | Board Of Regents, The University Of Texas System | Methods for rapid cloning and expression of hla class i cells |
CN115551994A (zh) | 2020-03-11 | 2022-12-30 | 倍特博有限公司 | 产生肝细胞的方法 |
TW202202155A (zh) | 2020-03-25 | 2022-01-16 | 美商薩那生物科技公司 | 用於治療神經病症及病況之低免疫原性神經細胞 |
JP2023522784A (ja) | 2020-04-27 | 2023-05-31 | ノバルティス アーゲー | 眼細胞療法のための方法及び組成物 |
CN115916962A (zh) * | 2020-04-27 | 2023-04-04 | 萨那生物技术股份有限公司 | 低免疫原性细胞的重复给药 |
WO2021231712A1 (en) * | 2020-05-15 | 2021-11-18 | Rxcell Inc. | Hypoimmunogenic cells and uses thereof in immune responses |
GB202007698D0 (en) * | 2020-05-22 | 2020-07-08 | Univ Ulster | A genetic test to predict anti-TNF drug response |
KR20230029659A (ko) * | 2020-05-26 | 2023-03-03 | 가부시키가이샤 헤리오스 | 저면역원성 세포 |
WO2022032282A1 (en) * | 2020-08-06 | 2022-02-10 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Methods and reagents for microbiome analysis |
US20230293581A1 (en) | 2020-08-13 | 2023-09-21 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
CN114746152A (zh) * | 2020-08-23 | 2022-07-12 | 应用干细胞有限公司 | Hla-f修饰的细胞和方法 |
WO2022072643A1 (en) * | 2020-09-30 | 2022-04-07 | Vor Biopharma Inc. | Compositions and methods for cd30 gene modification |
CN114517184A (zh) * | 2020-10-30 | 2022-05-20 | 未来智人再生医学研究院(广州)有限公司 | 一种表达adipsin的多能干细胞或其衍生物及应用 |
US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
CN114717232A (zh) * | 2020-12-22 | 2022-07-08 | 未来智人再生医学研究院(广州)有限公司 | 表达irf-1靶向抑制因子的多能干细胞及其衍生物与应用 |
EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
US11566230B2 (en) * | 2020-12-31 | 2023-01-31 | Crispr Therapeutics Ag | Universal donor cells |
WO2022146891A2 (en) | 2020-12-31 | 2022-07-07 | Sana Biotechnology, Inc. | Methods and compositions for modulating car-t activity |
AU2022206324A1 (en) | 2021-01-11 | 2023-07-20 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
EP4288088A2 (en) * | 2021-02-08 | 2023-12-13 | Intellia Therapeutics, Inc. | Lymphocyte activation gene 3 (lag3) compositions and methods for immunotherapy |
JP2024505672A (ja) * | 2021-02-08 | 2024-02-07 | インテリア セラピューティクス,インコーポレイテッド | 免疫療法のためのナチュラルキラー細胞受容体2b4組成物及び方法 |
EP4288089A2 (en) * | 2021-02-08 | 2023-12-13 | Intellia Therapeutics, Inc. | T-cell immunoglobulin and mucin domain 3 (tim3) compositions and methods for immunotherapy |
WO2022246293A1 (en) | 2021-05-19 | 2022-11-24 | Sana Biotechnology, Inc. | Hypoimmunogenic rhd negative primary t cells |
CA3216346A1 (en) | 2021-05-27 | 2022-12-01 | Edward Rebar | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
WO2023274385A1 (zh) * | 2021-07-01 | 2023-01-05 | 宁波茂行生物医药科技有限公司 | 靶向her2的通用型car-t细胞及其制备方法 |
EP4370544A2 (en) | 2021-07-14 | 2024-05-22 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
TW202321457A (zh) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | 靶向cd4之病毒載體之用途 |
AU2022325231A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
EP4384193A2 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
KR20240073006A (ko) | 2021-08-11 | 2024-05-24 | 사나 바이오테크놀로지, 인크. | 동종이계 세포 요법을 위한 유전자 변형된 1차 세포 |
KR20240053673A (ko) | 2021-08-11 | 2024-04-24 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포 내 유전자 발현을 변경하기 위한 유도성 시스템 |
KR20240087856A (ko) * | 2021-08-16 | 2024-06-19 | 빔 테라퓨틱스, 인크. | 지속성 동종 변형된 면역 세포 및 이의 사용 방법 |
WO2023028471A1 (en) * | 2021-08-24 | 2023-03-02 | Intellia Therapeutics, Inc. | Programmed cell death protein 1 (pd1) compositions and methods for cell-based therapy |
WO2023069790A1 (en) | 2021-10-22 | 2023-04-27 | Sana Biotechnology, Inc. | Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods |
