HK1157754A1 - Benzene or thiophene derivative and use thereof as vap-1 inhibitor vap-1 - Google Patents

Benzene or thiophene derivative and use thereof as vap-1 inhibitor vap-1

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Publication number
HK1157754A1
HK1157754A1 HK11111896.9A HK11111896A HK1157754A1 HK 1157754 A1 HK1157754 A1 HK 1157754A1 HK 11111896 A HK11111896 A HK 11111896A HK 1157754 A1 HK1157754 A1 HK 1157754A1
Authority
HK
Hong Kong
Prior art keywords
vap
inhibitor
benzene
thiophene derivative
thiophene
Prior art date
Application number
HK11111896.9A
Other languages
English (en)
Chinese (zh)
Inventor
松川達也
增崎和浩
川崎晶子
赤坂阿希子
河合陽介
Original Assignee
株式會社. -技術上野
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式會社. -技術上野 filed Critical 株式會社. -技術上野
Publication of HK1157754A1 publication Critical patent/HK1157754A1/xx

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    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為vap-1抑制劑之用途
JP6073677B2 (ja) 2009-06-12 2017-02-01 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 縮合複素環式化合物およびそれらの使用
UA112154C2 (uk) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
CA2784807C (en) * 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
AT509045B1 (de) 2010-01-29 2011-06-15 Planta Naturstoffe Vertriebsges M B H Verbindungen zur behandlung von asthma bronchiale
ES2628850T3 (es) * 2011-03-15 2017-08-04 Astellas Pharma Inc. Compuesto de guanidina
GB201118613D0 (en) * 2011-10-27 2011-12-07 Nat Univ Ireland Compounds
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
EP2921493B1 (de) 2011-12-27 2017-08-16 Bayer Intellectual Property GmbH Heteroarylpiperidin und -piperazinderivate
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
WO2014199171A1 (en) 2013-06-12 2014-12-18 Proximagen Limited New therapeutic uses of enzyme inhibitors
EP3057956B1 (en) 2013-10-18 2021-05-05 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
US20160264551A1 (en) 2013-10-18 2016-09-15 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
WO2015164604A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
CN104557717A (zh) * 2015-02-13 2015-04-29 佛山市赛维斯医药科技有限公司 酰肼类gpr119激动剂、制备方法及其用途
US10550121B2 (en) 2015-03-27 2020-02-04 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
GB201507048D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd Treatment of pain
JP2018080113A (ja) 2015-05-27 2018-05-24 株式会社アールテック・ウエノ 脳梗塞処置剤
JP2018076236A (ja) 2015-06-05 2018-05-17 株式会社アールテック・ウエノ がんを処置するための医薬組成物
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
EP4019515A1 (en) 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
AU2016366635A1 (en) 2015-12-07 2018-06-21 Benevolentai Cambridge Limited VAP-1 inhibitors for treating pain
CN105924490A (zh) * 2016-04-23 2016-09-07 徐月苗 坎地沙坦酯的药物组合物及其在生物医药中的应用
EP3564230B1 (en) 2016-12-28 2022-02-09 UBE Industries, Ltd. Substituted guanidine compound
HRP20220790T1 (hr) 2017-05-04 2022-09-16 Bayer Cropscience Aktiengesellschaft Derivati 2-{[2-(feniloksimetil)piridin-5-il]oksi}etanamina i srodni spojevi kao pesticidi, primjerice namijenjeni zaštiti bilja
CN107556348B (zh) * 2017-09-30 2019-05-10 四川大学 丙烯酰酸酯类化合物及其制备方法
SE544131C2 (en) * 2020-03-16 2022-01-04 Pvac Medical Tech Ltd Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE944954C (de) * 1954-03-27 1956-06-28 Cilag Ag Verfahren zur Herstellung neuer Carbonsaeurehydrazide
FR5035M (xx) * 1964-07-28 1967-05-02
FR1492793A (fr) * 1965-09-08 1967-08-25 Inst Francais Du Petrole Nouvelles résines hétérocycliques thermostables contenant des motifs benzimidazoles et oxadiazoles
DE1902931A1 (de) * 1969-01-22 1970-08-27 Bayer Ag Semicarbazid-alkylamin-Elastomerfaeden
