AU2002211216A1 - Substituted aminopropoxyaryl derivatives useful as agonists for lxr - Google Patents
Substituted aminopropoxyaryl derivatives useful as agonists for lxrInfo
- Publication number
- AU2002211216A1 AU2002211216A1 AU2002211216A AU1121602A AU2002211216A1 AU 2002211216 A1 AU2002211216 A1 AU 2002211216A1 AU 2002211216 A AU2002211216 A AU 2002211216A AU 1121602 A AU1121602 A AU 1121602A AU 2002211216 A1 AU2002211216 A1 AU 2002211216A1
- Authority
- AU
- Australia
- Prior art keywords
- lxr
- agonists
- substituted
- derivatives useful
- aminopropoxyaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Abstract
The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23314400P | 2000-09-18 | 2000-09-18 | |
US60233144 | 2000-09-18 | ||
US60/233,144 | 2000-09-18 | ||
PCT/US2001/027622 WO2002024632A2 (en) | 2000-09-18 | 2001-09-06 | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002211216A1 true AU2002211216A1 (en) | 2002-04-02 |
Family
ID=22876062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002211216A Abandoned AU2002211216A1 (en) | 2000-09-18 | 2001-09-06 | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040072868A1 (en) |
EP (1) | EP1318976B1 (en) |
JP (1) | JP2004509161A (en) |
AT (1) | ATE283253T1 (en) |
AU (1) | AU2002211216A1 (en) |
DE (1) | DE60107449T2 (en) |
ES (1) | ES2233700T3 (en) |
WO (1) | WO2002024632A2 (en) |
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US20050171084A1 (en) * | 2002-03-27 | 2005-08-04 | Cairns William J. | Methods of treatment with lxr modulators |
JP4471842B2 (en) * | 2002-03-27 | 2010-06-02 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Amide compound and method using the compound |
AU2003222083A1 (en) * | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Acid and ester compounds and methods of using the same |
WO2003082205A2 (en) * | 2002-03-27 | 2003-10-09 | Smithkline Beecham Corporation | Compounds and methods |
ES2337037T3 (en) * | 2002-03-27 | 2010-04-20 | Glaxosmithkline Llc | CERTAIN PHARMACEUTICALLY USEFUL REPLACED AMINOALKYL HETEROYCLES. |
US6987121B2 (en) | 2002-04-25 | 2006-01-17 | Smithkline Beecham Corporation | Compositions and methods for hepatoprotection and treatment of cholestasis |
CA2486651A1 (en) | 2002-05-24 | 2003-12-04 | Pharmacia Corporation | Sulfone liver x-receptor modulators |
MXPA04011691A (en) | 2002-05-24 | 2005-09-12 | Pharmacia Corp | Anilino liver x-receptor modulators. |
WO2004009091A1 (en) * | 2002-06-17 | 2004-01-29 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
EP1398032A1 (en) * | 2002-09-10 | 2004-03-17 | PheneX Pharmaceuticals AG | 4-Oxo-quinazolines as LXR nuclear receptor binding compounds |
EP1646394A2 (en) * | 2003-07-22 | 2006-04-19 | Glaxo Group Limited | Methods of treatment with lxr agonists |
JP2007500158A (en) * | 2003-07-28 | 2007-01-11 | グラクソ グループ リミテッド | Method for treating inflammatory bowel disease using LXR agonist |
WO2005023247A1 (en) * | 2003-09-03 | 2005-03-17 | Smithkline Beecham Corporation | Compounds and methods |
WO2005113499A1 (en) * | 2004-05-20 | 2005-12-01 | Sankyo Company, Limited | Indole compounds |
EP1758651A2 (en) * | 2004-06-24 | 2007-03-07 | Galapagos N.V. | Lxr agonists to promote bone homeostasis |
KR101021828B1 (en) | 2004-10-27 | 2011-03-17 | 다이이찌 산쿄 가부시키가이샤 | Benzene compound having 2 or more substituents |
WO2006109633A1 (en) * | 2005-04-07 | 2006-10-19 | Daiichi Sankyo Company, Limited | Substituted indole compound |
ES2438739T3 (en) * | 2005-06-28 | 2014-01-20 | Daiichi Sankyo Company, Limited | LXR ligand test procedure |
CL2007003035A1 (en) | 2006-10-24 | 2008-05-16 | Smithkline Beechman Corp | COMPOUNDS DERIVED FROM ISOXAZOL REPLACED, FARNESOID X RECEIVER AGONISTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; AND USE OF THE COMPOUND IN THE TREATMENT OF OBESITY, DIABETES MELLITUS, FIBROSIS IN ORGANS, |
