ES8501372A1 - Un procedimiento para la manufactura de cefoperazona sodica cristalina. - Google Patents

Un procedimiento para la manufactura de cefoperazona sodica cristalina.

Info

Publication number
ES8501372A1
ES8501372A1 ES524220A ES524220A ES8501372A1 ES 8501372 A1 ES8501372 A1 ES 8501372A1 ES 524220 A ES524220 A ES 524220A ES 524220 A ES524220 A ES 524220A ES 8501372 A1 ES8501372 A1 ES 8501372A1
Authority
ES
Spain
Prior art keywords
manufacture
sodium cefoperazone
cefoperazone
sodium
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524220A
Other languages
English (en)
Other versions
ES524220A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES524220A0 publication Critical patent/ES524220A0/es
Publication of ES8501372A1 publication Critical patent/ES8501372A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA MANUFACTURA DE CEFOPERAZONA SODICA CRISTALINA.CONSISTE EN COMBINAR UNA SOLUCION HIDROACETONICA QUE CONTIENE ALREDEDOR DE 3 A 30 EN PESO/VOLUMEN DE CEFOPERAZONA SODICA CON CUATRO VOLUMENES DE UNA SOLUCION DE ACETONA-CLORURO DE METILO (95:5 EN VOLUMEN), A UNA TEMPERATURA DE 5-40JC Y SEPARAR POR FILTRACION Y SECAR A VACIO (1,5 MM HG) A 42JC LA CEFOPERAZONA SODICA CRISTALINA RESULTANTE. LA SOLUCION HIDROACETONICA SE FORMA IN SITU POR COMBINACION DE UNA SOLUCION O SUSPENSION ACETONICA QUE CONTIENE ALREDEDOR DE 5 A 35 EN PESO/VOLUMEN DE CEFOPERAZONA EN FORMA DE ACIDO LIBRE CON UNA SOLUCION ACUOSA QUE CONTIENE ALREDEDOR DE UN EQUIVALENTE DE UNA BASE SELECCIONADA ENTRE EL GRUPO FORMADO POR HIDROXIDO SODICO, CARBONATO SODICO Y BICARBONATO SODICO.TIENE APLICACION COMO ANTIBIOTICO DE BBB-LACTOMA DE AMPLIO ESPECTRO.
ES524220A 1982-07-19 1983-07-18 Un procedimiento para la manufactura de cefoperazona sodica cristalina. Expired ES8501372A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/399,400 US4458070A (en) 1982-07-19 1982-07-19 Process for the manufacture of crystalline sodium cefoperazone

Publications (2)

Publication Number Publication Date
ES524220A0 ES524220A0 (es) 1984-11-16
ES8501372A1 true ES8501372A1 (es) 1984-11-16

Family

ID=23579363

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524220A Expired ES8501372A1 (es) 1982-07-19 1983-07-18 Un procedimiento para la manufactura de cefoperazona sodica cristalina.

Country Status (29)

Country Link
US (1) US4458070A (es)
EP (1) EP0101170B1 (es)
JP (1) JPS5929692A (es)
KR (1) KR860001495B1 (es)
AU (1) AU537776B2 (es)
CA (1) CA1190219A (es)
CS (1) CS235331B2 (es)
DD (1) DD213219A5 (es)
DE (1) DE3361849D1 (es)
DK (1) DK152051C (es)
EG (1) EG16058A (es)
ES (1) ES8501372A1 (es)
FI (1) FI75169C (es)
GR (1) GR79593B (es)
GT (1) GT198302734A (es)
HK (1) HK99487A (es)
HU (1) HU192961B (es)
IE (1) IE55433B1 (es)
IL (1) IL69261A (es)
MY (1) MY8700729A (es)
NO (1) NO161743C (es)
NZ (1) NZ204930A (es)
PH (1) PH19441A (es)
PL (1) PL145167B1 (es)
PT (1) PT77041B (es)
SG (1) SG69787G (es)
SU (1) SU1194281A3 (es)
YU (1) YU44123B (es)
ZA (1) ZA835201B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1242699A (en) * 1985-02-01 1988-10-04 Bristol-Myers Company Cefbuperazone and derivatives thereof
CN101863907B (zh) * 2010-07-07 2012-05-23 福建省福抗药业股份有限公司 一种头孢哌酮钠的结晶方法
CN104470933A (zh) * 2012-07-17 2015-03-25 中化帝斯曼制药有限公司荷兰公司 头孢哌酮钠新晶型
CN104327099A (zh) * 2014-09-29 2015-02-04 联合康兴（北京）医药科技有限公司 头孢哌酮钠化合物实体及组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087424A (en) * 1974-05-09 1978-05-02 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
GB1508071A (en) * 1976-01-19 1978-04-19 Toyama Chemical Co Ltd Cephalosporins and process for producing the same
DE2600880C2 (de) * 1976-01-12 1984-09-13 Toyama Chemical Co. Ltd., Tokio / Tokyo Cephalosporinverbindungen
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration

Also Published As

Publication number Publication date
DK330083A (da) 1984-01-20
EP0101170B1 (en) 1986-01-15
MY8700729A (en) 1987-12-31
IE55433B1 (en) 1990-09-12
ES524220A0 (es) 1984-11-16
JPH0157115B2 (es) 1989-12-04
SG69787G (en) 1988-02-19
GR79593B (es) 1984-10-31
KR840005456A (ko) 1984-11-12
NO832598L (no) 1984-01-20
EG16058A (en) 1987-10-30
PT77041B (en) 1986-04-09
NO161743B (no) 1989-06-12
DE3361849D1 (en) 1986-02-27
NO161743C (no) 1989-09-20
US4458070A (en) 1984-07-03
GT198302734A (es) 1984-12-25
EP0101170A1 (en) 1984-02-22
CA1190219A (en) 1985-07-09
PL145167B1 (en) 1988-08-31
DK152051B (da) 1988-01-25
DD213219A5 (de) 1984-09-05
YU44123B (en) 1990-02-28
SU1194281A3 (ru) 1985-11-23
FI832605A (fi) 1984-01-20
ZA835201B (en) 1985-02-27
DK330083D0 (da) 1983-07-18
AU537776B2 (en) 1984-07-12
YU154083A (en) 1986-06-30
PL243006A1 (en) 1984-08-13
KR860001495B1 (ko) 1986-09-27
FI75169B (fi) 1988-01-29
IE831666L (en) 1984-01-19
JPS5929692A (ja) 1984-02-16
IL69261A (en) 1987-03-31
DK152051C (da) 1988-08-29
HK99487A (en) 1987-12-31
IL69261A0 (en) 1983-11-30
PT77041A (en) 1983-08-01
HU192961B (en) 1987-08-28
FI75169C (fi) 1988-05-09
PH19441A (en) 1986-04-18
NZ204930A (en) 1985-12-13
FI832605A0 (fi) 1983-07-18
CS235331B2 (en) 1985-05-15
AU1692283A (en) 1984-01-26

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