US4036844A (en) 1972-04-04 1977-07-19 Beecham Group Limited Aryloxypyridines
US4053607A (en) 1972-04-04 1977-10-11 Beecham Group Limited Aryloxypyridine for treating hyperglycaemia
GB1437781A (en) * 1972-04-04 1976-06-03 Beecham Group Ltd Pyridine derivatives having hypoglycaemic activity
FR2186238A1 (en) * 1972-05-05 1974-01-11 Ferlux N-2-imidazolinyl-N'-acylhydrazides - with analgesic hypotensive and cardiac stimulant activity
EP0006171B1 (de) * 1978-06-09 1982-07-28 Hoechst Aktiengesellschaft Neue Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller
DE2835540A1 (de) * 1978-08-14 1980-02-28 Hoechst Ag Neue diamino-1,3,5-triazinylstilben-verbindungen und verfahren zu ihrer herstellung
JPS60239473A (ja) * 1984-05-15 1985-11-28 Fuji Photo Film Co Ltd 2−トリハロメチル−5−フエニル1,3,4−オキサジアゾ−ル化合物
JPS60241049A (ja) * 1984-05-16 1985-11-29 Fuji Photo Film Co Ltd 感光性組成物
IT1181871B (it) 1985-04-01 1987-09-30 Consiglio Nazionale Ricerche Inibitori selettivi delle benzilamminossidasi rispetto ad altre amminossidasi
US4985461A (en) * 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
JPS6470453A (en) * 1987-08-12 1989-03-15 Pennwalt Corp 2-hydroxybenzophenonehydrazide and derivative
AU4055593A (en) 1992-05-15 1993-12-13 University Of Saskatchewan Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis
US6005113A (en) * 1996-05-15 1999-12-21 Molecular Probes, Inc. Long wavelength dyes for infrared tracing
ES2136013B1 (es) * 1997-04-15 2000-07-01 Consejo Superior Investigacion Derivados de tieno y pirazolo (1,2,4) tiadiazina-1,1-dioxido farmacologicamente activos.
IT1292092B1 (it) 1997-06-05 1999-01-25 Geange Ltd Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
FR2792314B1 (fr) * 1999-04-15 2001-06-01 Adir Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20020002152A1 (en) * 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
RU2003103286A (ru) * 2000-07-05 2004-08-20 Байотай Терапис Корпорейшн (Fi) Ингибиторы медьсодержащих аминооксидаз
ES2168084B1 (es) 2000-11-07 2003-11-16 Univ Barcelona Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.
AU2002214505A1 (en) 2000-11-09 2002-05-21 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
ES2187334B1 (es) * 2001-01-17 2004-09-16 Les Laboratoires Servier Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU2002252976A1 (en) 2001-01-22 2002-09-19 Arpida Ag Hydrazones and their therapeutic use
DE60233111D1 (de) * 2001-02-14 2009-09-10 Karobio Ab Glucocorticoid-rezeptoren-modulatoren
CA2463615C (en) 2001-10-30 2011-07-26 Applied Research Systems Ars Holding N.V. Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps)
MXPA02010231A (es) 2001-11-27 2004-12-13 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
US6933294B2 (en) 2002-04-03 2005-08-23 Bristol-Myers Squibb Company Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
GB0209891D0 (en) 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
CA2484233A1 (en) * 2002-05-13 2003-11-27 Eli Lilly And Company Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes
FR2840609A1 (fr) * 2002-06-05 2003-12-12 Lipha Derives nitroso de la diphenylamine, compositions les contenant et leur utilisation en tant qu'antioxydants et donneurs spontanes d'oxyde nitrique
CA2490468A1 (fr) 2002-07-04 2004-01-22 Aventis Pharma S.A. Nouveaux derives acyl hydrazino du thiophene, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
CA2514573A1 (en) 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
US20060229346A1 (en) 2003-03-31 2006-10-12 Sucampo Ag Method for treating vascular hyperpermeable disease