CN101595096B (en) | 2006-11-30 | 2012-06-27 | 兴和株式会社 | Substituted carbinol compound |
US8993628B2 (en) * | 2007-02-23 | 2015-03-31 | City Of Hope | Synthetic ligands selective for LXRβ over LXRα, identification and methods of use thereof |
KR101171433B1 (en) * | 2007-03-30 | 2012-08-06 | 에프. 호프만-라 로슈 아게 | Imidazolidinone derivatives |
US7919509B2 (en) | 2008-02-29 | 2011-04-05 | Kowa Company, Ltd. | 2-oxochromene derivatives |
JP5511080B2 (en) | 2008-03-31 | 2014-06-04 | 興和株式会社 | 1,3-dihydroisobenzofuran derivative |
EP2272843A4 (en) | 2008-04-30 | 2011-07-20 | Kowa Co | Quinoline compound |
US8153634B2 (en) | 2008-05-29 | 2012-04-10 | Kowa Company, Ltd. | Carbinol derivatives having cyclic linker |
NZ595910A (en) | 2009-04-29 | 2013-06-28 | Kowa Co | Carbinol compound having heterocyclic linker |
CA2811145A1 (en) | 2010-09-07 | 2012-03-15 | Snu R&Db Foundation | Sesterterpene compound and use thereof |
EP2819993B1 (en) * | 2012-03-01 | 2020-09-02 | University Of Cincinnati | Ros-activated compounds as selective anti-cancer therapeutics |
HUE040231T2 (en) | 2012-03-02 | 2019-02-28 | Ralexar Therapeutics Inc | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
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AU2015204572B2 (en) * | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
AR103624A1 (en) | 2015-02-06 | 2017-05-24 | Intercept Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY |
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CA2090283A1 (en) * | 1992-02-28 | 1993-08-29 | Nobuyuki Hamanaka | Phenoxyacetic acid derivatives |
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WO1994025427A1 (en) * | 1993-04-26 | 1994-11-10 | Fujisawa Pharmaceutical Co., Ltd. | Ethanolamine derivatives useful for the treatment of gastrointestinal disorders |
AU3057697A (en) * | 1996-05-06 | 1997-11-26 | Eli Lilly And Company | Anti-viral compounds |
US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
WO2001060818A1 (en) * | 2000-02-14 | 2001-08-23 | Tularik Inc. | Lxr modulators |
JP4471842B2 (en) * | 2002-03-27 | 2010-06-02 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Amide compound and method using the compound |
WO2003082205A2 (en) * | 2002-03-27 | 2003-10-09 | Smithkline Beecham Corporation | Compounds and methods |
ES2337037T3 (en) * | 2002-03-27 | 2010-04-20 | Glaxosmithkline Llc | CERTAIN PHARMACEUTICALLY USEFUL REPLACED AMINOALKYL HETEROYCLES. |
-
2001
- 2001-09-06 JP JP2002528647A patent/JP2004509161A/en active Pending
- 2001-09-06 WO PCT/US2001/027622 patent/WO2002024632A2/en active IP Right Grant
- 2001-09-06 EP EP01979230A patent/EP1318976B1/en not_active Expired - Lifetime
- 2001-09-06 US US10/380,932 patent/US20040072868A1/en not_active Abandoned
- 2001-09-06 ES ES01979230T patent/ES2233700T3/en not_active Expired - Lifetime
- 2001-09-06 DE DE60107449T patent/DE60107449T2/en not_active Expired - Lifetime
- 2001-09-06 AT AT01979230T patent/ATE283253T1/en not_active IP Right Cessation
- 2001-09-06 AU AU2002211216A patent/AU2002211216A1/en not_active Abandoned
-
2005
- 2005-06-16 US US11/154,852 patent/US20050282908A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2004509161A (en) | 2004-03-25 |
ES2233700T3 (en) | 2005-06-16 |
US20050282908A1 (en) | 2005-12-22 |
WO2002024632A3 (en) | 2002-07-11 |
EP1318976A2 (en) | 2003-06-18 |
ATE283253T1 (en) | 2004-12-15 |
WO2002024632A2 (en) | 2002-03-28 |
DE60107449T2 (en) | 2005-12-08 |
EP1318976B1 (en) | 2004-11-24 |
DE60107449D1 (en) | 2004-12-30 |
US20040072868A1 (en) | 2004-04-15 |
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