HK1083097A1 - Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents - Google Patents

Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents

Info

Publication number
HK1083097A1
HK1083097A1 HK06103068A HK06103068A HK1083097A1 HK 1083097 A1 HK1083097 A1 HK 1083097A1 HK 06103068 A HK06103068 A HK 06103068A HK 06103068 A HK06103068 A HK 06103068A HK 1083097 A1 HK1083097 A1 HK 1083097A1
Authority
HK
Hong Kong
Prior art keywords
sub
derivatives useful
antibiotic agents
hydroxymethyl substituted
hydrogen
Prior art date
Application number
HK06103068A
Other languages
English (en)
Inventor
Gravestock Michael Barry
Hales Neil James
Carcanague Daniel Robert
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0304723A external-priority patent/GB0304723D0/en
Priority claimed from GB0318607A external-priority patent/GB0318607D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1083097A1 publication Critical patent/HK1083097A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06103068A 2003-03-01 2006-03-09 Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents HK1083097A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0304723A GB0304723D0 (en) 2003-03-01 2003-03-01 Chemical compounds
GB0318607A GB0318607D0 (en) 2003-08-08 2003-08-08 Chemical compounds
PCT/GB2004/000730 WO2004078753A1 (en) 2003-03-01 2004-02-24 Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents

Publications (1)

Publication Number Publication Date
HK1083097A1 true HK1083097A1 (en) 2006-06-23

Family

ID=32964061

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103068A HK1083097A1 (en) 2003-03-01 2006-03-09 Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents

Country Status (17)

Country Link
US (1) US7192974B2 (es)
EP (1) EP1599471B1 (es)
JP (1) JP2006519247A (es)
KR (1) KR20050106064A (es)
AT (1) ATE396991T1 (es)
AU (1) AU2004218206A1 (es)
BR (1) BRPI0407835A (es)
CA (1) CA2517706A1 (es)
CL (1) CL2004000400A1 (es)
DE (1) DE602004014107D1 (es)
ES (1) ES2305732T3 (es)
HK (1) HK1083097A1 (es)
MX (1) MXPA05009205A (es)
NO (1) NO20054523L (es)
TW (1) TW200500360A (es)
UY (1) UY28211A1 (es)
WO (1) WO2004078753A1 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027083A1 (en) * 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
MXPA04008312A (es) 2002-02-28 2004-11-26 Astrazeneca Ab Derivados de 3-cilil-5-(anillo de 5 miembros que contienen nitrogeno)-metil-oxazolidinona y sus uso como agentes antibacterianos.
BR0308018A (pt) 2002-02-28 2005-01-04 Astrazeneca Ab Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo
WO2005012271A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
MXPA05013132A (es) 2003-06-03 2006-05-25 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo y metodos de produccion y su uso.
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
MXPA06000228A (es) * 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
WO2005005399A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
ES2536001T3 (es) * 2003-07-29 2015-05-19 Melinta Therapeutics, Inc. Procedimiento para la síntesis de biariloxazolidinonas
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20050241110A1 (en) * 2004-04-09 2005-11-03 Bruce Baker Ergonomic handles, especially for garden tools
BRPI0511535A (pt) * 2004-05-25 2008-01-02 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, ou pró-droga do mesmo, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um sal farmaceuticamente aceitável, ou éster hidrolisável in-vivo do mesmo, ou de um seu éster hidrolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou sais farmaceuticamente aceitáveis ou ésteres hidrolisáveis in-vivo do mesmo
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2006106711A1 (ja) 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
KR101394307B1 (ko) 2005-06-08 2014-05-13 멜린타 테라퓨틱스, 인크. 트리아졸의 합성 방법
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP1946840B1 (en) * 2005-11-04 2019-08-21 NGK Insulators, Ltd. Honeycomb structure and honeycomb catalyst
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
WO2008035726A1 (fr) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant
US8258394B2 (en) * 2007-02-08 2012-09-04 Bradford G Baruh Retractable solar panel system
US20080190341A1 (en) * 2007-02-08 2008-08-14 Baruh Bradford G System and method of adjusting the location and position of the foresail on a sailboat
US20100065104A1 (en) * 2007-08-31 2010-03-18 Baruh Bradford G Retractable solar panel system
KR100848232B1 (ko) * 2007-04-12 2008-07-24 일동제약주식회사 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CN102702185A (zh) 2007-04-27 2012-10-03 卫材R&D管理有限公司 杂环取代吡啶衍生物的盐的结晶
WO2008156559A2 (en) * 2007-06-01 2008-12-24 Chx Technologies, Inc. Topical dental solution of chlorhexidine in sumatra benzoin bp/ep and methods of manufacturing and evaluating same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
WO2009120565A2 (en) 2008-03-25 2009-10-01 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
NZ587096A (en) 2008-03-26 2011-11-25 Global Alliance For Tb Drug Dev Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
ES2748505T3 (es) * 2008-10-10 2020-03-17 Merck Sharp & Dohme Métodos para la preparación de oxazolidinonas y composiciones que las contienen
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
JP2012516900A (ja) 2009-02-05 2012-07-26 トーカイ ファーマシューティカルズ，インク． ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ
WO2010103281A1 (en) * 2009-03-13 2010-09-16 Sun Chemical B.V. Cyclic carbamate compounds useful in energy-curable compositions
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101653570B1 (ko) * 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2626356A1 (en) * 2012-02-08 2013-08-14 Rheinische Friedrich-Wilhelms-Universität Bonn Thiamine analogues and their use as antibiotics
WO2014153215A1 (en) 2013-03-14 2014-09-25 University Of Maryland,Baltimore Office Of Technology Transfer Androgen receptor down-regulating agents and uses thereof
AU2014306698A1 (en) 2013-08-12 2016-01-28 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CN112707779B (zh) * 2020-12-26 2023-06-30 蚌埠中实化学技术有限公司 一种乙烯基环己烷的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE69216251T2 (de) * 1991-11-01 1997-05-15 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte aryl- und heteroaryl-phenyloxazolidinone
MXPA02012045A (es) * 2000-06-05 2003-10-15 Dong A Pharm Co Ltd Nuevos derivados de oxazolidinona y proceso para su preparacion.
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
RU2004111285A (ru) * 2001-09-11 2005-10-10 Астразенека Аб (Se) Оксазолидинон и/или изоксазолин в качестве антибактериальных средств
KR20050085193A (ko) * 2002-11-28 2005-08-29 아스트라제네카 아베 항균제로서의 옥사졸리디논 및(또는) 이속사졸린 유도체
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
UY28211A1 (es) 2004-09-30
US20060270637A1 (en) 2006-11-30
US7192974B2 (en) 2007-03-20
BRPI0407835A (pt) 2006-02-14
NO20054523D0 (no) 2005-09-30
TW200500360A (en) 2005-01-01
WO2004078753A1 (en) 2004-09-16
EP1599471B1 (en) 2008-05-28
KR20050106064A (ko) 2005-11-08
DE602004014107D1 (de) 2008-07-10
CL2004000400A1 (es) 2005-04-22
ES2305732T3 (es) 2008-11-01
CA2517706A1 (en) 2004-09-16
NO20054523L (no) 2005-12-01
EP1599471A1 (en) 2005-11-30
ATE396991T1 (de) 2008-06-15
MXPA05009205A (es) 2005-10-18
AU2004218206A1 (en) 2004-09-16
JP2006519247A (ja) 2006-08-24

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120224