MX2013004338A - Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). - Google Patents
Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas).Info
- Publication number
- MX2013004338A MX2013004338A MX2013004338A MX2013004338A MX2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A MX 2013004338 A MX2013004338 A MX 2013004338A
- Authority
- MX
- Mexico
- Prior art keywords
- lactococcus crispr
- cas sequences
- lactococcus
- crispr
- cas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
La presente invención se refiere a un ácido nucleico que comprende una región de repetición de CRISPR de Lactococcus y/o una región separadora de CRISPR de Lactococcus.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39497610P | 2010-10-20 | 2010-10-20 | |
US40531710P | 2010-10-21 | 2010-10-21 | |
PCT/US2011/057102 WO2012054726A1 (en) | 2010-10-20 | 2011-10-20 | Lactococcus crispr-cas sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013004338A true MX2013004338A (es) | 2013-05-20 |
Family
ID=44863288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013004338A MX2013004338A (es) | 2010-10-20 | 2011-10-20 | Secuencias de repeticiones palindromicas cortas separadas regularmente agrupadas-cas (crisp-cas). |
Country Status (11)
Country | Link |
---|---|
US (1) | US9951341B2 (es) |
EP (1) | EP2630156B1 (es) |
CN (1) | CN103261213A (es) |
AU (1) | AU2011316980A1 (es) |
BR (1) | BR112013009583A2 (es) |
CA (1) | CA2814810A1 (es) |
DK (1) | DK2630156T3 (es) |
EA (1) | EA201390586A1 (es) |
MX (1) | MX2013004338A (es) |
NZ (1) | NZ607870A (es) |
WO (1) | WO2012054726A1 (es) |
Families Citing this family (70)
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DK2336362T3 (en) | 2005-08-26 | 2019-01-21 | Dupont Nutrition Biosci Aps | USE OF CRISPR-ASSOCIATED GENES (CAS) |
ES2590925T3 (es) | 2006-05-19 | 2016-11-24 | Dupont Nutrition Biosciences Aps | Microorganismos marcados y métodos de marcado |
WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
GEP20217251B (en) | 2012-05-25 | 2021-04-26 | Charpentier Emmanuelle De Emanuel | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
KR102676910B1 (ko) | 2012-12-06 | 2024-06-19 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
CN111454951A (zh) | 2013-03-14 | 2020-07-28 | 卡里布生物科学公司 | 以核酸为靶的核酸的组合物和方法 |
EP3865586A1 (en) | 2013-03-15 | 2021-08-18 | The General Hospital Corporation | Increasing specificity for rna-guided genome editing |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
CN115261411A (zh) | 2013-04-04 | 2022-11-01 | 哈佛学院校长同事会 | 利用CRISPR/Cas***的基因组编辑的治疗性用途 |
US9902973B2 (en) | 2013-04-11 | 2018-02-27 | Caribou Biosciences, Inc. | Methods of modifying a target nucleic acid with an argonaute |
EP3019595A4 (en) | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS | |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
TW201542816A (zh) | 2013-09-18 | 2015-11-16 | Kymab Ltd | 方法、細胞與生物體 |
US10584358B2 (en) * | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
US10752906B2 (en) | 2013-11-05 | 2020-08-25 | President And Fellows Of Harvard College | Precise microbiota engineering at the cellular level |
PT3066201T (pt) | 2013-11-07 | 2018-06-04 | Massachusetts Inst Technology | Métodos e composições relacionadas com crispr com arng reguladores |
US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
CA2943775A1 (en) | 2014-03-25 | 2015-10-01 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
JP2017512481A (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーNorth Carolina State University | Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物 |
AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3633032A3 (en) | 2014-08-28 | 2020-07-29 | North Carolina State University | Novel cas9 proteins and guiding features for dna targeting and genome editing |
GB201506509D0 (en) | 2015-04-16 | 2015-06-03 | Univ Wageningen | Nuclease-mediated genome editing |
EP4233546A3 (en) * | 2015-05-06 | 2023-09-27 | SNIPR Technologies Limited | Altering microbial populations & modifying microbiota |
US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
CN108026536A (zh) | 2015-05-29 | 2018-05-11 | 北卡罗来纳州立大学 | 使用crispr核酸筛选细菌、古细菌、藻类和酵母的方法 |
KR20220158846A (ko) | 2015-06-15 | 2022-12-01 | 노쓰 캐롤라이나 스테이트 유니버시티 | 핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물 |
US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
US10648020B2 (en) | 2015-06-18 | 2020-05-12 | The Broad Institute, Inc. | CRISPR enzymes and systems |
US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
CA2996888A1 (en) | 2015-08-28 | 2017-03-09 | The General Hospital Corporation | Engineered crispr-cas9 nucleases |
US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
EP3356533A1 (en) | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
US11542466B2 (en) | 2015-12-22 | 2023-01-03 | North Carolina State University | Methods and compositions for delivery of CRISPR based antimicrobials |
DK3408382T3 (da) | 2016-01-27 | 2022-06-20 | Oncorus Inc | Onkolytiske virale vektorer og anvendelser deraf |
