FR3037958B1 - Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
FR3037958B1
FR3037958B1 FR1555753A FR1555753A FR3037958B1 FR 3037958 B1 FR3037958 B1 FR 3037958B1 FR 1555753 A FR1555753 A FR 1555753A FR 1555753 A FR1555753 A FR 1555753A FR 3037958 B1 FR3037958 B1 FR 3037958B1
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FR
France
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
acid derivatives
hydroxy acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1555753A
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English (en)
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FR3037958A1 (fr
Inventor
Zoltan SZLAVIK
Attila Paczal
Balazs BALINT
Andras Kotschy
Maia CHANRION
Olivier Geneste
James Edward Paul Davidson
James Brooke MURRAY
Szabolcs Sipos
Agnes Proszenyak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Vernalis R&D Ltd
Original Assignee
Laboratoires Servier SAS
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS, Vernalis R&D Ltd filed Critical Laboratoires Servier SAS
Priority to FR1555753A priority Critical patent/FR3037958B1/fr
Priority to UY0001036735A priority patent/UY36735A/es
Priority to GEAP201614680A priority patent/GEP20207076B/en
Priority to CUP2017000162A priority patent/CU20170162A7/xx
Priority to JP2017566288A priority patent/JP6773695B2/ja
Priority to RU2018102361A priority patent/RU2745430C9/ru
Priority to TNP/2017/000529A priority patent/TN2017000529A1/en
Priority to MA42231A priority patent/MA42231B1/fr
Priority to MYPI2017704890A priority patent/MY190243A/en
Priority to JOP/2016/0129A priority patent/JO3807B1/ar
Priority to HRP20230472TT priority patent/HRP20230472T1/hr
Priority to EP16731155.4A priority patent/EP3313849B8/fr
Priority to UAA201800619A priority patent/UA124759C2/uk
Priority to MX2017017008A priority patent/MX2017017008A/es
Priority to HUE16731155A priority patent/HUE061758T2/hu
Priority to TW105119603A priority patent/TWI715593B/zh
Priority to PCT/EP2016/064417 priority patent/WO2016207216A1/fr
Priority to CA2990083A priority patent/CA2990083C/fr
Priority to PT167311554T priority patent/PT3313849T/pt
Priority to AU2016282827A priority patent/AU2016282827B2/en
Priority to LTEPPCT/EP2016/064417T priority patent/LT3313849T/lt
Priority to PL16731155.4T priority patent/PL3313849T3/pl
Priority to US15/738,601 priority patent/US10322131B2/en
Priority to FIEP16731155.4T priority patent/FI3313849T3/fi
Priority to RS20230299A priority patent/RS64131B1/sr
Priority to PE2017002741A priority patent/PE20180949A1/es
Priority to CN201680048558.4A priority patent/CN107922432B/zh
Priority to BR112017027831A priority patent/BR112017027831A2/pt
Priority to ES16731155T priority patent/ES2944942T3/es
Priority to TW109118026A priority patent/TW202108590A/zh
Priority to KR1020187002026A priority patent/KR102620976B1/ko
Priority to EA201890124A priority patent/EA036503B1/ru
Priority to MDE20180439T priority patent/MD3313849T2/ro
Priority to SI201631700T priority patent/SI3313849T1/sl
Priority to DK16731155.4T priority patent/DK3313849T3/da
Priority to ARP160101882A priority patent/AR105104A1/es
Publication of FR3037958A1 publication Critical patent/FR3037958A1/fr
Priority to PH12017502314A priority patent/PH12017502314A1/en
Priority to CONC2017/0012845A priority patent/CO2017012845A2/es
Priority to IL256320A priority patent/IL256320A/en
Priority to SV2017005590A priority patent/SV2017005590A/es
Priority to ECIEPI201782825A priority patent/ECSP17082825A/es
Priority to ZA2017/08626A priority patent/ZA201708626B/en
Priority to DO2017000304A priority patent/DOP2017000304A/es
Priority to CL2017003316A priority patent/CL2017003316A1/es
Priority to SA517390586A priority patent/SA517390586B1/ar
Priority to HK18109701.1A priority patent/HK1250233A1/zh
Priority to HK18113626.5A priority patent/HK1254477A1/zh
Application granted granted Critical
Publication of FR3037958B1 publication Critical patent/FR3037958B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

Composés de formule (I) : où R1, R2, R3, R4, R5, R6, R7, R8, R14, A et n sont tels que définis dans la description. Médicaments.
FR1555753A 2015-06-23 2015-06-23 Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Active FR3037958B1 (fr)