WO2023109941A1 (en) * | 2021-12-16 | 2023-06-22 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Cell modification |
WO2023122337A1 (en) | 2021-12-23 | 2023-06-29 | Sana Biotechnology, Inc. | Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods |
WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
WO2023154578A1 (en) | 2022-02-14 | 2023-08-17 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
WO2023158756A1 (en) * | 2022-02-16 | 2023-08-24 | President And Fellows Of Harvard College | Hypoimmunogenic beta cells and methods of producing the same |
WO2023158836A1 (en) | 2022-02-17 | 2023-08-24 | Sana Biotechnology, Inc. | Engineered cd47 proteins and uses thereof |
KR20230131816A (ko) | 2022-03-04 | 2023-09-14 | 주식회사 툴젠 | 저면역원성 줄기세포, 줄기세포로부터 분화되거나 유래된 저면역원성 세포및 이의 제조방법 |
WO2023173123A1 (en) | 2022-03-11 | 2023-09-14 | Sana Biotechnology, Inc. | Genetically modified cells and compositions and uses thereof |
WO2023178165A2 (en) * | 2022-03-15 | 2023-09-21 | The Trustees Of Columbia University In The City Of New York | Conversion resistant/condition-resistant tregs and car tregs, methods of making and methods of using |
WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
US20230330264A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
US20240010991A1 (en) * | 2022-07-01 | 2024-01-11 | Janssen Biotech, Inc. | Materials and methods for bioengineered ipsc populations |
WO2024003349A1 (en) | 2022-07-01 | 2024-01-04 | Novo Nordisk A/S | Enhancing neuronal differentiation of ventral midbrain neural progenitor cells |
WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
GB202211117D0 (en) * | 2022-07-29 | 2022-09-14 | Replay Holdings Llc | Compositions and methods for non-immunogenecity |
WO2024023801A2 (en) * | 2022-07-29 | 2024-02-01 | Crispr Therapeutics Ag | Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene |
GB202212144D0 (en) | 2022-08-19 | 2022-10-05 | Resolution Therapeutics Ltd | Cells for therapy |
WO2024092015A1 (en) * | 2022-10-25 | 2024-05-02 | Wisconsin Alumni Research Foundation | Adhesion molecule inhibition for stem cell therapies |
WO2024097311A2 (en) | 2022-11-02 | 2024-05-10 | Sana Biotechnology, Inc. | Hypoimmunogenic mail cells, methods of making and methods of using same |
CN118207165A (zh) * | 2022-12-07 | 2024-06-18 | 士泽生物医药(苏州)有限公司 | 一种表达stc1的通用型细胞及其制备方法 |
WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272082A (en) | 1992-03-30 | 1993-12-21 | The Wistar Institute Of Anatomy & Biology | Cytotoxic T-ALL cell lines and uses therefor |
DK0883687T3 (da) | 1996-03-01 | 2005-03-07 | Euroscreen Sa | C-C CKR-5, CC-chemokinreceptor, derivater deraf og anvendelse deraf |
AU6869198A (en) | 1997-03-25 | 1998-10-20 | Morphogenesis, Inc. | Universal stem cells |
WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
EP2308996A1 (en) | 1998-03-30 | 2011-04-13 | NorthWest Biotherapeutics, Inc. | Therapeutic and diagnostic applications based on the role of the CXCR-4 and SDF-1 genes in tumourigenesis |
US20020012660A1 (en) | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
CA2404780A1 (en) | 2000-03-27 | 2001-10-04 | University Of Delaware | Targeted chromosomal genomic alterations with modified single stranded oligonucleotides |
US6875904B2 (en) | 2000-09-20 | 2005-04-05 | The Ohio State University Research Foundation | Animal model for identifying agents that inhibit or enhance CTLA4 signaling |
US8013143B2 (en) | 2002-02-20 | 2011-09-06 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA) |