EP3219799A1 (en) | 2016-03-17 | 2017-09-20 | IMBA-Institut für Molekulare Biotechnologie GmbH | Conditional crispr sgrna expression |
EP3445853A1 (en) | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
US11078481B1 (en) | 2016-08-03 | 2021-08-03 | KSQ Therapeutics, Inc. | Methods for screening for cancer targets |
CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
US11078483B1 (en) | 2016-09-02 | 2021-08-03 | KSQ Therapeutics, Inc. | Methods for measuring and improving CRISPR reagent function |
SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
BR112019021719A2 (pt) | 2017-04-21 | 2020-06-16 | The General Hospital Corporation | Variantes de cpf1 (cas12a) com especificidade para pam alterada |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
JP7324713B2 (ja) | 2017-05-25 | 2023-08-10 | ザ ジェネラル ホスピタル コーポレイション | 改善された精度および特異性を有する塩基エディター |
SG11202000691XA (en) | 2017-07-26 | 2020-02-27 | Oncorus Inc | Oncolytic viral vectors and uses thereof |
EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
EP3676376A2 (en) | 2017-08-30 | 2020-07-08 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
EP3861120A4 (en) | 2018-10-01 | 2023-08-16 | North Carolina State University | RECOMBINANT TYPE I CRISPR-CAS SYSTEM |
US20220177943A1 (en) * | 2018-10-01 | 2022-06-09 | Rodolphe Barrangou | Recombinant type i crispr-cas system and uses thereof for screening for variant cells |
WO2020163396A1 (en) | 2019-02-04 | 2020-08-13 | The General Hospital Corporation | Adenine dna base editor variants with reduced off-target rna editing |
WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
CA3228506A1 (en) * | 2021-08-12 | 2023-02-16 | Anne M. Millen | Compositions and methods for controlling adaptive immunity in bacteria |
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CN115287244B (zh) * | 2022-06-28 | 2023-07-25 | 北部湾大学 | 鱼源无乳链球菌internalin基因LRR结构域敲除突变株及其制备方法和应用 |
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US2225783A (en) | 1939-04-07 | 1940-12-24 | Lloyd B Jensen | Sausage treatment |
US3024116A (en) | 1959-02-24 | 1962-03-06 | Libby Mcneill And Libby | Food processing |
US3403032A (en) | 1967-10-04 | 1968-09-24 | Agriculture Usa | Pure culture fermentation process for pickled cucumbers |
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US3932674A (en) | 1974-11-29 | 1976-01-13 | The United States Of America | Controlled bulk vegetable fermentation |
US4140800A (en) | 1977-06-13 | 1979-02-20 | Leo Kline | Freeze-dried natural sour dough starter |
US4423079A (en) | 1980-07-14 | 1983-12-27 | Leo Kline | Growth promoting compositions for Lactobacillus sanfrancisco and method of preparation |
US4621058A (en) | 1983-04-11 | 1986-11-04 | Mid-America Dairymen, Inc. | Method of preparing cheese starter media |
NZ239639A (en) | 1990-09-05 | 1993-05-26 | Univ North Carolina State | Phage resistant fermentations using a bacterial culture of isogenic strains carrying different phage defense mechanisms |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US7919277B2 (en) * | 2004-04-28 | 2011-04-05 | Danisco A/S | Detection and typing of bacterial strains |
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DK2336362T3 (en) | 2005-08-26 | 2019-01-21 | Dupont Nutrition Biosci Aps | USE OF CRISPR-ASSOCIATED GENES (CAS) |
ES2590925T3 (es) | 2006-05-19 | 2016-11-24 | Dupont Nutrition Biosciences Aps | Microorganismos marcados y métodos de marcado |
MX2009009071A (es) | 2007-03-02 | 2009-09-24 | Danisco | Cultivos con resistencia mejorada a fagos. |
DK2362915T3 (en) * | 2008-11-07 | 2017-03-27 | Dupont Nutrition Biosci Aps | CRISPR SEQUENCES OF BIFIDOBACTERIA |
-
2011
- 2011-10-20 MX MX2013004338A patent/MX2013004338A/es unknown
- 2011-10-20 US US13/880,391 patent/US9951341B2/en active Active
- 2011-10-20 BR BR112013009583A patent/BR112013009583A2/pt not_active IP Right Cessation
- 2011-10-20 CN CN2011800487182A patent/CN103261213A/zh active Pending
- 2011-10-20 AU AU2011316980A patent/AU2011316980A1/en not_active Abandoned
- 2011-10-20 WO PCT/US2011/057102 patent/WO2012054726A1/en active Application Filing
- 2011-10-20 CA CA2814810A patent/CA2814810A1/en not_active Abandoned
- 2011-10-20 NZ NZ607870A patent/NZ607870A/en not_active IP Right Cessation
- 2011-10-20 EA EA201390586A patent/EA201390586A1/ru unknown
- 2011-10-20 EP EP11775892.0A patent/EP2630156B1/en active Active
- 2011-10-20 DK DK11775892.0T patent/DK2630156T3/en active
Also Published As
Publication number | Publication date |
---|---|
CN103261213A (zh) | 2013-08-21 |
EP2630156A1 (en) | 2013-08-28 |
US9951341B2 (en) | 2018-04-24 |
US20130288251A1 (en) | 2013-10-31 |
WO2012054726A1 (en) | 2012-04-26 |
AU2011316980A1 (en) | 2013-04-18 |
BR112013009583A2 (pt) | 2017-05-30 |
EP2630156B1 (en) | 2018-08-22 |
NZ607870A (en) | 2015-09-25 |
CA2814810A1 (en) | 2012-04-26 |
EA201390586A1 (ru) | 2014-11-28 |
DK2630156T3 (en) | 2018-12-17 |
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