HK1252113A1 - 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物 - Google Patents

新的氨基酸衍生物、其製備方法和包含它們的藥用組合物

Info

Publication number
HK1252113A1
HK1252113A1 HK18111502.8A HK18111502A HK1252113A1 HK 1252113 A1 HK1252113 A1 HK 1252113A1 HK 18111502 A HK18111502 A HK 18111502A HK 1252113 A1 HK1252113 A1 HK 1252113A1
Authority
HK
Hong Kong
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
aminoacid derivatives
new aminoacid
Prior art date
Application number
HK18111502.8A
Other languages
English (en)
Other versions
HK1252113B (zh
Inventor
Zoltán Szlávik
Zoltán Szabó
Márton Csékei
Attila Paczal
András Kotschy
Alain Bruno
Olivier Geneste
I-Jen Chen
James Edward Paul Davidson
James Brooke Murray
Levente Ondi
Gábor Radics
Szabolcs Sipos
Ágnes Proszenyák
Françoise Perron-Sierra
Balázs Bálint
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of HK1252113A1 publication Critical patent/HK1252113A1/zh
Publication of HK1252113B publication Critical patent/HK1252113B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
HK18111502.8A 2015-06-23 2018-09-06 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物 HK1252113B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1555747A FR3037956B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2016/064436 WO2016207226A1 (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
HK1252113A1 true HK1252113A1 (zh) 2019-05-17
HK1252113B HK1252113B (zh) 2020-01-10

Family

ID=54260901

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18109702.0A HK1250234A1 (zh) 2015-06-23 2018-07-26 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物
HK18111502.8A HK1252113B (zh) 2015-06-23 2018-09-06 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18109702.0A HK1250234A1 (zh) 2015-06-23 2018-07-26 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物

Country Status (42)

Country Link
US (1) US10457687B2 (zh)
EP (1) EP3313850B1 (zh)
JP (1) JP6741698B2 (zh)
KR (1) KR102620905B1 (zh)
CN (1) CN107709334B (zh)
AR (1) AR105101A1 (zh)
AU (1) AU2016282837B2 (zh)
CA (1) CA2990089C (zh)
CL (1) CL2017003163A1 (zh)
CO (1) CO2017012830A2 (zh)
CR (2) CR20170590A (zh)
CU (1) CU20170164A7 (zh)
CY (1) CY1120991T1 (zh)
DK (1) DK3313850T3 (zh)
EA (1) EA034587B1 (zh)
EC (1) ECSP17082546A (zh)
ES (1) ES2703997T3 (zh)
FR (1) FR3037956B1 (zh)
GE (1) GEP20207075B (zh)
HK (2) HK1250234A1 (zh)
HR (1) HRP20181806T1 (zh)
IL (1) IL256191B (zh)
JO (1) JO3430B1 (zh)
LT (1) LT3313850T (zh)
MA (1) MA42232B1 (zh)
MD (1) MD3313850T2 (zh)
MX (1) MX368845B (zh)
MY (1) MY189472A (zh)
PE (1) PE20190111A1 (zh)
PH (1) PH12017502266A1 (zh)
PL (1) PL3313850T3 (zh)
PT (1) PT3313850T (zh)
RS (1) RS57961B1 (zh)
RU (1) RU2747673C2 (zh)
SA (1) SA517390583B1 (zh)
SI (1) SI3313850T1 (zh)
SV (1) SV2017005588A (zh)
TN (1) TN2017000521A1 (zh)
TW (1) TWI631124B (zh)
UA (1) UA123267C2 (zh)
UY (1) UY36733A (zh)
WO (1) WO2016207226A1 (zh)

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FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2017300738A1 (en) 2016-07-22 2019-02-07 Les Laboratoires Servier Combination of a BCL-2 inhibitor and a MCL-1 inhibitor, uses and pharmaceutical compositions thereof
UY37560A (es) 2017-01-06 2018-07-31 Servier Lab Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
AU2018205735B2 (en) * 2017-01-06 2024-02-01 Les Laboratoires Servier Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
WO2018234433A1 (en) 2017-06-22 2018-12-27 Les Laboratoires Servier COMBINATION OF MCL-1 INHIBITOR AND CARE TREATMENT STANDARD FOR HEMATOLOGICAL CANCERS, USES AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS
UY37843A (es) 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
UY37842A (es) * 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
CN110964034B (zh) * 2018-09-29 2022-04-12 江苏恒瑞医药股份有限公司 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用
AR116635A1 (es) 2018-10-15 2021-05-26 Servier Lab Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen
TW202038960A (zh) 2018-11-14 2020-11-01 法商施維雅藥廠 Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物
CN111187277B (zh) * 2018-11-14 2022-04-12 江苏恒瑞医药股份有限公司 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2020236825A2 (en) 2019-05-20 2020-11-26 Novartis Ag Mcl-1 inhibitor antibody-drug conjugates and methods of use
WO2020254299A1 (en) 2019-06-17 2020-12-24 Les Laboratoires Servier Combination of a mcl-1 inhibitor and a standard of care treatment for breast cancer, uses and pharmaceutical compositions thereof
CN112457308B (zh) 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
US20240042051A1 (en) 2020-11-24 2024-02-08 Francesca Rocchetti Mcl-1 inhibitor antibody-drug conjugates and methods of use
US11957693B2 (en) 2021-06-11 2024-04-16 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-cancer agents
TW202317200A (zh) 2021-06-11 2023-05-01 美商基利科學股份有限公司 Ｍｃｌ－１抑制劑與抗體藥物接合物之組合
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