AU2003304425A1 (en) | 2002-06-04 | 2005-03-07 | Michele Calos | Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same |
US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
US20050260661A1 (en) * | 2004-05-05 | 2005-11-24 | Bernard Mach | Assays for the identification of modulators of MHC class II expression |
US20060024819A1 (en) | 2004-07-30 | 2006-02-02 | Finney Robert E | Integration vectors |
DK2336362T3 (en) | 2005-08-26 | 2019-01-21 | Dupont Nutrition Biosci Aps | USE OF CRISPR-ASSOCIATED GENES (CAS) |
JP2009531022A (ja) | 2006-02-17 | 2009-09-03 | ラパポート ファミリー インスティテュート フォー リサーチ イン ザ メディカル サイエンシーズ | Ccr5/ccr5リガンド関連疾患を治療するための分子およびその使用方法 |
US7951925B2 (en) | 2006-05-25 | 2011-05-31 | Sangamo Biosciences, Inc. | Methods and compositions for gene inactivation |
DE102006051516A1 (de) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
US9217026B2 (en) | 2006-11-13 | 2015-12-22 | Sangamo Biosciences, Inc. | Method of inactivating a glucocorticoid receptor gene in an isolated cell |
US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
WO2008102199A1 (en) | 2007-02-20 | 2008-08-28 | Cellectis | Meganuclease variants cleaving a dna target sequence from the beta-2-microglobulin gene and uses thereof |
US8105831B2 (en) | 2007-03-09 | 2012-01-31 | University Of Washington | Parvoviral production of HLA homozygous cells |
WO2009019528A1 (en) | 2007-08-03 | 2009-02-12 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof |
US8563314B2 (en) | 2007-09-27 | 2013-10-22 | Sangamo Biosciences, Inc. | Methods and compositions for modulating PD1 |
FR2925918A1 (fr) | 2007-12-28 | 2009-07-03 | Pasteur Institut | Typage et sous-typage moleculaire de salmonella par identification des sequences nucleotidiques variables des loci crispr |
US20110110897A1 (en) | 2008-01-11 | 2011-05-12 | Schwarz Richard P | Adult Human Cardiac-Derived Progenitor Cells |
EP2329017A2 (en) | 2008-08-04 | 2011-06-08 | Cellectis | Novel method to generate meganucleases with altered characteristics |
US20100076057A1 (en) | 2008-09-23 | 2010-03-25 | Northwestern University | TARGET DNA INTERFERENCE WITH crRNA |
CA3018487A1 (en) | 2008-10-20 | 2010-04-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin |
DK2362915T3 (en) | 2008-11-07 | 2017-03-27 | Dupont Nutrition Biosci Aps | CRISPR SEQUENCES OF BIFIDOBACTERIA |
US20120149115A1 (en) | 2009-06-11 | 2012-06-14 | Snu R&Db Foundation | Targeted genomic rearrangements using site-specific nucleases |
US20120192298A1 (en) | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
EP3594333B1 (en) | 2010-02-08 | 2023-11-01 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
US20110262406A1 (en) | 2010-04-21 | 2011-10-27 | Yale University | Compositions and methods for targeted inactivation of hiv cell surface receptors |
WO2012009337A2 (en) | 2010-07-12 | 2012-01-19 | Dana-Farber Cancer Institute, Inc. | Nlrc5 as a target to intervene mhc class 1-mediated immune responses |
MX2013004338A (es) | 2010-10-20 | 2013-05-20 | Dupont Nutrition Biosci Aps | Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). |
ES2700966T3 (es) | 2010-12-09 | 2019-02-20 | Univ Pennsylvania | Utilización de linfocitos T modificados con receptores de antígeno quiméricos para tratar el cáncer |
CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
JP2014513948A (ja) | 2011-04-20 | 2014-06-19 | ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | β2ミクログロブリン欠損細胞 |
