HK1254657A1 - 新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物 - Google Patents

新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物

Info

Publication number
HK1254657A1
HK1254657A1 HK18113625.6A HK18113625A HK1254657A1 HK 1254657 A1 HK1254657 A1 HK 1254657A1 HK 18113625 A HK18113625 A HK 18113625A HK 1254657 A1 HK1254657 A1 HK 1254657A1
Authority
HK
Hong Kong
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
new
hydroxyester derivatives
Prior art date
Application number
HK18113625.6A
Other languages
English (en)
Inventor
Zoltán Szlávik
András Kotschy
Maïa Chanrion
Didier Demarles
Olivier Geneste
James Edward Paul Davidson
James Brooke Murray
Szabolcs Sipos
Attila Paczal
Balázs Bálint
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of HK1254657A1 publication Critical patent/HK1254657A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
HK18113625.6A 2015-06-23 2018-10-24 新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物 HK1254657A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1555752A FR3037957B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2016/064433 WO2016207225A1 (en) 2015-06-23 2016-06-22 New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
HK1254657A1 true HK1254657A1 (zh) 2019-07-26

Family

ID=54608634

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18109026.9A HK1249506A1 (zh) 2015-06-23 2018-07-11 新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物
HK18113625.6A HK1254657A1 (zh) 2015-06-23 2018-10-24 新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18109026.9A HK1249506A1 (zh) 2015-06-23 2018-07-11 新的羥基酯衍生物、其製備方法以及含有它們的藥物組合物

Country Status (44)

Country Link
US (2) US10227358B2 (zh)
EP (1) EP3313851B1 (zh)
JP (1) JP6741697B2 (zh)
KR (1) KR20180019223A (zh)
CN (1) CN107709333B (zh)
AR (1) AR105103A1 (zh)
AU (1) AU2016282836B2 (zh)
BR (1) BR112017027414B1 (zh)
CA (1) CA2990088C (zh)
CL (1) CL2017003258A1 (zh)
CO (1) CO2017012786A2 (zh)
CR (1) CR20170564A (zh)
CU (1) CU20170160A7 (zh)
CY (1) CY1122542T1 (zh)
DK (1) DK3313851T3 (zh)
EA (1) EA033266B1 (zh)
EC (1) ECSP17081744A (zh)
ES (1) ES2759480T3 (zh)
FR (1) FR3037957B1 (zh)
GE (1) GEP20207074B (zh)
HK (2) HK1249506A1 (zh)
HR (1) HRP20200107T1 (zh)
HU (1) HUE047889T2 (zh)
IL (1) IL256270A (zh)
JO (1) JO3675B1 (zh)
MA (1) MA42239B1 (zh)
MD (1) MD3313851T2 (zh)
MX (1) MX2017016997A (zh)
MY (1) MY190561A (zh)
NZ (1) NZ738455A (zh)
PE (1) PE20180742A1 (zh)
PH (1) PH12017502246B1 (zh)
PL (1) PL3313851T3 (zh)
PT (1) PT3313851T (zh)
RS (1) RS59904B1 (zh)
RU (1) RU2734418C2 (zh)
SI (1) SI3313851T1 (zh)
SV (1) SV2017005587A (zh)
TN (1) TN2017000511A1 (zh)
TW (1) TWI604844B (zh)
UA (1) UA122228C2 (zh)
UY (1) UY36736A (zh)
WO (1) WO2016207225A1 (zh)
ZA (1) ZA201708460B (zh)