Priority Applications (47)

Application Number Priority Date Filing Date Title
FR1555753A FR3037958B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY0001036735A UY36735A (es) 2015-06-23 2016-06-16 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
GEAP201614680A GEP20207076B (en) 2015-06-23 2016-06-22 New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
CUP2017000162A CU20170162A7 (es) 2015-06-23 2016-06-22 Derivados de fenil-tieno(2,3-d)pirimidina-hidroxiácido útiles en el tratamiento del cáncer y enfermedades autoinmunes, método de preparación de los mismos y composiciones farmacéuticas que los contienen
JP2017566288A JP6773695B2 (ja) 2015-06-23 2016-06-22 新規なヒドロキシ酸誘導体、その製造方法、及びそれを含有する医薬組成物
RU2018102361A RU2745430C9 (ru) 2015-06-23 2016-06-22 Новые гидроксикислотные производные, способ их получения и фармацевтические композиции, содержащие их
TNP/2017/000529A TN2017000529A1 (en) 2015-06-23 2016-06-22 New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
MA42231A MA42231B1 (fr) 2015-06-23 2016-06-22 Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant
MYPI2017704890A MY190243A (en) 2015-06-23 2016-06-22 Hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
JOP/2016/0129A JO3807B1 (ar) 2015-06-23 2016-06-22 مشتقات حمض هيدروكسي جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها
HRP20230472TT HRP20230472T1 (hr) 2015-06-23 2016-06-22 Novi derivati hidroksikiseline, postupak njihove priprave i farmaceutski sastavi koji ih sadrže
EP16731155.4A EP3313849B8 (fr) 2015-06-23 2016-06-22 Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant
UAA201800619A UA124759C2 (uk) 2015-06-23 2016-06-22 Похідні гідроксикислот, спосіб їх отримання та фармацевтичні композиції, що їх містять
MX2017017008A MX2017017008A (es) 2015-06-23 2016-06-22 Nuevos derivados hidroxiacido, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
HUE16731155A HUE061758T2 (hu) 2015-06-23 2016-06-22 Új hidroxisav-származékok, eljárás elõállításukra és ezeket tartalmazó gyógyszerkészítmények
TW105119603A TWI715593B (zh) 2015-06-23 2016-06-22 新穎羥基酸衍生物，其製備方法及含彼等之醫藥組合物
PCT/EP2016/064417 WO2016207216A1 (fr) 2015-06-23 2016-06-22 Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant
CA2990083A CA2990083C (fr) 2015-06-23 2016-06-22 Derives hydroxyacides, procede pour leur preparation et compositions pharmaceutiques contenant ces derives
PT167311554T PT3313849T (pt) 2015-06-23 2016-06-22 Novos derivados de hidroxiácido, um processo para a sua preparação e composições farmacêuticas contendo os mesmos
AU2016282827A AU2016282827B2 (en) 2015-06-23 2016-06-22 New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
LTEPPCT/EP2016/064417T LT3313849T (lt) 2015-06-23 2016-06-22 Nauji hidroksirūgšties dariniai, jų gamybos būdas ir farmacinės kompozicijos, kurių sudėtyje jie yra
PL16731155.4T PL3313849T3 (pl) 2015-06-23 2016-06-22 Nowe pochodne hydroksykwasów, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US15/738,601 US10322131B2 (en) 2015-06-23 2016-06-22 Hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
FIEP16731155.4T FI3313849T3 (fi) 2015-06-23 2016-06-22 Uusia hydroksihappojohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
RS20230299A RS64131B1 (sr) 2015-06-23 2016-06-22 Novi derivati hidroksikiselina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
PE2017002741A PE20180949A1 (es) 2015-06-23 2016-06-22 Nuevos derivados hidroxiacido, un proceso para su preparacion y composiciones farmaceuticas que los contienen
CN201680048558.4A CN107922432B (zh) 2015-06-23 2016-06-22 新的羟基酸衍生物、其制备方法以及含有它们的药物组合物
BR112017027831A BR112017027831A2 (pt) 2015-06-23 2016-06-22 derivados de hidroxiácido, um processo para sua preparação e composições farmacêuticas contendo-os
ES16731155T ES2944942T3 (es) 2015-06-23 2016-06-22 Nuevos derivados hidroxiácidos, un procedimiento para su preparación y composiciones farmacéuticas que los contienen
TW109118026A TW202108590A (zh) 2015-06-23 2016-06-22 新穎羥基酸衍生物，其製備方法及含彼等之醫藥組合物
KR1020187002026A KR102620976B1 (ko) 2015-06-23 2016-06-22 신규한 하이드록시산 유도체, 이를 제조하는 방법 및 이를 함유하는 약제 조성물
EA201890124A EA036503B1 (ru) 2015-06-23 2016-06-22 Гидроксикислотные производные, способ их получения и фармацевтические композиции, содержащие их
MDE20180439T MD3313849T2 (ro) 2015-06-23 2016-06-22 Noi derivați de hidroxiacid, procedeu de preparare a acestora și compoziții farmaceutice care îi conțin
SI201631700T SI3313849T1 (sl) 2015-06-23 2016-06-22 Novi hidroksikislinski derivati, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
DK16731155.4T DK3313849T3 (da) 2015-06-23 2016-06-22 Nye hydroxysyrederivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder dem
ARP160101882A AR105104A1 (es) 2015-06-23 2016-06-23 Derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
PH12017502314A PH12017502314A1 (en) 2015-06-23 2017-12-14 New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
CONC2017/0012845A CO2017012845A2 (es) 2015-06-23 2017-12-14 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
IL256320A IL256320A (en) 2015-06-23 2017-12-14 History of new hydroxyacids, a process for their preparation and pharmaceutical preparations containing them
SV2017005590A SV2017005590A (es) 2015-06-23 2017-12-14 Nuevos derivados hidroxiacido un proceso para su preparacion y composiciones farmaceuticas que los contienen
ECIEPI201782825A ECSP17082825A (es) 2015-06-23 2017-12-15 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
ZA2017/08626A ZA201708626B (en) 2015-06-23 2017-12-18 New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
DO2017000304A DOP2017000304A (es) 2015-06-23 2017-12-20 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
CL2017003316A CL2017003316A1 (es) 2015-06-23 2017-12-21 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen.
SA517390586A SA517390586B1 (ar) 2015-06-23 2017-12-21 مشتقات حمض هيدروكسي جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها
HK18109701.1A HK1250233A1 (zh) 2015-06-23 2018-07-26 新的羥基酸衍生物、其製備方法以及含有它們的藥物組合物
HK18113626.5A HK1254477A1 (zh) 2015-06-23 2018-10-24 新的羥基酸衍生物、其製備方法以及含有它們的藥物組合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1555753A FR3037958B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR1555753 2015-06-23