AU2012286901B2 (en) | 2011-07-25 | 2016-10-27 | Sangamo Therapeutics, Inc. | Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
CA3099582A1 (en) | 2011-10-27 | 2013-05-02 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the hprt locus |
DE12858350T1 (de) | 2011-12-16 | 2021-10-07 | Modernatx, Inc. | Modifizierte mrna zusammensetzungen |
KR101833589B1 (ko) | 2012-02-24 | 2018-03-02 | 프레드 헛친슨 켄서 리서치 센터 | 이상혈색소증 치료를 위한 조성물 및 방법 |
JP6490426B2 (ja) | 2012-02-29 | 2019-03-27 | サンガモ セラピューティクス, インコーポレイテッド | ハンチントン病を治療するための方法および組成物 |
CA2870571A1 (en) * | 2012-04-17 | 2013-10-24 | University Of Washington Through Its Center For Commercialization | Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof |
WO2013177228A1 (en) | 2012-05-22 | 2013-11-28 | Loma Linda University | Generation of integration/transgene-free stem cells |
EP3276000A3 (en) | 2012-05-25 | 2018-02-21 | Cellectis | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
US9102936B2 (en) | 2012-06-11 | 2015-08-11 | Agilent Technologies, Inc. | Method of adaptor-dimer subtraction using a CRISPR CAS6 protein |
EP2880171B1 (en) | 2012-08-03 | 2018-10-03 | The Regents of The University of California | Methods and compositions for controlling gene expression by rna processing |
AU2013308770B2 (en) | 2012-08-29 | 2019-01-17 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
ES2824024T3 (es) | 2012-10-10 | 2021-05-11 | Sangamo Therapeutics Inc | Compuestos modificadores de células T y usos de los mismos |
KR102182847B1 (ko) | 2012-10-23 | 2020-11-27 | 주식회사 툴젠 | 표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도 |
JP2016500254A (ja) | 2012-12-05 | 2016-01-12 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 代謝疾患の調節のための方法および組成物 |
AU2013359212B2 (en) | 2012-12-12 | 2017-01-19 | Massachusetts Institute Of Technology | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
MX2015007550A (es) | 2012-12-12 | 2017-02-02 | Broad Inst Inc | Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas. |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
CN105121648B (zh) | 2012-12-12 | 2021-05-07 | 布罗德研究所有限公司 | 用于序列操纵的***、方法和优化的指导组合物的工程化 |
AU2013359262C1 (en) | 2012-12-12 | 2021-05-13 | Massachusetts Institute Of Technology | CRISPR-Cas component systems, methods and compositions for sequence manipulation |
US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
WO2014099744A1 (en) | 2012-12-17 | 2014-06-26 | President And Fellows Of Harvard College | Rna-guided human genome engineering |
CN111454951A (zh) | 2013-03-14 | 2020-07-28 | 卡里布生物科学公司 | 以核酸为靶的核酸的组合物和方法 |
CN104046593A (zh) * | 2013-03-14 | 2014-09-17 | 浙江大学 | 一种低免疫原性的人细胞及其制备方法 |
CA2906752A1 (en) | 2013-03-14 | 2014-09-25 | Children's Medical Center Corporation | Compositions and methods for reprogramming hematopoietic stem cell lineages |
WO2014151994A1 (en) | 2013-03-15 | 2014-09-25 | Kambiz Shekdar | Genome editing using effector oligonucleotides for therapeutic treatment |
US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
EP3865586A1 (en) | 2013-03-15 | 2021-08-18 | The General Hospital Corporation | Increasing specificity for rna-guided genome editing |
US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
AU2014235968B2 (en) | 2013-03-21 | 2018-05-24 | Ospedale San Raffaele Srl | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
CA3185368A1 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t cells derived from pluripotent stem cells |
CN115261411A (zh) | 2013-04-04 | 2022-11-01 | 哈佛学院校长同事会 | 利用CRISPR/Cas***的基因组编辑的治疗性用途 |
