FR3037956B1 - Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR3037956B1
FR3037956B1 FR1555747A FR1555747A FR3037956B1 FR 3037956 B1 FR3037956 B1 FR 3037956B1 FR 1555747 A FR1555747 A FR 1555747A FR 1555747 A FR1555747 A FR 1555747A FR 3037956 B1 FR3037956 B1 FR 3037956B1
Authority
FR
France
Prior art keywords
preparing
amino acid
pharmaceutical compositions
compositions containing
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1555747A
Other languages
English (en)
French (fr)
Other versions
FR3037956A1 (es
Inventor
Zoltan Szlavik
Zoltan Szabo
Marton Csekei
Attila Paczal
Andras Kotschy
Alain Bruno
Olivier Geneste
I-Jen Chen
James Edward Paul Davidson
James Brooke Murray
Levente Ondi
Gabor Radics
Szabolcs Sipos
Agnes Proszenyak
Sierra Francoise Perron
Balazs Balint
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Vernalis R&D Ltd
Original Assignee
Laboratoires Servier SAS
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS, Vernalis R&D Ltd filed Critical Laboratoires Servier SAS
Priority to FR1555747A priority Critical patent/FR3037956B1/fr
Priority to UY0001036733A priority patent/UY36733A/es
Priority to KR1020187002016A priority patent/KR102620905B1/ko
Priority to CR20170571A priority patent/CR20170571A/es
Priority to BR112017027645-3A priority patent/BR112017027645B1/pt
Priority to JOP/2016/0126A priority patent/JO3430B1/ar
Priority to CR20170590A priority patent/CR20170590A/es
Priority to MDE20180440T priority patent/MD3313850T2/ro
Priority to MX2017016996A priority patent/MX368845B/es
Priority to ES16731158T priority patent/ES2703997T3/es
Priority to EP16731158.8A priority patent/EP3313850B1/en
Priority to UAA201800620A priority patent/UA123267C2/uk
Priority to JP2017566280A priority patent/JP6741698B2/ja
Priority to CUP2017000164A priority patent/CU20170164A7/es
Priority to MA42232A priority patent/MA42232B1/fr
Priority to DK16731158.8T priority patent/DK3313850T3/en
Priority to EA201890123A priority patent/EA034587B1/ru
Priority to CA2990089A priority patent/CA2990089C/en
Priority to RU2018102372A priority patent/RU2747673C2/ru
Priority to TW105119598A priority patent/TWI631124B/zh
Priority to US15/737,783 priority patent/US10457687B2/en
Priority to GEAP201614679A priority patent/GEP20207075B/en
Priority to TNP/2017/000521A priority patent/TN2017000521A1/en
Priority to PT16731158T priority patent/PT3313850T/pt
Priority to LTEP16731158.8T priority patent/LT3313850T/lt
Priority to RS20181327A priority patent/RS57961B1/sr
Priority to AU2016282837A priority patent/AU2016282837B2/en
Priority to SI201630123T priority patent/SI3313850T1/sl
Priority to PL16731158T priority patent/PL3313850T3/pl
Priority to PCT/EP2016/064436 priority patent/WO2016207226A1/en
Priority to PE2017002702A priority patent/PE20190111A1/es
Priority to CN201680039612.9A priority patent/CN107709334B/zh
Priority to MYPI2017704883A priority patent/MY189472A/en
Priority to ARP160101879A priority patent/AR105101A1/es
Publication of FR3037956A1 publication Critical patent/FR3037956A1/fr
Application granted granted Critical
Publication of FR3037956B1 publication Critical patent/FR3037956B1/fr
Priority to IL256191A priority patent/IL256191B/en
Priority to CL2017003163A priority patent/CL2017003163A1/es
Priority to PH12017502266A priority patent/PH12017502266A1/en
Priority to SV2017005588A priority patent/SV2017005588A/es
Priority to CONC2017/0012830A priority patent/CO2017012830A2/es
Priority to ECIEPI201782546A priority patent/ECSP17082546A/es
Priority to SA517390583A priority patent/SA517390583B1/ar
Priority to HK18109702.0A priority patent/HK1250234A1/zh
Priority to HK18111502.8A priority patent/HK1252113B/zh
Priority to HRP20181806TT priority patent/HRP20181806T1/hr
Priority to CY181101321T priority patent/CY1120991T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
FR1555747A 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR3037956B1 (fr)