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FR3037958A1 FR3037958A1 (fr) 2016-12-30
FR3037958B1 true FR3037958B1 (fr) 2019-01-25

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Country Status (45)

Country Link
US (1) US10322131B2 (fr)
EP (1) EP3313849B8 (fr)
JP (1) JP6773695B2 (fr)
KR (1) KR102620976B1 (fr)
CN (1) CN107922432B (fr)
AR (1) AR105104A1 (fr)
AU (1) AU2016282827B2 (fr)
BR (1) BR112017027831A2 (fr)
CA (1) CA2990083C (fr)
CL (1) CL2017003316A1 (fr)
CO (1) CO2017012845A2 (fr)
CU (1) CU20170162A7 (fr)
DK (1) DK3313849T3 (fr)
DO (1) DOP2017000304A (fr)
EA (1) EA036503B1 (fr)
EC (1) ECSP17082825A (fr)
ES (1) ES2944942T3 (fr)
FI (1) FI3313849T3 (fr)
FR (1) FR3037958B1 (fr)
GE (1) GEP20207076B (fr)
HK (2) HK1250233A1 (fr)
HR (1) HRP20230472T1 (fr)
HU (1) HUE061758T2 (fr)
IL (1) IL256320A (fr)
JO (1) JO3807B1 (fr)
LT (1) LT3313849T (fr)
MA (1) MA42231B1 (fr)
MD (1) MD3313849T2 (fr)
MX (1) MX2017017008A (fr)
MY (1) MY190243A (fr)
PE (1) PE20180949A1 (fr)
PH (1) PH12017502314A1 (fr)
PL (1) PL3313849T3 (fr)
PT (1) PT3313849T (fr)
RS (1) RS64131B1 (fr)
RU (1) RU2745430C9 (fr)
SA (1) SA517390586B1 (fr)
SI (1) SI3313849T1 (fr)
SV (1) SV2017005590A (fr)
TN (1) TN2017000529A1 (fr)
TW (2) TW202108590A (fr)
UA (1) UA124759C2 (fr)
UY (1) UY36735A (fr)
WO (1) WO2016207216A1 (fr)
ZA (1) ZA201708626B (fr)

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FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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