CA2912375C (en) | 2013-05-13 | 2023-03-14 | Cellectis | Methods for engineering highly active t cell for immunotherapy |
CN116083487A (zh) | 2013-05-15 | 2023-05-09 | 桑格摩生物治疗股份有限公司 | 用于治疗遗传病状的方法和组合物 |
CA2913234A1 (en) | 2013-05-22 | 2014-11-27 | Northwestern University | Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis |
DK3309248T3 (da) | 2013-05-29 | 2021-08-02 | Cellectis | Fremgangsmåde til manipulering af T-celler til immunterapi under anvendelse af et RNA-guidet CAS-nuklease-system |
US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
WO2014204723A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions |
DK3011031T3 (da) | 2013-06-17 | 2020-12-21 | Broad Inst Inc | Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi |
EP3019595A4 (en) | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS | |
US10563225B2 (en) | 2013-07-26 | 2020-02-18 | President And Fellows Of Harvard College | Genome engineering |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
CA2926078C (en) * | 2013-10-17 | 2021-11-16 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
ES2881473T3 (es) | 2013-10-17 | 2021-11-29 | Sangamo Therapeutics Inc | Métodos de suministro y composiciones para la modificación por ingeniería genética del genoma mediada por nucleasas |
US20150139994A1 (en) | 2013-11-12 | 2015-05-21 | The Regents Of The University Of California | Compositions and methods for preventing allogeneic immune rejection |
US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
WO2015113063A1 (en) | 2014-01-27 | 2015-07-30 | Georgia Tech Research Corporation | Methods and systems for identifying crispr/cas off-target sites |
CA2940671A1 (en) | 2014-04-07 | 2015-10-15 | Novartis Ag | Treatment of cancer using anti-cd19 chimeric antigen receptor |
IL292512B2 (en) | 2014-04-18 | 2024-07-01 | Editas Medicine Inc | CRISPR-CAS-related methods, compositions and components for cancer immunotherapy |
SG11201700476VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
GB201418965D0 (zh) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
WO2016073955A2 (en) | 2014-11-06 | 2016-05-12 | President And Fellows Of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
SG11201705293WA (en) | 2014-12-29 | 2017-07-28 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
CN107208055B (zh) | 2015-01-17 | 2021-06-15 | 浙江大学 | 引起免疫原性反应降低的被修饰细胞 |
MX2017012407A (es) | 2015-03-27 | 2018-03-07 | Harvard College | Celulas t modificadas y métodos para hacer y usar las mismas. |
MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
EP3347458A4 (en) | 2015-09-09 | 2019-08-07 | Revivicor Inc. | MULTI TRANSGENIC PIG FOR XENOTRANSPLANTATION |
US20190262309A1 (en) | 2015-09-30 | 2019-08-29 | Vycellix, Inc | Enhanced Gene Delivery to Natural Killer Cells, Hematopoietic Stem Cells and Macrophages |
CN108368520B (zh) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
CN108699557A (zh) | 2015-12-04 | 2018-10-23 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
BR112019014257A2 (pt) | 2017-01-13 | 2020-04-28 | Univ California | método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina |
EP3638258A4 (en) | 2017-06-12 | 2021-09-08 | Sinai Health System | ALLOGRAFT TOLERANCE WITHOUT REQUIRING SYSTEMIC IMMUNE SUPPRESSION |
US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
-
2016
- 2016-05-09 US US15/572,776 patent/US10968426B2/en active Active
- 2016-05-09 CN CN201680040306.7A patent/CN107921148A/zh active Pending
- 2016-05-09 CA CA2988854A patent/CA2988854A1/en active Pending