Priority Applications (45)

Application Number Priority Date Filing Date Title
FR1555747A FR3037956B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY0001036733A UY36733A (es) 2015-06-23 2016-06-16 Nuevos derivados aminoácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
KR1020187002016A KR102620905B1 (ko) 2015-06-23 2016-06-22 신규한 아미노산 유도체, 이의 제조방법, 및 이를 함유한 약제 조성물
CR20170571A CR20170571A (es) 2015-06-23 2016-06-22 Nuevos derivados aminoácido, un proceso para su preparación y composiciones farmaceúticas que los contienen.
BR112017027645-3A BR112017027645B1 (pt) 2015-06-23 2016-06-22 Derivados de aminoácido, processo para sua preparação,composições farmacêuticas contendoos, combinação e uso dos mesmos
JOP/2016/0126A JO3430B1 (ar) 2015-06-23 2016-06-22 مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها
CR20170590A CR20170590A (es) 2015-06-23 2016-06-22 Nuevos derivados hidroxiácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
MDE20180440T MD3313850T2 (ro) 2015-06-23 2016-06-22 Noi derivaţi de aminoacizi, procedeu pentru prepararea acestora şi compoziţii farmaceutice care îi conţin
MX2017016996A MX368845B (es) 2015-06-23 2016-06-22 Nuevos derivados aminoácido, un proceso para su preparación y composiciones farmacéuticas que los contienen.
ES16731158T ES2703997T3 (es) 2015-06-23 2016-06-22 Nuevos derivados de aminoácidos, un proceso para su preparación y composiciones farmacéuticas que los contienen
EP16731158.8A EP3313850B1 (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
UAA201800620A UA123267C2 (uk) 2015-06-23 2016-06-22 Похідні амінокислот, спосіб їх отримання та фармацевтичні композиції, що їх містять
JP2017566280A JP6741698B2 (ja) 2015-06-23 2016-06-22 新規なアミノ酸誘導体、その製造方法、及びそれを含有する医薬組成物
CUP2017000164A CU20170164A7 (es) 2015-06-23 2016-06-22 Compuestos n-tieno (2,3-d)pirimidinil-d-fenilalanina, método para preparar los mismos y composiciones farmacéuticas que los contienen
MA42232A MA42232B1 (fr) 2015-06-23 2016-06-22 Nouveaux dérivés d'acide aminé, leur procédé de préparation et compositions pharmaceutiques les contenant
DK16731158.8T DK3313850T3 (en) 2015-06-23 2016-06-22 NEW AMINO ACID DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA201890123A EA034587B1 (ru) 2015-06-23 2016-06-22 Новые аминокислотные производные, способ их получения и фармацевтические композиции, содержащие их
CA2990089A CA2990089C (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
RU2018102372A RU2747673C2 (ru) 2015-06-23 2016-06-22 Новые аминокислотные производные, способ их получения и фармацевтические композиции, содержащие их
TW105119598A TWI631124B (zh) 2015-06-23 2016-06-22 新穎胺基酸衍生物，其製備方法及含彼等之醫藥組合物
US15/737,783 US10457687B2 (en) 2015-06-23 2016-06-22 Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
GEAP201614679A GEP20207075B (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
TNP/2017/000521A TN2017000521A1 (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
PT16731158T PT3313850T (pt) 2015-06-23 2016-06-22 Novos derivados de aminoácidos, um processo para a sua preparação e composições farmacêuticas que os contêm
LTEP16731158.8T LT3313850T (lt) 2015-06-23 2016-06-22 Nauji aminorūgščių dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos
RS20181327A RS57961B1 (sr) 2015-06-23 2016-06-22 Novi derivati aminokiselina, postupak njihove izrade i farmaceutske kompozicije koje ih sadrže
AU2016282837A AU2016282837B2 (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
SI201630123T SI3313850T1 (sl) 2015-06-23 2016-06-22 Novi derivati aminokislin, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
PL16731158T PL3313850T3 (pl) 2015-06-23 2016-06-22 Nowe pochodne aminokwasów, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
PCT/EP2016/064436 WO2016207226A1 (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
PE2017002702A PE20190111A1 (es) 2015-06-23 2016-06-22 Nuevos derivados aminoacido, un proceso para su preparacion y composiciones farmaceuticas que los contienen
CN201680039612.9A CN107709334B (zh) 2015-06-23 2016-06-22 新的氨基酸衍生物、其制备方法和包含它们的药用组合物
MYPI2017704883A MY189472A (en) 2015-06-23 2016-06-22 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
ARP160101879A AR105101A1 (es) 2015-06-23 2016-06-23 Derivados aminoácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
IL256191A IL256191B (en) 2015-06-23 2017-12-07 New amino acid compounds, a process for their preparation and pharmaceutical preparations containing them
CL2017003163A CL2017003163A1 (es) 2015-06-23 2017-12-11 Nuevos derivados aminoácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
PH12017502266A PH12017502266A1 (en) 2015-06-23 2017-12-11 New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
SV2017005588A SV2017005588A (es) 2015-06-23 2017-12-12 Nuevos derivados aminoacido, un proceso para su preparacion y composiciones farmaceuticas que los contienen
CONC2017/0012830A CO2017012830A2 (es) 2015-06-23 2017-12-13 Compuestos de n-tieno [2,3-d] pirimidinil-d-fenilalanina, método de preparación de los mismos y composiciones farmacéuticas que los contienen
ECIEPI201782546A ECSP17082546A (es) 2015-06-23 2017-12-14 Nuevos derivados aminoácido, un proceso para su preparación y composiciones farmacéuticas que los contienen
SA517390583A SA517390583B1 (ar) 2015-06-23 2017-12-21 مشتقات حمض أميني جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها
HK18109702.0A HK1250234A1 (zh) 2015-06-23 2018-07-26 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物
HK18111502.8A HK1252113B (zh) 2015-06-23 2018-09-06 新的氨基酸衍生物、其製備方法和包含它們的藥用組合物
HRP20181806TT HRP20181806T1 (hr) 2015-06-23 2018-10-31 Novi aminokiselinski derivati, postupak za njihovu pripravu te farmaceutski pripravci koji ih sadrže
CY181101321T CY1120991T1 (el) 2015-06-23 2018-12-10 Νεα παραγωγα αμινοξεος, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1555747A FR3037956B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR3037956A1 FR3037956A1 (es) 2016-12-30
FR3037956B1 true FR3037956B1 (fr) 2017-08-04