DE10348023A1 (de) 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
TW200529812A (en) * 2003-12-26 2005-09-16 Chugai Pharmaceutical Co Ltd Benzamide derivatives
FI20040270A0 (fi) 2004-02-20 2004-02-20 Biotie Therapies Oyj Kuparia sisältävien amiinioksidaasien imhibiittoreina käyttökelpoiset hydratsinoalkoholijohdannaiset
JP2007223901A (ja) * 2004-03-24 2007-09-06 Takeda Chem Ind Ltd 複素環化合物およびその用途
CA2575411A1 (en) * 2004-07-27 2006-02-02 Astellas Pharma Inc. Thiazole derivatives having vap-1 inhibitory activity
CA2579889A1 (en) * 2004-09-09 2006-03-16 Astellas Pharma Inc. Thiazole derivatives having vap-1 inhibitory activity
JP2006106100A (ja) * 2004-09-30 2006-04-20 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US7312181B2 (en) * 2005-04-08 2007-12-25 Cropsolution, Inc. Acylated thiosemicarbazides as herbicides
WO2006110516A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories Acylhydrazide p2x7 antagonists and uses thereof
WO2006120125A1 (en) 2005-05-10 2006-11-16 F. Hoffmann-La Roche Ag Diacylglycerol acyltransferase inhibitors
TWI368617B (en) * 2005-07-15 2012-07-21 Nissan Chemical Ind Ltd Thiophene compounds and thrombopoietin receptor activators
JP2009510013A (ja) 2005-09-30 2009-03-12 エフ.ホフマン−ラ ロシュ アーゲー Nnrt阻害剤
FR2894964B1 (fr) * 2005-12-19 2008-02-22 Cerep Sa Composes a base de quatre cycles aromatiques, preparation et utilisations
WO2007080114A2 (en) * 2006-01-11 2007-07-19 Biotech Igg Ab Macromolecule conjugate
US7674811B2 (en) * 2006-03-14 2010-03-09 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
TW200811155A (en) * 2006-05-30 2008-03-01 Glaxo Group Ltd Compounds
ATE498615T1 (de) * 2006-07-14 2011-03-15 Chemocentryx Inc Triazolylphenylbenzensulfonamide
AU2007292993B2 (en) * 2006-09-07 2013-01-24 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
US8183264B2 (en) 2006-09-21 2012-05-22 Eisai R&D Managment Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
WO2008046216A1 (en) 2006-10-18 2008-04-24 Methylgene, Inc. Kinase inhibitors and uses thereof
US20090035306A1 (en) 2006-11-29 2009-02-05 Kalypsys, Inc. Quinazolinone modulators of tgr5
TW200835687A (en) * 2006-11-30 2008-09-01 R Tech Ueno Ltd Thiazole derivatives and their use as VAP-1 inhibitor
JP4232821B2 (ja) 2006-12-06 2009-03-04 トヨタ自動車株式会社 空気圧制御システムおよび空気圧制御装置
WO2008078725A1 (ja) 2006-12-26 2008-07-03 Daiichi Sankyo Company, Limited チアゼピン誘導体
CN103224493A (zh) * 2007-01-29 2013-07-31 参天制药株式会社 具有血管新生抑制活性的新型噁二唑衍生物及噻二唑衍生物
JP2010532312A (ja) 2007-01-30 2010-10-07 バイオジェン・アイデック・エムエイ・インコーポレイテッド 1−h−ピラゾロ(3,4b)ピリミジン誘導体および有糸***キナーゼの調節剤としてのその使用
MX2009010034A (es) 2007-03-22 2009-10-12 Hoffmann La Roche Pirimidodiazepinas sustituidas utiles inhibidores de la plk1.
CN101657433A (zh) * 2007-03-29 2010-02-24 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
US8268850B2 (en) 2007-05-04 2012-09-18 Irm Llc Pyrimidine derivatives and compositions as C-kit and PDGFR kinase inhibitors
EP2172221A4 (en) 2007-06-25 2010-06-23 R Tech Ueno Ltd COMPOSITION FOR OPHTHALMIC DISEASE ASSOCIATED WITH HYPOXIA OR ISCHEMIA
ES2530995T3 (es) * 2007-09-28 2015-03-09 Anthrogenesis Corp Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana
JP5298626B2 (ja) 2007-10-17 2013-09-25 ソニー株式会社 ネットワークシステム、ネットワーク家電機器、コンテンツ/メタデータの同期処理方法、及びコンピュータ・プログラム
JPWO2009051223A1 (ja) 2007-10-19 2011-03-03 株式会社アールテック・ウエノ 白内障処置のための医薬組成物
CN101932325B (zh) 2007-11-30 2014-05-28 新联基因公司 Ido抑制剂
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為vap-1抑制劑之用途
WO2009100536A1 (en) * 2008-02-15 2009-08-20 Methylgene Inc. Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為vap-1抑制劑之用途

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