- 2016-05-09 WO PCT/US2016/031551 patent/WO2016183041A2/en active Application Filing
- 2016-05-09 EP EP16793348.0A patent/EP3294342A4/en active Pending
- 2016-05-09 JP JP2018510704A patent/JP2018515139A/ja not_active Withdrawn
- 2016-05-09 AU AU2016261600A patent/AU2016261600B2/en active Active
-
2018
- 2018-10-18 HK HK18113328.6A patent/HK1254190A1/zh unknown
-
2021
- 2021-01-13 US US17/148,556 patent/US11618881B2/en active Active
- 2021-08-26 AU AU2021221859A patent/AU2021221859B2/en active Active
- 2021-10-09 US US17/497,927 patent/US11492591B2/en active Active
-
2022
- 2022-04-25 JP JP2022071747A patent/JP2022090109A/ja active Pending
- 2022-11-23 US US17/993,667 patent/US20230323288A1/en active Pending
- 2022-11-23 US US17/993,674 patent/US12031154B2/en active Active
- 2022-11-23 US US17/993,659 patent/US20240141288A1/en active Pending
- 2022-11-23 US US17/993,680 patent/US12031155B2/en active Active
-
2024
- 2024-05-20 AU AU2024203322A patent/AU2024203322A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US12031154B2 (en) | 2024-07-09 |
US20210261916A1 (en) | 2021-08-26 |
AU2021221859A1 (en) | 2021-09-30 |
US20230303969A1 (en) | 2023-09-28 |
CA2988854A1 (en) | 2016-11-17 |
US20230303968A1 (en) | 2023-09-28 |
AU2016261600B2 (en) | 2021-09-23 |
JP2022090109A (ja) | 2022-06-16 |
EP3294342A4 (en) | 2018-11-07 |
CN107921148A (zh) | 2018-04-17 |
EP3294342A2 (en) | 2018-03-21 |
US12031155B2 (en) | 2024-07-09 |
WO2016183041A2 (en) | 2016-11-17 |
AU2016261600A1 (en) | 2018-01-04 |
US10968426B2 (en) | 2021-04-06 |
US20220112459A1 (en) | 2022-04-14 |
US20190309259A1 (en) | 2019-10-10 |
WO2016183041A3 (en) | 2017-01-05 |
US11492591B2 (en) | 2022-11-08 |
AU2021221859B2 (en) | 2024-06-13 |
US20230323288A1 (en) | 2023-10-12 |
AU2024203322A1 (en) | 2024-06-06 |
AU2021221859A9 (en) | 2021-10-14 |
US11618881B2 (en) | 2023-04-04 |
JP2018515139A (ja) | 2018-06-14 |
US20240141288A1 (en) | 2024-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1254190A1 (zh) | 通用供體幹細胞和相關方法 | |
HK1250481A1 (zh) | 經過修飾的t細胞及其製備和使用方法 | |
IL259586B (en) | Genetically modified stem cells and their uses | |
HK1232140A1 (zh) | 微類器官以及製造和使用它們的方法 | |
EP3334820C0 (en) | EXPANDED AND INDUCED PLURIPOTENT STEM CELLS, METHODS OF MANUFACTURE AND USE | |
EP3102681A4 (en) | Trifunctional t cell-antigen coupler and methods and uses thereof | |
SG11201606934SA (en) | Improved reprogramming methods and cell culture platforms | |
HK1255101A1 (zh) | 用於得到調節性t細胞的方法及其用途 | |
EP3107996A4 (en) | Tscm cells and methods for use | |
EP3328331A4 (en) | DEVICE AND METHOD FOR BODY TEMPERATURE CONTROL | |
IL254156A0 (en) | Methods for producing neural stem cells and their use | |
PL3586821T3 (pl) | Kompozycje stymulujące komórki macierzyste i sposoby | |
EP3299023A4 (en) | MESENCHYMAL SUBSTITUTE CELL CULTIVATED IN HYPOXIA AND USE THEREOF | |
GB201701509D0 (en) | Pluripotenet stem cells | |
GB201416293D0 (en) | Methods and preparations | |
GB201613078D0 (en) | Stem cells and cancer | |
EP3288570A4 (en) | Modified stem cells and uses thereof | |
EP3101121A4 (en) | Odontogenic stem cells and use of genetically modified odontogenic stem cells | |
GB201408091D0 (en) | Methods and uses | |
EP3438251A4 (en) | SPECIFIC PLURIPOTENT STEM CELL STIMULATED BY DIFFERENTIATION | |
GB201418980D0 (en) | Cell assay kit and method | |
GB201703069D0 (en) | Universal donor cells | |
IL250272A0 (en) | Enzyme without sugar residue and its uses | |
SG10201403640XA (en) | Stem cells | |
GB201412545D0 (en) | Enzymatic processes and uses |