JO3430B1 - مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها - Google Patents

مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها

Info

Publication number
JO3430B1
JO3430B1 JOP/2016/0126A JOP20160126A JO3430B1 JO 3430 B1 JO3430 B1 JO 3430B1 JO P20160126 A JOP20160126 A JO P20160126A JO 3430 B1 JO3430 B1 JO 3430B1
Authority
JO
Jordan
Prior art keywords
sub
preparation
pharmaceutical compositions
compositions containing
aminoacid derivatives
Prior art date
Application number
JOP/2016/0126A
Other languages
English (en)
Inventor
James Edward Paul Davidson
Francoise Perron-Sierra
Agnes Proszenyak
Alain Bruno
Zoltan Szlavik
Attila Paczal
Andras Kotschy
Levente Ondi
Marton Csekei
Olivier Geneste
James Brooke Murray
Zoltan Szabo
I-Jen Chen
Balazs Balint
Szabolcs Sipos
Gabor Radics
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Application granted granted Critical
Publication of JO3430B1 publication Critical patent/JO3430B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

يتعلق الاختراع الحالي بمركبات لها الصيغة (<span dir="LTR">I</span>)<span dir="LTR">:</span> حيث تكون <span dir="LTR">R<sub>1</sub></span>، <span dir="LTR">R<sub>2</sub></span>، <span dir="LTR">R<sub>5</sub></span>، <span dir="LTR">R<sub>6</sub></span>، <span dir="LTR">R<sub>7</sub></span>، <span dir="LTR">R<sub>12</sub></span>، <span dir="LTR">X</span>، <span dir="LTR">Y</span>، <span dir="LTR">A</span>، <span dir="LTR">E</span> و<span dir="LTR">n</span> مثلما تم تحديده في الوصف. الأدوية.
JOP/2016/0126A 2015-06-23 2016-06-22 مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها JO3430B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1555747A FR3037956B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
JO3430B1 true JO3430B1 (ar) 2019-10-20

Family

ID=54260901

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0126A JO3430B1 (ar) 2015-06-23 2016-06-22 مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها

Country Status (42)

Country Link
US (1) US10457687B2 (ar)
EP (1) EP3313850B1 (ar)
JP (1) JP6741698B2 (ar)
KR (1) KR102620905B1 (ar)
CN (1) CN107709334B (ar)
AR (1) AR105101A1 (ar)
AU (1) AU2016282837B2 (ar)
CA (1) CA2990089C (ar)
CL (1) CL2017003163A1 (ar)
CO (1) CO2017012830A2 (ar)
CR (2) CR20170590A (ar)
CU (1) CU20170164A7 (ar)
CY (1) CY1120991T1 (ar)
DK (1) DK3313850T3 (ar)
EA (1) EA034587B1 (ar)
EC (1) ECSP17082546A (ar)
ES (1) ES2703997T3 (ar)
FR (1) FR3037956B1 (ar)
GE (1) GEP20207075B (ar)
HK (2) HK1250234A1 (ar)
HR (1) HRP20181806T1 (ar)
IL (1) IL256191B (ar)
JO (1) JO3430B1 (ar)
LT (1) LT3313850T (ar)
MA (1) MA42232B1 (ar)
MD (1) MD3313850T2 (ar)
MX (1) MX368845B (ar)
MY (1) MY189472A (ar)
PE (1) PE20190111A1 (ar)
PH (1) PH12017502266A1 (ar)
PL (1) PL3313850T3 (ar)
PT (1) PT3313850T (ar)
RS (1) RS57961B1 (ar)
RU (1) RU2747673C2 (ar)
SA (1) SA517390583B1 (ar)
SI (1) SI3313850T1 (ar)
SV (1) SV2017005588A (ar)
TN (1) TN2017000521A1 (ar)
TW (1) TWI631124B (ar)
UA (1) UA123267C2 (ar)
UY (1) UY36733A (ar)
WO (1) WO2016207226A1 (ar)