Family

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Family Applications (1)

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FR1555747A Expired - Fee Related FR3037956B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (42)

Country Link
US (1) US10457687B2 (es)
EP (1) EP3313850B1 (es)
JP (1) JP6741698B2 (es)
KR (1) KR102620905B1 (es)
CN (1) CN107709334B (es)
AR (1) AR105101A1 (es)
AU (1) AU2016282837B2 (es)
CA (1) CA2990089C (es)
CL (1) CL2017003163A1 (es)
CO (1) CO2017012830A2 (es)
CR (2) CR20170590A (es)
CU (1) CU20170164A7 (es)
CY (1) CY1120991T1 (es)
DK (1) DK3313850T3 (es)
EA (1) EA034587B1 (es)
EC (1) ECSP17082546A (es)
ES (1) ES2703997T3 (es)
FR (1) FR3037956B1 (es)
GE (1) GEP20207075B (es)
HK (2) HK1250234A1 (es)
HR (1) HRP20181806T1 (es)
IL (1) IL256191B (es)
JO (1) JO3430B1 (es)
LT (1) LT3313850T (es)
MA (1) MA42232B1 (es)
MD (1) MD3313850T2 (es)
MX (1) MX368845B (es)
MY (1) MY189472A (es)
PE (1) PE20190111A1 (es)
PH (1) PH12017502266A1 (es)
PL (1) PL3313850T3 (es)
PT (1) PT3313850T (es)
RS (1) RS57961B1 (es)
RU (1) RU2747673C2 (es)
SA (1) SA517390583B1 (es)
SI (1) SI3313850T1 (es)
SV (1) SV2017005588A (es)
TN (1) TN2017000521A1 (es)
TW (1) TWI631124B (es)
UA (1) UA123267C2 (es)
UY (1) UY36733A (es)
WO (1) WO2016207226A1 (es)