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FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2017300738A1 (en) 2016-07-22 2019-02-07 Les Laboratoires Servier Combination of a BCL-2 inhibitor and a MCL-1 inhibitor, uses and pharmaceutical compositions thereof
WO2018126898A1 (zh) * 2017-01-05 2018-07-12 河南美泰宝生物制药有限公司 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用
AU2018205735B2 (en) * 2017-01-06 2024-02-01 Les Laboratoires Servier Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
UY37560A (es) 2017-01-06 2018-07-31 Servier Lab Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
WO2018234433A1 (en) * 2017-06-22 2018-12-27 Les Laboratoires Servier COMBINATION OF MCL-1 INHIBITOR AND CARE TREATMENT STANDARD FOR HEMATOLOGICAL CANCERS, USES AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS
UY37843A (es) 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
UY37842A (es) * 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
WO2019101144A1 (zh) * 2017-11-23 2019-05-31 北京赛林泰医药技术有限公司 Mcl-1选择性抑制剂及其制备和用途
CN108424417B (zh) * 2017-12-21 2019-09-20 河南真实生物科技有限公司 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用
CN110964034B (zh) * 2018-09-29 2022-04-12 江苏恒瑞医药股份有限公司 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用
TW202038960A (zh) 2018-11-14 2020-11-01 法商施維雅藥廠 Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物
CN111187277B (zh) * 2018-11-14 2022-04-12 江苏恒瑞医药股份有限公司 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
BR112021010072A2 (pt) * 2018-12-06 2021-08-24 Les Laboratoires Servier Formas cristalinas de um inibidor mcl-1, processo para sua preparação e composições farmacêuticas contendo as mesmas
WO2020236825A2 (en) 2019-05-20 2020-11-26 Novartis Ag Mcl-1 inhibitor antibody-drug conjugates and methods of use
WO2020254299A1 (en) 2019-06-17 2020-12-24 Les Laboratoires Servier Combination of a mcl-1 inhibitor and a standard of care treatment for breast cancer, uses and pharmaceutical compositions thereof
KR20220099125A (ko) * 2019-10-03 2022-07-12 캘리포니아 인스티튜트 오브 테크놀로지 Mcl1 억제제 및 이의 용도
US20240042051A1 (en) 2020-11-24 2024-02-08 Francesca Rocchetti Mcl-1 inhibitor antibody-drug conjugates and methods of use
WO2022216946A1 (en) * 2021-04-07 2022-10-13 California Institute Of Technology Mcl1 inhibitors and uses thereof
US11957693B2 (en) 2021-06-11 2024-04-16 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-cancer agents
TW202317200A (zh) 2021-06-11 2023-05-01 美商基利科學股份有限公司 Ｍｃｌ－１抑制劑與抗體藥物接合物之組合
CN113651663B (zh) * 2021-08-20 2024-03-29 浙大宁波理工学院 一种氘代芳香羰基类化合物的制备方法
WO2023057484A1 (en) 2021-10-06 2023-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

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ES2217956B1 (es) * 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
KR101139314B1 (ko) * 2003-08-29 2012-04-26 베르날리스(캠브리지)리미티드 피리미도티오펜 화합물
EP2262815A4 (en) * 2008-03-05 2012-04-11 Methylgene Inc Inhibitors of protein intolerance activity
CN102464667B (zh) * 2010-11-03 2014-06-04 中国科学院上海药物研究所 一类五元杂环并嘧啶类化合物及其制备方法和用途
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
US10227358B2 (en) 2019-03-12
JP6741697B2 (ja) 2020-08-19
PE20180742A1 (es) 2018-04-27
BR112017027414A2 (pt) 2018-08-28
MA42239B1 (fr) 2020-02-28
US20180170947A1 (en) 2018-06-21
MD3313851T2 (ro) 2020-02-29
CR20170564A (es) 2018-02-20
JP2018522855A (ja) 2018-08-16
ZA201708460B (en) 2021-06-30
ES2759480T3 (es) 2020-05-11
SI3313851T1 (sl) 2020-03-31
KR20180019223A (ko) 2018-02-23
RU2018102365A (ru) 2019-07-23
FR3037957A1 (zh) 2016-12-30
NZ738455A (en) 2024-03-22
CA2990088A1 (en) 2016-12-29
TWI604844B (zh) 2017-11-11
AU2016282836B2 (en) 2020-07-09
US10711010B2 (en) 2020-07-14
EP3313851A1 (en) 2018-05-02
HRP20200107T1 (hr) 2020-04-03
RS59904B1 (sr) 2020-03-31
RU2734418C2 (ru) 2020-10-16
MX2017016997A (es) 2018-09-07
CY1122542T1 (el) 2021-01-27
RU2018102365A3 (zh) 2019-09-23
TN2017000511A1 (en) 2019-04-12
JO3675B1 (ar) 2020-08-27
WO2016207225A1 (en) 2016-12-29
PH12017502246A1 (en) 2018-05-28
HUE047889T2 (hu) 2020-05-28
CU20170160A7 (es) 2018-05-08
PT3313851T (pt) 2020-01-06
EA201890125A1 (ru) 2018-06-29
UA122228C2 (uk) 2020-10-12
CN107709333A (zh) 2018-02-16
PH12017502246B1 (en) 2018-05-28
MY190561A (en) 2022-04-27
EA033266B1 (ru) 2019-09-30
CA2990088C (en) 2021-04-13
HK1249506A1 (zh) 2018-11-02
CO2017012786A2 (es) 2018-04-10
PL3313851T3 (pl) 2020-05-18
IL256270A (en) 2018-02-28
TW201709911A (zh) 2017-03-16
ECSP17081744A (es) 2018-02-28
GEP20207074B (en) 2020-03-10
US20190161496A1 (en) 2019-05-30
EP3313851B1 (en) 2019-11-06
CL2017003258A1 (es) 2018-06-01
SV2017005587A (es) 2018-04-11
CN107709333B (zh) 2021-01-01
AU2016282836A1 (en) 2018-01-18
FR3037957B1 (fr) 2019-01-25
AR105103A1 (es) 2017-09-06
BR112017027414B1 (pt) 2023-12-19
UY36736A (es) 2016-12-30
DK3313851T3 (da) 2020-01-27

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