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FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2017300738A1 (en) 2016-07-22 2019-02-07 Les Laboratoires Servier Combination of a BCL-2 inhibitor and a MCL-1 inhibitor, uses and pharmaceutical compositions thereof
UY37560A (es) 2017-01-06 2018-07-31 Servier Lab Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
AU2018205735B2 (en) * 2017-01-06 2024-02-01 Les Laboratoires Servier Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
WO2018234433A1 (en) 2017-06-22 2018-12-27 Les Laboratoires Servier COMBINATION OF MCL-1 INHIBITOR AND CARE TREATMENT STANDARD FOR HEMATOLOGICAL CANCERS, USES AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS
UY37843A (es) 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
UY37842A (es) * 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
CN110964034B (zh) * 2018-09-29 2022-04-12 江苏恒瑞医药股份有限公司 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用
AR116635A1 (es) 2018-10-15 2021-05-26 Servier Lab Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen
TW202038960A (zh) 2018-11-14 2020-11-01 法商施維雅藥廠 Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物
CN111187277B (zh) * 2018-11-14 2022-04-12 江苏恒瑞医药股份有限公司 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2020236825A2 (en) 2019-05-20 2020-11-26 Novartis Ag Mcl-1 inhibitor antibody-drug conjugates and methods of use
WO2020254299A1 (en) 2019-06-17 2020-12-24 Les Laboratoires Servier Combination of a mcl-1 inhibitor and a standard of care treatment for breast cancer, uses and pharmaceutical compositions thereof
CN112457308B (zh) 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
US20240042051A1 (en) 2020-11-24 2024-02-08 Francesca Rocchetti Mcl-1 inhibitor antibody-drug conjugates and methods of use
US11957693B2 (en) 2021-06-11 2024-04-16 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-cancer agents
TW202317200A (zh) 2021-06-11 2023-05-01 美商基利科學股份有限公司 Ｍｃｌ－１抑制劑與抗體藥物接合物之組合
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

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FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MA42232B1 (fr) 2018-11-30
UY36733A (es) 2016-12-30
UA123267C2 (uk) 2021-03-10
PL3313850T3 (pl) 2019-04-30
HK1252113B (zh) 2020-01-10
SV2017005588A (es) 2018-06-01
TWI631124B (zh) 2018-08-01
MX368845B (es) 2019-10-18
AR105101A1 (es) 2017-09-06
MA42232A (fr) 2016-12-29
EA201890123A1 (ru) 2018-05-31
RS57961B1 (sr) 2019-01-31
US10457687B2 (en) 2019-10-29
IL256191A (en) 2018-02-28
KR20180015261A (ko) 2018-02-12
HK1250234A1 (zh) 2018-12-07
DK3313850T3 (en) 2019-01-28
TN2017000521A1 (en) 2019-04-12
AU2016282837A1 (en) 2018-01-18
RU2747673C2 (ru) 2021-05-12
MY189472A (en) 2022-02-16
TW201712018A (zh) 2017-04-01
PH12017502266B1 (en) 2018-06-11
HRP20181806T1 (hr) 2018-12-28
MD3313850T2 (ro) 2019-02-28
EP3313850B1 (en) 2018-10-03
FR3037956B1 (fr) 2017-08-04
ECSP17082546A (es) 2018-02-28
PE20190111A1 (es) 2019-01-15
HK1252113A1 (zh) 2019-05-17
EP3313850A1 (en) 2018-05-02
RU2018102372A (ru) 2019-07-23
IL256191B (en) 2020-03-31
FR3037956A1 (ar) 2016-12-30
WO2016207226A1 (en) 2016-12-29
KR102620905B1 (ko) 2024-01-04
JP2018522856A (ja) 2018-08-16
CA2990089C (en) 2020-11-03
ES2703997T3 (es) 2019-03-13
CA2990089A1 (en) 2016-12-29
SI3313850T1 (sl) 2019-01-31
LT3313850T (lt) 2018-11-26
CO2017012830A2 (es) 2018-03-28
CN107709334B (zh) 2021-04-13
CN107709334A (zh) 2018-02-16
SA517390583B1 (ar) 2022-02-20
PH12017502266A1 (en) 2018-06-11
EA034587B1 (ru) 2020-02-25
AU2016282837B2 (en) 2020-05-28
GEP20207075B (en) 2020-03-10
MX2017016996A (es) 2018-08-23
CR20170571A (es) 2018-02-20
US20190031675A1 (en) 2019-01-31
BR112017027645A2 (pt) 2018-08-28
JP6741698B2 (ja) 2020-08-19
CU20170164A7 (es) 2018-05-08
PT3313850T (pt) 2018-11-29
CL2017003163A1 (es) 2018-06-15
CY1120991T1 (el) 2019-12-11
CR20170590A (es) 2018-02-26
RU2018102372A3 (ar) 2019-11-06

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