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FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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UY37560A (es) 2017-01-06 2018-07-31 Servier Lab Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
AU2018205735B2 (en) * 2017-01-06 2024-02-01 Les Laboratoires Servier Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
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UY37842A (es) * 2017-08-15 2019-03-29 Abbvie Inc Inhibidores de mcl-1 macrocíclicos y métodos de uso
CN110964034B (zh) * 2018-09-29 2022-04-12 江苏恒瑞医药股份有限公司 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用
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CN111187277B (zh) * 2018-11-14 2022-04-12 江苏恒瑞医药股份有限公司 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
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WO2020254299A1 (en) 2019-06-17 2020-12-24 Les Laboratoires Servier Combination of a mcl-1 inhibitor and a standard of care treatment for breast cancer, uses and pharmaceutical compositions thereof
CN112457308B (zh) 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
US20240042051A1 (en) 2020-11-24 2024-02-08 Francesca Rocchetti Mcl-1 inhibitor antibody-drug conjugates and methods of use
US11957693B2 (en) 2021-06-11 2024-04-16 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-cancer agents
TW202317200A (zh) 2021-06-11 2023-05-01 美商基利科學股份有限公司 Ｍｃｌ－１抑制劑與抗體藥物接合物之組合
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

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FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MA42232B1 (fr) 2018-11-30
UY36733A (es) 2016-12-30
UA123267C2 (uk) 2021-03-10
PL3313850T3 (pl) 2019-04-30
HK1252113B (zh) 2020-01-10
SV2017005588A (es) 2018-06-01
TWI631124B (zh) 2018-08-01
MX368845B (es) 2019-10-18
AR105101A1 (es) 2017-09-06
MA42232A (fr) 2016-12-29
EA201890123A1 (ru) 2018-05-31
RS57961B1 (sr) 2019-01-31
US10457687B2 (en) 2019-10-29
IL256191A (en) 2018-02-28
KR20180015261A (ko) 2018-02-12
HK1250234A1 (zh) 2018-12-07
JO3430B1 (ar) 2019-10-20
DK3313850T3 (en) 2019-01-28
TN2017000521A1 (en) 2019-04-12
AU2016282837A1 (en) 2018-01-18
RU2747673C2 (ru) 2021-05-12
MY189472A (en) 2022-02-16
TW201712018A (zh) 2017-04-01
PH12017502266B1 (en) 2018-06-11
HRP20181806T1 (hr) 2018-12-28
MD3313850T2 (ro) 2019-02-28
EP3313850B1 (en) 2018-10-03
ECSP17082546A (es) 2018-02-28
PE20190111A1 (es) 2019-01-15
HK1252113A1 (zh) 2019-05-17
EP3313850A1 (en) 2018-05-02
RU2018102372A (ru) 2019-07-23
IL256191B (en) 2020-03-31
FR3037956A1 (es) 2016-12-30
WO2016207226A1 (en) 2016-12-29
KR102620905B1 (ko) 2024-01-04
JP2018522856A (ja) 2018-08-16
CA2990089C (en) 2020-11-03
ES2703997T3 (es) 2019-03-13
CA2990089A1 (en) 2016-12-29
SI3313850T1 (sl) 2019-01-31
LT3313850T (lt) 2018-11-26
CO2017012830A2 (es) 2018-03-28
CN107709334B (zh) 2021-04-13
CN107709334A (zh) 2018-02-16
SA517390583B1 (ar) 2022-02-20
PH12017502266A1 (en) 2018-06-11
EA034587B1 (ru) 2020-02-25
AU2016282837B2 (en) 2020-05-28
GEP20207075B (en) 2020-03-10
MX2017016996A (es) 2018-08-23
CR20170571A (es) 2018-02-20
US20190031675A1 (en) 2019-01-31
BR112017027645A2 (pt) 2018-08-28
JP6741698B2 (ja) 2020-08-19
CU20170164A7 (es) 2018-05-08
PT3313850T (pt) 2018-11-29
CL2017003163A1 (es) 2018-06-15
CY1120991T1 (el) 2019-12-11
CR20170590A (es) 2018-02-26
RU2018102372A3 (es) 2019-11-06

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