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IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
DE10058663A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Thienopyrimidinen
US20070213305A1 (en) * 2005-11-02 2007-09-13 Cytovia, Inc. N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
DK2276346T3 (en) * 2008-04-30 2017-02-27 Nat Health Research Institutes FUSED BICYCLIC PYRIMIDINE COMPOUNDS AS AURORAKINASE INHIBITORS
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
CN102464667B (zh) * 2010-11-03 2014-06-04 中国科学院上海药物研究所 一类五元杂环并嘧啶类化合物及其制备方法和用途
MY159059A (en) * 2010-12-20 2016-12-15 Glenmark Pharmaceuticals Sa 2-amino-4-arylthiazole compounds as trpa1 antagonists
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014078957A1 (en) * 2012-11-20 2014-05-30 The Royal Institution For The Advancement Of Learning/Mcgill University Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MA42232B1 (fr) 2018-11-30
UY36733A (es) 2016-12-30
UA123267C2 (uk) 2021-03-10
PL3313850T3 (pl) 2019-04-30
HK1252113B (zh) 2020-01-10
SV2017005588A (es) 2018-06-01
TWI631124B (zh) 2018-08-01
MX368845B (es) 2019-10-18
AR105101A1 (es) 2017-09-06
MA42232A (fr) 2016-12-29
EA201890123A1 (ru) 2018-05-31
RS57961B1 (sr) 2019-01-31
US10457687B2 (en) 2019-10-29
IL256191A (en) 2018-02-28
KR20180015261A (ko) 2018-02-12
HK1250234A1 (zh) 2018-12-07
JO3430B1 (ar) 2019-10-20
DK3313850T3 (en) 2019-01-28
TN2017000521A1 (en) 2019-04-12
AU2016282837A1 (en) 2018-01-18
RU2747673C2 (ru) 2021-05-12
MY189472A (en) 2022-02-16
TW201712018A (zh) 2017-04-01
PH12017502266B1 (en) 2018-06-11
HRP20181806T1 (hr) 2018-12-28
MD3313850T2 (ro) 2019-02-28
EP3313850B1 (en) 2018-10-03
FR3037956B1 (fr) 2017-08-04
ECSP17082546A (es) 2018-02-28
PE20190111A1 (es) 2019-01-15
EP3313850A1 (en) 2018-05-02
RU2018102372A (ru) 2019-07-23
IL256191B (en) 2020-03-31
FR3037956A1 (zh) 2016-12-30
WO2016207226A1 (en) 2016-12-29
KR102620905B1 (ko) 2024-01-04
JP2018522856A (ja) 2018-08-16
CA2990089C (en) 2020-11-03
ES2703997T3 (es) 2019-03-13
CA2990089A1 (en) 2016-12-29
SI3313850T1 (sl) 2019-01-31
LT3313850T (lt) 2018-11-26
CO2017012830A2 (es) 2018-03-28
CN107709334B (zh) 2021-04-13
CN107709334A (zh) 2018-02-16
SA517390583B1 (ar) 2022-02-20
PH12017502266A1 (en) 2018-06-11
EA034587B1 (ru) 2020-02-25
AU2016282837B2 (en) 2020-05-28
GEP20207075B (en) 2020-03-10
MX2017016996A (es) 2018-08-23
CR20170571A (es) 2018-02-20
US20190031675A1 (en) 2019-01-31
BR112017027645A2 (pt) 2018-08-28
JP6741698B2 (ja) 2020-08-19
CU20170164A7 (es) 2018-05-08
PT3313850T (pt) 2018-11-29
CL2017003163A1 (es) 2018-06-15
CY1120991T1 (el) 2019-12-11
CR20170590A (es) 2018-02-26
RU2018102372A3 (zh) 2019-11-06

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